Metabolism of propranolol in the human maternal-placental-foetal unit.

abstract：:The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a ...

journal_title：European journal of clinical pharmacology

authors： Streete JM,Berry DJ,Newberry JE,Crome P

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:In elderly patients, both falls and impaired memory are considerable medical problems. Hypnotics, which are frequently administered to this patient group for the treatment of insomnia, should ideally not impair equilibrium or memory functions. This double-blind, randomised, four-way, cross-over study investig...

journal_title：European journal of clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Tarral A,Gandon JM

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To investigate the characteristics of ADRs in patients admitting at the emergency room of a tertiary hospital. METHODS:We collected the patient records of 1600 emergency room visits of a university hospital in 2018. The patient files were studied retrospectively and all possible ADRs were identified and regist...

journal_title：European journal of clinical pharmacology

authors： Kauppila M,Backman JT,Niemi M,Lapatto-Reiniluoto O

更新日期：2020-11-13 00:00:00

abstract：:In 8 social drinkers, the effect of a single dose of Liv.52 or placebo on ethanol absorption has been studied after ingestion of 30 ml whisky in 5 min. The t1/2 absorption with Liv.52 was 3.62 min, significantly less than after placebo, 6.29 min. The peak concentration after Liv.52 (49.9 mg.100 ml-1) was significantly...

journal_title：European journal of clinical pharmacology

authors： Chauhan BL,Kulkarni RD

更新日期：1991-01-01 00:00:00

abstract：:The aim of this multicentre randomised double blind study was to compare the efficacy and safety of the 200-300 mg sustained release diltiazem formulation administered once daily (200-300 SR) with standard diltiazem (D) given three or four times daily to patients with stable angina. Patients aged 59 years, with a repr...

journal_title：European journal of clinical pharmacology

authors： Trimarco B,Radzik D,Van Mieghem W,Neveux E,Wajman A,Attali P,Ponsonnaille J

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to clarify the stereoselective properties in lansoprazole metabolism by monitoring the metabolic consumption for each enantiomer and the formation of the main metabolites, lansoprazole sulfone and 5-hydroxylansoprazole, in the presence of human liver microsomal enzymes. METH...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Hamada A,Nakamura C,Arimori K,Nakano M

更新日期：2001-12-01 00:00:00

abstract：:Seven patients with acutely elevated diastolic blood pressure (DBP greater than or equal to 135 mmHg) were treated with repeated injections of diazoxide 1 mg/kg body weight i.v. at 10-min intervals. If the DBP was not reduced to 110 mmHg or less after 5 injections, a dose of 5 mg/kg was given. Serum diazoxide (total a...

journal_title：European journal of clinical pharmacology

authors： McNair A,Andreasen F,Nielsen PE

更新日期：1983-01-01 00:00:00

abstract：:In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Weeke B

更新日期：1985-01-01 00:00:00

abstract：:Migraine is the most common cause of vascular headache and a highly prevalent illness. In the last 20 years, the discovery of new agents has increased clinical research on migraine. In most of clinical trials that have been conducted, the efficacy was established using a placebo as a control treatment. The objective o...

journal_title：European journal of clinical pharmacology

authors： Macedo A,Farré M,Baños JE

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS:A randomized, double-blind, cross-over study design with two phases, which were separated by a washout pe...

journal_title：European journal of clinical pharmacology

authors： Kantola T,Kivistö KT,Neuvonen PJ

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:SPT-07A is an intravenous injection of (+)-2-borneol being developed for the treatment of acute ischemic stroke. This study aimed to investigate the pharmacokinetics, pharmacodynamics, safety, tolerability, and mass balance of SPT-07A after sequentially administered single and multiple infusions of SPT-07A at 1...

journal_title：European journal of clinical pharmacology

authors： Wang W,Wang Y,Zhao W,Zhong J,Wang Y,Chen X

更新日期：2020-06-01 00:00:00

abstract：:We have studied the pharmacodynamic effects of ramipril, propranolol, and their combination, as well as the effect of propranolol on the pharmacokinetics of ramipril in 12 healthy men (age 24 (SD 6) y, weight 72 (7) kg). Propranolol and placebo, ramipril and placebo, or propranolol and ramipril were given orally for f...

journal_title：European journal of clinical pharmacology

authors： van Griensven JM,Seibert-Grafe M,Schoemaker HC,Frölich M,Cohen AF

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Ultraviolet radiation exposure is the most important exogenous risk factor for cutaneous malignancies. It is possible that phototoxic drugs promote the development of cutaneous melanoma (CM) by intensifying the effect of ultraviolet light on the skin. We investigated the association between the use of common sy...

journal_title：European journal of clinical pharmacology

authors： Siiskonen SJ,Koomen ER,Visser LE,Herings RM,Guchelaar HJ,Stricker BH,Nijsten TE

更新日期：2013-07-01 00:00:00

abstract：:The pharmacokinetics of a single dose of netilmicin (NM) was studied in 6 healthy volunteers. Elimination of the drug was followed in serum and urine for 24 h and 72 h, respectively. NM concentrations were measured with a modified radioenzymatic assay. A three compartment open model was employed to calculate the pharm...

journal_title：European journal of clinical pharmacology

authors： Wenk M,Spring P,Vozeh S,Follath F

更新日期：1979-11-01 00:00:00

abstract：:Twenty patients (5 females, 15 males) with severe heart failure (NYHA IV), due to coronary artery disease in 14, and congestive cardiomyopathy in 6, received an intravenous bolus of the calcium blocker nisoldipine 0.2 mg followed by a continuous infusion of 0.2 micrograms.kg-1.min-1. Haemodynamic measurements were per...

journal_title：European journal of clinical pharmacology

authors： Erlemeier HH,Kupper W,Bleifeld W

更新日期：1990-01-01 00:00:00

abstract：:The diabetogenic effect of deflazacort (DF), an oxazolinic synthetic corticosteroid, was studied in 12 healthy adult subjects with a positive family history of diabetes mellitus. Three oral glucose tests (oGTT) were performed at 9.00 a.m., after a 12 h fast, following randomized administration of Placebo (PL), or Defl...

journal_title：European journal of clinical pharmacology

authors： Pagano G,Lombardi A,Ferraris GM,Imbimbo B,Cavallo Perin P

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To assess the initial uptake in use and co-prescribing patterns of sildenafil. METHODS:We examined prescription details of the Eastern Health Board Region (including Dublin) of the General Medical Services (GMS) in Ireland, which provides detail on prescriptions dispensed in primary care for this population ...

journal_title：European journal of clinical pharmacology

authors： Williams D,Feely J

更新日期：2001-03-01 00:00:00

abstract：:The effect of nevirapine once-daily dosing on the pharmacokinetics of methadone and its main metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, was evaluated in ten HIV positive patients on stable methadone therapy. Nevirapine 200 mg once daily was administered orally from day 1 to day 14. On day 15, nevir...

journal_title：European journal of clinical pharmacology

authors： Arroyo E,Valenzuela B,Portilla J,Climent-Grana E,Pérez-Ruixo JJ,Merino E

更新日期：2007-07-01 00:00:00

abstract：PURPOSE:Tolcapone is an efficacious catechol-O-methyltransferase inhibitor for Parkinson's disease (PD). However, safety issues hampered its use in clinical practice. We aimed to provide evidence of safety and efficacy of tolcapone by a systematic literature review to support clinicians' choices in the use of an enlarg...

journal_title：European journal of clinical pharmacology

authors： Artusi CA,Sarro L,Imbalzano G,Fabbri M,Lopiano L

更新日期：2021-01-07 00:00:00

abstract：:The plasma kinetics of timolol administered orally and intravenously to 5 male subjects were examined. Bioavailability was reduced by 25% when the drug was taken orally. Mean plasma half-life after oral dosing was 4.86 h, and after intravenous administration it was 4.56 h; the difference was not significant. The volum...

journal_title：European journal of clinical pharmacology

authors： Else OF,Sorenson H,Edwards IR

更新日期：1978-12-18 00:00:00

abstract：:Individual variation in the half-life of caffeine in the body was measured by HPLC analysis of saliva samples. The mean for adult males and non-pregnant females was 3.4 h (range 2-5 h, n = 25), and 8.3 h (range 3-16 h, n = 57) for pregnant women. After delivery, in most cases the values returned to normal within one m...

journal_title：European journal of clinical pharmacology

authors： Knutti R,Rothweiler H,Schlatter C

更新日期：1981-01-01 00:00:00

abstract：AIMS:To determine whether the variability in cytochrome P(450) (CYP)3A4 metabolic function is exhibited at both transcription and translation levels and to examine the population distribution of CYP3A4 enzyme kinetics, protein, and mRNA. METHODS:Enzyme kinetics of testosterone 6beta-hydroxylation, immunoblot CYP3A4 pr...

journal_title：European journal of clinical pharmacology

authors： Sy SK,Ciaccia A,Li W,Roberts EA,Okey A,Kalow W,Tang BK

更新日期：2002-08-01 00:00:00

abstract：PURPOSE:The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS:When prescribing for older pa...

journal_title：European journal of clinical pharmacology

authors： Brewer L,Williams D,Moore A

更新日期：2011-04-01 00:00:00

abstract：PURPOSE:As an inhibitor of HMG-CoA reductase that catalyses the first step of cholesterol synthesis, pitavastatin undergoes little hepatic metabolism; however, it is a substrate of uptake and efflux transporters. Since pitavastatin is potentially co-administered with agents that affect transporter activities, the pharm...

journal_title：European journal of clinical pharmacology

authors： Chen Y,Zhang W,Huang WH,Tan ZR,Wang YC,Huang X,Zhou HH

更新日期：2013-11-01 00:00:00

abstract：:The pharmacokinetics of isosorbide-5-mononitrate (IS-5-MN) has been studied in two groups of healthy volunteers after oral (n = 20) and intravenous (n = 11) administration of 20 mg, which had previously been proved to be as effective as 20 mg sustained-release isosorbide dinitrate (ISDN). IS-5-MN in serum was measured...

journal_title：European journal of clinical pharmacology

authors： Abshagen U,Betzien G,Endele R,Kaufmann B

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To describe the epidemiology of psychotropic drug use in a sample of Italian outpatient psychiatric services. METHODS:Drug-utilisation survey conducted within the framework of a broader prospective follow-up study with 67 Italian outpatient psychiatric services. RESULTS:The data concern 2322 patients recrui...

journal_title：European journal of clinical pharmacology

authors： Tognoni G

更新日期：1999-11-01 00:00:00

abstract：:The pharmacokinetics of fluocortolone and its effect on the circadian rhythm of plasma cortisol and ACTH have been studied during different schedules of oral administration. Groups of 6 healthy male adults were given a single daily dose of fluocortolone 5, 10 and 20 mg, and another group received 20 mg every second da...

journal_title：European journal of clinical pharmacology

authors： Tüber U,Posern U,Bickel U,Matthes H,Voigt K

更新日期：1988-01-01 00:00:00

abstract：:Milrinone, a new, nonglycosidic inotropic agent with peripheral vasodilating properties, was given as a single oral 5 mg dose to 7 healthy subjects, 7 patients with moderate renal impairment (CRI I, creatinine clearance 30-63 ml/min) and 7 patients with severe renal impairment had hypertension. The mean urinary recove...

journal_title：European journal of clinical pharmacology

authors： Larsson R,Liedholm H,Andersson KE,Keane MA,Henry G

更新日期：1986-01-01 00:00:00

abstract：BACKGROUNDS AND AIMS:Development of safe and effective rescue regimens for eradication failure of Helicobacter pylori infection by standard regimens is an urgent task. We designed the prospective study to compare the efficacy of two rescue regimens after eradication failure by the standard triple therapy. METHODS:One ...

journal_title：European journal of clinical pharmacology

authors： Shirai N,Sugimoto M,Kodaira C,Nishino M,Ikuma M,Kajimura M,Ohashi K,Ishizaki T,Hishida A,Furuta T

更新日期：2007-08-01 00:00:00

abstract：PURPOSE:The pharmacokinetics of orally administered immediate-release, twice-daily (BID) and modified-release, once-daily (QD) formulations of tacrolimus have high interindividual variability. We investigated factors affecting interindividual variability of tacrolimus bioavailability in renal transplant patients. METH...

journal_title：European journal of clinical pharmacology

authors： Niioka T,Kagaya H,Miura M,Numakura K,Saito M,Inoue T,Habuchi T,Satoh S

更新日期：2013-09-01 00:00:00