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Effects of the alpha-glucosidase inhibitor 1 desoxynojirimycin (Bay m 1099) on postprandial blood glucose, serum insulin and C-peptide levels in type II diabetic patients.

Abstract：

:Bay m 1099 is a newly developed inhibitor of intestinal alpha-glucosidase. Its ability to lower postprandial plasma glucose, serum insulin and C-peptide levels in Type II diabetics has been investigated. Fifteen obese Type II diabetic patients with inadequate metabolic control during sulphonylurea treatment received a standardized diet and were treated either with Bay m 1099, b.d. (100 mg before breakfast and dinner) or placebo for 3 days, according to a double-blind cross-over design. The postprandial blood glucose level was significantly lower during Bay m 1099 treatment compared to placebo after breakfast and dinner (AUC after breakfast p less than 0.001). The reduced postprandial hyperglycaemia was associated with a decrease in meal stimulated serum insulin and C-peptide levels. Thus, Bay m 1099 may be a useful addition in the treatment of Type II diabetic patients.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Schnack C,Röggla G,Luger A,Schernthaner G

doi

10.1007/BF00607953

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

417-9

issue

4

eissn

0031-6970

issn

1432-1041

journal_volume

30

pub_type

临床试验,杂志文章

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