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Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers.

Abstract：

:The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-venous oxygen difference and CBF. Studies were done before and 1 h after i.v. injection of 5 mg propranolol and after three weeks on oral propranolol 80 mg/d for 1 week and 160 mg/d for 2 weeks. Cerebrovascular CO2 reactivity in terms of the A-V oxygen difference was tested on all three occasions during hypercapnia and hyperventilation. CBF, CMRO2 and cerebrovascular CO2 reactivity remained stable both after acute and after 3 weeks of treatment with propranolol.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Madsen PL,Vorstrup S,Schmidt JF,Paulson OB

doi

10.1007/BF00315115

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

295-7

issue

3

eissn

0031-6970

issn

1432-1041

journal_volume

39

pub_type

杂志文章

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