Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.


PURPOSE:Propofol anesthesia is usually accompanied by hypotensive responses, which are at least in part mediated by nitric oxide (NO). Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation. We examined here whether ARG1 and ARG2 genotypes and haplotypes affect the changes in blood pressure and NO bioavailability in response to propofol. METHODS:Venous blood samples were collected from 167 patients at baseline and after 10 min of anesthesia with propofol. Genotypes were determined by polymerase chain reaction. Nitrite concentrations were measured by using an ozone-based chemiluminescence assay, while NOx (nitrites + nitrates) levels were determined by using the Griess reaction. RESULTS:We found that patients carrying the AG + GG genotypes for the rs3742879 polymorphism in ARG2 gene and the ARG2 GC haplotype show lower increases in nitrite levels and lower decreases in blood pressure after propofol anesthesia. On the other hand, subjects carrying the variant genotypes for the rs10483801 polymorphism in ARG2 gene show more intense decreases in blood pressure (CA genotype) and/or higher increases in nitrite levels (CA and AA genotypes) in response to propofol. CONCLUSION:Our results suggest that ARG2 variants affect the hypotensive responses to propofol, possibly by modifying NO bioavailability. TRIAL REGISTRATION:NCT02442232.


Eur J Clin Pharmacol


Oliveira-Paula GH,Coeli-Lacchini FB,Ferezin LP,Ferreira GC,Pinheiro LC,Paula-Garcia WN,Garcia LV,Tanus-Santos JE,Lacchini R




Has Abstract


2021-01-07 00:00:00








  • Captopril does not interact with the pharmacodynamics and pharmacokinetics of digitoxin in healthy man.

    abstract::The chronic oral administration of 0.07 mg digitoxin o.d. for up to 58 days to 12 healthy volunteers caused a small drop in mean heart rate HR (95% CI: -7.9 to -1.6 beats.min-1), in mean diastolic blood pressure (95% CI: -8.3 to -0.4 mmHg), shortening of the QTc-interval (95% CI: -42 to -19 ms), shortening of the HR-c...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: de Mey C,Elich D,Schroeter V,Butzer R,Belz GG

    更新日期:1992-01-01 00:00:00

  • Assessment of a relative therapeutic index between inhaled formoterol and salbuterol in asthma patients.

    abstract:OBJECTIVE:To quantify the relation between local and systemic magnitudes of effects of inhaled formoterol and salbutamol. METHODS:Twenty-eight stable asthmatic patients completed this double-blind, randomised crossover study. Pre-drug administration FEV1 (mean 2.08 L) was 49-93% of predicted and reversibility 16-82% a...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rosenborg J,Larsson P,Rott Z,Böcskei C,Poczi M,Juhász G

    更新日期:2002-07-01 00:00:00

  • Effect of itraconazole on the concentrations of tacrolimus and cyclosporine in the blood of patients receiving allogeneic hematopoietic stem cell transplants.

    abstract:PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

    更新日期:2013-06-01 00:00:00

  • Amitriptyline and ethanol: pharmacokinetic and pharmacodynamic interaction.

    abstract::Amitriptyline has clinically important interactions with ethanol. Five healthy volunteers received 25 mg of amitriptyline orally, preceded by one hour and followed for eight hours by oral ethanol (or juice), dosed to achieve and maintain blood ethanol concentrations of 800 mg/l. In the presence of ethanol, amitriptyli...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Dorian P,Sellers EM,Reed KL,Warsh JJ,Hamilton C,Kaplan HL,Fan T

    更新日期:1983-01-01 00:00:00

  • The pharmacokinetics of slow-release procainamide.

    abstract::Procainamide was given to 20 patients with normal renal function as an i.v. bolus of 500 mg followed by 1.0 or 1.5 g eight-hourly by mouth in the form of a slow release preparation (Durules). 97.6 +/- 27.1 (SD)% of the oral procainamide was absorbed, the absorption half life being 1.54 h. The elimination half life fol...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Tilstone WJ,Lawson DH,Campbell W,Hutton I,Lawrie TD

    更新日期:1978-12-01 00:00:00

  • Effect of entacapone, a COMT inhibitor, on the pharmacokinetics of levodopa and on cardiovascular responses in patients with Parkinson's disease.

    abstract::In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate variation to standard s...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Myllylä VV,Sotaniemi KA,Illi A,Suominen K,Keränen T

    更新日期:1993-01-01 00:00:00

  • Cadralazine versus prazosin as second-step treatment in hypertensive patients on beta-blockers: a randomized multicentre study. The Italian Multicentre Study Group.

    abstract::A randomized multicentre between-patient study comparison has been made of the efficacy and tolerability of cadralazine and prazosin, both administered for 6 weeks to hypertensive patients with a supine diastolic blood pressure (DBP) greater than or equal to 95 mmHg whilst on a beta-adrenoceptor-blocker. The doses of ...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Caponnetto S,Valvo E,Mocarelli P,Alberti D,Savonitto S

    更新日期:1991-01-01 00:00:00

  • Kinetics of the Fab fragments of digoxin antibodies and of bound digoxin in patients with severe digoxin intoxication.

    abstract::17 patients with severe digoxin intoxication were successfully treated with 320 to 480 mg Fab fragments of digoxin-specific IgG from sheep. The infusion period ranged between 0.5 and 7 h. Serum and urine concentrations of digoxin bound to Fab fragments, and in 11 cases unbound Fab fragments in serum, were determined d...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Schaumann W,Kaufmann B,Neubert P,Smolarz A

    更新日期:1986-01-01 00:00:00

  • Utilization of oral antihyperglycemic drugs over a 7-year period (1998-2004) in a Hungarian population and adherence to drug therapy.

    abstract:OBJECTIVE:To describe the quantitative and qualitative changes in the utilization of oral antihyperglycemic drugs (OAHDs) between 1998 and 2004 and to analyze patients' adherence to OAHD therapy. METHODS:We conducted a retrospective analysis of the electronic database of the Hungarian National Health Fund Administrati...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Doró P,Benko R,Kosik E,Matuz M,Tóth K,Soós G

    更新日期:2005-12-01 00:00:00

  • Fabry disease and treatment with agalsidase alpha: unsuspected cardiac arrhythmia in two heterozygous women. In reference to pharmacovigilance.

    abstract:CASE REPORTS:Two women treated with agalsidase alpha for Fabry disease developed severe heart dysfunctions a few months after the beginning of enzyme replacement therapy (ERT). An adverse effect caused by the treatment was suspected; therefore we informed the French pharmacovigilance authorities about these two events....

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Mougenot P,Lidove O,Caillaud C,Arnaud P,Papo T

    更新日期:2008-06-01 00:00:00

  • Bioavailability and pharmacokinetics of phenytoin during pregnancy.

    abstract::Five epileptic women needing to commence phenytoin therapy during pregnancy received a single intravenous and a single oral dose of phenytoin several days apart before starting regular intake of the drug. Plasma phenytoin concentration - time data were analysed by three different pharmacokinetic techniques. However as...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Lander CM,Smith MT,Chalk JB,de Wytt C,Symoniw P,Livingstone I,Eadie MJ

    更新日期:1984-01-01 00:00:00

  • Thiopurine S-methyltransferase as a target for drug interactions.

    abstract:OBJECTIVE:The present study was undertaken to investigate the possible effects of various agents on thiopurine methyltransferase (TPMT) activity in red blood cells (RBCs) from patients with chronic inflammatory bowel disease (IBD). METHODS:In three groups of patients with very high, normal and intermediate TPMT activi...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Xin HW,Fischer C,Schwab M,Klotz U

    更新日期:2005-07-01 00:00:00

  • Sick population--treated population: the need for a better definition. The VALIDATA Group.

    abstract::There are many questions concerned with therapy and its application. Depending on the perspective of the study there can be several "populations" which, when considered individually, may give different, or even inconsistent conclusions. These populations are: the sick population, the therapist's target population, the...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Collet JP,Boissel JP

    更新日期:1991-01-01 00:00:00

  • Clinical evidence supporting the marketing authorization of biosimilars in Europe.

    abstract:PURPOSE:To review the marketing authorization of biosimilars and provide a critical analysis of the pivotal trials supporting their approval by the European Medicines Agency (EMA). METHODS:EMA website to identify the biosimilars approved up to July 2019 and the European Public Assessment Report for information on pivo...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Allocati E,Bertele' V,Gerardi C,Garattini S,Banzi R

    更新日期:2020-04-01 00:00:00

  • Capecitabine plus oxaliplatin (XELOX) compared with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in advanced gastric cancer: meta-analysis of randomized controlled trials.

    abstract:PURPOSE:The study aims to compare the efficacy and safety of capecitabine plus oxaliplatin (XELOX) with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in patients with advanced gastric cancer. METHODS:Five databases were searched up to June 2014, without language restrictions. The outcomes included overall respo...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,meta分析


    authors: Xu HB,Huang F,Su R,Shen FM,Lv QZ

    更新日期:2015-05-01 00:00:00

  • Influence of smoking and gender on the disposition kinetics of metoprolol.

    abstract::The purpose of this study was to examine the influence of cigarette smoking and gender on the pharmacokinetics of metoprolol. Eighteen volunteers with no evidence of clinical disease each randomly received the following doses of metoprolol tartrate: 100 mg orally, 200 mg orally and 20 mg as a constant-rate intravenous...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Schaaf LJ,Campbell SC,Mayersohn MB,Vagedes T,Perrier DG

    更新日期:1987-01-01 00:00:00

  • Incidence and severity of intravenous drug errors in a German hospital.

    abstract:OBJECTIVE:To determine the incidence of errors in preparing and administering intravenous (i.v.) drugs, identify the stages in the process at which errors occurred and evaluate their clinical importance. METHODS:A prospective ethnographic study using disguised observation was carried out on two wards in one German non...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Taxis K,Barber N

    更新日期:2004-01-01 00:00:00

  • Aspirin in people with dementia, long-term benefits, and harms: a systematic review.

    abstract:PURPOSE:People with dementia may have indications for aspirin prescription and clinicians are asked to balance the potential risks against benefits. This review examines the evidence for the risk and benefit of long-term aspirin use in people with dementia aged over 65 years, including randomised controlled trials and ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Davis KAS,Bishara D,Molokhia M,Mueller C,Perera G,Stewart RJ

    更新日期:2021-01-22 00:00:00

  • Population pharmacokinetics of PEGylated liposomal CPT-11 (IHL-305) in patients with advanced solid tumors.

    abstract:PURPOSE:To investigate pharmacokinetics (PK) of encapsulated CPT-11, released CPT-11 and the active metabolite SN-38 following administration of IHL-305 and to identify factors that may influence IHL-305 PK. METHODS:Plasma samples from 39 patients with solid tumors were collected in a phase I study. IHL-305 was admini...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Wu H,Infante JR,Keedy VL,Jones SF,Chan E,Bendell JC,Lee W,Zamboni BA,Ikeda S,Kodaira H,Rothenberg ML,Burris HA 3rd,Zamboni WC

    更新日期:2013-12-01 00:00:00

  • Clinical implications of assessment of apixaban levels in elderly atrial fibrillation patients: J-ELD AF registry sub-cohort analysis.

    abstract:PURPOSE:To investigate the distribution of plasma apixaban levels and their relationships with clinical outcomes in elderly patients with atrial fibrillation (AF). METHOD:The J-ELD AF Registry is a multicenter prospective observational study of Japanese non-valvular AF patients aged ≥75 years taking an on-label dose o...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Suzuki S,Yamashita T,Akao M,Okumura K,J-ELD AF investigators.

    更新日期:2020-08-01 00:00:00

  • Modelling the influence of MDR1 polymorphism on digoxin pharmacokinetic parameters.

    abstract:OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

    更新日期:2007-05-01 00:00:00

  • Effect of aminoglycosides on proximal tubular membranes of the human kidney.

    abstract::The effect of the aminoglycosides amikacin, gentamicin, netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects. Fifteen adults were each given gentamicin, sisomicin or tobramycin 3 mg/kg bodyweight, 10 subjects received netilmicin 3 mg/kg or amikacin 15 m...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Mondorf AW,Breier J,Hendus J,Scherberich JE,Mackenrodt G,Shah PM,Stille W,Schoeppe W

    更新日期:1978-05-17 00:00:00

  • Sex-by-formulation interaction in bioequivalence trials with transdermal patches.

    abstract:PURPOSE:The existence of a sex-by-formulation interaction in bioequivalence studies implies that the bioequivalence results (i.e., the test/reference ratio of the pharmacokinetic parameters) obtained in one sex are not similar to those obtained in the other sex. Therefore, results obtained in studies including only mal...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: González-Rojano E,Marcotegui J,Morales-Alcelay S,Álvarez C,Gordon J,Abad-Santos F,García-Arieta A

    更新日期:2019-06-01 00:00:00

  • The use of driving impairing medicines: a European survey.

    abstract:AIM:To analyse the consumption of a number of medicines with a known potential for increasing the risk of road traffic accidents in the general population of Europe. METHODS:Questionnaires were distributed through the European Drug Utilization Research Group (EuroDURG) and Post-Innovation Learning through Life-events ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Ravera S,Hummel SA,Stolk P,Heerdink RE,de Jong-van den Berg LT,de Gier JJ

    更新日期:2009-11-01 00:00:00

  • Evaluation of the safety of fexofenadine from experience gained in general practice use in England in 1997.

    abstract:BACKGROUND:Fexofenadine is the active metabolite of the non-sedating anti-histamine terfenadine. Pre-licensing clinical trials in over 6000 patients suggested it was effective and well tolerated. OBJECTIVE:To assess the tolerability and safety of fexofenadine immediately after its availability on the UK market in Marc...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Craig-McFeely PM,Acharya NV,Shakir SA

    更新日期:2001-07-01 00:00:00

  • Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands.

    abstract:OBJECTIVES:Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands. METHODS:In the Netherlands, health professionals and patients can report suspected ADRs to the Pharmacovigilance Centre Lareb. ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: de Vries TW,de Langen-Wouterse JJ,van Puijenbroek E,Duiverman EJ,de Jong-Van den Berg LT

    更新日期:2006-05-01 00:00:00

  • Pharmacokinetics and biotransformation of the new benzodiazepine, lormetazepam, in man. III. Repeated administration and transfer to neonates via breast milk.

    abstract::The concentrations of lormetazepam and its glucuronide in plasma and milk were determined during administration of 10 daily doses of lormetazepam 2 mg (2 tablets of Noctamid-1) to five mothers delivered by Caesarian section. Their babies were breast-fed throughout the study, and the plasma levels of lormetazepam and i...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Hümpel M,Stoppelli I,Milia S,Rainer E

    更新日期:1982-01-01 00:00:00

  • The effects and side effects of laquinimod for the treatment of multiple sclerosis patients: a systematic review and meta-analysis of clinical trials.

    abstract:PURPOSE:Although studies have shown the efficacy of laquinimod (LAQ) on disease progression in patients with multiple sclerosis (MS), there is some controversy about whether it improves the types of outcomes and side effects. The main purpose of the present study was to systematically review and meta-analyze the effica...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,meta分析


    authors: Rouhi F,Mohammadpour Z,Noureini SK,Abbastabar H,Harirchian MH,Bitarafan S

    更新日期:2020-05-01 00:00:00

  • Study of the use of vitamin K in neonates in France.

    abstract:OBJECTIVE:Because of the risk of haemorrhagic disease of the newborn as a result of a deficit in vitamin K, it is generally agreed that newborns should receive vitamin K. However, there is no consensus concerning the route of administration, dose, number of doses, or dose frequency. METHODS:We studied patterns of vita...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Jonville-Bera AP,Autret E

    更新日期:1997-01-01 00:00:00

  • Parental reporting of adverse drug events and other drug-related problems in children in Finland.

    abstract:PURPOSE:Drug-related problems (DRPs) are common in paediatric pharmacotherapy, but few studies describe them from the parents' perspective. In the present survey, we have investigated the lifetime prevalence and type of DRPs in children in Finland. METHODS:This was a population-based survey of a random sample of 6,000...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Lindell-Osuagwu L,Sepponen K,Farooqui S,Kokki H,Hämeen-Anttila K,Vainio K

    更新日期:2013-04-01 00:00:00