The influence of haemodialysis and haemofiltration on the clearance of torasemide in renal failure.

abstract：:The pharmacokinetics of biperiden was studied and compared with pharmacodynamics (pupil size, accommodation, self-rating mood scale) in 6 healthy volunteers. A single-blind cross-over design was employed with placebo and biperiden (4 mg as commercially available tablets). After a lag time of 0.5 h, biperiden was rapid...

journal_title：European journal of clinical pharmacology

authors： Hollmann M,Brode E,Greger G,Müller-Peltzer H,Wetzelsberger N

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than...

journal_title：European journal of clinical pharmacology

authors： McVerry RM,Lethbridge J,Martin N,Mukerjee SK,Littler T,Tallis R,Sibeon R,Orme ML

更新日期：1986-01-01 00:00:00

abstract：:The effects of acute introduction and withdrawal of trimeprazine (Vallergan), an antihistaminic phenothiazine derivative with known sedative effects, were investigated by a single blind polygraphic study in 8 healthy volunteers. A baseline placebo was given on Nights 1-3, followed either by 10 mg or 20 mg of the drug ...

journal_title：European journal of clinical pharmacology

authors： Kayed K,Hansen T,Godtlibsen OB

更新日期：1977-03-11 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors block angiotensin II formation and release bradykinin, which is effective in the regulation of oxidoinflammatory injury. Some reports denote alterations in the effectiveness of ACE inhibitors in association with ACE insertion/deletion (I/D) gene polymorphisms. T...

journal_title：European journal of clinical pharmacology

authors： Urhan Küçük M,Sucu N,Şahan Firat S,Aytaçoğlu BN,Vezir Ö,Bozali C,Canacankatan N,Kul S,Tunçtan B

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:Monoamine oxidase inhibitors (MAOIs) are uncommonly used due to their high frequency of adverse effects, including tachycardia and hypertension. Recently, there has been renewed interest in the role of this class of drugs in treating a variety of psychiatric disorders. The clinical features of MAOI overdose ...

journal_title：European journal of clinical pharmacology

authors： Waring WS,Wallace WA

更新日期：2007-11-01 00:00:00

abstract：:The effect of treatment with diflunisal on the steady-state pharmacokinetics of indomethacin has been studied in 16 healthy volunteers. The steady-state plasma concentration and AUC of indomethacin were significantly increased two- to threefold during treatment with diflunisal and its total clearance and total volume ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Verbesselt R,Tjandra-Maga TB,De Schepper PJ

更新日期：1989-01-01 00:00:00

abstract：:The incidence of vasodilation-related events (flushing, headache, dizziness and oedema) was determined in a total of 37,670 patients treated with diltiazem, nicardipine, isradipine or amlodipine and studied by Prescription-Event Monitoring between 1984 and 1991. Event rates are expressed as the percentage of patients ...

journal_title：European journal of clinical pharmacology

authors： Kubota K,Pearce GL,Inman WH

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to describe determinants of current and subsequent benzodiazepine use in an elderly population, the Paquid cohort. METHODS:The study was conducted on a cohort of 2,792 community-dwelling subjects 65 years of age or more living in the Gironde department, southwestern France. B...

journal_title：European journal of clinical pharmacology

authors： Fourrier A,Letenneur L,Dartigues JF,Moore N,Bégaud B

更新日期：2001-08-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is an event that has a detrimental impact on drug development and patient safety; therefore the identification of novel biomarkers that are both sensitive and specific to the liver would have great benefit. Inflammation is known to be associated with human cases of DILI, and given the ...

journal_title：European journal of clinical pharmacology

authors： Laverty HG,Antoine DJ,Benson C,Chaponda M,Williams D,Kevin Park B

更新日期：2010-10-01 00:00:00

abstract：:Propranolol (P) and all of its major known metabolites were found in maternal plasma, cord plasma and neonatal plasma in 10 women at term, irrespective of the P doses administered and the time elapsed (up to 15 h) between administration of the last P dose and delivery. The ratios of cord plasma to simultaneous materna...

journal_title：European journal of clinical pharmacology

authors： Smith MT,Livingstone I,Eadie MJ,Hooper WD,Triggs EJ

更新日期：1983-01-01 00:00:00

abstract：:The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t 1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under ...

journal_title：European journal of clinical pharmacology

authors： Narang AP,Datta DV,Nath N,Mathur VS

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To assess the effect of ciprofloxacin on the pharmacokinetics of ropivacaine. METHODS. In a double-blind, randomised, cross-over study, nine healthy volunteers were treated for 2.5 days with 500 mg oral ciprofloxacin or placebo twice daily. On day 3, they received a single dose of 0.6 mg/kg ropivacaine intrav...

journal_title：European journal of clinical pharmacology

authors： Jokinen MJ,Olkkola KT,Ahonen J,Neuvonen PJ

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

journal_title：European journal of clinical pharmacology

authors： Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

更新日期：2007-05-01 00:00:00

abstract：:The effect of ethanol intake on disopyramide elimination was examined in an open crossover study in six healthy volunteers. No effect of ethanol on the elimination half-life or total body clearance of disopyramide was found, although it did decrease the percentage of mono-N-dealkylated disopyramide excreted in the uri...

journal_title：European journal of clinical pharmacology

authors： Olsen H,Bredesen JE,Lunde PK

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Theophylline is metabolized to 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine, and 1-methylxanthine by CYP1A2 and partly by CYP2E1. Because 1,3-DMU is the major metabolite of theophylline, the 1,3-DMU/theophylline ratio is viewed as a good indicator of theophylline metabolic clearance. Here, we investigate...

journal_title：European journal of clinical pharmacology

authors： Yoon Y,Park HD,Park KU,Kim JQ,Chang YS,Song J

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The study aims to compare the efficacy and safety of capecitabine plus oxaliplatin (XELOX) with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in patients with advanced gastric cancer. METHODS:Five databases were searched up to June 2014, without language restrictions. The outcomes included overall respo...

journal_title：European journal of clinical pharmacology

authors： Xu HB,Huang F,Su R,Shen FM,Lv QZ

更新日期：2015-05-01 00:00:00

abstract：:Data on forged prescriptions in Sweden in 1982-1986 were studied as an indicator in an epidemiological survey of medication abuse. The annual number of prescription forgeries doubled during the 5-year period. Psychotropic drugs accounted for 62% and analgesics for 25% of all forgeries. Benzodiazepines were the major s...

journal_title：European journal of clinical pharmacology

authors： Bergman U,Dahl-Puustinen ML

更新日期：1989-01-01 00:00:00

abstract：:The effect of long-term treatment on the absorption and disposition of metoprolol has been evaluated in 8 healthy, non-smoking, elderly individuals (mean age 74.5 years) and in a control group of 8 healthy, young individuals. Two trace doses of [3H]metoprolol were given i.v., first concomitantly with a single oral 50 ...

journal_title：European journal of clinical pharmacology

authors： Larsson M,Landahl S,Lundborg P,Regårdh CG

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of cefoxitin was studied in 6 healthy volunteers and in 5 patients with a pleural effusion after administration of a single dose of 30 mg/kg i.v. infusion. The serum and pleural fluid concentrations of cefoxitin were determined microbiologically. The elimination half-life of the antibiotic from pl...

journal_title：European journal of clinical pharmacology

authors： Otero MJ,Garcia MJ,Barrueco M,Dominguez-Gil A,Gomez F,Portugal Alvarez J

更新日期：1984-01-01 00:00:00

abstract：:Pharmacokinetic parameters of prazosin (t1/2, tmax, Cmax and AUC have been studied in 18 hypertensive patients with varying degrees of chronic renal failure (serum creatinine ranging from 1.6 to 11.4 mg/dl). An oral dose of 2 mg of prazosin was added to the preexisting antihypertensive medication. The degree of renal ...

journal_title：European journal of clinical pharmacology

authors： Lameire N,Gordts J

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Xanthine oxidase (XO) is one of the two interconvertible forms of xanthine oxidoreductase and well-studied for its role in purine catabolism and that of other purine analogues, drugs especially. Our study investigated the incidence of polymorphism in phenotypes along with the influence of gender and age on e...

journal_title：European journal of clinical pharmacology

authors： Adehin A,Bolaji OO

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the interactions of itraconazole (ITCZ) with orally administered calcineurin inhibitors (CNIs) in Japanese allogeneic hematopoietic stem cell transplant (HSCT) recipients. METHODS:Sixteen HSCT patients (8 patients each receiving tacrolimus or cyclosporine) were enro...

journal_title：European journal of clinical pharmacology

authors： Nara M,Takahashi N,Miura M,Niioka T,Kagaya H,Fujishima N,Saitoh H,Kameoka Y,Tagawa H,Hirokawa M,Sawada K

更新日期：2013-06-01 00:00:00

abstract：:The effects of intravenous strophanthin K (0.125 and 0.25 MG) and lanatoside C (0.4, 0.8 and 1.6 mg) on systolic time intervals (STI) and impedance plethysmographic (IP)P values were studied in ten patients with compensated coronary heart disease. The heart rate decreased significantly during a two-hour study in the l...

journal_title：European journal of clinical pharmacology

authors： Matos L,Békés M,Polák G,Rausch J,Török E

更新日期：1975-10-10 00:00:00

abstract：PURPOSE:Drug utilization studies have applied different methods to various data types to describe medication use, which hampers comparisons across populations. The aim of this study was to describe the time trends in antidepressant prescribing in the last decade and the variation in the prevalence, calculated in a unif...

journal_title：European journal of clinical pharmacology

authors： Abbing-Karahagopian V,Huerta C,Souverein PC,de Abajo F,Leufkens HG,Slattery J,Alvarez Y,Miret M,Gil M,Oliva B,Hesse U,Requena G,de Vries F,Rottenkolber M,Schmiedl S,Reynolds R,Schlienger RG,de Groot MC,Klungel OH,va

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVE:Nafamostat mesilate, a potent protease inhibitor, is widely used for the treatment of pancreatitis, disseminated intravascular coagulation and as an anticoagulant in haemodialysis. However, hyperkalaemia associated with nafamostat mesilate has been reported. It is thought to be due to decreased urinary potass...

journal_title：European journal of clinical pharmacology

authors： Ookawara S,Tabei K,Sakurai T,Sakairi Y,Furuya H,Asano Y

更新日期：1996-01-01 00:00:00

abstract：:A randomised, placebo controlled clinical trial was conducted to examine the efficacy of a homeopathic after-bite gel in the symptomatic relief of mosquito bites. Sixty eight healthy volunteers were bitten under laboratory conditions by Aedes aegypti mosquitoes at three spots, on the ventral aspect of the forearm. One...

journal_title：European journal of clinical pharmacology

authors： Hill N,Stam C,Tuinder S,van Haselen RA

更新日期：1995-01-01 00:00:00

abstract：:The binding equilibria of warfarin and phenprocoumon with defatted human serum albumin were studied by equilibrium dialysis in 33 mM sodium phosphate buffer, pH 7.4, 37 degrees C. The binding isotherms for both ligands were consistent with binding to two similar and independent sites in the albumin molecule. The bindi...

journal_title：European journal of clinical pharmacology

authors： Vorum H,Jørgensen HR,Brodersen R

更新日期：1993-01-01 00:00:00

abstract：:It is uncertain as to the extent which gastrointestinal (GI) haemorrhage related to NSAIDs is due to a local, topical effect or to an action related to systemic absorption. We hypothesised that, should systemic drug concentrations be of importance, plasma levels of NSAIDs might be higher in patients who had developed ...

journal_title：European journal of clinical pharmacology

authors： Wynne HA,Rawlins MD

更新日期：1993-01-01 00:00:00

abstract：:Procaine esterase activity in plasma from patients with renal failure is decreased by 40%. Since cyanate is formed from urea and readily carbamylates certain blood proteins, a possible role for cyanate in the depression of plasma esterase activity in uraemic patients was considered. However, in vitro carbamylation of ...

journal_title：European journal of clinical pharmacology

authors： Calvo R,Carlos R,Erill S

更新日期：1983-01-01 00:00:00

abstract：:Glucocorticoids (GCs) exert different activities that are useful for the treatment of several haematologic disorders. The synergistic effect with cytotoxic drugs is important for the therapy of lymphoproliferative diseases. The inhibition of macrophages prevents acute haemolysis and platelets destruction in autoimmune...

journal_title：European journal of clinical pharmacology

authors： Gobbi M,Scudeletti M

更新日期：1993-01-01 00:00:00