Initial clinical experience of lorcainide (Ro 13-1042), a new antiarrhythmic agent.

Abstract:

:Lorcainide is a promising antiarrhythmic agent that belongs to the class of local anesthetics. It was tested in 7 patients with malignant ventricular arrhythmias that were resistant to other antiarrhythmic agents. Lorcainide was effective in all cases (complete disappearance of arrhythmias in 6 cases and more than 50% disappearance in the 7th case), and the tolerance was within acceptable limits. The drug was effective at rest, as assessed by 24-h dynamic electrocardiographic monitoring, and during physical exercise. Longer studies with more patients are warranted, since the drug appears to be a promising antiarrhythmic agent.

journal_name

Eur J Clin Pharmacol

authors

Cocco G,Strozzi C

doi

10.1007/BF00607440

subject

Has Abstract

pub_date

1978-11-16 00:00:00

pages

105-9

issue

2

eissn

0031-6970

issn

1432-1041

journal_volume

14

pub_type

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