Decreased and variable systemic availability of zidovudine in patients with AIDS if administered with a meal.

abstract：BACKGROUND:Zolmitriptan is a 5HT(1B/1D) receptor agonist effective in the acute treatment of migraine. Clinical trials in the USA and Europe have demonstrated the optimal oral therapeutic dose to be 2.5 mg. The 2.5-mg oral tablet has recently been licensed in Japan. OBJECTIVE:To compare the pharmacokinetics of zolmitr...

journal_title：European journal of clinical pharmacology

authors： Yates RA,Tateno M,Nairn K,Ikegami A,Dane A,Kemp J

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Opicapone is a novel third generation catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to compare the levodopa pharmacokinetic profile throughout a day driven by the COMT inhibition either following repeated doses of opicapone or concomitant administration with enta...

journal_title：European journal of clinical pharmacology

authors： Rocha JF,Falcão A,Santos A,Pinto R,Lopes N,Nunes T,Wright LC,Vaz-da-Silva M,Soares-da-Silva P

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Knowledge about the metabolism of anti-parasitic drugs (APDs) will be helpful in ongoing efforts to optimise dosage recommendations in clinical practise. This study was performed to further identify the cytochrome P(450) (CYP) enzymes that metabolise major APDs and evaluate the possibility of predicting in vi...

journal_title：European journal of clinical pharmacology

authors： Li XQ,Björkman A,Andersson TB,Gustafsson LL,Masimirembwa CM

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:This work aimed at building a population pharmacokinetic (PK) model for lamivudine (LMV), stavudine (STV) and zidovudine (ZDV), estimating their inter and intraindividual PK variability and investigating the influence of different covariates. METHODS:Population PK of LMV, STV and ZDV was separately evaluated...

journal_title：European journal of clinical pharmacology

authors： Panhard X,Legrand M,Taburet AM,Diquet B,Goujard C,Mentré F,Cophar 1 - ANRS 102 Study Group.

更新日期：2007-11-01 00:00:00

abstract：PURPOSE:The aim of this study was to examine whether educational meetings and group detailing could increase the use of drugs from the ward lists or the drug formulary in hospitals. METHODS:Twelve medical wards from two hospitals were randomized into three groups: control, basic and extended intervention. All wards ha...

journal_title：European journal of clinical pharmacology

authors： Plet HT,Kjeldsen LJ,Christensen Rde P,Nielsen GS,Hallas J

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

journal_title：European journal of clinical pharmacology

authors： Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Propofol anesthesia is usually accompanied by hypotensive responses, which are at least in part mediated by nitric oxide (NO). Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation. We examined here whether ARG1 and ARG2 ...

journal_title：European journal of clinical pharmacology

authors： Oliveira-Paula GH,Coeli-Lacchini FB,Ferezin LP,Ferreira GC,Pinheiro LC,Paula-Garcia WN,Garcia LV,Tanus-Santos JE,Lacchini R

更新日期：2021-01-07 00:00:00

abstract：:Guidelines presented previously for the analysis of plasma concentration versus time data for a drug exhibiting concentration-dependent plasma protein binding were successfully applied to the distributional parameters of a new cephalosporin, ceftriaxone. This approach provided several striking observations when the ph...

journal_title：European journal of clinical pharmacology

authors： McNamara PJ,Gibaldi M,Stoeckel K

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

journal_title：European journal of clinical pharmacology

authors： Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

更新日期：2013-06-01 00:00:00

abstract：:The concentrations of lormetazepam and its glucuronide in plasma and milk were determined during administration of 10 daily doses of lormetazepam 2 mg (2 tablets of Noctamid-1) to five mothers delivered by Caesarian section. Their babies were breast-fed throughout the study, and the plasma levels of lormetazepam and i...

journal_title：European journal of clinical pharmacology

authors： Hümpel M,Stoppelli I,Milia S,Rainer E

更新日期：1982-01-01 00:00:00

abstract：:We have studied the pharmacokinetics of tulobuterol given transdermally or by aerosol inhalation in healthy male volunteers. Tulobuterol was rapidly absorbed after inhalation, with a tmax of 0.8-1.5 h. The Cmax and the AUC increased linearly with dose. Tulobuterol was well absorbed after transdermal administration, wi...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakano M,Kosuge K,Kanamaru M,Nakashima M

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Pharmacology and pharmacotherapy education is being increasingly integrated in medical curricula, which might lead to a specific loss of knowledge in these subjects. This, in turn, could lead to harmful prescribing errors, especially in vulnerable older patients. METHODS:Teachers who coordinated education in D...

journal_title：European journal of clinical pharmacology

authors： Keijsers CJ,de Wit JE,Tichelaar J,Brouwers JR,de Wildt DJ,de Vries PG,Jansen PA

更新日期：2015-05-01 00:00:00

abstract：:A cross-over study of kinetics has been undertaken in 12 healthy adults volunteers using two sustained-release theophylline products that allow once a day dosing (Theo-Dur tablets and Dilatrane A.P. bead filled capsules) to compare the i.v. pharmacokinetic profiles when taken with an hyperlipidic meal and a balanced s...

journal_title：European journal of clinical pharmacology

authors： Brazier JL,Benchekroun Y,Gillet A,Andre C

更新日期：1989-01-01 00:00:00

abstract：:A study, using non-invasive techniques, was carried out in ten patients with essential hypertension to examine the mechanism of the hypotensive effect of propranolol when used in combination with a potent vasodilator antihypertensive - minoxidil. The hypotensive effect of minoxidil, a mean (+/- SEM) decrease of 42.4 +...

journal_title：European journal of clinical pharmacology

authors： O'Malley K,Velasco M,Wells J,McNay J

更新日期：1976-03-22 00:00:00

abstract：AIM:To analyse the consumption of a number of medicines with a known potential for increasing the risk of road traffic accidents in the general population of Europe. METHODS:Questionnaires were distributed through the European Drug Utilization Research Group (EuroDURG) and Post-Innovation Learning through Life-events ...

journal_title：European journal of clinical pharmacology

authors： Ravera S,Hummel SA,Stolk P,Heerdink RE,de Jong-van den Berg LT,de Gier JJ

更新日期：2009-11-01 00:00:00

abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

journal_title：European journal of clinical pharmacology

authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

更新日期：1986-01-01 00:00:00

abstract：:The four sulphonamides studied--furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid--bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the fou...

journal_title：European journal of clinical pharmacology

authors： Zini R,d'Athis P,Hoareau A,Tillement JP

更新日期：1976-06-15 00:00:00

abstract：OBJECTIVE:To study the main comedications associated with major bleeding during anticoagulant therapy with coumarins in a non-selected population under everyday circumstances. METHODS:The study population for this retrospective cohort study included all new users of phenprocoumon or acenocoumarol aged 40-80 years, dur...

journal_title：European journal of clinical pharmacology

authors： Penning-van Beest F,Erkens J,Petersen KU,Koelz HR,Herings R

更新日期：2005-07-01 00:00:00

abstract：:In healthy normal subjects following the administration of labetalol the pharmacological effects were measured and compared with the plasma concentrations achieved. The inhibition of exercise induced tachycardia and inhibition of exercise induced increases in systolic pressure were significantly related to the adminis...

journal_title：European journal of clinical pharmacology

authors： Richards DA,Maconochie JG,Bland RE,Hopkins R,Woodings EP,Martin LE

更新日期：1977-01-03 00:00:00

abstract：:In 8 healthy subjects the absorption of cimetidine was investigated when given alone, together with 60 ml aluminium/magnesium hydroxide containing antacid (neutralising capacity 26 mmol HCl/10 ml), and together with liquid metoclopramide 14 mg. The antacid significantly (P less than 0.01) reduced the bioavailability (...

journal_title：European journal of clinical pharmacology

authors： Gugler R,Brand M,Somogyi A

更新日期：1981-01-01 00:00:00

abstract：:The purpose of this study was to examine the influence of cigarette smoking and gender on the pharmacokinetics of metoprolol. Eighteen volunteers with no evidence of clinical disease each randomly received the following doses of metoprolol tartrate: 100 mg orally, 200 mg orally and 20 mg as a constant-rate intravenous...

journal_title：European journal of clinical pharmacology

authors： Schaaf LJ,Campbell SC,Mayersohn MB,Vagedes T,Perrier DG

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:Spontaneous reporting of adverse drug reactions (ADRs) is one approach to increasing our knowledge on the risks of drugs in clinical practice. Under-reporting is a shortcoming of this system. OBJECTIVES:To evaluate if repeated e-mails with attachments on ADR information can affect (1) the reporting of ADRs ...

journal_title：European journal of clinical pharmacology

authors： Johansson ML,Brunlöf G,Edward C,Wallerstedt SM

更新日期：2009-05-01 00:00:00

abstract：PURPOSE:Ticagrelor is a reversibly binding P2Y12 receptor antagonist for the prevention of atherothrombotic events in patients with acute coronary syndrome. Previous in vitro studies showed that ticagrelor is a substrate and inhibitor of P-glycoprotein (ABCB1). Therefore, we examined the potential interaction between d...

journal_title：European journal of clinical pharmacology

authors： Teng R,Butler K

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS:A randomized, double-blind, cross-over study design with two phases, which were separated by a washout pe...

journal_title：European journal of clinical pharmacology

authors： Kantola T,Kivistö KT,Neuvonen PJ

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:We examined the extent of concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications (CMs) and identified its associated factors. METHODS:A retrospective cohort study was conducted using one million random samples from the Longitudinal Health Insurance Database 2005 in Taiwan. High-ri...

journal_title：European journal of clinical pharmacology

authors： Tsai HH,Lin HW,Chien CR,Li TC

更新日期：2013-03-01 00:00:00

abstract：:In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Weeke B

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:Problem-oriented drug information is characterised by health professionals actively seeking drug information through various sources. In this study our objective was to determine the quality and impact of problem-oriented drug information among physicians. METHODS:Evaluation forms accompanying 163 written a...

journal_title：European journal of clinical pharmacology

authors： Schjøtt J,Pomp E,Gedde-Dahl A

更新日期：2002-02-01 00:00:00

abstract：:A randomised, placebo controlled clinical trial was conducted to examine the efficacy of a homeopathic after-bite gel in the symptomatic relief of mosquito bites. Sixty eight healthy volunteers were bitten under laboratory conditions by Aedes aegypti mosquitoes at three spots, on the ventral aspect of the forearm. One...

journal_title：European journal of clinical pharmacology

authors： Hill N,Stam C,Tuinder S,van Haselen RA

更新日期：1995-01-01 00:00:00

abstract：:Eight patients were given flunitrazepam 2 mg orally, once daily for 28 consecutive days. The time-course of the plasma concentration of unchanged flunitrazepam and its principal metabolites were studied in detail after the first and last doses. Additional blood samples were collected immediately before administration ...

journal_title：European journal of clinical pharmacology

authors： Wickstrøm E,Amrein R,Haefelfinger P,Hartmann D

更新日期：1980-01-01 00:00:00

abstract：:Twenty-four healthy volunteers participated in a study on the disposition of ergotamine following oral and rectal administration. Plasma samples were collected surrounding each dose of medication and a new mass spectrometry method was used for quantitation of the samples. A mean peak plasma concentration of 454 pg/ml ...

journal_title：European journal of clinical pharmacology

authors： Sanders SW,Haering N,Mosberg H,Jaeger H

更新日期：1986-01-01 00:00:00