Population pharmacokinetic modeling of sustained release lithium in the serum, erythrocytes and urine of patients with bipolar disorder.


PURPOSE:Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of srLi, administered once a day, in adults. The present study describes srLi PK in the serum and erythrocytes of bipolar patients. METHODS:To assess srLi PK, we studied prospectively 17 French bipolar patients on a median dose of 1000 mg (600-1600) for at least 2 years. Serum (S), erythrocyte (E) concentrations, and urinary (U) amount were collected over 8 h after 15 days of morning intake using monitoring electronic medical system (MEMs). Population PK parameters were estimated using the SAEM algorithm (MONOLIX 4.3.3 software). RESULTS:Using a population approach, we built a PK population model of srLi including one S compartment (VS = 23.0 L, ClS = 1.21 L h-1), one E compartment (VE = 64.7 L, ClSE = 3.63 L h-1, ClES = 9.46 L h-1), and one U compartment (F = 0.62) and estimate the ratio of concentrations to Li in E over S at 0.38 with 27% between-subject variability. CONCLUSION:This is a PK model of srLi once a day in bipolar patients using a population approach simultaneously describing Li concentrations in serum, erythrocytes, and urine which provide an estimate of the ratio of concentration in erythrocyte over serum and its between-subject variability (BSV).


Eur J Clin Pharmacol


Couffignal C,Bertrand J,Sportiche S,Jarroir M,El Balkhi S,Djebrani-Oussedik N,Poupon J,Declèves X,Mentré F,Bellivier F




Has Abstract


2019-04-01 00:00:00














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    abstract:INTRODUCTION:In order to discover how well the discipline of clinical pharmacology (CP) has developed in Europe, a questionnaire survey was undertaken in 31 countries. METHODS:The senior delegate of each of the 31 countries on the Council of the European Association for Clinical Pharmacology and Therapeutics (EACPT) w...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Orme M,Sjöqvist F

    更新日期:2013-09-01 00:00:00

  • Effect of Liv.52, a herbal preparation, on absorption and metabolism of ethanol in humans.

    abstract::In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg.100 ml-1) was significantly...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Chauhan BL,Kulkarni RD

    更新日期:1991-01-01 00:00:00

  • Relationship between plasma concentrations and pharmacological effects of labetalol.

    abstract::In healthy normal subjects following the administration of labetalol the pharmacological effects were measured and compared with the plasma concentrations achieved. The inhibition of exercise induced tachycardia and inhibition of exercise induced increases in systolic pressure were significantly related to the adminis...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Richards DA,Maconochie JG,Bland RE,Hopkins R,Woodings EP,Martin LE

    更新日期:1977-01-03 00:00:00

  • Arginase II polymorphisms modify the hypotensive responses to propofol by affecting nitric oxide bioavailability.

    abstract:PURPOSE:Propofol anesthesia is usually accompanied by hypotensive responses, which are at least in part mediated by nitric oxide (NO). Arginase I (ARG1) and arginase II (ARG2) compete with NO synthases for their common substrate L-arginine, therefore influencing the NO formation. We examined here whether ARG1 and ARG2 ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Oliveira-Paula GH,Coeli-Lacchini FB,Ferezin LP,Ferreira GC,Pinheiro LC,Paula-Garcia WN,Garcia LV,Tanus-Santos JE,Lacchini R

    更新日期:2021-01-07 00:00:00

  • Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium.

    abstract::The linearity of the pharmacokinetics of the metamizol metabolites 4-methyl-amino-antipyrine (4-MAA), 4-amino-antipyrine (4-AA), 4-formyl-aminoantipyrine (4-FAA), and 4-acetyl-amino-antipyrine (4-AcAA) has been studied after administration to 15 healthy male volunteers of single oral doses of 750, 1500, and 3000 mg me...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


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    更新日期:1990-01-01 00:00:00

  • Under-reporting of adverse drug reactions. Estimate based on a spontaneous reporting scheme and a sentinel system.

    abstract:OBJECTIVE:Spontaneous reporting is the most common method used in pharmacovigilance and the best one to generate signals on new or rare adverse drug reactions (ADRs). Under-reporting is a major drawback of this system. The objective of this study was to quantify the extent of under-reporting in general practice and to ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Alvarez-Requejo A,Carvajal A,Bégaud B,Moride Y,Vega T,Arias LH

    更新日期:1998-08-01 00:00:00

  • Propranolol pharmacokinetics and pharmacodynamics after single doses and at steady-state.

    abstract::The duration and extent of cardiac beta-blockade and their relationship to propranolol pharmacokinetics were assessed in nine healthy volunteers. Each subject received 160 mg of regular propranolol (R), 160 mg of sustained-release propranolol (SR) and no drug (control), both as single doses and once daily for 7 days. ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Lalonde RL,Pieper JA,Straka RJ,Bottorff MB,Mirvis DM

    更新日期:1987-01-01 00:00:00

  • Decreased serum activity of semicarbazide-sensitive amine oxidase (SSAO) in patients treated with second generation antipsychotics: a link to impaired glucose metabolism?

    abstract:OBJECTIVE:Although the treatment of schizophrenia with many second generation antipsychotics is known to be associated with metabolic changes, such as hyperglycemia or hypercholesterolemia, the underlying mechanisms of these adverse reactions remain unclear. In light of the recent focus on the involvement of semicarbaz...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Roessner V,Weber A,Becker A,Beck G,Frieling H,Bleich S

    更新日期:2007-05-01 00:00:00

  • Concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications: a population-based cohort study.

    abstract:PURPOSE:We examined the extent of concurrent use of antiplatelets, anticoagulants, or digoxin with Chinese medications (CMs) and identified its associated factors. METHODS:A retrospective cohort study was conducted using one million random samples from the Longitudinal Health Insurance Database 2005 in Taiwan. High-ri...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Tsai HH,Lin HW,Chien CR,Li TC

    更新日期:2013-03-01 00:00:00

  • Drug-associated non-pyrogenic hyperthermia: a narrative review.

    abstract:PURPOSE:Hyperthermia occurs when heat accumulation surpasses the body's ability for heat dissipation. Many drugs may affect thermoregulation. This narrative review aimed to provide an overview of the current literature concerning reports of drug-associated non-pyrogenic hyperthermia. METHODS:A comprehensive search was...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Bongers KS,Salahudeen MS,Peterson GM

    更新日期:2020-01-01 00:00:00

  • Debrisoquine oxidation polymorphism in a Tasmanian population.

    abstract::The debrisoquine hydroxylation phenotype was studied in 152 unselected healthy Tasmanian subjects, who were mostly Caucasians of British ancestry. Following a 10 mg oral dose of debrisoquine (D), the ratio of D/4-hydroxydebrisoquine excreted in 8-h urine (metabolic ratio, MR) was determined. MR values were bimodally d...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Veronese ME,McLean S

    更新日期:1991-01-01 00:00:00

  • Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine.

    abstract::The peripheral histamine-inhibiting and central sedative effects of single oral doses (SOD) and of repeated administration for one week (steady state, SS), of 20 mg hydroxyzine HCL and 10 mg cetirizine have been assessed in 12 healthy volunteers, in a double-blind placebo-controlled cross-over study. Peripheral H1-rec...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Levander S,Ståhle-Bäckdahl M,Hägermark O

    更新日期:1991-01-01 00:00:00

  • Disopyramide concentrations in human plasma and saliva: comparison of disopyramide concentrations in saliva and plasma unbound concentrations.

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    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Sagawa K,Mohri K,Shimada S,Shimizu M,Muramatsu J

    更新日期:1997-01-01 00:00:00

  • A systematic review and meta-analysis of microbial contamination of parenteral medication prepared in a clinical versus pharmacy environment.

    abstract:PURPOSE:Preparation of parenteral medication in hospitals is a complex process with a risk of microbial contamination of the product, especially when inappropriately prepared. Contaminated parenteral medications can cause severe complications to patients and increase morbidity in hospitals. The aim of this literature r...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,meta分析,评审


    authors: Larmené-Beld KHM,Frijlink HW,Taxis K

    更新日期:2019-05-01 00:00:00

  • Acute effect of prednisone and deflazacort on glucose tolerance in prediabetic subjects.

    abstract::The diabetogenic effect of deflazacort (DF), an oxazolinic synthetic corticosteroid, was studied in 12 healthy adult subjects with a positive family history of diabetes mellitus. Three oral glucose tests (oGTT) were performed at 9.00 a.m., after a 12 h fast, following randomized administration of Placebo (PL), or Defl...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Pagano G,Lombardi A,Ferraris GM,Imbimbo B,Cavallo Perin P

    更新日期:1982-01-01 00:00:00

  • Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine.

    abstract::The pharmacokinetics and metabolism of quinidine were investigated in extensive and poor metabolisers of sparteine. No differences in plasma clearance, terminal half life, volume of distribution or cumulative urinary excretion of quinidine, 3-hydroxyquinidine and quinidine-N-oxide were observed between phenotypes. Thu...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Mikus G,Ha HR,Vozeh S,Zekorn C,Follath F,Eichelbaum M

    更新日期:1986-01-01 00:00:00

  • Factors predicting hospital readmissions related to adverse drug reactions.

    abstract:OBJECTIVE:To analyse the contribution of adverse drug reactions (ADR) to hospital readmissions. METHODS:This was a case-control study in which unscheduled admissions of patients who had been admitted to the hospital during the two previous months were assessed during a 21-month period. The patient was considered a cas...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Ruiz B,García M,Aguirre U,Aguirre C

    更新日期:2008-07-01 00:00:00

  • Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.

    abstract::Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Lönnerholm G,Lindström B,Paalzow L,Sedin G

    更新日期:1983-01-01 00:00:00

  • Interactions between cardioactive drugs and antidepressants.

    abstract::The most important cardiovascular interactions between cardioactive drugs and monoamino-oxidase inhibitors or tricyclic antidepressants are reviewed. Post-ganglion blocking agents (e.g., guanethidine), clonidine, reserpine, and alpha-methyl-dopa should not be used in patients needing antide-present therapy. For hypert...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


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  • How reimbursement databases can be used to support drug utilisation studies: example using the main French national health insurance system database.

    abstract:INTRODUCTION:Reimbursement databases are potentially invaluable tools to develop and conduct pharmacoepidemiological studies on drug use. However, two types of factors that may influence the performance of a database can be distinguished: firstly, factors related to the constitution of the database, and secondly, facto...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Latry P,Molimard M,Bégaud B,Martin-Latry K

    更新日期:2010-07-01 00:00:00

  • Edoxaban population pharmacokinetics and exposure-response analysis in patients with non-valvular atrial fibrillation.

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Yin OQ,Tetsuya K,Miller R

    更新日期:2014-11-01 00:00:00

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Miyabo S,Nakamura T,Kuwazima S,Kishida S

    更新日期:1981-01-01 00:00:00

  • Stimulation of drug metabolism by rifampicin in patients with cirrhosis or cholestasis measured by increased hexobarbital and tolbutamide clearance.

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Zilly W,Breimer DD,Richter E

    更新日期:1977-04-20 00:00:00

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Hultqvist C,Borgå O

    更新日期:1987-01-01 00:00:00

  • Effect of fenofibrate on the level of asymmetric dimethylarginine in individuals with hypertriglyceridemia.

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    authors: Yang TL,Chen MF,Xia X,Luo BL,Li YJ

    更新日期:2006-03-01 00:00:00

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    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Acébal E,Subirá S,Spatz J,Faleni R,Merzbacher B,Gales A,Moizeszowicz J

    更新日期:1976-06-15 00:00:00

  • Association between N-desethylamiodarone/amiodarone ratio and amiodarone-induced thyroid dysfunction.

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Yamato M,Wada K,Fujimoto M,Hosomi K,Hayashi T,Oita A,Takada M

    更新日期:2017-03-01 00:00:00

  • Effect of a single-dose rifampin on the pharmacokinetics of pitavastatin in healthy volunteers.

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验


    authors: Chen Y,Zhang W,Huang WH,Tan ZR,Wang YC,Huang X,Zhou HH

    更新日期:2013-11-01 00:00:00

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Han N,Yun HY,Hong JY,Kim IW,Ji E,Hong SH,Kim YS,Ha J,Shin WG,Oh JM

    更新日期:2013-01-01 00:00:00

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    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Nagakawa Y,Akedo Y,Kaku S,Orimo H

    更新日期:1990-01-01 00:00:00