Abstract：
PURPOSE:To investigate adherence rates to hospital drug formularies (HDFs) and cost of drugs in hospitals. METHODS:Data on drugs used during 2010 were analyzed for ten hospitals (two hospitals from each of the five regions), constituting 30 % of hospitals and 45 % of hospital beds in Denmark. Drug use data from individual hospitals were retrieved from the hospital pharmacies. Adherence to the HDFs was analyzed for selected substances characterised by extensive use both in primary and secondary sectors (ATC codes A10, B03, C03, C07, C08, C09, C10, J01, N02, N05 and R03). Within each group, we also identified the drugs constituting 90 % of the volume (= DU90%) and the adherence to the HDF in this segment (Index of Adherence). RESULTS:Substances used by hospitals varied between 598 and 1,093. The proportion of used substances that were on the HDF varied between 14 % and 44 %. University hospitals used a significantly higher total number of substances (median 165 vs. 139, p = 0.019) and cost/DDD [(median 5 vs. 2 Euros, p = 0.033), p = 0.033] in the DU90% segment than the regional hospitals. Index of adherence varied between 43 % and 91 %. For the selected ATC codes, the index of adherence was between 76 % and 100 %. CONCLUSIONS:Adherence to the selected ATC groups was high, which means that the most commonly used substances are included in the HDFs, even though a variation existed. A large variation existed between the hospitals in the number of substances at HDFs.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Plet HT,Hallas J,Kjeldsen LJdoi
10.1007/s00228-013-1540-6subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1837-43issue
10eissn
0031-6970issn
1432-1041journal_volume
69pub_type
杂志文章abstract：:We have compared the effect on ventilation of ketorolac, an injectable non-steroidal analgesic, with that of morphine in a randomized, double-blind, cross-over study, using two doses of ketorolac (10 and 90 mg i.m.) and one of morphine (10 mg i.m.). The effect on ventilation was measured with a CO2 rebreathing techniq...
journal_title：European journal of clinical pharmacology
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journal_title：European journal of clinical pharmacology
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00558273
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abstract：:The effect of nomifensin (Hoechst 36984), a synthetic psychotropic drug whose structure differs from MAO inhibitors and tricyclics, was studied in a double blind comparative trial with desimipramine in patients with various depressive syndromes. Forty-three patients (23 in the nomifensin group and 20 in the desimipram...
journal_title：European journal of clinical pharmacology
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
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journal_title：European journal of clinical pharmacology
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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abstract：:Hemodynamic changes for 30 min after intravenous administration of molsidomin 4 mg were studied in 10 patients. Pulmonary artery pressure, pulmonary wedge pressure, right atrial pressure and aortic pressure decreased significantly after 15 min, and after 30 min they were still below the control level. Heart rate incre...
journal_title：European journal of clinical pharmacology
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journal_title：European journal of clinical pharmacology
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journal_title：European journal of clinical pharmacology
pub_type： 杂志文章
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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journal_title：European journal of clinical pharmacology
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更新日期：2020-10-01 00:00:00
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journal_title：European journal of clinical pharmacology
pub_type： 临床试验,杂志文章
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pub_type： 临床试验,杂志文章
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