Evidence for a GABAergic control of the exercise-induced rise in GH in man.

abstract：OBJECTIVE:We investigated whether interindividual differences in the pharmacokinetic disposition of lansoprazole are attributed to the genetic polymorphism of CYP2C19 which occurred by two mutations. CYP2C19m1 and CYP2C19m2, in 20 Japanese subjects. METHODS:Polymerase chain reaction (PCR) restriction fragment length p...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Nakamura C,Arimori K,Fujiyama S,Nakano M

更新日期：1997-01-01 00:00:00

abstract：:In an open, randomised, cross-over study we investigated the effect of a single 200 mg oral dose of entacapone, a novel catechol-O-methyltransferase (COMT) inhibitor, on the pharmacokinetics and metabolism of levodopa/carbidopa, and on the cardiovascular responses (blood pressure and pulse rate variation to standard s...

journal_title：European journal of clinical pharmacology

authors： Myllylä VV,Sotaniemi KA,Illi A,Suominen K,Keränen T

更新日期：1993-01-01 00:00:00

abstract：:Plasma levels of canrenone and 'total metabolites' after base hydrolysis were compared in young and elderly subjects following single and multiple doses of spironolactone. After the initial dose on Day 1, plasma levels of canrenone and 'total metabolites' were higher in the young than in the elderly group, and signifi...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Bourne DW,Triggs EJ,Smithurst BA

更新日期：1984-01-01 00:00:00

abstract：:Quinidine is a very potent inhibitor of CYP2D6, but the role of the enzyme in the biotransformation of quinidine has only been investigated in a single in vitro study and in two small in vivo experiments, with contradictory results. The present investigation was designed to present definite evaluation of whether quini...

journal_title：European journal of clinical pharmacology

authors： Nielsen F,Rosholm JU,Brøsen K

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Pharmacology and pharmacotherapy education is being increasingly integrated in medical curricula, which might lead to a specific loss of knowledge in these subjects. This, in turn, could lead to harmful prescribing errors, especially in vulnerable older patients. METHODS:Teachers who coordinated education in D...

journal_title：European journal of clinical pharmacology

authors： Keijsers CJ,de Wit JE,Tichelaar J,Brouwers JR,de Wildt DJ,de Vries PG,Jansen PA

更新日期：2015-05-01 00:00:00

abstract：:In a double-blind, placebo-controlled cross-over study, the plasma atrial natriuretic peptide (ANP) levels of nine young and ten elderly hypertensive patients were compared after placebo and after treatment with 120 mg verapamil given three times daily over 4 weeks. During placebo, plasma ANP levels proved to be highe...

journal_title：European journal of clinical pharmacology

authors： Van Bortel LM,Schiffers PM,Böhm RO,Mooij JM,Rahn KH,Struyker Boudier HA

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

journal_title：European journal of clinical pharmacology

authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

更新日期：2000-05-01 00:00:00

abstract：:The systemic effects of single and multiple doses of inhaled fluticasone propionate (FP) and budesonide were examined in 24 healthy male volunteers (age range 18-29 years). The study was of an open, placebo-controlled, randomized, three-way crossover design. On each study day, multiple blood samples were taken over a ...

journal_title：European journal of clinical pharmacology

authors： Lönnebo A,Grahnén A,Jansson B,Brundin RM,Ling-Andersson A,Eckernäs SA

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Tigecycline is one of few antibiotics active against multidrug-resistant bacteria; however, the assessment of dosing strategies to optimize its activity is needed. The purpose was to use Monte Carlo Simulation (MCS) to determine if safe tigecycline dosing options attaining breakpoints for pharmacokinetic/pharma...

journal_title：European journal of clinical pharmacology

authors： Kispal B,Walker SAN

更新日期：2021-02-01 00:00:00

abstract：:The cardiovascular and respiratory actions of the adrenergic beta adrenoceptive drug sotalol have been studied in an open, short term trial. Fifteen patients with angina performed standardized orthostatic and exercise tests before and after injection of 20 mg sotalol intravenously. Although there was a significant red...

journal_title：European journal of clinical pharmacology

authors： Areskog NH,Cullhed I,Ringqvist I,Ström G

更新日期：1975-08-14 00:00:00

abstract：OBJECTIVE:To determine the response of haemodynamic and oxygen-transport parameters to phenylephrine in a dose-response fashion in septic non-hypotensive, vasodilated surgical intensive care unit (ICU) patients. DESIGN:Prospective study. SETTING:Surgical ICU of a tertiary care, university medical centre. PATIENTS:Te...

journal_title：European journal of clinical pharmacology

authors： Flancbaum L,Dick M,Dasta J,Sinha R,Choban P

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to investigate the possible effects of various agents on thiopurine methyltransferase (TPMT) activity in red blood cells (RBCs) from patients with chronic inflammatory bowel disease (IBD). METHODS:In three groups of patients with very high, normal and intermediate TPMT activi...

journal_title：European journal of clinical pharmacology

authors： Xin HW,Fischer C,Schwab M,Klotz U

更新日期：2005-07-01 00:00:00

abstract：PURPOSE:Sacubitril/valsartan (LCZ696) is a first-in-class angiotensin receptor neprilysin inhibitor (ARNI) indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (NYHA class II-IV) and reduced ejection fraction. This study was aimed to evaluate ...

journal_title：European journal of clinical pharmacology

authors： Langenickel TH,Jordaan P,Petruck J,Kode K,Pal P,Vaidya S,Chandra P,Rajman I

更新日期：2016-08-01 00:00:00

abstract：:The binding of propranolol, a drug commonly used in cardiovascular disorders, to alpha 1-acid glycoprotein (AGP) was studied in vitro in malnutrition. Compared to normal and hospital controls, the level of AGP was found to be elevated in undernourished subjects with and without infection. In the same patients the free...

journal_title：European journal of clinical pharmacology

authors： Jagadeesan V,Krishnaswamy K

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:Persistence to statins is low, in part due to lack of perception of cardiovascular (CV) risk. High values of low-density lipoprotein cholesterol (LDL-C) might increase the motivation for patients to be persistent. We investigated whether the baseline LDL-C value influences the discontinuation of statin treatmen...

journal_title：European journal of clinical pharmacology

authors： Citarella A,Linder M,Kieler H,Berglind IA,Sundström A,Wettermark B,Andersen M

更新日期：2016-03-01 00:00:00

abstract：:Ple 1053 (Azosemid) is a diuretic which resembles furosemide chemically and in its mode of action. When administered intravenously, Ple 1053 was approximately 5 times more potent on a weight basis than furosemide, its dose-response relationship was closer and the slope was steeper. After oral administration Ple 1053 a...

journal_title：European journal of clinical pharmacology

authors： Krück F,Bablok W,Besenfelder E,Betzien G,Kaufmann B

更新日期：1978-11-27 00:00:00

abstract：:The effects of the beta-blocker atenolol on vigilance, concentration, and psychophysiological condition were determined by measuring visual reaction time and choice reaction time in volunteers subjected to combined physical and mental stress. Atenolol 50 mg or placebo were administered for three days in a double-blind...

journal_title：European journal of clinical pharmacology

authors： Harms D

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommende...

journal_title：European journal of clinical pharmacology

authors： Wusk B,Kullak-Ublick GA,Rammert C,von Eckardstein A,Fried M,Rentsch KM

更新日期：2004-03-01 00:00:00

abstract：PURPOSE:Although CYP3A4/5 enzymes play the predominant role in the metabolism of simvastatin and lovastatin, polymorphisms in CYP2D6 were reported to be associated with the cholesterol-lowering effect and/or tolerability of simvastatin. This study was performed to examine whether common CYP2D6 polymorphisms affect the ...

journal_title：European journal of clinical pharmacology

authors： Yin OQ,Mak VW,Hu M,Fok BS,Chow MS,Tomlinson B

更新日期：2012-06-01 00:00:00

abstract：PURPOSE:The purpose of the present study was to examine the relationship between the incidence of hyperammonemia and changes in the prescribing of concomitant antiepileptic drugs (AEDs) in patients receiving valproic acid. METHODS:We evaluated 40,363 plasma samples from 6009 epilepsy patients obtained from 2006 to 201...

journal_title：European journal of clinical pharmacology

authors： Yamamoto Y,Takahashi Y,Imai K,Mishima N,Kagawa Y,Inoue Y

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Inconsistent results of lipid-lowering medications (LLMs) on improved cancer survival need more investigations. We tested the hypothesis that adherence to the drug would be associated with a lower cancer-specific mortality in a homogeneous population who has ever used the drug. METHODS:Utilising data from the ...

journal_title：European journal of clinical pharmacology

authors： Feng JL,Qin X

更新日期：2020-10-08 00:00:00

abstract：:Six children, aged 2 months - 4 years, received theophylline 5-6 mg/kg intravenously. Its disposition could be described by a two-compartment open model, the mean serum half life (t 1/2 beta) was 3.75 h, i.e., shorter than in adults, but there was a considerable interindividual variation (1.8-7.0 h, in one patient 13....

journal_title：European journal of clinical pharmacology

authors： Bolme P,Edlund PO,Eriksson M,Paalzow L,Winbladh B

更新日期：1979-09-01 00:00:00

abstract：:Changes in phenytoin concentrations caused by switching valproate formulations with different absorption rates were retrospectively investigated in eleven epileptic patients receiving treatment with both drugs. Total plasma phenytoin concentrations were measured before and after a standard tablet of valproate was repl...

journal_title：European journal of clinical pharmacology

authors： Suzuki Y,Nagai T,Mano T,Arai H,Kodaka R,Matsuoka T,Itagaki Y,Ono J,Okada S

更新日期：1995-01-01 00:00:00

abstract：:Propranolol (P) and all of its major known metabolites were found in maternal plasma, cord plasma and neonatal plasma in 10 women at term, irrespective of the P doses administered and the time elapsed (up to 15 h) between administration of the last P dose and delivery. The ratios of cord plasma to simultaneous materna...

journal_title：European journal of clinical pharmacology

authors： Smith MT,Livingstone I,Eadie MJ,Hooper WD,Triggs EJ

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study aims to explore exposure-response relationship for panobinostat in this ...

journal_title：European journal of clinical pharmacology

authors： Mu S,Kuroda Y,Shibayama H,Hino M,Tajima T,Corrado C,Lin R,Waldron E,Binlich F,Suzuki K

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS:When prescribing for older pa...

journal_title：European journal of clinical pharmacology

authors： Brewer L,Williams D,Moore A

更新日期：2011-04-01 00:00:00

abstract：:In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. ...

journal_title：European journal of clinical pharmacology

authors： Lombardi C,Missale C,De Cotiis R,Spedini C,Pizzoccolo G,Memo M,Albertini A,Spano PF

更新日期：1988-01-01 00:00:00

abstract：:The effect of the angiotensin converting enzyme inhibitor, perindopril, on autonomic function was assessed in a double blind, placebo controlled, crossover study in 10 normotensive males. Eight milligram of perindopril given orally lowered blood pressure without a change in heart rate. Perindopril enhanced the vagally...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Lees KR,Reid JL

更新日期：1986-01-01 00:00:00

abstract：:Current pharmacotherapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is not optimal, and the biological and physiological complexity of these severe lung injury syndromes requires consideration of combined-agent treatments or agents with pleiotropic action. In this regard, exogenous eryth...

journal_title：European journal of clinical pharmacology

authors： Kakavas S,Demestiha T,Vasileiou P,Xanthos T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS:A randomized, double-blind, cross-over study design with two phases, which were separated by a washout pe...

journal_title：European journal of clinical pharmacology

authors： Kantola T,Kivistö KT,Neuvonen PJ

更新日期：1999-01-01 00:00:00