Drug binding in the undernourished: a study of the binding of propranolol to alpha 1-acid glycoprotein.

abstract：PURPOSE:The existence of gender differences in the management of statin therapy among patients with chronic heart failure (HF) is still poorly investigated. We aimed at exploring the effect of gender on statin prescription rates and adequacy of dosing and on the association between statin therapy and all-cause 1-year m...

journal_title：European journal of clinical pharmacology

authors： Ballo P,Balzi D,Barchielli A,Turco L,Franconi F,Zuppiroli A

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:Nafamostat mesilate, a potent protease inhibitor, is widely used for the treatment of pancreatitis, disseminated intravascular coagulation and as an anticoagulant in haemodialysis. However, hyperkalaemia associated with nafamostat mesilate has been reported. It is thought to be due to decreased urinary potass...

journal_title：European journal of clinical pharmacology

authors： Ookawara S,Tabei K,Sakurai T,Sakairi Y,Furuya H,Asano Y

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Ultraviolet radiation exposure is the most important exogenous risk factor for cutaneous malignancies. It is possible that phototoxic drugs promote the development of cutaneous melanoma (CM) by intensifying the effect of ultraviolet light on the skin. We investigated the association between the use of common sy...

journal_title：European journal of clinical pharmacology

authors： Siiskonen SJ,Koomen ER,Visser LE,Herings RM,Guchelaar HJ,Stricker BH,Nijsten TE

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was investigated in patients with septic shock. METHODS:Blood was sampled at intervals before, during and after 12-h infusion of L-NAME 1 mg x kg(-1) x h(-1) in nine septic shock patients for det...

journal_title：European journal of clinical pharmacology

authors： Avontuur JA,Buijk SL,Bruining HA

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:To investigate (1) the pharmacokinetic and pharmacodynamic profiles of desmopressin in men from an age group with a high incidence of nocturia; and (2) circadian variation in the pharmacokinetic parameters. METHODS:The study had an open, randomised, four-way cross-over design. Desmopressin was administered o...

journal_title：European journal of clinical pharmacology

authors： Rembratt A,Graugaard-Jensen C,Senderovitz T,Norgaard JP,Djurhuus JC

更新日期：2004-08-01 00:00:00

abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

journal_title：European journal of clinical pharmacology

authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

更新日期：1989-01-01 00:00:00

abstract：:The time-courses of plasma carbamazepine concentrations were followed in six apparently healthy adult subjects who, at different times, took single oral drug doses of 200, 400, 500, 600, 700, 800 and 900 mg. There were some suggestions of impaired bioavailability of the drug when given in tablet form. The following va...

journal_title：European journal of clinical pharmacology

authors： Cotter LM,Eadie MJ,Hooper WD,Lander CM,Smith GA,Tyrer JH

更新日期：1977-12-28 00:00:00

abstract：OBJECTIVE:To study the influence of CYP3A4 inhibition by ketoconazole on the disposition of venlafaxine in individuals with different CYP2D6 pheno- and genotypes. METHODS:In an open two-phase study, 21 healthy volunteers with known CYP2D6 pheno- and genotype [14 extensive metabolisers (EMs), 7 poor metabolisers (PMs)]...

journal_title：European journal of clinical pharmacology

authors： Lindh JD,Annas A,Meurling L,Dahl ML,AL-Shurbaji A

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:This study aims to compare the prevalence of potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs) using several screening tools in an Irish community-dwelling older cohort, to assess if the prevalence changes over time and to determine factors associated with any change. METHOD...

journal_title：European journal of clinical pharmacology

authors： Moriarty F,Bennett K,Fahey T,Kenny RA,Cahir C

更新日期：2015-04-01 00:00:00

abstract：:The effect of a new dopamine receptor stimulating agent, piribedil (ET 495), was studied in 10 patients with Parkinson's syndrome, who had had no or a poor response to previous L-DOPA treatment, or had displayed marked side effects during L-DOPA administration. Piribedil produced significant improvement of the functio...

journal_title：European journal of clinical pharmacology

authors： Engel J,Granerus AK,Svanborg A

更新日期：1975-04-04 00:00:00

abstract：:Ten healthy subjects took single oral doses of placebo, 8.8 +/- 1.8 mg motapizone, 40 +/- 13 mg captopril, 25 mg dihydralazine, 20 mg nifedipine and 4.5 +/- 1.1 mg prazosin in random order, and, as the last preparation 500 mg acetylsalicylic acid. Thrombocyte aggregation induced "ex-vivo" with collagen, ADP and adrena...

journal_title：European journal of clinical pharmacology

authors： Schulz V,Fischer W,Hanselle U,Huhmann W,Zietsch V

更新日期：1986-01-01 00:00:00

abstract：:The number of marketed non-steroidal anti-inflammatory agents varies widely from one European country to another, partly as a consequence of differing regulatory policies. During a four-year period, nine of 18 applications to market such drugs in the Netherlands failed; the remaining nine compounds were all licenced; ...

journal_title：European journal of clinical pharmacology

authors： Dukes MN,Lunde I

更新日期：1981-01-01 00:00:00

abstract：:Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

journal_title：European journal of clinical pharmacology

authors： Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

更新日期：1992-01-01 00:00:00

abstract：:The effects of guar gum (GG) and microcrystalline cellulose (MC) on metabolic control and serum lipids were compared in a double-blind, cross-over trial in 18 poorly controlled Type 2 diabetic patients. There were two 12 week treatment periods separated by a 4 week wash-out period. A significant reduction in fasting B...

journal_title：European journal of clinical pharmacology

authors： Niemi MK,Keinänen-Kiukaanniemi SM,Salmela PI

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to determine whether mefenamic acid and salicylic acid inhibit the sulfation of (-)-salbutamol and minoxidil in the human liver and duodenum, and if so, to ascertain whether the 50% inhibitory concentration (IC50) estimates are different in the two tissues. METHODS:Sulfotran...

journal_title：European journal of clinical pharmacology

authors： Vietri M,Pietrabissa A,Spisni R,Mosca F,Pacifici GM

更新日期：2000-09-01 00:00:00

abstract：PURPOSE:There are concerns regarding appropriate use of antibiotics in dentistry practice. Data on dental antibiotic prescribing patterns by dentists is relatively limited. This nationwide study aimed to examine dentists' antibiotic prescriptions in a diagnosis-based manner in Turkey. METHODS:This retrospective study ...

journal_title：European journal of clinical pharmacology

authors： Koyuncuoglu CZ,Aydin M,Kirmizi NI,Aydin V,Aksoy M,Isli F,Akici A

更新日期：2017-08-01 00:00:00

abstract：:Eleven patients with hepatic cirrhosis or cholestasis were treated with rifampicin for 7 to 132 days. Ten patients received hexobarbital (7.32 mg/kg) and five received tolbutamide (20 mg/kg) by i.v. infusion prior to and after rifampicin treatment; plasma concentrations of the two test compounds were determined during...

journal_title：European journal of clinical pharmacology

authors： Zilly W,Breimer DD,Richter E

更新日期：1977-04-20 00:00:00

abstract：:The pharmacokinetics of phenylethylmalonamide (PEMA) were studied in 6 elderly men after oral administration of a single 400 mg dose. Peak PEMA serum levels were obtained within 4 h of intake, half-life values ranged from 30.7-57.9 h in these elderly men. The elimination half-life was twice as long when compared to a ...

journal_title：European journal of clinical pharmacology

authors： Streete JM,Berry DJ,Newberry JE,Crome P

更新日期：1987-01-01 00:00:00

abstract：:The relationship between the serum protein binding of carbamazepine (CBZ) and carbamazepine-10,11 epoxide (CBZ-E) and the concentration of alpha 1-acid glycoprotein (AAG) and albumin (HSA) was examined in 39 CBZ-treated epileptic children aged 4 months to 12 years. A significant inverse correlation was found between t...

journal_title：European journal of clinical pharmacology

authors： Contin M,Riva R,Albani F,Perucca E,Lamontanara G,Baruzzi A

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Troglitazone is an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which has been shown to improve the metabolic control of type 2 diabetes. Troglitazone undergoes hepatic metabolism to an inactive sulphate conjugate and an oxidative quinone metabolite with minor activity. The ob...

journal_title：European journal of clinical pharmacology

authors： Ott P,Ranek L,Young MA

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:We used a retrospective data mining approach to explore the association between serum amiodarone (AMD) and N-desethylamiodarone (DEA) concentrations and thyroid-related hormone levels. METHODS:Laboratory data sets from January 2012 to April 2016 were extracted from the computerized hospital information system ...

journal_title：European journal of clinical pharmacology

authors： Yamato M,Wada K,Fujimoto M,Hosomi K,Hayashi T,Oita A,Takada M

更新日期：2017-03-01 00:00:00

abstract：:It is uncertain as to the extent which gastrointestinal (GI) haemorrhage related to NSAIDs is due to a local, topical effect or to an action related to systemic absorption. We hypothesised that, should systemic drug concentrations be of importance, plasma levels of NSAIDs might be higher in patients who had developed ...

journal_title：European journal of clinical pharmacology

authors： Wynne HA,Rawlins MD

更新日期：1993-01-01 00:00:00

abstract：:A questionnaire survey was carried out to explore differences in the approach to treatment of patients with Type II diabetes between physicians in Northern Ireland, Norway and Sweden, and to discover to what extent it could account for the three-fold difference in drug use between the countries. A representative sampl...

journal_title：European journal of clinical pharmacology

authors： Griffiths K,McDevitt DG,Andrew M,Baksaas I,Helgeland A,Jervell J,Lunde PK,Oydvin K,Agenäs I,Bergman U

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:To determine whether patients with idiopathic systemic lupus erythematosus (SLE) are associated with impaired CYP2D6 activity and to gain insight into whether there is an association between particular CYP2D6 genotypes and susceptibility to SLE, and whether CYP2D6 polymorphism is linked to any specific clini...

journal_title：European journal of clinical pharmacology

authors： Kortunay S,Bozkurt A,Bathum L,Basci NE,Calgüneri M,Brøsen K,Kayaalp SO

更新日期：1999-03-01 00:00:00

abstract：:Interaction of the main metabolites of diazepam and chlordiazepoxide with alcohol was measured in two subacute double-blind cross-over experiments on 40 healthy, young volunteers. The drugs were administered for two week periods. The variables measured were choice reaction time and accuracy, eye-hand co-ordination, di...

journal_title：European journal of clinical pharmacology

authors： Palva ES,Linnoila M

更新日期：1978-07-30 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors block angiotensin II formation and release bradykinin, which is effective in the regulation of oxidoinflammatory injury. Some reports denote alterations in the effectiveness of ACE inhibitors in association with ACE insertion/deletion (I/D) gene polymorphisms. T...

journal_title：European journal of clinical pharmacology

authors： Urhan Küçük M,Sucu N,Şahan Firat S,Aytaçoğlu BN,Vezir Ö,Bozali C,Canacankatan N,Kul S,Tunçtan B

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:To study the distribution of the thiopurine methyltransferase (TPMT) genotype among azathioprine (Aza)-tolerant and -intolerant patients with various disorders, and to investigate a possible relationship with the Aza metabolite levels. METHODS:Forty-six Aza-tolerant and six Aza-intolerant patients had the TP...

journal_title：European journal of clinical pharmacology

authors： Reuther LO,Vainer B,Sonne J,Larsen NE

更新日期：2004-01-01 00:00:00

abstract：:The kinetics of 14C-metformin have been studied in five healthy subjects after oral and intravenous administration. The intravenous dose was distributed to a small central compartment of 9.9 +/- 1.61 (X +/- SE), from which its elimination could be described using three-compartment open model. The elimination half-life...

journal_title：European journal of clinical pharmacology

authors： Pentikäinen PJ,Neuvonen PJ,Penttilä A

更新日期：1979-09-01 00:00:00

abstract：:The mode and site of action of the new diuretic agent piretanide were investigated in man. The effect of a single oral dose of 12 mg was compared with that of furosemide 80 mg p.o. iin 6 patients with the nephrotic syndrome. Piretanide showed a greater diuretic and natriuretic response than furosemide during maximal w...

journal_title：European journal of clinical pharmacology

authors： Marone C,Reubi FC

更新日期：1980-01-01 00:00:00

abstract：:Pharmacokinetic interactions between antipyrine and acetaminophen were evaluated in 7 healthy volunteers. On 3 occasions subjects received: 1, antipyrine 1.0 g intravenously (i.v.); 2, acetaminophen 650 mg i.v.; 3, antipyrine 1.0 g and acetaminophen 650 mg i.v. simultaneously. Between Trials 1 and 3, antipyrine elimin...

journal_title：European journal of clinical pharmacology

authors： Blyden GT,Greenblatt DJ,LeDuc BW,Scavone JM

更新日期：1988-01-01 00:00:00