General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments.

abstract：BACKGROUND:Monoamine oxidase inhibitors (MAOIs) are uncommonly used due to their high frequency of adverse effects, including tachycardia and hypertension. Recently, there has been renewed interest in the role of this class of drugs in treating a variety of psychiatric disorders. The clinical features of MAOI overdose ...

journal_title：European journal of clinical pharmacology

authors： Waring WS,Wallace WA

更新日期：2007-11-01 00:00:00

abstract：:Bay m 1099 is a newly developed inhibitor of intestinal alpha-glucosidase. Its ability to lower postprandial plasma glucose, serum insulin and C-peptide levels in Type II diabetics has been investigated. Fifteen obese Type II diabetic patients with inadequate metabolic control during sulphonylurea treatment received a...

journal_title：European journal of clinical pharmacology

authors： Schnack C,Röggla G,Luger A,Schernthaner G

更新日期：1986-01-01 00:00:00

abstract：:Glucocorticoids (GCs) exert different activities that are useful for the treatment of several haematologic disorders. The synergistic effect with cytotoxic drugs is important for the therapy of lymphoproliferative diseases. The inhibition of macrophages prevents acute haemolysis and platelets destruction in autoimmune...

journal_title：European journal of clinical pharmacology

authors： Gobbi M,Scudeletti M

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Ilaprazole, the latest proton pump inhibitor, can be used with clarithromycin and amoxicillin as a triple therapy regimen for eradicating Helicobacter pylori. The aim of this study was to evaluate pharmacokinetic drug interactions and safety profiles after coadministration of clarithromycin, amoxicillin, and il...

journal_title：European journal of clinical pharmacology

authors： Jin BH,Yoo BW,Park J,Kim JH,Lee JY,Shin JS,Park MS

更新日期：2018-09-01 00:00:00

abstract：PURPOSE:We investigated the role of genetic, physiological, environmental, and epigenetic factors in regulating CYP2A6 expression and nicotine metabolism. METHODS:Human livers (n = 67) were genotyped for CYP2A6 alleles and assessed for nicotine metabolism and CYP2A6 expression (mRNA and protein). In addition, a subset...

journal_title：European journal of clinical pharmacology

authors： Al Koudsi N,Hoffmann EB,Assadzadeh A,Tyndale RF

更新日期：2010-03-01 00:00:00

abstract：:Amoxycillin and ofloxacin are both well absorbed after oral administration, despite being hydrophilic. We have studied the possibility of competition between these two drugs for a carrier-mediated transport system, since both drugs are absorbed by saturable processes in the rat small intestine. Oral doses of amoxycill...

journal_title：European journal of clinical pharmacology

authors： Paintaud G,Alván G,Hellgren U,Nilsson-Ehle I

更新日期：1993-01-01 00:00:00

abstract：:We have studied the pharmacokinetics of tulobuterol given transdermally or by aerosol inhalation in healthy male volunteers. Tulobuterol was rapidly absorbed after inhalation, with a tmax of 0.8-1.5 h. The Cmax and the AUC increased linearly with dose. Tulobuterol was well absorbed after transdermal administration, wi...

journal_title：European journal of clinical pharmacology

authors： Uematsu T,Nakano M,Kosuge K,Kanamaru M,Nakashima M

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:The present study was carried out to investigate current prescribing and dispensing practices in the largest two teaching hospitals in Sudan and compare them with those of published studies in developing countries. METHODS:A descriptive, quantitative and cross-sectional study was conducted among hospital outpa...

journal_title：European journal of clinical pharmacology

authors： Awad AI,Himad HA

更新日期：2006-12-01 00:00:00

abstract：PURPOSE:Methylenedioxymethamphetamine (MDMA, ecstasy) is used recreationally and frequently leads to sympathomimetic toxicity. MDMA produces cardiovascular and subjective stimulant effects that were shown to partially depend on the norepinephrine transporter (NET)-mediated release of norepinephrine and stimulation of α...

journal_title：European journal of clinical pharmacology

authors： Vizeli P,Meyer Zu Schwabedissen HE,Liechti ME

更新日期：2018-03-01 00:00:00

abstract：PURPOSE:The pharmacokinetics of orally administered immediate-release, twice-daily (BID) and modified-release, once-daily (QD) formulations of tacrolimus have high interindividual variability. We investigated factors affecting interindividual variability of tacrolimus bioavailability in renal transplant patients. METH...

journal_title：European journal of clinical pharmacology

authors： Niioka T,Kagaya H,Miura M,Numakura K,Saito M,Inoue T,Habuchi T,Satoh S

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To compare 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) as substrates for the methylation reaction catalysed by the enzyme thiopurine S-methyltransferase (TPMT). METHODS:TPMT activity in haemolysed red blood cells of healthy blood donors was determined twice, using the same experimental setting and equa...

journal_title：European journal of clinical pharmacology

authors： Kröplin T,Iven H

更新日期：2000-07-01 00:00:00

abstract：:The pharmacokinetics of 3H-16-epi-gitoxin have been investigated after oral administration: The peak serum level occurred after 30-60 min, and its subsequent decline was in two phases with half-lives of 3.5 and 19.5 h, respectively. Within 3 days 66-70% of the administered radioactivity were eliminated by renal excret...

journal_title：European journal of clinical pharmacology

authors： Haustein KO

更新日期：1977-07-19 00:00:00

abstract：OBJECTIVE:Contraception is recommended for female patients during ursodeoxycholic acid (UDCA) treatment for the potential teratogenic effect of this bile acid, and the aim of our study was to determine whether this treatment affects the bioavailability of ethinylestradiol (EE2). METHODS:In this double-blind, randomise...

journal_title：European journal of clinical pharmacology

authors： Baisini O,Benini F,Petraglia F,Kuhnz W,Scalia S,Marschall HU,Brunetti G,Tauschel HD,Lanzini A

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Triptans are contraindicated in patients with known or suspected coronary artery disease (CAD); however, few studies have evaluated triptans in patients with obstructive CAD to quantify the vasoconstrictive effect on diseased coronary vessels. METHODS:Patients undergoing percutaneous transluminal coronary a...

journal_title：European journal of clinical pharmacology

authors： Newman CM,Starkey I,Buller N,Seabra-Gomes R,Kirby S,Hettiarachchi J,Cumberland D,Hillis WS

更新日期：2005-11-01 00:00:00

abstract：:In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patient...

journal_title：European journal of clinical pharmacology

authors： Ochs H,Bodem G,Schäfer PK,Kodrat G,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：:Guidelines presented previously for the analysis of plasma concentration versus time data for a drug exhibiting concentration-dependent plasma protein binding were successfully applied to the distributional parameters of a new cephalosporin, ceftriaxone. This approach provided several striking observations when the ph...

journal_title：European journal of clinical pharmacology

authors： McNamara PJ,Gibaldi M,Stoeckel K

更新日期：1983-01-01 00:00:00

abstract：:The efficacy of bopindolol and atenolol in the treatment of patients with chronic stable angina pectoris have been compared in a double blind, randomized study. Both bopindolol 1 mg and atenolol 100 mg for 6 weeks increased mean exercise time (25% and 22%, respectively, compared to placebo), time to angina (27% and 25...

journal_title：European journal of clinical pharmacology

authors： Fitscha P,Meisner W,Tiso B

更新日期：1990-01-01 00:00:00

abstract：:Acute studies of clonidine suggest that it lowers blood pressure by central enhancement of baroreflex sensitivity coupled with diminished evidence of sympathetic outflow, but longterm clonidine data have not been conclusive. We examined effects of one month of low dose clonidine (0.4 +/- 0.15 mg/day) alone in 13 essen...

journal_title：European journal of clinical pharmacology

authors： Cohen IM,O'Connor DT,Preston RA,Stone RA

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:The continuous growth of antidepressant consumption and expenditure, especially for selective serotonin reuptake inhibitors (SSRIs), has led to the adoption of several policy measures directed toward cost control in Western countries. In Italy, copayment policies have been heterogeneously introduced at a region...

journal_title：European journal of clinical pharmacology

authors： Damiani G,Federico B,Silvestrini G,Bianchi CB,Anselmi A,Iodice L,Ronconi A,Navarra P,Da Cas R,Raschetti R,Ricciardi W

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:The anti-obesity drug Xenical (orlistat, Roche) was launched on the Swedish market in February 1999. The sales peaked in May 1999 and then declined. The purpose of this study was to investigate the press coverage of Xenical during the period 1998-2000 and, if possible, relate press attention to Xenical sales ...

journal_title：European journal of clinical pharmacology

authors： Brounéus F,Dahlin A,Beermann B

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVES:To analyse reports of drug-induced myocardial infarction and chest pain sent to a national reporting centre. To review which drugs were suspected of exhibiting these adverse events and what mechanisms were involved. METHODS:During the 20-year period 1975 through 1994, a total of 19,141 reports on adverse re...

journal_title：European journal of clinical pharmacology

authors： Ottervanger JP,Wilson JH,Stricker BH

更新日期：1997-01-01 00:00:00

abstract：PURPOSE:To correct overdosing of drugs requiring adjustment based on renal function in intensive-care patients. METHODS:In a prospective intervention study, we estimated individual glomerular filtration rate and assessed whether medication required dose adjustment based on renal function. Senior clinicians received a ...

journal_title：European journal of clinical pharmacology

authors： Bertsche T,Fleischer M,Pfaff J,Encke J,Czock D,Haefeli WE

更新日期：2009-08-01 00:00:00

abstract：:The gastric inhibitory effects of CM57755, a new histamine H2 receptor antagonist, have been compared in ten healthy male volunteers with the actions of an equal dose of cimetidine and with placebo. The inhibitory effect of CM57755 was virtually identical with, and not significantly different from the effects of cimet...

journal_title：European journal of clinical pharmacology

authors： Wilson JA,Johnston D,Penston J,Wormsley KG

更新日期：1986-01-01 00:00:00

abstract：:Potentiation of the anticoagulant-effect of warfarin by amiodarone was studied in 30 patients. Thirteen received both drugs concurrently, and 17 received warfarin alone and the combination sequentially. Warfarin doses were adjusted to maintain the prothrombin time between 25-30% of control and its kinetics were compar...

journal_title：European journal of clinical pharmacology

authors： Almog S,Shafran N,Halkin H,Weiss P,Farfel Z,Martinowitz U,Bank H

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVES:To investigate the risk factors for noncompliance in elderly home-care recipients; and to evaluate to what extent regular home visits and drug counseling by a pharmacist contribute to compliance. SUBJECTS:One hundred and sixty-three elderly home-care recipients aged 62 years and over took part in this study...

journal_title：European journal of clinical pharmacology

authors： Okuno J,Yanagi H,Tomura S,Oka M,Hara S,Hirano C,Tsuchiya S

更新日期：1999-04-01 00:00:00

abstract：AIM:Our aim was to characterize utilization patterns for drugs used to treat attention deficit/hyperactivity disorder (ADHD) on the level of the individual patient among Danish users, focusing on treatment duration, doses used, and concurrent use of ADHD and non-ADHD drugs. METHODS:Using the Danish Registry of Medicin...

journal_title：European journal of clinical pharmacology

authors： Pottegård A,Bjerregaard BK,Glintborg D,Kortegaard LS,Hallas J,Moreno SI

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:The Drug Burden Index (DBI) is a tool to quantify the anticholinergic and sedative load of drugs. Establishing functional correlates of the DBI could optimize drug prescribing in patients with dementia. In this cross-sectional study, we determined the relationship between DBI and cognitive and physical function...

journal_title：European journal of clinical pharmacology

authors： Sanders LMJ,Hortobágyi T,van Staveren G,Taxis K,Boersma F,Klein HC,Bossers WJR,Blankevoort CG,Scherder EJA,Van der Zee EA,van Heuvelen MJG

更新日期：2017-12-01 00:00:00

abstract：:In a multicentre, double-blind, crossover, placebo-controlled study, the antihypertensive effect of labetalol 100 mg and chlorthalidone 10 mg, given alone or in combination, has been assessed in 32 hypertensive patients. The combination had a greater effect in reducing blood pressure than did its separate components. ...

journal_title：European journal of clinical pharmacology

authors： Lechi A,Pomari S,Berto R,Buniotto P,Parrinello A,Marini F,Cogo L,Tomasi A,Baretta G

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:To review the marketing authorization of biosimilars and provide a critical analysis of the pivotal trials supporting their approval by the European Medicines Agency (EMA). METHODS:EMA website to identify the biosimilars approved up to July 2019 and the European Public Assessment Report for information on pivo...

journal_title：European journal of clinical pharmacology

authors： Allocati E,Bertele' V,Gerardi C,Garattini S,Banzi R

更新日期：2020-04-01 00:00:00

abstract：:The influence of a benzodiazepine (triazolam) on the body temperature of poor sleepers during nights disturbed by airplane noises has been examined. Subjects were divided into 3 groups each of 8 men. Following a double-blind design, Group A (controls) received a placebo for 6 consecutive nights, Group B received 0.25 ...

journal_title：European journal of clinical pharmacology

authors： Libert JP,Weber LD,Amoros C,Muzet A,Ehrhart J,Follenius M

更新日期：1984-01-01 00:00:00