Association between CYP2B6 polymorphisms and Nevirapine-induced SJS/TEN: a pharmacogenetics study.

abstract：PURPOSE:The aim of this study was to assess the pharmacokinetics and protein binding of cefazolin in morbidly obese patients undergoing bariatric surgery, to study the influence of bodyweight measures and age on pharmacokinetic parameters and to evaluate unbound cefazolin concentrations over time in this population. M...

journal_title：European journal of clinical pharmacology

authors： van Kralingen S,Taks M,Diepstraten J,van de Garde EM,van Dongen EP,Wiezer MJ,van Ramshorst B,Vlaminckx B,Deneer VH,Knibbe CA

更新日期：2011-10-01 00:00:00

abstract：:Hemodynamic changes for 30 min after intravenous administration of molsidomin 4 mg were studied in 10 patients. Pulmonary artery pressure, pulmonary wedge pressure, right atrial pressure and aortic pressure decreased significantly after 15 min, and after 30 min they were still below the control level. Heart rate incre...

journal_title：European journal of clinical pharmacology

authors： Karsch KR,Rentrop KP,Blanke H,Kreuzer H

更新日期：1978-06-19 00:00:00

abstract：BACKGROUND:Tamoxifen is one of the cornerstones of endocrine therapy for breast cancer. Recently, the decreased activity CYP3A4*22 allele and the loss of function CYP3A5*3 allele have been described as potential factors that could help to explain the inter-patient variability in tamoxifen metabolism. The aim of this st...

journal_title：European journal of clinical pharmacology

authors： Sanchez Spitman AB,Moes DJAR,Gelderblom H,Dezentje VO,Swen JJ,Guchelaar HJ

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Current evidence suggests that erythropoiesis-stimulating agents (ESAs), including erythropoietin and darbepoetin, may have a direct cardio-protective effect. However, randomized controlled trials (RCTs) assessing the efficacy and safety of ESAs in patients with acute ST-segment elevation myocardial infarction ...

journal_title：European journal of clinical pharmacology

authors： Li J,Xu H,Gao Q,Wen Y

更新日期：2012-05-01 00:00:00

abstract：:The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxyc...

journal_title：European journal of clinical pharmacology

authors： Merkel U,Sigusch H,Hoffmann A

更新日期：1994-01-01 00:00:00

abstract：:The pharmacokinetic parameters of deacetyl metipranolol were determined after i.v. infusion of increasing doses (6-25mg) in 17 normal volunteers. In a second cross-over trial, deacetyl metipranolol 10 and 20mg were infused in a further 10 subjects, and in a third trial another 20 volunteers received metipranolol 40mg ...

journal_title：European journal of clinical pharmacology

authors： Abshagen U,Betzien G,Kaufmann B,Endele G

更新日期：1982-01-01 00:00:00

abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

journal_title：European journal of clinical pharmacology

authors： Kostev K,Jacob L

更新日期：2019-05-01 00:00:00

abstract：:We have evaluated the effects of repaglinide, a new non-sulphonylurea oral hypoglycaemic agent that has a stimulatory effect on insulin secretion. Forty-four patients with NIDDM, already treated with a sulphonylurea, took part in an open, randomised, group comparison study of 12 weeks duration, during which they recei...

journal_title：European journal of clinical pharmacology

authors： Wolffenbuttel BH,Nijst L,Sels JP,Menheere PP,Müller PG,Kruseman AC

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Fexofenadine is the active metabolite of the non-sedating anti-histamine terfenadine. Pre-licensing clinical trials in over 6000 patients suggested it was effective and well tolerated. OBJECTIVE:To assess the tolerability and safety of fexofenadine immediately after its availability on the UK market in Marc...

journal_title：European journal of clinical pharmacology

authors： Craig-McFeely PM,Acharya NV,Shakir SA

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:Psychotropic drug use among nursing home residents with regard to diagnostic indications and patient- and institution characteristics was analysed. METHODS:A cross-sectional study of medication data from 1552 residents at 23 nursing homes in Bergen, Norway, was performed. Psychotropic drug use (neuroleptics,...

journal_title：European journal of clinical pharmacology

authors： Ruths S,Straand J,Nygaard HA

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVES:Evidence exists to suggest that diclofenac is metabolised by CYP2C9. The present study was undertaken in order to evaluate the effect of the single CYP2C9*3 variant on drug metabolism using diclofenac as a probe drug. METHODS:A single dose of diclofenac was administered orally to 12 healthy subjects in whom...

journal_title：European journal of clinical pharmacology

authors： Shimamoto J,Ieiri I,Urae A,Kimura M,Irie S,Kubota T,Chiba K,Ishizaki T,Otsubo K,Higuchi S

更新日期：2000-04-01 00:00:00

abstract：:In Belgium, all dispensed drugs are provided with package inserts. Traditional physician-orientated inserts are gradually being replaced by patient package inserts (PPIs). The present survey is focused on the use of inserts for antihypertensive drugs and their impact on the reported occurrence and attribution of adver...

journal_title：European journal of clinical pharmacology

authors： Van Haecht CH,Vander Stichele R,Bogaert MG

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:The aim of this study is to validate medication proxies for the identification of children diagnosed with atopic disorders that can be applied in various types of epidemiological research. METHODS:Records of 7439 children, aged between 0 and 10 years, in the period 2001 until 2010, were retrieved from the Regi...

journal_title：European journal of clinical pharmacology

authors： Mulder B,Groenhof F,Kocabas LI,Bos HJ,De Vries TW,Hak E,Schuiling-Veninga C

更新日期：2016-01-01 00:00:00

abstract：:In an open triple crossover study in 8 patients with essential hypertension, the possibility has been investigated of whether the blood pressure lowering effect of hydrochlorothiazide 50 mg once daily was attenuated by co-administration for 4 weeks of ibuprofen 400 mg t.i.d., diclofenac 25 mg t.i.d. or sulindac 200 mg...

journal_title：European journal of clinical pharmacology

authors： Koopmans PP,Thien T,Gribnau FW

更新日期：1987-01-01 00:00:00

abstract：:The antihypertensive effect of a new vasodilator with betablocking properties (SK & F 92657) was investigated in 10 patients with mild to moderate essential hypertension. After a mean treatment period of 26,5 weeks (6,5-49 weeks) blood pressure was significantly reduced, from 168 +/- 22/106 +/- 6 mmHg to 144 +/- 19/94...

journal_title：European journal of clinical pharmacology

authors： Lüscher T,Havelka J,Greminger P,Tuma J,Täuber M,Siegenthaler W,Vetter W

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of the CYP2D6 genotype on the pharmacokinetics of tropisetron in healthy Korean subjects. METHODS:A single 5-mg capsule of tropisetron was administered orally to 13 healthy subjects. Plasma concentrations were determined by validated HPLC procedures and data were analyzed by using nonc...

journal_title：European journal of clinical pharmacology

authors： Kim MK,Cho JY,Lim HS,Hong KS,Chung JY,Bae KS,Oh DS,Shin SG,Lee SH,Lee DH,Min B,Jang IJ

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Bariatric surgery can influence the prevalence and incidence of comorbidities, as well as the pharmacokinetics of drugs. This might lead to changes in the use of drugs. This study aimed to assess the influence of bariatric surgery on the use of medication in patients before and after surgery, focusing on type, ...

journal_title：European journal of clinical pharmacology

authors： Yska JP,van der Meer DH,Dreijer AR,Eilander W,Apers JA,Emous M,Totté ER,Wilffert B,van Roon EN

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:Persistence to statins is low, in part due to lack of perception of cardiovascular (CV) risk. High values of low-density lipoprotein cholesterol (LDL-C) might increase the motivation for patients to be persistent. We investigated whether the baseline LDL-C value influences the discontinuation of statin treatmen...

journal_title：European journal of clinical pharmacology

authors： Citarella A,Linder M,Kieler H,Berglind IA,Sundström A,Wettermark B,Andersen M

更新日期：2016-03-01 00:00:00

abstract：:The effect beta-adrenoceptor blockade on the pressor response to tyramine has been investigated in 6 healthy volunteers, each submitted to an i.v. tyramine pressor test before and after 7 days of propranolol 40 mg b.d. or indenolol 60 mg o.d. Tyramine was given as i.v. boluses of 1-6 mg, alternating with saline, in a ...

journal_title：European journal of clinical pharmacology

authors： Colombo F,Sega R,Mailland F,Rigo R,Palvarini L,Libretti A

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:We investigated the frequencies of the functionally important variants of the CYP2A6 gene in black African populations. METHODS:Using genomic DNA sequencing, polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR, the allele frequencies of CYP2A6 *1A, *1B, *2, *4A, *...

journal_title：European journal of clinical pharmacology

authors： Gyamfi MA,Fujieda M,Kiyotani K,Yamazaki H,Kamataki T

更新日期：2005-02-01 00:00:00

abstract：PURPOSE:Although CYP3A4/5 enzymes play the predominant role in the metabolism of simvastatin and lovastatin, polymorphisms in CYP2D6 were reported to be associated with the cholesterol-lowering effect and/or tolerability of simvastatin. This study was performed to examine whether common CYP2D6 polymorphisms affect the ...

journal_title：European journal of clinical pharmacology

authors： Yin OQ,Mak VW,Hu M,Fok BS,Chow MS,Tomlinson B

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Visual hallucinations (VHs) are frequent non-motor complication of Parkinson's disease (PD), associated to a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and psychosis in Alzheimer's disease, addictions, schizophrenia, and bipolar disorder. Howe...

journal_title：European journal of clinical pharmacology

authors： Ferrari M,Comi C,Marino F,Magistrelli L,De Marchi F,Cantello R,Riboldazzi G,Bono G,Cosentino M

更新日期：2016-11-01 00:00:00

abstract：:A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

journal_title：European journal of clinical pharmacology

authors： Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

更新日期：1979-09-01 00:00:00

abstract：:The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance...

journal_title：European journal of clinical pharmacology

authors： Voet D,Mareels S,Afschrift M,De Buyzere M,Rietzschel E,Duprez D

更新日期：1995-01-01 00:00:00

abstract：:The pharmacokinetics of biperiden was studied and compared with pharmacodynamics (pupil size, accommodation, self-rating mood scale) in 6 healthy volunteers. A single-blind cross-over design was employed with placebo and biperiden (4 mg as commercially available tablets). After a lag time of 0.5 h, biperiden was rapid...

journal_title：European journal of clinical pharmacology

authors： Hollmann M,Brode E,Greger G,Müller-Peltzer H,Wetzelsberger N

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVE:The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP > or = 115 mmHg). PATIENTS:The ages of the patients ranged from...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Afolabi MA,Balogun MO,Adigun AQ,Ajayi OE,Akintomide AO

更新日期：1996-01-01 00:00:00

abstract：:The pharmacokinetic profiles of transdermal timolol 6 and 24 mg (as 5 and 20% w/v patches) was studied in four healthy young volunteers. To assess its bioavailability, the pharmacokinetics of an IV infusion of timolol maleate 5 mg was also determined in the same subjects. When the 20% (w/v) timolol patch was applied, ...

journal_title：European journal of clinical pharmacology

authors： Kubota K,Yamada T,Kikuchi K,Koyama E,Ishizaki T

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Pharmacokinetic parameters are important for dose adjustment of aminoglycosides, but they are highly variable in neonates. In this study the pharmacokinetics of a netilmicin loading dose was investigated on the first postnatal day in preterm neonates with very low gestational age (GA). METHODS:In an open pro...

journal_title：European journal of clinical pharmacology

authors： Rengelshausen J,Beedgen B,Tsamouranis K,Mikus G,Walter-Sack I,Haefeli WE,Linderkamp O

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVE:To assess the initial uptake in use and co-prescribing patterns of sildenafil. METHODS:We examined prescription details of the Eastern Health Board Region (including Dublin) of the General Medical Services (GMS) in Ireland, which provides detail on prescriptions dispensed in primary care for this population ...

journal_title：European journal of clinical pharmacology

authors： Williams D,Feely J

更新日期：2001-03-01 00:00:00

abstract：:We gave 24 healthy elderly volunteers with a perceived sleep onset of at least 30 minutes zolpidem 5 mg, zolpidem 10 mg, or placebo for 7 days in a double-blind, three-way, crossover study. The morning after nocturnal dosing, psychomotor performance and cognitive ability were measured using tests which are sensitive t...

journal_title：European journal of clinical pharmacology

authors： Fairweather DB,Kerr JS,Hindmarch I

更新日期：1992-01-01 00:00:00