The influence of chronic treatment with verapamil on plasma atrial natriuretic peptide levels in young and elderly hypertensive patients.

abstract：PURPOSE:Aflibercept, a fully humanized vascular endothelial growth factor (VEGF)-targeted agent, has emerged as an effective therapy in the treatment of various solid tumors. We carried out an up-to-date meta-analysis to determine the risk of fatal adverse events (FAEs) in cancer patients treated with aflibercept. MET...

journal_title：European journal of clinical pharmacology

authors： Qi WX,Tang LN,Shen Z,Yao Y

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:Psychotropic drug use among nursing home residents with regard to diagnostic indications and patient- and institution characteristics was analysed. METHODS:A cross-sectional study of medication data from 1552 residents at 23 nursing homes in Bergen, Norway, was performed. Psychotropic drug use (neuroleptics,...

journal_title：European journal of clinical pharmacology

authors： Ruths S,Straand J,Nygaard HA

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:To study the influence of CYP3A4 inhibition by ketoconazole on the disposition of venlafaxine in individuals with different CYP2D6 pheno- and genotypes. METHODS:In an open two-phase study, 21 healthy volunteers with known CYP2D6 pheno- and genotype [14 extensive metabolisers (EMs), 7 poor metabolisers (PMs)]...

journal_title：European journal of clinical pharmacology

authors： Lindh JD,Annas A,Meurling L,Dahl ML,AL-Shurbaji A

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:To assess the initial uptake in use and co-prescribing patterns of sildenafil. METHODS:We examined prescription details of the Eastern Health Board Region (including Dublin) of the General Medical Services (GMS) in Ireland, which provides detail on prescriptions dispensed in primary care for this population ...

journal_title：European journal of clinical pharmacology

authors： Williams D,Feely J

更新日期：2001-03-01 00:00:00

abstract：:Twenty three patients with essential hypertension who were uncontrolled on diuretic and/or beta-receptor antagonist therapy were treated additionally with the vasodilator, pinacidil, in an open study. Significant reduction in mean blood pressure was achieved. Supine and erect systolic and diastolic blood pressure fell...

journal_title：European journal of clinical pharmacology

authors： D'Arcy V,Laher M,McCoy D,Sullivan P,Walsh CH,Hickey MP

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:To develop quality prescribing indicators for general practitioners (GPs) who are non-monitored and not included in pay-for-performance programs, and to determine compliance with incentivized and non-incentivized indicators. STUDY DESIGN:Descriptive cross sectional study. SETTING:Aljarafe Primary Health Car...

journal_title：European journal of clinical pharmacology

authors： Fernández Urrusuno R,Montero Balosa MC,Pérez Pérez P,Pascual de la Pisa B

更新日期：2013-10-01 00:00:00

abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

journal_title：European journal of clinical pharmacology

authors： Kostev K,Jacob L

更新日期：2019-05-01 00:00:00

abstract：:A study, using non-invasive techniques, was carried out in ten patients with essential hypertension to examine the mechanism of the hypotensive effect of propranolol when used in combination with a potent vasodilator antihypertensive - minoxidil. The hypotensive effect of minoxidil, a mean (+/- SEM) decrease of 42.4 +...

journal_title：European journal of clinical pharmacology

authors： O'Malley K,Velasco M,Wells J,McNay J

更新日期：1976-03-22 00:00:00

abstract：PURPOSE:Tolvaptan is a selective vasopressin V2 receptor antagonist that can be given orally once daily for treatment of clinically significant hypervolemic and euvolemic hyponatremia (US and Europe) or extracellular volume expansion despite taking other diuretics (Japan). In vitro studies indicated that tolvaptan was ...

journal_title：European journal of clinical pharmacology

authors： Shoaf SE,Mallikaarjun S,Bricmont P

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:To study the effect of renal impairment on the pharmacokinetics of sertindole. METHODS:A single 4 mg oral dose of sertindole was given to normal subjects (n = 6) and subjects with various degrees of impaired renal function (n = 18) classified into mild, moderate, and severe/hemodialysis based on their creati...

journal_title：European journal of clinical pharmacology

authors： Wong SL,Menacherry S,Mulford D,Schmitz PJ,Locke C,Granneman GR

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:The purpose of this study is to determine the impacts of CYP3A5 polymorphism on tacrolimus concentration and the proportion of patients within a target therapeutic range during the first week after transplantation together with the 3-month acute rejection rate in kidney transplant patients receiving a minimized...

journal_title：European journal of clinical pharmacology

authors： Yaowakulpatana K,Vadcharavivad S,Ingsathit A,Areepium N,Kantachuvesiri S,Phakdeekitcharoen B,Sukasem C,Sra-Ium S,Sumethkul V,Kitiyakara C

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin or acenocoumarol) and a higher bleeding rate. OBJECTIVES:To determine the relative frequencies of different risk factors for OA overdose including di...

journal_title：European journal of clinical pharmacology

authors： Verstuyft C,Robert A,Morin S,Loriot MA,Flahault A,Beaune P,Funck-Brentano C,Jaillon P,Becquemont L

更新日期：2003-03-01 00:00:00

abstract：:Thirty patients suffering from essential hypertension were treated successively with placebo, hydralazine alone, and pindolol (Visken) combined with hydralazine. Hydralazine caused a statistically significant reduction in blood pressure and an increase in pulse rate as compared with the placebo: palpitations were an i...

journal_title：European journal of clinical pharmacology

authors： Persson I

更新日期：1975-12-19 00:00:00

abstract：PURPOSE:Gefitinib is one of the standard treatments for non-small cell lung cancer (NSCLC) with epidermal growth factor receptor mutations. It has been reported that acid suppressants (AS) decrease the anti-tumor effect of gefitinib by reducing its solubility. AS is sometimes necessary in cancer patients; however, prev...

journal_title：European journal of clinical pharmacology

authors： Saito Y,Takekuma Y,Kobayashi M,Shinagawa N,Shimizu Y,Kinoshita I,Dosaka-Akita H,Iseki K,Sugawara M

更新日期：2020-10-07 00:00:00

abstract：OBJECTIVE:More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommende...

journal_title：European journal of clinical pharmacology

authors： Wusk B,Kullak-Ublick GA,Rammert C,von Eckardstein A,Fried M,Rentsch KM

更新日期：2004-03-01 00:00:00

abstract：:Carvedilol and nitrendipine were given for 12 weeks in a double-blind study to 81 elderly patients (greater than or equal to 60 years) with essential hypertension. The effects on blood pressure were measured (Riva Rocci) before medication and after 2 h with the patient in a lying and standing position after 4 weeks of...

journal_title：European journal of clinical pharmacology

authors： Krönig B,Widmann L,Staiger C,Machwirth M,Stienen U,Hennig M,Müller-Beckmann B

更新日期：1990-01-01 00:00:00

abstract：PURPOSE:We assessed reported associations of CYP3A5 *1 allele with a delay in achieving target tacrolimus concentrations, and occurrence of biopsy-confirmed subclinical acute rejection (SAR) and chronic allograft nephropathy (CAN) in Japanese subjects. METHODS:Forty-one renal allograft recipients were studied. The tar...

journal_title：European journal of clinical pharmacology

authors： Satoh S,Saito M,Inoue T,Kagaya H,Miura M,Inoue K,Komatsuda A,Tsuchiya N,Suzuki T,Habuchi T

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:In order to document the stereoselective distribution in joints of a chiral nonsteroidal anti-inflammatory drug, the relative affinities of the enantiomers of tiaprofenic acid in synovium and for cartilage were compared. METHODS:The distribution of tiaprofenic acid in synovium and in cartilage was studied 25...

journal_title：European journal of clinical pharmacology

authors： Lapicque F,Mainard D,Gillet P,Payan E,Bannwarth B,Netter P

更新日期：1996-01-01 00:00:00

abstract：:Drug shortages in developed countries pose a serious public health problem and have far-reaching implications for healthcare providers and their patients. Given the current state of the market, with the limited number of manufacturers and the array of manufacturing quality issues, drug shortages have become a global c...

journal_title：European journal of clinical pharmacology

authors： Dill S,Ahn J

更新日期：2014-12-01 00:00:00

abstract：:The pharmacokinetics of theophylline was investigated in five hyperthyroid, five hypothyroid, and five euthyroid patients, all with chronic obstructive pulmonary disease. Wide individual variability was found in theophylline kinetics, but the rate of elimination of theophylline was significantly higher in hyperthyroid...

journal_title：European journal of clinical pharmacology

authors： Pokrajac M,Simić D,Varagić VM

更新日期：1987-01-01 00:00:00

abstract：:Propranolol (P) and all of its major known metabolites were found in maternal plasma, cord plasma and neonatal plasma in 10 women at term, irrespective of the P doses administered and the time elapsed (up to 15 h) between administration of the last P dose and delivery. The ratios of cord plasma to simultaneous materna...

journal_title：European journal of clinical pharmacology

authors： Smith MT,Livingstone I,Eadie MJ,Hooper WD,Triggs EJ

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:This study aimed to estimate the total healthcare costs associated with elderly chronic pain (CP) patients, define cost-related factors in this population, and examine cost evolution over two years. METHOD:This is an ancillary study from the CP S.AGE subcohort, including non-institutionalized patients aged o...

journal_title：European journal of clinical pharmacology

authors： Lazkani A,Delespierre T,Bauduceau B,Pasquier F,Bertin P,Berrut G,Corruble E,Doucet J,Falissard B,Forette F,Hanon O,Benattar-Zibi L,Piedvache C,Becquemont L

更新日期：2015-08-01 00:00:00

abstract：:The effect of the angiotensin converting enzyme inhibitor, perindopril, on autonomic function was assessed in a double blind, placebo controlled, crossover study in 10 normotensive males. Eight milligram of perindopril given orally lowered blood pressure without a change in heart rate. Perindopril enhanced the vagally...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Lees KR,Reid JL

更新日期：1986-01-01 00:00:00

abstract：:In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Follo...

journal_title：European journal of clinical pharmacology

authors： Seymour RA,Williams FM,Oxley A,Ward A,Fearns M,Brighan K,Rawlins MD,Jones PM

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than...

journal_title：European journal of clinical pharmacology

authors： McVerry RM,Lethbridge J,Martin N,Mukerjee SK,Littler T,Tallis R,Sibeon R,Orme ML

更新日期：1986-01-01 00:00:00

abstract：:Accidental intoxication with tramadol of a 6-month old infant was followed by severe cerebral depression. Studies on serum, cerebrospinal fluid, and urine drug levels indicated complete penetration of the blood-cerebrospinal fluid barrier by tramadol. ...

journal_title：European journal of clinical pharmacology

authors： Riedel F,von Stockhausen HB

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

journal_title：European journal of clinical pharmacology

authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:Lithium (Li), the first-line treatment of bipolar disorder, was first developed as an immediate-release form with a routine therapeutic drug monitoring 12 h after the last dose. In Europe, the most commonly prescribed form is a sustained release (srLi). Yet no pharmacokinetics (PK) study has been published of s...

journal_title：European journal of clinical pharmacology

authors： Couffignal C,Bertrand J,Sportiche S,Jarroir M,El Balkhi S,Djebrani-Oussedik N,Poupon J,Declèves X,Mentré F,Bellivier F

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVE:The extrapolated area under the concentration-time curve (AUC0-infinity) for any drug is considered by operating guidelines as the primary parameter related to the extent of absorption in single-dose bioavailability and bioequivalence trials. Not more than 20% should be added to the experimental AUC (AUC0-t) ...

journal_title：European journal of clinical pharmacology

authors： Marzo A,Monti NC,Vuksic D

更新日期：1999-11-01 00:00:00

abstract：:In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing upright were measured in ...

journal_title：European journal of clinical pharmacology

authors： Lemmer B,Scheidel B,Blume H,Becker HJ

更新日期：1991-01-01 00:00:00