Sequential versus concomitant therapy for treatment of Helicobacter pylori infection: an updated systematic review and meta-analysis.

abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

journal_title：European journal of clinical pharmacology

authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

更新日期：1992-01-01 00:00:00

abstract：:In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal, or after a test meal alone. The rise in serum insulin levels per...

journal_title：European journal of clinical pharmacology

authors： Mulder H,Schopman W Sr,van der Lely AJ

更新日期：1991-01-01 00:00:00

abstract：:Serum concentrations of parathyroid hormone (s-PTH) calcium, phosphorus and alkaline phosphatase were measured during treatment with furosemide or bumetanide for congestive heart failure. Significant elevations both of s-PTH and alkaline phosphatase were found, whereas serum calcium concentration was decreased. The ch...

journal_title：European journal of clinical pharmacology

authors： Elmgreen J,Tougaard L,Leth A,Christensen MS

更新日期：1980-10-01 00:00:00

abstract：:Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significant...

journal_title：European journal of clinical pharmacology

authors： Schmidt C,Gavoille R,Perez P,Schmitt J

更新日期：1989-01-01 00:00:00

abstract：:The effect of spironolactone on cardiac contractility indices was studied by externally recording systolic time intervals in four digitalized and four non-digitalized patients with ischaemic heart disease. A negative inotropic effect was found after spironolactone 100mg b.i.d. in all eight patients, as measured by an ...

journal_title：European journal of clinical pharmacology

authors： Waldorff S,Berning J,Buch J,Steiness E

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:The population pharmacokinetics (PK) of lopinavir in tuberculosis (TB)/human immunodeficiency virus (HIV) co-infected South African children taking super-boosted lopinavir (lopinavir/ritonavir ratio 1:1) as part of antiretroviral treatment in the presence of rifampicin were compared with the population PK of lo...

journal_title：European journal of clinical pharmacology

authors： Elsherbiny D,Ren Y,McIlleron H,Maartens G,Simonsson US

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:We investigated whether interindividual differences in the pharmacokinetic disposition of lansoprazole are attributed to the genetic polymorphism of CYP2C19 which occurred by two mutations. CYP2C19m1 and CYP2C19m2, in 20 Japanese subjects. METHODS:Polymerase chain reaction (PCR) restriction fragment length p...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Nakamura C,Arimori K,Fujiyama S,Nakano M

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:High-density lipoprotein (HDL)-associated antioxidant paraoxonase (PON) may reduce low-density lipoprotein (LDL) oxidation and prevent atherosclerosis. The aim of this present study was to investigate the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor atorvastatin on hydroge...

journal_title：European journal of clinical pharmacology

authors： Harangi M,Seres I,Varga Z,Emri G,Szilvássy Z,Paragh G,Remenyik E

更新日期：2004-12-01 00:00:00

abstract：:A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0-72 h), AUC...

journal_title：European journal of clinical pharmacology

authors： Benkö S,Grézal G,Nagy E,Klebovich I

更新日期：1992-01-01 00:00:00

abstract：:The effect of the GABAergic drug sodium valproate (SV) on the exercise-induced release of growth hormone (GH) was investigated in 10 healthy males. The exercise test consisted of using a stationary bicycle ergometer at 450 kg/min for 20 min. SV 600 mg blunted the increase in GH induced by the exercise, suggesting GABA...

journal_title：European journal of clinical pharmacology

authors： Steardo L,Iovino M,Monteleone P,Agrusta M,Orio F

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:To analyse reports of drug-induced myocardial infarction and chest pain sent to a national reporting centre. To review which drugs were suspected of exhibiting these adverse events and what mechanisms were involved. METHODS:During the 20-year period 1975 through 1994, a total of 19,141 reports on adverse re...

journal_title：European journal of clinical pharmacology

authors： Ottervanger JP,Wilson JH,Stricker BH

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:This multicenter, double-blind, placebo-controlled, parallel-group study was designed to assess the acute effects of intravenous mibefradil on the electrophysiologic characteristics of the human heart. METHODS:Seventy-one patients referred for routine electrophysiologic testing were randomized to receive one...

journal_title：European journal of clinical pharmacology

authors： Rosenquist M,Brembilla-Perrot B,Meinertz T,Neugebauer A,Crijns HJ,Smeets JL,van der Vring JA,Fromer M,Kobrin I

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To aid prescribers in assessing a patient's risk for statin-induced myopathy (SIM), we performed a comprehensive review of currently known risk factors and calculated aggregated odds ratios for each risk factor through a meta-analysis. METHODS:This meta-analysis was done through four phases: (1) Identification...

journal_title：European journal of clinical pharmacology

authors： Nguyen KA,Li L,Lu D,Yazdanparast A,Wang L,Kreutz RP,Whipple EC,Schleyer TK

更新日期：2018-09-01 00:00:00

abstract：:The systemic effects of single and multiple doses of inhaled fluticasone propionate (FP) and budesonide were examined in 24 healthy male volunteers (age range 18-29 years). The study was of an open, placebo-controlled, randomized, three-way crossover design. On each study day, multiple blood samples were taken over a ...

journal_title：European journal of clinical pharmacology

authors： Lönnebo A,Grahnén A,Jansson B,Brundin RM,Ling-Andersson A,Eckernäs SA

更新日期：1996-01-01 00:00:00

abstract：:The pharmacokinetics of lignocaine has been compared after epidural anaesthesia in diabetics and non-diabetic patients. Epidural lignocaine 8 mg.kg-1 was given to 8 well controlled Type II diabetic and 8 non-diabetic patients and the plasma drug concentration in serial blood samples were measured by HPLC. The plasma l...

journal_title：European journal of clinical pharmacology

authors： Peeyush M,Ravishankar M,Adithan C,Shashindran CH

更新日期：1992-01-01 00:00:00

abstract：AIM:Our aim was to characterize utilization patterns for drugs used to treat attention deficit/hyperactivity disorder (ADHD) on the level of the individual patient among Danish users, focusing on treatment duration, doses used, and concurrent use of ADHD and non-ADHD drugs. METHODS:Using the Danish Registry of Medicin...

journal_title：European journal of clinical pharmacology

authors： Pottegård A,Bjerregaard BK,Glintborg D,Kortegaard LS,Hallas J,Moreno SI

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:To investigate the impact of valproic acid (VPA) and genetic polymorphism of the major metabolizing enzyme (UGT1A4, UGT2B7) of lamotrigine (LTG) and VPA on LTG concentration in Chinese epileptic children. METHODS:Three single nucleotide polymorphisms (UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2) were analyzed by p...

journal_title：European journal of clinical pharmacology

authors： Liu L,Zhao L,Wang Q,Qiu F,Wu X,Ma Y

更新日期：2015-11-01 00:00:00

abstract：:Since little is known of the number and types of binding sites on alpha 1-acid glycoprotein (AAG) and because drug-drug protein binding interactions often fail to fit a simple model, a study of the effect of 9 known AAG binding drugs on lidocaine free fraction (LFF) was performed. Serum was obtained from 10 healthy ma...

journal_title：European journal of clinical pharmacology

authors： Goolkasian DL,Slaughter RL,Edwards DJ,Lalka D

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:Visual hallucinations (VHs) are frequent non-motor complication of Parkinson's disease (PD), associated to a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and psychosis in Alzheimer's disease, addictions, schizophrenia, and bipolar disorder. Howe...

journal_title：European journal of clinical pharmacology

authors： Ferrari M,Comi C,Marino F,Magistrelli L,De Marchi F,Cantello R,Riboldazzi G,Bono G,Cosentino M

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Laryngoscopy and tracheal intubation are associated with hemodynamic responses that might increase morbidity and mortality in some patients. Lornoxicam is a nonsteroidal anti-inflammatory drug, which, when added to fentanyl, successfully attenuated the pressor response of intubation. The aim o...

journal_title：European journal of clinical pharmacology

authors： Daabiss M,Hashish M

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:To investigate the usefulness of the 3-hydroxylation of quinine as a biomarker reaction for the activity of CYP3A4 in man and to study the interindividual variation in the metabolic ratio (MR), i.e. quinine/3-hydroxyquinine. METHODS:Data from a previous study (A) was used for determination of the MR of quini...

journal_title：European journal of clinical pharmacology

authors： Mirghani RA,Ericsson O,Tybring G,Gustafsson LL,Bertilsson L

更新日期：2003-05-01 00:00:00

abstract：:The sulphation of (+) and (-) terbutaline was investigated in specimens of human intestinal mucosa isolated from the duodenum, ileum, ascending colon and sigmoid colon and in specimens of liver and lung. The lung specimens came from 8 current smokers and 11 ex-smokers, the latter having stopped at least 3 months befor...

journal_title：European journal of clinical pharmacology

authors： Pacifici GM,Eligi M,Giuliani L

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:Maintenance of the structural and functional integrity of the skeleton is a critical function of a continuous remodeling driven by highly associated processes of bone resorption and synthetic activities driven by osteoclasts and osteoblasts, respectively. Acceleration of bone turnover, accompanied with a dis...

journal_title：European journal of clinical pharmacology

authors： Leeming DJ,Alexandersen P,Karsdal MA,Qvist P,Schaller S,Tankó LB

更新日期：2006-10-01 00:00:00

abstract：:Bay m 1099 is a newly developed inhibitor of intestinal alpha-glucosidase. Its ability to lower postprandial plasma glucose, serum insulin and C-peptide levels in Type II diabetics has been investigated. Fifteen obese Type II diabetic patients with inadequate metabolic control during sulphonylurea treatment received a...

journal_title：European journal of clinical pharmacology

authors： Schnack C,Röggla G,Luger A,Schernthaner G

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Spontaneous reporting systems in European countries are crucial for collecting adverse drug reaction (ADR) reports. The aim of this study was to evaluate reporting activity among countries and their strategy to increase the number of reports. We also established the best measure for assessment quantity of repor...

journal_title：European journal of clinical pharmacology

authors： Srba J,Descikova V,Vlcek J

更新日期：2012-07-01 00:00:00

abstract：OBJECTIVE:To describe trends in opioid consumption in Israel (morphine, methadone, oxycodone, pethidine, fentanyl, buprenorphine, codeine, and dextropropoxyphene) over the 9 years, 2000-2008, and to explore explanations for changes in consumption, in amounts and the pattern. METHODS:Data for the 2000-2008 period (all ...

journal_title：European journal of clinical pharmacology

authors： Ponizovsky AM,Marom E,Zeldin A,Cherny NI

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:Adverse drug events (ADEs) are harmful and occur with alarming frequency in critically ill patients. Complex pharmacotherapy with multiple medications increases the probability of a drug interaction (DI) and ADEs in patients in intensive care units (ICUs). The objective of the study is to determine the frequenc...

journal_title：European journal of clinical pharmacology

authors： Reis AM,Cassiani SH

更新日期：2011-06-01 00:00:00

abstract：:In an open triple crossover study in 8 patients with essential hypertension, the possibility has been investigated of whether the blood pressure lowering effect of hydrochlorothiazide 50 mg once daily was attenuated by co-administration for 4 weeks of ibuprofen 400 mg t.i.d., diclofenac 25 mg t.i.d. or sulindac 200 mg...

journal_title：European journal of clinical pharmacology

authors： Koopmans PP,Thien T,Gribnau FW

更新日期：1987-01-01 00:00:00

abstract：:Enprofylline 1 mg/kg, a new potent antiasthmatic xanthine derivative, which is mainly eliminated by renal excretion, was given intravenously to 6 normal subjects with and without oral pretreatment with 1 g probenecid. The latter caused a drop in the average total body clearance of enprofylline from 21 to 9.8 l/h, and ...

journal_title：European journal of clinical pharmacology

authors： Borgå O,Larsson R,Lunell E

更新日期：1986-01-01 00:00:00

abstract：:Pharmacokinetic and metabolic studies with 3H-etilefrine were performed to assess the importance of a first-pass effect on the pharmacodynamic action of this sympathomimetic amine. Identical amounts of 3H-activity, ca. 80% of the dose, were excreted in the urine after intravenous or oral administration, which indicate...

journal_title：European journal of clinical pharmacology

authors： Hengstmann JH,Weyand U,Dengler HJ

更新日期：1975-12-19 00:00:00