Abstract：
:The pharmacokinetics of temocapril hydrochloride, a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, has been studied in patients with mild (Group II) to severe (Group III) renal insufficiency in comparison with subjects with normal renal function (Group I). The pharmacokinetic parameters of the active diacid metabolite, including Cmax, AUC and half-life (t1/2), showed only slight changes between the three groups: AUC (0-inaffinity) was significantly larger in Group III than Group I, and t1/2 tended to be prolonged in Group III, but the change was not significant. The urinary recovery of the diacid was significantly decreased in Group III. (Group I, 28.1%, Group II, 21.6%, Group III, 12.8%). Compared with other ACE inhibitors, which are mainly excreted through the kidney, the plasma concentration of the active diacid metabolite was hardly influenced by renal function. It was speculated that lowering of the dose of temocapril might be recommended only in patients with severe renal insufficiency.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Nakashima M,Yamamoto J,Shibata M,Uematsu T,Shinjo H,Akahori T,Shioya H,Sugiyama K,Kawahara Ydoi
10.1007/BF02284968subject
Has Abstractpub_date
1992-01-01 00:00:00pages
657-9issue
6eissn
0031-6970issn
1432-1041journal_volume
43pub_type
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journal_title：European journal of clinical pharmacology
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