当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Responses of glomerular filtration, renal blood flow and salt-water handling to acute cardioselective and non-selective beta-adrenoceptor blockade in essential hypertension.

Responses of glomerular filtration, renal blood flow and salt-water handling to acute cardioselective and non-selective beta-adrenoceptor blockade in essential hypertension.

Abstract：

:The effects on renal hemodynamics and salt-water handling of equipotent doses of the cardioselective beta-blocker metoprolol (M, 100 mg) and of the non-selective (intrinsic sympathetic activity) beta-antagonist pindolol (P, 10 mg) were compared in 30 WHO Grade 1-2 hypertensive men. M lowered pulse rate more than P. Systolic pressure was equally reduced by both agents, and diastolic and mean pressures were decreased only after P. Glomerular filtration rate was not significantly altered by either antagonist, and renal blood flow decreased by approximately 11% both after M and P. Renal vascular resistance was unchanged after P, and was increased by 10% after M. It is concluded that, like the effects on central haemodynamics, ISA is more important in the renal response to beta-adrenoceptor blockade than is beta-receptor selectivity.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Koch G,Fransson L,Karlegärd L,Kothari P

doi

10.1007/BF00558292

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

343-5

issue

4

eissn

0031-6970

issn

1432-1041

journal_volume

36

pub_type

临床试验,杂志文章,随机对照试验

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