Pharmacokinetic study of i.v. infusions of adriamycin.

abstract：OBJECTIVES:To investigate the risk factors for noncompliance in elderly home-care recipients; and to evaluate to what extent regular home visits and drug counseling by a pharmacist contribute to compliance. SUBJECTS:One hundred and sixty-three elderly home-care recipients aged 62 years and over took part in this study...

journal_title：European journal of clinical pharmacology

authors： Okuno J,Yanagi H,Tomura S,Oka M,Hara S,Hirano C,Tsuchiya S

更新日期：1999-04-01 00:00:00

abstract：PURPOSE:The use of melatonin is increasing among Swedish children and adolescents despite deficient knowledge of usage in these groups. The aim of this study was to investigate the use of melatonin in Swedish children and adolescents according to age, gender, dosage, treatment duration, and use of attention deficit hyp...

journal_title：European journal of clinical pharmacology

authors： Furster C,Hallerbäck MU

更新日期：2015-07-01 00:00:00

abstract：:Plasma aspirin, salicylate and salicyluric acid concentrations were monitored in young, elderly and alcoholic subjects after ingestion of a single 1.2 g dose of soluble aspirin. The plasma aspirin, salicylate and unbound salicylate concentration-time profiles varied considerably between individual subjects. Most of th...

journal_title：European journal of clinical pharmacology

authors： Roberts MS,Rumble RH,Wanwimolruk S,Thomas D,Brooks PM

更新日期：1983-01-01 00:00:00

abstract：:Ple 1053 (Azosemid) is a diuretic which resembles furosemide chemically and in its mode of action. When administered intravenously, Ple 1053 was approximately 5 times more potent on a weight basis than furosemide, its dose-response relationship was closer and the slope was steeper. After oral administration Ple 1053 a...

journal_title：European journal of clinical pharmacology

authors： Krück F,Bablok W,Besenfelder E,Betzien G,Kaufmann B

更新日期：1978-11-27 00:00:00

abstract：:The antihypertensive effect of labetalol (L) was compared with that of clonidine (C) in a randomized cross-over study in 17 hypertensive outpatients on bendrofluazide (B). After treatment for two weeks with B(5 mg qd), either L (100 mg tid) or C (0.1 mg tid) was given and their doses were titrated at 2-weekly visits u...

journal_title：European journal of clinical pharmacology

authors： Lilja M,Jounela AJ,Karppanen H

更新日期：1982-01-01 00:00:00

abstract：:In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Weeke B

更新日期：1985-01-01 00:00:00

abstract：:One hundred consecutive digitalis serum level determination requests and results were analyzed to evaluate the rational of ordering the test and utilizing the results at his hospital. Sixty-six percent of the reasons given for ordering the test were categorized as "acceptable". As many as 25% of physicians requesting ...

journal_title：European journal of clinical pharmacology

authors： Hladik WB 3rd,Dujovne CA

更新日期：1979-07-01 00:00:00

abstract：OBJECTIVE:To study the effects of possible interactions between levosimendan and warfarin on pharmacokinetics and pharmacodynamics. Furthermore, the effects of levosimendan on blood coagulation were investigated. METHODS:Open, randomised cross-over design with two treatment phases was used. During one phase, levosimen...

journal_title：European journal of clinical pharmacology

authors： Antila S,Jarvinen A,Honkanen T,Lehtonen L

更新日期：2000-12-01 00:00:00

abstract：AIMS:The goal of this study was to analyze persistence and the treatment-free interval in patients being prescribed biological drugs in rheumatology practices in Germany. METHODS:Patients who received a first prescription of biological drugs between 2008 and 2016 in 21 rheumatologists in Germany were included in this ...

journal_title：European journal of clinical pharmacology

authors： Kostev K,Jacob L

更新日期：2019-05-01 00:00:00

abstract：:To evaluate the influence of the stomach and the cholinergic system on gallbladder contraction induced by physiological stimuli, the reduction in gallbladder volume in 7 healthy volunteers has been studied by real-time ultrasonography after the oral and intraduodenal administration of olive oil, preceded by pretreatme...

journal_title：European journal of clinical pharmacology

authors： Marzio L,Di Felice F,Celiberti V,Pieramico O,Grossi L,DiGioacchino M,Imbimbo BP,Cuccurullo F

更新日期：1990-01-01 00:00:00

abstract：AIMS:To determine whether the variability in cytochrome P(450) (CYP)3A4 metabolic function is exhibited at both transcription and translation levels and to examine the population distribution of CYP3A4 enzyme kinetics, protein, and mRNA. METHODS:Enzyme kinetics of testosterone 6beta-hydroxylation, immunoblot CYP3A4 pr...

journal_title：European journal of clinical pharmacology

authors： Sy SK,Ciaccia A,Li W,Roberts EA,Okey A,Kalow W,Tang BK

更新日期：2002-08-01 00:00:00

abstract：:Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

journal_title：European journal of clinical pharmacology

authors： Lönnerholm G,Lindström B,Paalzow L,Sedin G

更新日期：1983-01-01 00:00:00

abstract：:The inhibitory action of azelastine hydrochloride (Azeptin) on the respiratory burst in peripheral polymorphonuclear leukocytes (PMN) and pulmonary alveolar macrophages (PAM) has been studied. Azeptin in vitro suppressed chemiluminescence and superoxide (O2-) generation by human PMN in a dose- and time-dependent manne...

journal_title：European journal of clinical pharmacology

authors： Ueta E,Osaki T,Kawasaki N,Nomura Y

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To describe the quantitative and qualitative changes in the utilization of oral antihyperglycemic drugs (OAHDs) between 1998 and 2004 and to analyze patients' adherence to OAHD therapy. METHODS:We conducted a retrospective analysis of the electronic database of the Hungarian National Health Fund Administrati...

journal_title：European journal of clinical pharmacology

authors： Doró P,Benko R,Kosik E,Matuz M,Tóth K,Soós G

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:A double-blind, placebo-controlled parallel study was conducted on the effect of mibefradil, both an L- and T-type Ca2+-channel blocker with a more selective blockade of T-type channels, administered once daily for 1 week to normal male subjects, on blood pressure, intracellular cationic concentrations, sodiu...

journal_title：European journal of clinical pharmacology

authors： Lijnen P,Fagard R,Petrov V

更新日期：1999-02-01 00:00:00

abstract：PURPOSE:Perhexiline is a prophylactic anti-ischaemic agent with weak calcium antagonist effect which has been increasingly utilised in the management of refractory angina. The metabolic clearance of perhexiline is modulated by CYP2D6 metaboliser status and stereoselectivity. The current study sought to (1) determine wh...

journal_title：European journal of clinical pharmacology

authors： Chong CR,Drury NE,Licari G,Frenneaux MP,Horowitz JD,Pagano D,Sallustio BC

更新日期：2015-12-01 00:00:00

abstract：PURPOSE:Tocilizumab, a monoclonal antibody directed against the IL-6 receptor, might block detrimental effects of IL-6 on transplantation. IL-6 plays a considerable role in cytokine storm after stem cell transplantation as well as graft versus host disease, and it has also been shown to be involved in solid organ allog...

journal_title：European journal of clinical pharmacology

authors： Mosharmovahed B,Fatahi Y,Mohebbi B,Ghorbanian SA,Assadiasl S

更新日期：2020-06-01 00:00:00

abstract：PURPOSE:Ticagrelor is a reversibly binding P2Y12 receptor antagonist for the prevention of atherothrombotic events in patients with acute coronary syndrome. Previous in vitro studies showed that ticagrelor is a substrate and inhibitor of P-glycoprotein (ABCB1). Therefore, we examined the potential interaction between d...

journal_title：European journal of clinical pharmacology

authors： Teng R,Butler K

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVE:In the present randomized, fourway crossover study we determined the effects of two oral doses each of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man. METHODS:Twelve healthy female volunteers received for 2 consecutive days, followed by a 5-day drug-free interval, one of the...

journal_title：European journal of clinical pharmacology

authors： Stichtenoth DO,Tsikas D,Gutzki FM,Frölich JC

更新日期：1996-01-01 00:00:00

abstract：:To assess the duration of the antihypertensive effect of the dihydropiridine calcium antagonist felodipine in conventional (C-F) and slow-release (ER-F) formulations, 12 patients with essential hypertension underwent ambulatory blood pressure monitoring (ABPM) at the end of a 2-week treatment period with C-F 5 mg b.d....

journal_title：European journal of clinical pharmacology

authors： Porcellati C,Verdecchia P,Gatteschi C,Benemio G,Guerrieri M,Boldrini F,Pollavini G

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:Intravenous (IV) magnesium sulfate (MgSO4) is used as adjunct therapy to treat acute asthma exacerbations. Despite its clinical use, there is a limited understanding of the disposition of magnesium in children. METHODS:To explore the pharmacokinetics (PK) of IV MgSO4 in this population, we collected retrospect...

journal_title：European journal of clinical pharmacology

authors： Rower JE,Liu X,Yu T,Mundorff M,Sherwin CM,Johnson MD

更新日期：2017-03-01 00:00:00

abstract：:The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxyc...

journal_title：European journal of clinical pharmacology

authors： Merkel U,Sigusch H,Hoffmann A

更新日期：1994-01-01 00:00:00

abstract：:Pharmacokinetic and pharmacodynamic properties of a new controlled-release (CR) formulation of metoprolol have been compared with those of atenolol. Metoprolol CR (100 mg and 200 mg), atenolol (50 mg and 100 mg) and placebo were each given once daily for four days in a double-blind, cross-over study to ten healthy men...

journal_title：European journal of clinical pharmacology

authors： Blomqvist I,Westergren G,Sandberg A,Jonsson UE,Lundborg P

更新日期：1988-01-01 00:00:00

abstract：:Ten healthy subjects took single oral doses of placebo, 8.8 +/- 1.8 mg motapizone, 40 +/- 13 mg captopril, 25 mg dihydralazine, 20 mg nifedipine and 4.5 +/- 1.1 mg prazosin in random order, and, as the last preparation 500 mg acetylsalicylic acid. Thrombocyte aggregation induced "ex-vivo" with collagen, ADP and adrena...

journal_title：European journal of clinical pharmacology

authors： Schulz V,Fischer W,Hanselle U,Huhmann W,Zietsch V

更新日期：1986-01-01 00:00:00

abstract：:Four subjects received 5 mg 14C-glipizide orally, 3 subjects 1 mg intravenously and 2 subjects 5 mg 14C-glibenclamide orally. Plasma levels of radioactivity, and urinary and faecal excretion were measured. For both drugs the disappearance of radioactivity from plasma followed complex kinetics and the apparent half-liv...

journal_title：European journal of clinical pharmacology

authors： Balant L,Fabre J,Zahnd GR

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Laryngoscopy and tracheal intubation are associated with hemodynamic responses that might increase morbidity and mortality in some patients. Lornoxicam is a nonsteroidal anti-inflammatory drug, which, when added to fentanyl, successfully attenuated the pressor response of intubation. The aim o...

journal_title：European journal of clinical pharmacology

authors： Daabiss M,Hashish M

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:Time of drug administration may significantly influence its effect. The aim of the present study was to investigate the effect of ASA (administrated in the morning or in the evening) on the anti-hypertensive effect and diurnal blood pressure profile in the high-risk group of cardiovascular patients. METHODS:Al...

journal_title：European journal of clinical pharmacology

authors： Krasińska B,Paluszkiewicz L,Miciak-Ławicka E,Krasinski M,Rzymski P,Tykarski A,Krasiński Z

更新日期：2021-01-01 00:00:00

abstract：:It is uncertain as to the extent which gastrointestinal (GI) haemorrhage related to NSAIDs is due to a local, topical effect or to an action related to systemic absorption. We hypothesised that, should systemic drug concentrations be of importance, plasma levels of NSAIDs might be higher in patients who had developed ...

journal_title：European journal of clinical pharmacology

authors： Wynne HA,Rawlins MD

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Studies demonstrating mortality benefit of beta blockers (BB) after myocardial infarction (MI) were conducted before the era of percutaneous intervention and widespread use of statins. Recent retrospective studies show inconsistent results regarding which subgroups of coronary artery disease (CAD) patients' ben...

journal_title：European journal of clinical pharmacology

authors： Verma S,Peterson EL,Liu B,Sabbah HN,Williams LK,Lanfear DE

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:The present study was undertaken to investigate the possible effects of various agents on thiopurine methyltransferase (TPMT) activity in red blood cells (RBCs) from patients with chronic inflammatory bowel disease (IBD). METHODS:In three groups of patients with very high, normal and intermediate TPMT activi...

journal_title：European journal of clinical pharmacology

authors： Xin HW,Fischer C,Schwab M,Klotz U

更新日期：2005-07-01 00:00:00