Vasodilation-related adverse events in diltiazem and dihydropyridine calcium antagonists studied by prescription-event monitoring.


:The incidence of vasodilation-related events (flushing, headache, dizziness and oedema) was determined in a total of 37,670 patients treated with diltiazem, nicardipine, isradipine or amlodipine and studied by Prescription-Event Monitoring between 1984 and 1991. Event rates are expressed as the percentage of patients who experienced these events during the six months after the first prescription. The rates for all these events with the newer vasoselective dihydropyridines (nicardipine, isradipine and amlodipine) were higher than those with diltiazem. Among the three dihydropyridines, there were large individual differences in the rates. With nicardipine, the frequency of each of the four vasodilation-related events were similar to one another (approximately 3%). With isradipine, the rates were also similar to one another but all were approximately twice those measured in the nicardipine study (approximately 6%). These differences may have been due to confounding factors such as the publicity about adverse drug reactions, the indication for use by individual patients or the doses actually being used at the time the event occurred. With amlodipine, in contrast, the rate for oedema was two to four times larger than the rates for flushing, headache or dizziness.


Eur J Clin Pharmacol


Kubota K,Pearce GL,Inman WH




Has Abstract


1995-01-01 00:00:00












  • Urinary 6beta-hydroxycortisol: a validated test for evaluating drug induction or drug inhibition mediated through CYP3A in humans and in animals.

    abstract::6beta-Hydroxycortisol (6beta-OHF) urinary excretion has, for a long time, been considered a marker of drug induction and, more recently, of drug inhibition in humans and in laboratory animals, but its specificity is still under debate. In this work, we review 277 papers devoted to 6beta-OHF urinary excretion. We have ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Galteau MM,Shamsa F

    更新日期:2003-12-01 00:00:00

  • Erythropoetin as a novel agent with pleiotropic effects against acute lung injury.

    abstract::Current pharmacotherapy for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is not optimal, and the biological and physiological complexity of these severe lung injury syndromes requires consideration of combined-agent treatments or agents with pleiotropic action. In this regard, exogenous eryth...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审


    authors: Kakavas S,Demestiha T,Vasileiou P,Xanthos T

    更新日期:2011-01-01 00:00:00

  • In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3A.

    abstract:OBJECTIVES:To evaluate zolpidem as a mechanism-based inactivator of human CYP3A in vitro, and to assess its metabolic interaction potential with CYP3A drugs (in vitro-in vivo extrapolation; IV-IVE). METHODS:A co- vs. pre-incubation strategy was used to quantify time-dependent inhibition of human liver microsomal (HLM)...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Polasek TM,Sadagopal JS,Elliot DJ,Miners JO

    更新日期:2010-03-01 00:00:00

  • Antihypertensive effects of urapidil and clonidine: a double-blind cross-over study.

    abstract::The antihypertensive effects of urapidil and clonidine have been studied in a double-blind cross-over trial in 11 hypertensive outpatients with mild to moderate hypertension, at rest and during isometric exercise. Urapidil 30 mg b.i.d. significantly decreased the standing diastolic blood pressure (p less than 0.05) an...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kanniainen E,Heikkilä O,Jääskeläinen T,Lilja M,Jounela AJ

    更新日期:1985-01-01 00:00:00

  • Pharmacodynamics and arteriovenous difference of intravenous naloxone in healthy volunteers exposed to remifentanil.

    abstract:PURPOSE:Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known whether there are arteriovenous concentration differences for naloxone. The aim was thus to further...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Tylleskar I,Skulberg AK,Skarra S,Nilsen T,Dale O

    更新日期:2018-12-01 00:00:00

  • Prizidilol (SK & F 92657), a new vasodilator with beta-blocking properties in the treatment of essential hypertension.

    abstract::The antihypertensive effect of a new vasodilator with betablocking properties (SK & F 92657) was investigated in 10 patients with mild to moderate essential hypertension. After a mean treatment period of 26,5 weeks (6,5-49 weeks) blood pressure was significantly reduced, from 168 +/- 22/106 +/- 6 mmHg to 144 +/- 19/94...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Lüscher T,Havelka J,Greminger P,Tuma J,Täuber M,Siegenthaler W,Vetter W

    更新日期:1982-01-01 00:00:00

  • Adherence to hospital drug formularies and cost of drugs in hospitals in Denmark.

    abstract:PURPOSE:To investigate adherence rates to hospital drug formularies (HDFs) and cost of drugs in hospitals. METHODS:Data on drugs used during 2010 were analyzed for ten hospitals (two hospitals from each of the five regions), constituting 30 % of hospitals and 45 % of hospital beds in Denmark. Drug use data from indivi...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Plet HT,Hallas J,Kjeldsen LJ

    更新日期:2013-10-01 00:00:00

  • Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity.

    abstract:OBJECTIVE:To study the distribution of the thiopurine methyltransferase (TPMT) genotype among azathioprine (Aza)-tolerant and -intolerant patients with various disorders, and to investigate a possible relationship with the Aza metabolite levels. METHODS:Forty-six Aza-tolerant and six Aza-intolerant patients had the TP...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究


    authors: Reuther LO,Vainer B,Sonne J,Larsen NE

    更新日期:2004-01-01 00:00:00

  • The effect of operational stressors on ibuprofen pharmacokinetics.

    abstract:PURPOSE:To determine whether two of the major operational stressors associated with military missions in Afghanistan: dry heat and long durations of soldier patrol (SP), alter the pharmacokinetics of ibuprofen. METHODS:Thirteen healthy and physically fit participants (19-32 years) were randomized to a four-arm crossov...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Boscarino C,Edginton AN,Peng H,Riggs KW,Szeitz A,Cheung B

    更新日期:2013-01-01 00:00:00

  • Measuring medication adherence in older community-dwelling patients with multimorbidity.

    abstract:PURPOSE:Older people with several chronic conditions require multiple drugs from different classes to be adequately treated. This study aims to: (i) measure medication adherence across multiple conditions and therapeutic drug groups in older community-dwelling patients, and (ii) examine the effect of multimorbidity on ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,多中心研究


    authors: Kim S,Bennett K,Wallace E,Fahey T,Cahir C

    更新日期:2018-03-01 00:00:00

  • A double blind trial of UK-38,485, an orally active thromboxane synthetase inhibitor, in the treatment of Raynaud's syndrome.

    abstract::Ten patients with moderate to severe Raynaud's syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment peri...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rustin MH,Grimes SM,Kovacs IB,Cooke ED,Bowcock SA,Sowemimo-Coker SO,Turner P,Kirby JD

    更新日期:1984-01-01 00:00:00

  • Network meta-analyses of antiepileptic drug efficacy and tolerability in drug-resistant focal epilepsies: a clinical perspective.

    abstract:PURPOSE:Network meta-analysis (NMA) is a new technique that allows multiple treatment comparisons and provides estimates of effect sizes for all possible pair-wise comparisons. Several NMAs of antiepileptic drug (AED) efficacy and tolerability in individuals with refractory focal epilepsy, however, came to non-specific...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,meta分析


    authors: Zaccara G,Giovannelli F,Bell GS,Sander JW

    更新日期:2014-06-01 00:00:00

  • Long-term nicotine substitution after application of a 16-hour nicotine patch in smoking cessation.

    abstract::The purpose of the study was to examine long-term nicotine substitution and its variability during use of a nicotine patch. In two smoking cessation studies a 16-h nicotine patch, releasing 15 mg nicotine, was applied daily for 16 h over 12 weeks, to 167 smokers. Salivary cotinine was highly correlated with plasma cot...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nørregaard J,Tønnesen P,Simonsen K,Säwe U

    更新日期:1992-01-01 00:00:00

  • Non-steroidal anti-inflammatory drugs: use and co-treatment with potentially interacting medications in the elderly.

    abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used in the elderly. NSAIDs may cause a series of adverse drug reactions, of which gastrointestinal, renovascular/cardiovascular and bleeding complications are of particular concern. Concomitant use of several other drugs may further increase the risk...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Vandraas KF,Spigset O,Mahic M,Slørdal L

    更新日期:2010-08-01 00:00:00

  • Under-reporting of adverse drug reactions. Estimate based on a spontaneous reporting scheme and a sentinel system.

    abstract:OBJECTIVE:Spontaneous reporting is the most common method used in pharmacovigilance and the best one to generate signals on new or rare adverse drug reactions (ADRs). Under-reporting is a major drawback of this system. The objective of this study was to quantify the extent of under-reporting in general practice and to ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Alvarez-Requejo A,Carvajal A,Bégaud B,Moride Y,Vega T,Arias LH

    更新日期:1998-08-01 00:00:00

  • Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.

    abstract:OBJECTIVE:The multidrug resistance gene 1 (MDR1) seems to play a role in the carcinogenesis of colorectal tumors. The importance of MDR1 SNPs 2677G > T/A in exon 21 and 3435C > T in exon 26 for cancer susceptibility, however, has not yet been clearly defined. METHODS:Two hundred and eighty-five colorectal cancer patie...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Osswald E,Johne A,Laschinski G,Arjomand-Nahad F,Malzahn U,Kirchheiner J,Gerloff T,Meisel C,Mrozikiewicz PM,Chernov J,Roots I,Köpke K

    更新日期:2007-01-01 00:00:00

  • Long acting beta-blockers in the twenty fourth hour.

    abstract::Fifteen mild to moderate hypertensives were submitted to exercise testing using a bicycle ergometer with a fixed load. Heart rate, blood pressure and ECG were recorded throughout 5 min exercise and 10 min recovery. Oxygen uptake was measured during the final minute of exercise and blood glucose estimation and serum dr...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Hackett GI,Harrison P,Kershaw S

    更新日期:1983-01-01 00:00:00

  • Pharmacokinetics and biotransformation of the new benzodiazepine, lormetazepam, in man. III. Repeated administration and transfer to neonates via breast milk.

    abstract::The concentrations of lormetazepam and its glucuronide in plasma and milk were determined during administration of 10 daily doses of lormetazepam 2 mg (2 tablets of Noctamid-1) to five mothers delivered by Caesarian section. Their babies were breast-fed throughout the study, and the plasma levels of lormetazepam and i...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Hümpel M,Stoppelli I,Milia S,Rainer E

    更新日期:1982-01-01 00:00:00

  • Cardiovascular and respiratory effects of the beta-adrenoceptive antagonist sotalol: studies in health, angina pectoris and obstructive lung disease.

    abstract::The cardiovascular and respiratory actions of the adrenergic beta adrenoceptive drug sotalol have been studied in an open, short term trial. Fifteen patients with angina performed standardized orthostatic and exercise tests before and after injection of 20 mg sotalol intravenously. Although there was a significant red...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Areskog NH,Cullhed I,Ringqvist I,Ström G

    更新日期:1975-08-14 00:00:00

  • Treatment of acute renal colic in a French emergency department: a comparison of simulated cases and real cases in acute pain assessment and management.

    abstract:OBJECTIVE:Use of analgesic drugs in acute renal colic varies widely in different countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency pr...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Jean R,Ducasse JL,Montastruc JL,Lapeyre-Mestre M

    更新日期:2001-11-01 00:00:00

  • The use of driving impairing medicines: a European survey.

    abstract:AIM:To analyse the consumption of a number of medicines with a known potential for increasing the risk of road traffic accidents in the general population of Europe. METHODS:Questionnaires were distributed through the European Drug Utilization Research Group (EuroDURG) and Post-Innovation Learning through Life-events ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Ravera S,Hummel SA,Stolk P,Heerdink RE,de Jong-van den Berg LT,de Gier JJ

    更新日期:2009-11-01 00:00:00

  • Apparent dose-dependence of chloroquine pharmacokinetics due to limited assay sensitivity and short sampling times.

    abstract::We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Tett SE,Cutler DJ

    更新日期:1987-01-01 00:00:00

  • An analysis of the clinical development of drugs in Norway for the year 2000: the completion of research and publication of results.

    abstract:OBJECTIVE:In Norway, very little data are available on the relation between the total number of research projects on the clinical development of drugs that have been started, the number of these projects in which the research phase has been completed and the number of projects for which results have been published. The...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Hole OP,Nitter-Hauge S,Cederkvist HR,Winther FO

    更新日期:2009-03-01 00:00:00

  • Pharmacokinetics and pharmacodynamics of propafenone during acute and chronic administration.

    abstract::The pharmacokinetics of propafenone and 5-OH-propafenone and their relationship with the antiarrhythmic action and side effects have been studied in 10 patients with stable, frequent, premature ventricular beats (224-928 premature ventricular complexes/h). Observations were made after a single dose of propafenone 300 ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Giani P,Landolina M,Giudici V,Bianchini C,Ferrario G,Marchi S,Riva E,Latini R

    更新日期:1988-01-01 00:00:00

  • Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.

    abstract::Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Lönnerholm G,Lindström B,Paalzow L,Sedin G

    更新日期:1983-01-01 00:00:00

  • Inhibition of pentagastrin-stimulated gastric acid secretion and plasma levels of the new histamine H2-receptor antagonist ramixotidine dihydrochloride (CM 57755) in human volunteers.

    abstract::The new competitive histamine H2-receptor antagonist, ramixotidine 2 HCl (CM 57755), has been tested in healthy male volunteers for its ability to inhibit pentagastrin-stimulated gastric acid secretion. In the first study, in 8 subjects, pentagastrin 6 was injected s.c., 90 min after the following 4 or...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Brassinne A,Dresse A,Basilisco G,Manara L

    更新日期:1987-01-01 00:00:00

  • Comparison of bopindolol and atenolol in chronic stable angina pectoris.

    abstract::The efficacy of bopindolol and atenolol in the treatment of patients with chronic stable angina pectoris have been compared in a double blind, randomized study. Both bopindolol 1 mg and atenolol 100 mg for 6 weeks increased mean exercise time (25% and 22%, respectively, compared to placebo), time to angina (27% and 25...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fitscha P,Meisner W,Tiso B

    更新日期:1990-01-01 00:00:00

  • Lack of relationship between quinidine pharmacokinetics and the sparteine oxidation polymorphism.

    abstract::Quinidine is a very potent inhibitor of CYP2D6, but the role of the enzyme in the biotransformation of quinidine has only been investigated in a single in vitro study and in two small in vivo experiments, with contradictory results. The present investigation was designed to present definite evaluation of whether quini...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章


    authors: Nielsen F,Rosholm JU,Brøsen K

    更新日期:1995-01-01 00:00:00

  • Binding of teicoplanin to human serum albumin.

    abstract::The interaction between the main components of the new glycopeptide antibiotic teicoplanin, A2-2, A2-3, A2-4, A2-5 and A3-1, and human serum albumin has been studied in vitro by equilibrium dialysis (pH 7.4, 37 degrees C). From Scatchard analysis of the data, the calculated association constants (Ka) were: A2-2, 2.47 ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Assandri A,Bernareggi A

    更新日期:1987-01-01 00:00:00

  • Influence of clinical and genetic factors on warfarin dose requirements among Japanese patients.

    abstract:OBJECTIVE:The aim of this study was to investigate the influence of clinical and genetic factors on warfarin dose requirements in the Japanese population. METHODS:We enrolled 125 patients on stable warfarin anticoagulant therapy with an international normalized ratio maintained between 1.5 and 3.0. PCR-based methods w...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章


    authors: Ohno M,Yamamoto A,Ono A,Miura G,Funamoto M,Takemoto Y,Otsu K,Kouno Y,Tanabe T,Masunaga Y,Nonen S,Fujio Y,Azuma J

    更新日期:2009-11-01 00:00:00