当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Pharmacokinetics and pharmacodynamics of controlled-release metoprolol: a comparison with atenolol.

Pharmacokinetics and pharmacodynamics of controlled-release metoprolol: a comparison with atenolol.

Abstract：

:Pharmacokinetic and pharmacodynamic properties of a new controlled-release (CR) formulation of metoprolol have been compared with those of atenolol. Metoprolol CR (100 mg and 200 mg), atenolol (50 mg and 100 mg) and placebo were each given once daily for four days in a double-blind, cross-over study to ten healthy men. The plasma concentration-time profiles were more even with metoprolol CR than with atenolol over the 24-h dose interval, shown by the lower fluctuation ratio and the longer time period during which the plasma concentration exceeded 50% of the maximum concentration. All four active treatment regimens reduced exercise heart rate over the 24-h period compared with placebo. However, the reduction in both exercise heart rate and systolic blood pressure (SBP) was more even with metoprolol CR than with atenolol. The remaining beta 1-blockade after 24 h, expressed as the percentage reduction in exercise heart rate in relation to placebo, was significantly greater after the administration of metoprolol CR, 200 mg, than after either dose of atenolol. At this time the beta 1-blockade with metoprolol CR, 100 mg, was similar to that with atenolol, 100 mg. At peak plasma concentrations, 4 h after the dose, the subjects experienced less fatigue during exercise with metoprolol CR than with atenolol.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Blomqvist I,Westergren G,Sandberg A,Jonsson UE,Lundborg P

doi

10.1007/BF00578408

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

S19-24

eissn

0031-6970

issn

1432-1041

journal_volume

33 Suppl

pub_type

临床试验,杂志文章

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