Renal effects of the new calcium channel blocking drug isradipine.

abstract：OBJECTIVE:To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in hypertensive patients. METHODS:Ten hypertensive patients on chronic verapamil treatment participated in a two-day study. On day 1 200 ml of water was given 1 hour before, and together with the morni...

journal_title：European journal of clinical pharmacology

authors： Zaidenstein R,Dishi V,Gips M,Soback S,Cohen N,Weissgarten J,Blatt A,Golik A

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the population pharmacokinetics (PK) and exposure-response relationship of edoxaban in patients with non-valvular atrial fibrillation (AF). METHODS:Concentration data from 1,134 subjects in 11 clinical studies (eight phase I, one phase II, and two phase III) were used to p...

journal_title：European journal of clinical pharmacology

authors： Yin OQ,Tetsuya K,Miller R

更新日期：2014-11-01 00:00:00

abstract：:In a double-blind cross-over study bepridil 900 mg followed by 300 mg daily for 11 days was given to 37 insulin (Type I) or non-insulin (Type II)-dependent diabetic patients. It did not modify the metabolic control of the patients as levels of glucose in blood and urine, doses of insulin and oral hypoglycaemic drugs, ...

journal_title：European journal of clinical pharmacology

authors： Husted SE,Pedersen C,Nielsen HK,Apoil E,Nielsen OH,Lindvig K,Krusell LR,Høegholm A

更新日期：1988-01-01 00:00:00

abstract：:General well-being, adverse effects and anti-hypertensive efficacy have been investigated in a double blind, parallel-group, dose-response multicentre study of diltiazem and metoprolol monotherapy for hypertension. 128 patients with primary hypertension were included from 10 participating centres. The patients were ra...

journal_title：European journal of clinical pharmacology

authors： Dahlöf C,Hedner T,Thulin T,Gustafsson S,Olsson SO

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of rifampicin on the pharmacokinetics of itraconazole in humans. METHODS:Our study was conducted with six healthy normal volunteers and three AIDS patients. All subjects received a 200 mg single dose of oral itraconazole on day 1 and day 15 and 600 mg of oral rifampicin once daily ...

journal_title：European journal of clinical pharmacology

authors： Jaruratanasirikul S,Sriwiriyajan S

更新日期：1998-04-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate the association between migration status and education level and the use of recommended drugs after first acute myocardial infarction (MI). METHODS:A nationwide cohort study performed in Sweden from January 1, 2006 to August 1, 2008. The cohort consisted of 49,037 in...

journal_title：European journal of clinical pharmacology

authors： Dzayee DA,Moradi T,Beiki O,Alfredsson L,Ljung R

更新日期：2015-04-01 00:00:00

abstract：:An open, dose-titration study of alfuzosin, a new selective post-synaptic alpha 1-adrenoceptor antagonist with additional direct vasodilator properties has been performed. After a 3-week run-in placebo period, 12 patients with essential hypertension received alfuzosin 5 mg oral b.d., and then the dose was doubled ever...

journal_title：European journal of clinical pharmacology

authors： Leto di Priolo S,Priore P,Cocco G,Sfrisi C,Cazor JL

更新日期：1988-01-01 00:00:00

abstract：:The effects of single oral doses of mequitazine (5 and 10 mg), terfenadine (60 mg) and triprolidine (10 mg) as active controls, and placebo were evaluated on visuo-motor coordination, digit symbol substitution, critical flicker fusion and dynamic visual acuity, and on subjective assessments of mood and well-being in s...

journal_title：European journal of clinical pharmacology

authors： Nicholson AN,Stone BM

更新日期：1983-01-01 00:00:00

abstract：:General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readil...

journal_title：European journal of clinical pharmacology

authors： Vaughan DP,Mallard DJ,Trainor A,Mitchard M

更新日期：1975-02-28 00:00:00

abstract：:The effects of guar gum (GG) and microcrystalline cellulose (MC) on metabolic control and serum lipids were compared in a double-blind, cross-over trial in 18 poorly controlled Type 2 diabetic patients. There were two 12 week treatment periods separated by a 4 week wash-out period. A significant reduction in fasting B...

journal_title：European journal of clinical pharmacology

authors： Niemi MK,Keinänen-Kiukaanniemi SM,Salmela PI

更新日期：1988-01-01 00:00:00

abstract：:Clonazepam (CNP) and its principal metabolite in plasma, 7-amino-CNP (ACNP), have been investigated in a prospective study of 27 newly diagnosed epileptics and correlated with specified side-effects. At a daily dose of 6 mg, the average plasma levels of both substances were about 50ng/ml, and individual values ranged ...

journal_title：European journal of clinical pharmacology

authors： Sjö O,Hvidberg EF,Naestoft J,Lund M

更新日期：1975-04-04 00:00:00

abstract：:A single dose of 60 mg trimetazidine (the normal daily dose) improved exercise capacity in angina pectoris, as reflected by an increase in the duration of exercise, total work performed, and improvement in ECG signs of ischaemia. All these effects occurred without any detectable chronotropic or vasomotor effect. The i...

journal_title：European journal of clinical pharmacology

authors： Sellier P,Audouin P,Payen B,Corona P,Duong TC,Ourbak P

更新日期：1987-01-01 00:00:00

abstract：:The kinetics of triamterene and its active phase II metabolite were studied in 32 patients with various degrees of impaired renal function; the creatinine clearances ranged from 135 to 10 ml/min. The area under the plasma concentration-time curves (AUC) for triamterene were not influenced by kidney function, but the A...

journal_title：European journal of clinical pharmacology

authors： Knauf H,Möhrke W,Mutschler E

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:We investigated the role of genetic, physiological, environmental, and epigenetic factors in regulating CYP2A6 expression and nicotine metabolism. METHODS:Human livers (n = 67) were genotyped for CYP2A6 alleles and assessed for nicotine metabolism and CYP2A6 expression (mRNA and protein). In addition, a subset...

journal_title：European journal of clinical pharmacology

authors： Al Koudsi N,Hoffmann EB,Assadzadeh A,Tyndale RF

更新日期：2010-03-01 00:00:00

abstract：:The antihypertensive effect of a new vasodilator with betablocking properties (SK & F 92657) was investigated in 10 patients with mild to moderate essential hypertension. After a mean treatment period of 26,5 weeks (6,5-49 weeks) blood pressure was significantly reduced, from 168 +/- 22/106 +/- 6 mmHg to 144 +/- 19/94...

journal_title：European journal of clinical pharmacology

authors： Lüscher T,Havelka J,Greminger P,Tuma J,Täuber M,Siegenthaler W,Vetter W

更新日期：1982-01-01 00:00:00

abstract：:It was considered that double-blind crossover studies of therapeutic efficacy after acute injury could well be done in patients who required surgical removal of impacted wisdom teeth from both sides of the lower jaw. In the present trial 24 healthy patients received either placebo or ibuprofen (Brufen: 400 mg three ti...

journal_title：European journal of clinical pharmacology

authors： Lökken P,Olsen I,Bruaset I,Norman-Pedersen K

更新日期：1975-04-04 00:00:00

abstract：PURPOSE:Tolcapone is an efficacious catechol-O-methyltransferase inhibitor for Parkinson's disease (PD). However, safety issues hampered its use in clinical practice. We aimed to provide evidence of safety and efficacy of tolcapone by a systematic literature review to support clinicians' choices in the use of an enlarg...

journal_title：European journal of clinical pharmacology

authors： Artusi CA,Sarro L,Imbalzano G,Fabbri M,Lopiano L

更新日期：2021-01-07 00:00:00

abstract：OBJECTIVE:To develop quality prescribing indicators for general practitioners (GPs) who are non-monitored and not included in pay-for-performance programs, and to determine compliance with incentivized and non-incentivized indicators. STUDY DESIGN:Descriptive cross sectional study. SETTING:Aljarafe Primary Health Car...

journal_title：European journal of clinical pharmacology

authors： Fernández Urrusuno R,Montero Balosa MC,Pérez Pérez P,Pascual de la Pisa B

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study aims to explore exposure-response relationship for panobinostat in this ...

journal_title：European journal of clinical pharmacology

authors： Mu S,Kuroda Y,Shibayama H,Hino M,Tajima T,Corrado C,Lin R,Waldron E,Binlich F,Suzuki K

更新日期：2016-02-01 00:00:00

abstract：PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

journal_title：European journal of clinical pharmacology

authors： Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Ticagrelor is a reversibly binding P2Y12 receptor antagonist for the prevention of atherothrombotic events in patients with acute coronary syndrome. Previous in vitro studies showed that ticagrelor is a substrate and inhibitor of P-glycoprotein (ABCB1). Therefore, we examined the potential interaction between d...

journal_title：European journal of clinical pharmacology

authors： Teng R,Butler K

更新日期：2013-10-01 00:00:00

abstract：PURPOSE:The antihypertensive effect of angiotensin-converting enzyme inhibitors (ACEi) is attributed partially to increased nitric oxide bioavailability. It is possible that functional polymorphisms in endothelial nitric oxide synthase (eNOS) and bradykinin receptor B2 (BDKRB2) genes may affect the antihypertensive res...

journal_title：European journal of clinical pharmacology

authors： Silva PS,Fontana V,Luizon MR,Lacchini R,Silva WA Jr,Biagi C,Tanus-Santos JE

更新日期：2013-02-01 00:00:00

abstract：:The bronchodilator effect and side-effects of a single oral dose of enprofylline were compared with the corresponding actions of a therapeutic dose of theophylline in 20 asthmatic patients, in a randomized cross-over clinical trial. Enprofylline 4 mg/kg and theophylline 8 mg/kg produced mean maximum plasma levels of 4...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Søndergaard I,Weeke B

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The pharmacokinetics of orally administered immediate-release, twice-daily (BID) and modified-release, once-daily (QD) formulations of tacrolimus have high interindividual variability. We investigated factors affecting interindividual variability of tacrolimus bioavailability in renal transplant patients. METH...

journal_title：European journal of clinical pharmacology

authors： Niioka T,Kagaya H,Miura M,Numakura K,Saito M,Inoue T,Habuchi T,Satoh S

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:NXY-059 is a nitrone-based, free-radical trapping agent being developed for the treatment of acute ischaemic stroke. Elimination of NXY-059 is primarily renal. The objective of the study was to investigate the pharmacokinetics of NXY-059 in subjects with renal impairment. METHODS:Twenty-four subjects with a ...

journal_title：European journal of clinical pharmacology

authors： Strid S,Borgå O,Edenius C,Jostell KG,Odergren T,Weil A

更新日期：2002-09-01 00:00:00

abstract：PURPOSE:The purpose of this study was to systematically review evidence regarding the association between regimen complexity and adherence. METHODS:Articles were searched in MEDLINE, LILACS, Cochrane, CINAHL, PsycINFO and references of included studies. Search terms included medication regimen complexity, medication a...

journal_title：European journal of clinical pharmacology

authors： Pantuzza LL,Ceccato MDGB,Silveira MR,Junqueira LMR,Reis AMM

更新日期：2017-11-01 00:00:00

abstract：PURPOSE:To investigate adherence rates to hospital drug formularies (HDFs) and cost of drugs in hospitals. METHODS:Data on drugs used during 2010 were analyzed for ten hospitals (two hospitals from each of the five regions), constituting 30 % of hospitals and 45 % of hospital beds in Denmark. Drug use data from indivi...

journal_title：European journal of clinical pharmacology

authors： Plet HT,Hallas J,Kjeldsen LJ

更新日期：2013-10-01 00:00:00

abstract：OBJECTIVES:To compare the systemic exposure for intranasal mometasone furoate (MF) and fluticasone propionate (FP) aqueous nasal sprays (ANS) in terms of serum and urinary cortisol parameters and plasma pharmacokinetics. METHODS:Twelve healthy subjects completed this three-way, cross-over study. They received FPANS (5...

journal_title：European journal of clinical pharmacology

authors： Daley-Yates PT,Kunka RL,Yin Y,Andrews SM,Callejas S,Ng C

更新日期：2004-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to assess the pharmacokinetics and protein binding of cefazolin in morbidly obese patients undergoing bariatric surgery, to study the influence of bodyweight measures and age on pharmacokinetic parameters and to evaluate unbound cefazolin concentrations over time in this population. M...

journal_title：European journal of clinical pharmacology

authors： van Kralingen S,Taks M,Diepstraten J,van de Garde EM,van Dongen EP,Wiezer MJ,van Ramshorst B,Vlaminckx B,Deneer VH,Knibbe CA

更新日期：2011-10-01 00:00:00

abstract：:Ten patients with moderate to severe Raynaud's syndrome were recruited into a four week randomised double blind crossover study to compare the efficacy of UK-38,485 50 mg, a new thromboxane synthetase inhibitor with that of placebo. With the doses used there was no significant difference between the two treatment peri...

journal_title：European journal of clinical pharmacology

authors： Rustin MH,Grimes SM,Kovacs IB,Cooke ED,Bowcock SA,Sowemimo-Coker SO,Turner P,Kirby JD

更新日期：1984-01-01 00:00:00