Fabry disease and treatment with agalsidase alpha: unsuspected cardiac arrhythmia in two heterozygous women. In reference to pharmacovigilance.

Abstract:

CASE REPORTS:Two women treated with agalsidase alpha for Fabry disease developed severe heart dysfunctions a few months after the beginning of enzyme replacement therapy (ERT). An adverse effect caused by the treatment was suspected; therefore we informed the French pharmacovigilance authorities about these two events. CONCLUSIONS:Collecting data systematically about adverse effects which might be caused by drugs is essential for orphan diseases in order to detect potential adverse effects which cannot be suspected at first.

journal_name

Eur J Clin Pharmacol

authors

Mougenot P,Lidove O,Caillaud C,Arnaud P,Papo T

doi

10.1007/s00228-007-0460-8

subject

Has Abstract

pub_date

2008-06-01 00:00:00

pages

635-9

issue

6

eissn

0031-6970

issn

1432-1041

journal_volume

64

pub_type

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