Comparative study of the cardiac and peripheral vascular effects of strophantin K and lanatoside C in coronary heart disease.

abstract：:(1) Plasma protein binding of salicylate was studied in 14 patients with cutaneous hepatic porphyria (CHP) and 11 normal subjects using ultrafiltration with centrifugation (membrane cones) and continuous ultrafiltrations. (2) Albumin and haemoglobin levels were significantly reduced in patients with CHP, and salicylat...

journal_title：European journal of clinical pharmacology

authors： Steele WH,Boobis SW,Moore MR,Goldberg A,Brodie MJ,Summer DJ

更新日期：1978-06-19 00:00:00

abstract：:The bioavailability of four preparations containing dihydrotachysterol (DHT2) was tested in two separate trials with administration of single, oral doses of 1 mg per individual. The relative bioavailability of corresponding preparations (capsules vs capsules and oral solution vs oral solution) was tested in a randomis...

journal_title：European journal of clinical pharmacology

authors： Koytchev R,Alken RG,Vagaday M,Kunter U,Kirkov V

更新日期：1994-01-01 00:00:00

abstract：AIM:Mizoribine (MZR) is an immunosuppressant for the prevention of allograft rejection in Asian countries, but the great variability in pharmacokinetics (PK) limits its clinical use. This study was to explore genetic and clinical factors that affect the MZR PK process. METHODS:Blood samples and clinical data were coll...

journal_title：European journal of clinical pharmacology

authors： Dai R,Li J,Wu J,Fu Q,Yan J,Zhong G,Wang C,Chen X,Chen P

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:The existence of gender differences in the management of statin therapy among patients with chronic heart failure (HF) is still poorly investigated. We aimed at exploring the effect of gender on statin prescription rates and adequacy of dosing and on the association between statin therapy and all-cause 1-year m...

journal_title：European journal of clinical pharmacology

authors： Ballo P,Balzi D,Barchielli A,Turco L,Franconi F,Zuppiroli A

更新日期：2016-03-01 00:00:00

abstract：:Ninety-six depressed outpatients from 5 centres were given viloxazine 200-400 mg/day. The treatment produced significant clinical improvement as evaluated by the Hamilton Rating Scale for Depression. Thirteen patients dropped-out because of possible side effects. Many untoward symptoms were described by all the patien...

journal_title：European journal of clinical pharmacology

authors： Maistrello I,Grassi G,Bertolino A,Valerio P,Pistollato G,Soverini S

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The study aims to compare the efficacy and safety of capecitabine plus oxaliplatin (XELOX) with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in patients with advanced gastric cancer. METHODS:Five databases were searched up to June 2014, without language restrictions. The outcomes included overall respo...

journal_title：European journal of clinical pharmacology

authors： Xu HB,Huang F,Su R,Shen FM,Lv QZ

更新日期：2015-05-01 00:00:00

abstract：:Twenty-nine cases of self-poisoning with antidepressants (amitriptyline, imipramine, clomipramine, maprotiline, doxepine, nortriptyline, opipramol) were examined by frequent observation of CNS effects, heart rate, blood pressure and standard ECG, 24h-ECG-monitoring, measurement of systolic time intervals, EEG recordin...

journal_title：European journal of clinical pharmacology

authors： Pedersen OL,Gram LF,Kristensen CB,Møller M,Thayssen P,Bjerre M,Kragh-SøRensen P,Klitgaard NA,Sindrup E,Hole P,Brinklø M

更新日期：1982-01-01 00:00:00

abstract：:The bronchodilator effect and side-effects of a single oral dose of enprofylline were compared with the corresponding actions of a therapeutic dose of theophylline in 20 asthmatic patients, in a randomized cross-over clinical trial. Enprofylline 4 mg/kg and theophylline 8 mg/kg produced mean maximum plasma levels of 4...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Søndergaard I,Weeke B

更新日期：1984-01-01 00:00:00

abstract：:Six children, aged 2 months - 4 years, received theophylline 5-6 mg/kg intravenously. Its disposition could be described by a two-compartment open model, the mean serum half life (t 1/2 beta) was 3.75 h, i.e., shorter than in adults, but there was a considerable interindividual variation (1.8-7.0 h, in one patient 13....

journal_title：European journal of clinical pharmacology

authors： Bolme P,Edlund PO,Eriksson M,Paalzow L,Winbladh B

更新日期：1979-09-01 00:00:00

abstract：PURPOSE:The quality of drug therapy is an important issue for nursing homes. This study aimed to assess the prevalence of polypharmacy and potentially inappropriate medications (PIMs) in a large sample of nursing home residents by using the data recorded during the preparation of pill dispensers. METHODS:This is a cro...

journal_title：European journal of clinical pharmacology

authors： Herr M,Grondin H,Sanchez S,Armaingaud D,Blochet C,Vial A,Denormandie P,Ankri J

更新日期：2017-05-01 00:00:00

abstract：:In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patient...

journal_title：European journal of clinical pharmacology

authors： Ochs H,Bodem G,Schäfer PK,Kodrat G,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：:Acute studies of clonidine suggest that it lowers blood pressure by central enhancement of baroreflex sensitivity coupled with diminished evidence of sympathetic outflow, but longterm clonidine data have not been conclusive. We examined effects of one month of low dose clonidine (0.4 +/- 0.15 mg/day) alone in 13 essen...

journal_title：European journal of clinical pharmacology

authors： Cohen IM,O'Connor DT,Preston RA,Stone RA

更新日期：1981-01-01 00:00:00

abstract：:To evaluate the magnitude and duration of the antihypertensive effect of sustained release (SRO) isradipine, 37 uncomplicated essential hypertensive patients (diastolic blood pressure 100-115 mm Hg after a one month run-in on placebo) were randomised to receive, according to a double-blind cross-over design, isradipin...

journal_title：European journal of clinical pharmacology

authors： Arzilli F,Gandolfi E,Del Prato C,Innocenti P,Ponzanelli F,Caiazza A,Ghisoni F,Saba P,Giuntoli F,Borgnino C

更新日期：1993-01-01 00:00:00

abstract：:The effect of treatment with diflunisal on the steady-state pharmacokinetics of indomethacin has been studied in 16 healthy volunteers. The steady-state plasma concentration and AUC of indomethacin were significantly increased two- to threefold during treatment with diflunisal and its total clearance and total volume ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Verbesselt R,Tjandra-Maga TB,De Schepper PJ

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Case report of a pharmacokinetic interaction between diltiazem and nortriptyline. METHODS:Determination of plasma nortriptyline concentrations by HPLC. Calculation of nortriptyline clearances and half-life by formulae used routinely in therapeutic drug monitoring. RESULTS:The average plasma concentration of...

journal_title：European journal of clinical pharmacology

authors： Krähenbühl S,Smith-Gamble V,Hoppel CL

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVES:To explore the views and perspectives of children on the unlicensed/off-label use of medicines in children and on the participation of children in clinical trials. METHODS:Focus-group discussions, involving school children, were carried out in a range of primary and secondary schools in Northern Ireland. A ...

journal_title：European journal of clinical pharmacology

authors： Mukattash T,Trew K,Hawwa AF,McElnay JC

更新日期：2012-02-01 00:00:00

abstract：:The concentration of chlorpromazine (CPZ) in hair was measured to demonstrate its value as an index of individual dosage history and compliance. An animal study using pigmented rats was conducted to confirm the dose-dependent accumulation of CPZ in hair. The concentration of CPZ in hair, newly regrown on a denuded are...

journal_title：European journal of clinical pharmacology

authors： Sato H,Uematsu T,Yamada K,Nakashima M

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:The use of melatonin is increasing among Swedish children and adolescents despite deficient knowledge of usage in these groups. The aim of this study was to investigate the use of melatonin in Swedish children and adolescents according to age, gender, dosage, treatment duration, and use of attention deficit hyp...

journal_title：European journal of clinical pharmacology

authors： Furster C,Hallerbäck MU

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:Drug utilization studies have applied different methods to various data types to describe medication use, which hampers comparisons across populations. The aim of this study was to describe the time trends in antidepressant prescribing in the last decade and the variation in the prevalence, calculated in a unif...

journal_title：European journal of clinical pharmacology

authors： Abbing-Karahagopian V,Huerta C,Souverein PC,de Abajo F,Leufkens HG,Slattery J,Alvarez Y,Miret M,Gil M,Oliva B,Hesse U,Requena G,de Vries F,Rottenkolber M,Schmiedl S,Reynolds R,Schlienger RG,de Groot MC,Klungel OH,va

更新日期：2014-07-01 00:00:00

abstract：:The levels of doxycycline in serum, bile and the gallbladder wall were determined in 25 patients during cholecystectomy, by means of bioassay after previous intravenous administration of doxycycline. The mean biliary level exceeded 20 microgram/ml, and the mean level in the gallbladder wall was greater than 2 microgra...

journal_title：European journal of clinical pharmacology

authors： Moorthi K,Wiederholt K

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:The aim was to develop a model to describe the population pharmacokinetics of nevirapine in South African human immunodeficiency virus (HIV)-infected patients who were taking nevirapine-based antiretroviral therapy concomitantly or in the absence of rifampicin-based tuberculosis therapy. METHODS:Patients wer...

journal_title：European journal of clinical pharmacology

authors： Elsherbiny D,Cohen K,Jansson B,Smith P,McIlleron H,Simonsson US

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To investigate statin use in the elderly by age (≥ 80 vs. 65-79 years) in relation to established indications. METHODS:A population-based cohort, including data from four registers, encompassing inhabitants in Region Västra Götaland, Sweden, was used. Statin users were defined as those filling statin prescript...

journal_title：European journal of clinical pharmacology

authors： Sundvall H,Fastbom J,Wallerstedt SM,Vitols S

更新日期：2019-07-01 00:00:00

abstract：:Infusion of a therapeutic dose of sparteine sulphate, increased the basal plasma insulin level and lowered plasma glucose. When an intravenous glucose tolerance test was performed with the infusion, the total insulin AUC was significantly larger than in absence of sparteine (2025 vs 1464 microU/ml X min), plasma gluco...

journal_title：European journal of clinical pharmacology

authors： Sgambato S,Paolisso G,Passariello N,Varricchio M,D'Onofrio F

更新日期：1987-01-01 00:00:00

abstract：:General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were ra...

journal_title：European journal of clinical pharmacology

authors： Dahlöf C,Hedner T,Thulin T,Gustafsson S,Olsson SO

更新日期：1991-01-01 00:00:00

abstract：INTRODUCTION:Epidural hydromorphone could be useful in obstetric analgesia as there is a need for a more water-soluble opioid than sufentanil or fentanyl with prolonged analgesic effect. To our knowledge, the pharmacokinetics of epidural hydromorphone has not been evaluated in parturients. MATERIALS AND METHODS:In thi...

journal_title：European journal of clinical pharmacology

authors： Puhto T,Kokki M,Hakomäki H,Spalding M,Gunnar T,Alahuhta S,Vakkala M

更新日期：2020-07-01 00:00:00

abstract：PURPOSE:The aim of the study was to develop a European list of potentially inappropriate medications (PIM) for older people, which can be used for the analysis and comparison of prescribing patterns across European countries and for clinical practice. METHODS:A preliminary PIM list was developed, based on the German P...

journal_title：European journal of clinical pharmacology

authors： Renom-Guiteras A,Meyer G,Thürmann PA

更新日期：2015-07-01 00:00:00

abstract：:We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjec...

journal_title：European journal of clinical pharmacology

authors： Takabatake T,Ohta H,Yamamoto Y,Ishida Y,Hara H,Nakamura S,Ushiogi Y,Satoh S,Hattori N

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:Time of drug administration may significantly influence its effect. The aim of the present study was to investigate the effect of ASA (administrated in the morning or in the evening) on the anti-hypertensive effect and diurnal blood pressure profile in the high-risk group of cardiovascular patients. METHODS:Al...

journal_title：European journal of clinical pharmacology

authors： Krasińska B,Paluszkiewicz L,Miciak-Ławicka E,Krasinski M,Rzymski P,Tykarski A,Krasiński Z

更新日期：2021-01-01 00:00:00

abstract：:Ten patients with moderate to severe Raynaud's syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment peri...

journal_title：European journal of clinical pharmacology

authors： Rustin MH,Grimes SM,Kovacs IB,Cooke ED,Bowcock SA,Sowemimo-Coker SO,Turner P,Kirby JD

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to investigate the contributions of non-genetic and genetic factors on the variability of stable warfarin doses in Thai patients. METHODS:A total of 250 Thai patients with stable warfarin doses were enrolled in the study. Demographics and clinical data, e.g., age, body mass index, ind...

journal_title：European journal of clinical pharmacology

authors： Wattanachai N,Kaewmoongkun S,Pussadhamma B,Makarawate P,Wongvipaporn C,Kiatchoosakun S,Vannaprasaht S,Tassaneeyakul W

更新日期：2017-08-01 00:00:00