Abstract：
OBJECTIVE:To investigate the effect of grapefruit juice (GJ) on the pharmacokinetics of orally administered verapamil in hypertensive patients. METHODS:Ten hypertensive patients on chronic verapamil treatment participated in a two-day study. On day 1 200 ml of water was given 1 hour before, and together with the morning verapamil dose; on the day 2, water was replaced by GJ in the same order. Serial blood samples were collected and the concentrations of verapamil and its main dealkylated metabolite (D-617) were determined by high-performance liquid chromatography (HPLC). The area under the concentration versus time curve of verapamil (AUCv) and its metabolite D-617 (AUCM) were calculated before and after GJ ingestion. The peak serum concentration (Cmax) and the time until its appearance (tmax) were also determined. RESULTS:GJ did not affect Cmax, tmax, AUCv or AUVm. The AUCv/AUCm ratio (AUCR) was slightly, but significantly, increased after GJ (1.67 vs 1.92). CONCLUSIONS:A single administration of GJ with short-acting verapamil has no significant effect on the pharmacokinetics, of verapamil.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Zaidenstein R,Dishi V,Gips M,Soback S,Cohen N,Weissgarten J,Blatt A,Golik Adoi
10.1007/s002280050470subject
Has Abstractpub_date
1998-06-01 00:00:00pages
337-40issue
4eissn
0031-6970issn
1432-1041journal_volume
54pub_type
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