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Pharmacokinetics of naproxen in elderly patients.

Abstract：

:The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than in the controls (60.1 vs. 43.3 micrograms X ml-1). The AUC (0-24) was significantly higher in the elderly subjects only when normalized for body weight (9.1 vs. 5.4 micrograms X ml-1 X h kg-1 p less than or equal to 0.02). The AUC was significantly higher in the elderly group compared to the control group also in the normalized form. The apparent clearance of naproxen was reduced in the elderly compared to the control patients (315 vs. 628 ml X h-1). The percentage protein binding of naproxen was the same in both groups (99.8%) but the free concentration of naproxen was significantly higher in the elderly patients than in the control patients (141 vs. 89.8 ng X ml-1). Although there was no excess of side effects in the elderly patients it is suggested that when naproxen is given to elderly patients, therapy should be started at the lower end of the dosage range.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

McVerry RM,Lethbridge J,Martin N,Mukerjee SK,Littler T,Tallis R,Sibeon R,Orme ML

doi

10.1007/BF00613525

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

463-8

issue

4

eissn

0031-6970

issn

1432-1041

journal_volume

31

pub_type

杂志文章

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