Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.

abstract：:The effects of a 10 day administration of clomipramine (25-50 mg t.i.d.), alprazolam (0.25-0.75 mg t.i.d.) and placebo were assessed in normal volunteers in a double-blind cross-over study. A battery of physiological, psychomotor and cognitive tests was administered both before and 3 h after drug on days 1, 5 and 10. ...

journal_title：European journal of clinical pharmacology

authors： Allen D,Curran HV,Lader M

更新日期：1991-01-01 00:00:00

abstract：:The effects of acute introduction and withdrawal of trimeprazine (Vallergan), an antihistaminic phenothiazine derivative with known sedative effects, were investigated by a single blind polygraphic study in 8 healthy volunteers. A baseline placebo was given on Nights 1-3, followed either by 10 mg or 20 mg of the drug ...

journal_title：European journal of clinical pharmacology

authors： Kayed K,Hansen T,Godtlibsen OB

更新日期：1977-03-11 00:00:00

abstract：:We have given 12 healthy subjects the H1-antihistamine ebastine (20 mg) or placebo in a double-blind, crossover study for one week each. The subjects were tested for drug effects on Day 6 of each period, and for interactions of ebastine with ethanol (0.8 g.kg-1) on Day 7. On both days, the testing runs were done at ba...

journal_title：European journal of clinical pharmacology

authors： Mattila MJ,Kuitunen T,Plétan Y

更新日期：1992-01-01 00:00:00

abstract：:We have evaluated the effects of repaglinide, a new non-sulphonylurea oral hypoglycaemic agent that has a stimulatory effect on insulin secretion. Forty-four patients with NIDDM, already treated with a sulphonylurea, took part in an open, randomised, group comparison study of 12 weeks duration, during which they recei...

journal_title：European journal of clinical pharmacology

authors： Wolffenbuttel BH,Nijst L,Sels JP,Menheere PP,Müller PG,Kruseman AC

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:In a double blind, randomised, placebo-controlled, cross-over study 12 healthy male volunteers were allocated to receive felodipine + placebo, cyclosporine + placebo, and felodipine + cyclosporine in order to investigate the interaction between the calcium channel blocker felodipine and cyclosporine as it aff...

journal_title：European journal of clinical pharmacology

authors： Madsen JK,Jensen JD,Jensen LW,Pedersen EB

更新日期：1996-01-01 00:00:00

abstract：:Accidental intoxication with tramadol of a 6-month old infant was followed by severe cerebral depression. Studies on serum, cerebrospinal fluid, and urine drug levels indicated complete penetration of the blood-cerebrospinal fluid barrier by tramadol. ...

journal_title：European journal of clinical pharmacology

authors： Riedel F,von Stockhausen HB

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the pharmacokinetics and protein binding of cefazolin in morbidly obese patients undergoing bariatric surgery, to study the influence of bodyweight measures and age on pharmacokinetic parameters and to evaluate unbound cefazolin concentrations over time in this population. M...

journal_title：European journal of clinical pharmacology

authors： van Kralingen S,Taks M,Diepstraten J,van de Garde EM,van Dongen EP,Wiezer MJ,van Ramshorst B,Vlaminckx B,Deneer VH,Knibbe CA

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Because of the risk of haemorrhagic disease of the newborn as a result of a deficit in vitamin K, it is generally agreed that newborns should receive vitamin K. However, there is no consensus concerning the route of administration, dose, number of doses, or dose frequency. METHODS:We studied patterns of vita...

journal_title：European journal of clinical pharmacology

authors： Jonville-Bera AP,Autret E

更新日期：1997-01-01 00:00:00

abstract：:The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxyc...

journal_title：European journal of clinical pharmacology

authors： Merkel U,Sigusch H,Hoffmann A

更新日期：1994-01-01 00:00:00

abstract：PURPOSE:The existence of gender differences in the management of statin therapy among patients with chronic heart failure (HF) is still poorly investigated. We aimed at exploring the effect of gender on statin prescription rates and adequacy of dosing and on the association between statin therapy and all-cause 1-year m...

journal_title：European journal of clinical pharmacology

authors： Ballo P,Balzi D,Barchielli A,Turco L,Franconi F,Zuppiroli A

更新日期：2016-03-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs). METHODS:A cross-sectional study of 383 residents from six Australian RACFs was conducted. The pr...

journal_title：European journal of clinical pharmacology

authors： Lalic S,Jamsen KM,Wimmer BC,Tan EC,Hilmer SN,Robson L,Emery T,Bell JS

更新日期：2016-09-01 00:00:00

abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

journal_title：European journal of clinical pharmacology

authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

更新日期：1989-01-01 00:00:00

abstract：:The influence of time of drug administration on pharmacokinetics of theophylline was studied both after ingestion of a sustained-release tablet, containing choline theophyllinate ( Zy 15061-S. R.; Teovent ; Sabidal ; ZYMA S.A.) and after intravenous infusion of aminophylline to eight healthy volunteers. Both drugs wer...

journal_title：European journal of clinical pharmacology

authors： Jonkman JH,van der Boon WJ,Balant LP,Schoenmaker R,Holtkamp A

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:To assess (1) whether the utilisation of codeine or propoxyphene differs among the three major Swedish cities (Stockholm, Göteborg and Malmö) and between urban and semirural areas; (2) if so, whether it co-varies with the utilisation of other potentially dependence-promoting drugs, benzodiazepines; (3) what ...

journal_title：European journal of clinical pharmacology

authors： Henricson K,Carlsten A,Ranstam J,Rametsteiner G,Stenberg P,Wessling A,Melander A

更新日期：1999-10-01 00:00:00

abstract：PURPOSE:Preparation of parenteral medication in hospitals is a complex process with a risk of microbial contamination of the product, especially when inappropriately prepared. Contaminated parenteral medications can cause severe complications to patients and increase morbidity in hospitals. The aim of this literature r...

journal_title：European journal of clinical pharmacology

authors： Larmené-Beld KHM,Frijlink HW,Taxis K

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:To examine the effect of fluconazole, a potent inhibitor of CYP2C9 and CYP2C19, on the pharmacokinetics of rosuvastatin in healthy volunteers. Significantly increased plasma concentrations of fluvastatin have been observed following co-administration with fluconazole. METHODS:This was a randomised, double-bl...

journal_title：European journal of clinical pharmacology

authors： Cooper KJ,Martin PD,Dane AL,Warwick MJ,Schneck DW,Cantarini MV

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to clarify the stereoselective properties in lansoprazole metabolism by monitoring the metabolic consumption for each enantiomer and the formation of the main metabolites, lansoprazole sulfone and 5-hydroxylansoprazole, in the presence of human liver microsomal enzymes. METH...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Hamada A,Nakamura C,Arimori K,Nakano M

更新日期：2001-12-01 00:00:00

abstract：:The pharmacokinetics of midazolam has been studied in patients recovering from cardiac surgery, who required sedation for postoperative mechanical ventilation. Twelve males (mean age 64.5 years) with severe heart disease received an infusion of midazolam 15 mg.h-1 for 4 h, starting 1 to 3 h post surgery. Multiple bloo...

journal_title：European journal of clinical pharmacology

authors： Maitre PO,Funk B,Crevoisier C,Ha HR

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

journal_title：European journal of clinical pharmacology

authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was investigated in patients with septic shock. METHODS:Blood was sampled at intervals before, during and after 12-h infusion of L-NAME 1 mg x kg(-1) x h(-1) in nine septic shock patients for det...

journal_title：European journal of clinical pharmacology

authors： Avontuur JA,Buijk SL,Bruining HA

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Dosing of vancomycin in pediatric patients undergoing continuous venous-venous hemodiafiltration (CVVHDF) is challenging. Characterization of vancomycin pharmacokinetics can assist with dosing and attainment of goal serum concentrations. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS:Patient...

journal_title：European journal of clinical pharmacology

authors： Moffett BS,Morris J,Munoz F,Arikan AA

更新日期：2019-08-01 00:00:00

abstract：:The pharmacokinetic parameters of deacetyl metipranolol were determined after i.v. infusion of increasing doses (6-25mg) in 17 normal volunteers. In a second cross-over trial, deacetyl metipranolol 10 and 20mg were infused in a further 10 subjects, and in a third trial another 20 volunteers received metipranolol 40mg ...

journal_title：European journal of clinical pharmacology

authors： Abshagen U,Betzien G,Kaufmann B,Endele G

更新日期：1982-01-01 00:00:00

abstract：:The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Reiner A,Arrigoni Martelli E,Conte U,Colombo P,La Manna A

更新日期：1987-01-01 00:00:00

abstract：AIM:It has been reported that verapamil and atorvastatin are inhibitors of both P-glycoprotein (P-gp) and microsomal cytochrome P450 (CYP) 3A4, and verapamil is a substrate of both P-gp and CYP3A4. Thus, it could be expected that atorvastatin would alter the absorption and metabolism of verapamil. METHODS:The pharmaco...

journal_title：European journal of clinical pharmacology

authors： Choi DH,Shin WG,Choi JS

更新日期：2008-05-01 00:00:00

abstract：:The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-veno...

journal_title：European journal of clinical pharmacology

authors： Madsen PL,Vorstrup S,Schmidt JF,Paulson OB

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:The aims of the present analysis were to determine prevalence of transaminase elevation in placebo-treated healthy volunteers in our historical phase I clinical trials and to assess which factors were associated with it. METHODS:We performed a retrospective analysis of alanine transaminase (ALT) levels in 481 ...

journal_title：European journal of clinical pharmacology

authors： Cai Z,Christianson AM,Ståhle L,Keisu M

更新日期：2009-10-01 00:00:00

abstract：:The study was done in healthy volunteers to investigate the vasoconstrictor activity of three commercially available formulations of fluocinolone acetonide (Synalar gel, cream and ointment) and to determine whether they were bioequivalent. The influence of dilution of the cream formulation on activity was also examine...

journal_title：European journal of clinical pharmacology

authors： Gao HY,Li Wan Po A

更新日期：1994-01-01 00:00:00

abstract：:Amitriptyline has clinically important interactions with ethanol. Five healthy volunteers received 25 mg of amitriptyline orally, preceded by one hour and followed for eight hours by oral ethanol (or juice), dosed to achieve and maintain blood ethanol concentrations of 800 mg/l. In the presence of ethanol, amitriptyli...

journal_title：European journal of clinical pharmacology

authors： Dorian P,Sellers EM,Reed KL,Warsh JJ,Hamilton C,Kaplan HL,Fan T

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Although the treatment of schizophrenia with many second generation antipsychotics is known to be associated with metabolic changes, such as hyperglycemia or hypercholesterolemia, the underlying mechanisms of these adverse reactions remain unclear. In light of the recent focus on the involvement of semicarbaz...

journal_title：European journal of clinical pharmacology

authors： Roessner V,Weber A,Becker A,Beck G,Frieling H,Bleich S

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:To investigate possible differences in the time course of vasodilating effects of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in humans. METHODS:We measured forearm blood flow (FBF) by strain gauge plethymography and cyclic GMP spillover during and after intra-arterial infusions of BNP...

journal_title：European journal of clinical pharmacology

authors： Minami H,Yasu T,Tagawa T,Yamakawa K,Ueda S

更新日期：2008-09-01 00:00:00