Elevated serum parathyroid hormone concentration during treatment with high ceiling diuretics.

abstract：:Eight patients were given flunitrazepam 2 mg orally, once daily for 28 consecutive days. The time-course of the plasma concentration of unchanged flunitrazepam and its principal metabolites were studied in detail after the first and last doses. Additional blood samples were collected immediately before administration ...

journal_title：European journal of clinical pharmacology

authors： Wickstrøm E,Amrein R,Haefelfinger P,Hartmann D

更新日期：1980-01-01 00:00:00

abstract：:The plasma levels and myocardial content of verapamil and its metabolites norverapamil, N-dealkylverapamil and N-dealkylnorverapamil were determined in 15 patients with valvular [3] or ischaemic [12] heart disease. The mean myocardial plasma concentration ratio (M/P) was 7.05 for verapamil, 11.45 for norverapamil, 8.9...

journal_title：European journal of clinical pharmacology

authors： Padrini R,Barbieri E,Piovan D,Toffoli M,Motta A,Trevi GP,Ferrari M

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical function...

journal_title：European journal of clinical pharmacology

authors： Sanders LMJ,Hortobágyi T,van Staveren G,Taxis K,Boersma F,Klein HC,Bossers WJR,Blankevoort CG,Scherder EJA,Van der Zee EA,van Heuvelen MJG

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Valsartan (V), a specific inhibitor of the angiotensin II receptor subtype, AT1, has been developed for treatment of hypertension. Combination therapy with a beta-adrenoceptor blocking agent might be considered in cases with insufficient efficacy of V alone. Therefore, an interaction trial was performed to ev...

journal_title：European journal of clinical pharmacology

authors： Czendlik CH,Sioufi A,Preiswerk G,Howald H

更新日期：1997-01-01 00:00:00

abstract：:The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 d...

journal_title：European journal of clinical pharmacology

authors： MacFarland RT,Marcus FI,Fenster PE,Graves PE,Perrier D

更新日期：1984-01-01 00:00:00

abstract：:Theophylline disposition after an intravenous test dose of aminophylline was determined in 83 subjects: 7 patients with and 58 without congestive heart failure (CHF), and 18 healthy controls. Based on the pharmacokinetics of theophylline in the individual, the oral dosage of aminophylline was scheduled to attain stead...

journal_title：European journal of clinical pharmacology

authors： Horai Y,Ishizaki T,Sasaki T,Watanabe M,Kabe J

更新日期：1982-01-01 00:00:00

abstract：:It is uncertain as to the extent which gastrointestinal (GI) haemorrhage related to NSAIDs is due to a local, topical effect or to an action related to systemic absorption. We hypothesised that, should systemic drug concentrations be of importance, plasma levels of NSAIDs might be higher in patients who had developed ...

journal_title：European journal of clinical pharmacology

authors： Wynne HA,Rawlins MD

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:To correct overdosing of drugs requiring adjustment based on renal function in intensive-care patients. METHODS:In a prospective intervention study, we estimated individual glomerular filtration rate and assessed whether medication required dose adjustment based on renal function. Senior clinicians received a ...

journal_title：European journal of clinical pharmacology

authors： Bertsche T,Fleischer M,Pfaff J,Encke J,Czock D,Haefeli WE

更新日期：2009-08-01 00:00:00

abstract：:The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pl...

journal_title：European journal of clinical pharmacology

authors： Otero MJ,Garcia MJ,Barrueco M,Dominguez-Gil A,Gomez F,Portugal Alvarez J

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:We proposed a statistical criterion to detect drug-drug interactions causing adverse drug reactions in spontaneous reporting systems. METHODS:The used criterion quantitatively measures the discrepancy between the observed and expected number of adverse events via chi-square statistics. We compared the performa...

journal_title：European journal of clinical pharmacology

authors： Gosho M,Maruo K,Tada K,Hirakawa A

更新日期：2017-06-01 00:00:00

abstract：AIM:The investigations reported here aimed to evaluate the incremental benefit for dose finding by concentration-response analysis versus dose-response analysis. METHODS:Trials were simulated using an Emax model for a range of scenarios of drug properties, trial design options and target response levels. The simulated...

journal_title：European journal of clinical pharmacology

authors： Berges A,Chen C

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:To test whether treatment with fenofibrate decreases asymmetric dimethylarginine (ADMA) level in hypertriglyceridemic individuals. METHODS:In the present study, 45 subjects with hypertriglyceridemia were recruited to receive treatment with fenofibrate (200 mg/d). Serum concentrations of ADMA, malondialdehyde...

journal_title：European journal of clinical pharmacology

authors： Yang TL,Chen MF,Xia X,Luo BL,Li YJ

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:This study was performed to investigate whether it is possible to use saliva instead of blood usually used for therapeutic drug monitoring (TDM) of disopyramide. METHODS:Six healthy male volunteers ingested 200 mg of disopyramide base, and the disopyramide concentrations in saliva and plasma (total and unbou...

journal_title：European journal of clinical pharmacology

authors： Sagawa K,Mohri K,Shimada S,Shimizu M,Muramatsu J

更新日期：1997-01-01 00:00:00

abstract：:Investigations were undertaken to evaluate which uraemic solutes decrease drug protein binding. This was done by performing HPLC-fractionation of uraemic biological fluids and studying the effect of addition of a lyophilisate of each fraction to normal plasma containing standard quantities of radiolabelled drugs. From...

journal_title：European journal of clinical pharmacology

authors： Vanholder R,De Smet R,Ringoir S

更新日期：1993-01-01 00:00:00

abstract：:The aim of laboratory screening in Phase I is to exclude subjects with subclinical illness, who might be at increased risk in the study, and who might also adversely influence interpretation of the results. A new method for laboratory screening, based on Bayesian probability theory, is proposed, which consists of: 1. ...

journal_title：European journal of clinical pharmacology

authors： Sibille M,Vital Durand D

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study aims to explore exposure-response relationship for panobinostat in this ...

journal_title：European journal of clinical pharmacology

authors： Mu S,Kuroda Y,Shibayama H,Hino M,Tajima T,Corrado C,Lin R,Waldron E,Binlich F,Suzuki K

更新日期：2016-02-01 00:00:00

abstract：:Plasma concentrations of nitrazepam were measured by gas-liquid chromatography in: young healthy volunteers, in geriatric and psychiatric patients and in epileptic children. The disposition of nitrazepam was described in terms of a two-compartment open model. After a single oral dose of nitrazepam 5 mg the most promin...

journal_title：European journal of clinical pharmacology

authors： Kangas L,Iisalo E,Kanto J,Lehtinen V,Pynnönen S,Ruikka I,Salminen J,Sillanpää M,Syvälahti E

更新日期：1979-04-17 00:00:00

abstract：OBJECTIVE:In vitro studies with human liver microsomes have suggested that the oxidative conversion of mexiletine (MX) to its metabolites is catalyzed by CYP2D6 and is significantly impaired in microsomes with the CYP2D6*10/*10 genotype. Therefore, we examined the influence of the CYP2D6*10 allele on MX pharmacokinetic...

journal_title：European journal of clinical pharmacology

authors： Otani M,Fukuda T,Naohara M,Maune H,Senda C,Yamamoto I,Azuma J

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:Adverse drug reactions as well as vitamin D deficiency are issues of public health concern in older people. However, relatively little is known about the impact of drug use on vitamin D status. Our primary aim is to explore associations between drug use and vitamin D status in older people. Furthermore, prevale...

journal_title：European journal of clinical pharmacology

authors： van Orten-Luiten AC,Janse A,Dhonukshe-Rutten RA,Witkamp RF

更新日期：2016-05-01 00:00:00

abstract：PURPOSE:The study aimed to test the hypothesis that hospital electronic prescribing and medicine administration system (HEPMA) implementation impacted patient discharge letter quality, nature and frequency of prescribing errors. METHOD:A quasi experimental before and after retrospective case note review was conducted ...

journal_title：European journal of clinical pharmacology

authors： Mills PR,Weidmann AE,Stewart D

更新日期：2017-10-01 00:00:00

abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

journal_title：European journal of clinical pharmacology

authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

更新日期：1992-01-01 00:00:00

abstract：:The metabolism of hydralazine in a group of slow acetylator patients with the drug-induced lupus syndrome was compared with the metabolism in asymptomatic control subjects. There were no toxicologically significant difference in metabolite excretion between the groups which reached statistical significance, although t...

journal_title：European journal of clinical pharmacology

authors： Timbrell JA,Facchini V,Harland SJ,Mansilla-Tinoco R

更新日期：1984-01-01 00:00:00

abstract：:In a double-blind, placebo-controlled study nasal saline and histamine provocation tests were performed in patients with perennial allergic rhinitis in order to assess changes in eosinophil influx and non-specific nasal reactivity after 8 days of treatment with ipratropium bromide. A "nasal pool" method was used to tr...

journal_title：European journal of clinical pharmacology

authors： Górski P,Pazdrak K,Ruta U

更新日期：1993-01-01 00:00:00

abstract：:The effect of dexfenfluramine (dF) on body weight, blood pressure and noradrenergic activity were studied in 30 obese hypertensive patients randomly divided into two groups and treated for 3 months either with dF (30 mg daily; 16 subjects) or placebo (Pl; 14 subjects). 11 patients from the dF group and 9 patients give...

journal_title：European journal of clinical pharmacology

authors： Kolanowski J,Younis LT,Vanbutsele R,Detry JM

更新日期：1992-01-01 00:00:00

abstract：:The use of cimetidine in general practice was studied in relation to the guidelines approved by the Dutch National Drug Regulatory Agency (DRA). National and regional figures showed that the frequency with which cimetidine was prescribed in general practice was greater than could be explained on the basis of approved ...

journal_title：European journal of clinical pharmacology

authors： Haayer FM,van der Werf GT,Wieringa NF,Wesseling H

更新日期：1983-01-01 00:00:00

abstract：:The benzamide-derivative moclobemide (Ro 11-1163) is a new short-acting, reversible MAO-inhibitor, preferentially affecting Type A MAO, which is, being developed as an antidepressant agent. The effect of moclobemide on heart rate, blood pressure, electrocardiographic and systolic time intervals was assessed in eight h...

journal_title：European journal of clinical pharmacology

authors： Gasic S,Korn A,Eichler HG,Oberhummer I,Zapotoczky HG

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Nevirapine (NVP) is a non-nucleoside reverse transcriptase inhibitor, widely prescribed for type 1 human immunodeficiency virus infection. A small proportion of individuals treated with NVP experience severe cutaneous adverse events, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)....

journal_title：European journal of clinical pharmacology

authors： Ciccacci C,Di Fusco D,Marazzi MC,Zimba I,Erba F,Novelli G,Palombi L,Borgiani P,Liotta G

更新日期：2013-11-01 00:00:00

abstract：:The effect of procainamide (P) on left ventricular function as measured by the systolic time intervals (STI) was studied in 14 patients with primary myocardial disease. P, 7.5 mg/kg body weight, was given intravenously at a rate of 100 mg per minute. Administration of P produced a decrease in left ventricular performa...

journal_title：European journal of clinical pharmacology

authors： Geleris P,Boudoulas H,Schaal SF,Lewis RP,Lima JJ

更新日期：1980-10-01 00:00:00

abstract：PURPOSE:this study aimed to investigate the effect of antivirals ritonavir and lopinavir/ritonavir on the pharmacokinetics and pharmacodynamics of oral oxycodone, a widely used opioid receptor agonist used in the treatment of moderate to severe pain. METHODS:a randomized crossover study design with three phases at int...

journal_title：European journal of clinical pharmacology

authors： Nieminen TH,Hagelberg NM,Saari TI,Neuvonen M,Neuvonen PJ,Laine K,Olkkola KT

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To investigate the usefulness of the 3-hydroxylation of quinine as a biomarker reaction for the activity of CYP3A4 in man and to study the interindividual variation in the metabolic ratio (MR), i.e. quinine/3-hydroxyquinine. METHODS:Data from a previous study (A) was used for determination of the MR of quini...

journal_title：European journal of clinical pharmacology

authors： Mirghani RA,Ericsson O,Tybring G,Gustafsson LL,Bertilsson L

更新日期：2003-05-01 00:00:00