Methylation of 6-mercaptopurine and 6-thioguanine by thiopurine S-methyltransferase. A comparison of activity in red blood cell samples of 199 blood donors.

abstract：OBJECTIVES:To explore the views and perspectives of children on the unlicensed/off-label use of medicines in children and on the participation of children in clinical trials. METHODS:Focus-group discussions, involving school children, were carried out in a range of primary and secondary schools in Northern Ireland. A ...

journal_title：European journal of clinical pharmacology

authors： Mukattash T,Trew K,Hawwa AF,McElnay JC

更新日期：2012-02-01 00:00:00

abstract：PURPOSE:To explore and compare the opinions of physicians, pharmacists and potential users on the readability of a package insert of an over-the-counter medicine. METHODS:Exploratory study based on the administration of a semi-open questionnaire. This instrument was developed according to the readability guideline of ...

journal_title：European journal of clinical pharmacology

authors： Pires CM,Cavaco AM

更新日期：2014-05-01 00:00:00

abstract：PURPOSE:Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study aims to explore exposure-response relationship for panobinostat in this ...

journal_title：European journal of clinical pharmacology

authors： Mu S,Kuroda Y,Shibayama H,Hino M,Tajima T,Corrado C,Lin R,Waldron E,Binlich F,Suzuki K

更新日期：2016-02-01 00:00:00

abstract：:Exposure to reserpine was compared in 181 women interviewed prior to biopsy and found to have breast cancer and 307 women found to have a benign disorder of the breast. The age-adjusted relative risk of breast cancer in those who had taken reserpine was 0.6 (95% confidence limits: 0.4 and 1.1). When the 181 breast can...

journal_title：European journal of clinical pharmacology

authors： Kewitz H,Jesdinsky HJ,Schröter PM,Lindtner E

更新日期：1977-01-03 00:00:00

abstract：BACKGROUND:Serious adverse effects have been observed with some non-sedative H1-antihistamines (terfenadine and astemizole) when they were associated with drugs known to inhibit their metabolism. However, this is not a class effect, and this interaction should be considered on a case-by-case basis. The aim of this stud...

journal_title：European journal of clinical pharmacology

authors： Peytavin G,Gautran C,Otoul C,Cremieux AC,Moulaert B,Delatour F,Melac M,Strolin-Benedetti M,Farinotti R

更新日期：2005-06-01 00:00:00

abstract：:The pharmacokinetics of a new sustained-release preparation of theophylline (Dilatrane à Action Prolongée capsules filled with homogenous microgranules) has been after its studied administration to 7 healthy volunteers at 8 p.m. in order to achieve therapeutic levels at night and in the morning. In separate trials the...

journal_title：European journal of clinical pharmacology

authors： Soubeyrand J,Comet F,Gillet A,Georges D,Brazier JL

更新日期：1984-01-01 00:00:00

abstract：OBJECTIVES:A temporal relationship between the increasing use of antibiotics and the increasing levels of antibiotic resistance has been established for Streptococcus pneumoniae. There are also data that support the presence of a geographic correlation between the level of resistance and the pattern of use among differ...

journal_title：European journal of clinical pharmacology

authors： Boccia D,Alegiani SS,Pantosti A,Moro ML,Traversa G

更新日期：2004-04-01 00:00:00

abstract：:17 patients with severe digoxin intoxication were successfully treated with 320 to 480 mg Fab fragments of digoxin-specific IgG from sheep. The infusion period ranged between 0.5 and 7 h. Serum and urine concentrations of digoxin bound to Fab fragments, and in 11 cases unbound Fab fragments in serum, were determined d...

journal_title：European journal of clinical pharmacology

authors： Schaumann W,Kaufmann B,Neubert P,Smolarz A

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to clarify the stereoselective properties in lansoprazole metabolism by monitoring the metabolic consumption for each enantiomer and the formation of the main metabolites, lansoprazole sulfone and 5-hydroxylansoprazole, in the presence of human liver microsomal enzymes. METH...

journal_title：European journal of clinical pharmacology

authors： Katsuki H,Hamada A,Nakamura C,Arimori K,Nakano M

更新日期：2001-12-01 00:00:00

abstract：:The hypothesis has been tested that an unusual maternal acetylator phenotype can predispose to congenital malformations in the fetus. The acetylator phenotype of normal caucasian control women and of mothers of malformed children was established by measuring urinary sulphadimidine and its acetylated metabolite. A furt...

journal_title：European journal of clinical pharmacology

authors： Stoll C,Roth MP,Dott B,Doumit N,Alembik Y,Welsch M,Imbs JL

更新日期：1989-01-01 00:00:00

abstract：:Three groups of patients with biliary tract disease treated by cholecystectomy were given ceftriaxone. In Group 1 single doses of 150 mg and 1500 mg were given on Days 1 and 5 after cholecystectomy. In Group 2 2 g was given daily for 6 days and the cholecystectomy was on Day 2. Patients in Group 3 received 2 g every 1...

journal_title：European journal of clinical pharmacology

authors： Hayton WL,Schandlik R,Stoeckel K

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:As an inhibitor of HMG-CoA reductase that catalyses the first step of cholesterol synthesis, pitavastatin undergoes little hepatic metabolism; however, it is a substrate of uptake and efflux transporters. Since pitavastatin is potentially co-administered with agents that affect transporter activities, the pharm...

journal_title：European journal of clinical pharmacology

authors： Chen Y,Zhang W,Huang WH,Tan ZR,Wang YC,Huang X,Zhou HH

更新日期：2013-11-01 00:00:00

abstract：:In this study we have investigated the effect of co-dergocrine, a selective DA2-agonist, on plasma aldosterone concentrations (PAC) in twelve patients with essential hypertension both in basal conditions and during sodium depletion. Sodium depletion resulted in an increase of PAC from 38 (13) pg/ml to 297 (21) pg/ml. ...

journal_title：European journal of clinical pharmacology

authors： Lombardi C,Missale C,De Cotiis R,Spedini C,Pizzoccolo G,Memo M,Albertini A,Spano PF

更新日期：1988-01-01 00:00:00

abstract：:Six women, 13 to 16 weeks pregnant, and 12 women at 38 to 40 weeks gestation, received oral oxazepam about 12 h before legal abortion, by hysterotomy in the former and before elective caesarean section in the latter group. The concentrations of free and conjugated oxazepam in maternal and fetal plasma were determined ...

journal_title：European journal of clinical pharmacology

authors： Kangas L,Erkkola R,Kanto J,Eronen M

更新日期：1980-04-01 00:00:00

abstract：:Changes in phenytoin concentrations caused by switching valproate formulations with different absorption rates were retrospectively investigated in eleven epileptic patients receiving treatment with both drugs. Total plasma phenytoin concentrations were measured before and after a standard tablet of valproate was repl...

journal_title：European journal of clinical pharmacology

authors： Suzuki Y,Nagai T,Mano T,Arai H,Kodaka R,Matsuoka T,Itagaki Y,Ono J,Okada S

更新日期：1995-01-01 00:00:00

abstract：:Thirty patients with mild or moderate essential hypertension, and a fixed elevation of diastolic blood pressure, were randomly allocated to three groups and treated with propranolol 40 mg x 4 (Group 1), 80 mg x 4 (group 2) and 160 mg x 4 (Group 3). Blood pressure (BP), pulse rate (PR), plasma renin activity (PRA), pla...

journal_title：European journal of clinical pharmacology

authors： Pedersen EB,Kornerup HJ,Pedersen OL,Andreasen F,Bjerregaard P

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To investigate the influence of theophylline on erythropoiesis in chronic obstructive pulmonary disease (COPD) and explore the potential underlying mechanisms. METHODS:We evaluated the haematological parameters and erythropoietin (EPO) values in 38 COPD patients, 18 of which had been treated with theophyllin...

journal_title：European journal of clinical pharmacology

authors： Tsantes AE,Tassiopoulos ST,Papadhimitriou SI,Bonovas S,Poulakis N,Vlachou A,Filioussi K,Loukopoulos D

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The aim of this meta-analysis was to gather current data and evaluate not only the risk of gastrointestinal (GI) perforation with bevacizumab, but also the potential risk factors for this adverse event. MATERIALS AND METHODS:We carried out a literature search in PubMed for randomized controlled trials (RCTs...

journal_title：European journal of clinical pharmacology

authors： Qi WX,Shen Z,Tang LN,Yao Y

更新日期：2014-08-01 00:00:00

abstract：:The peripheral histamine-inhibiting and central sedative effects of single oral doses (SOD) and of repeated administration for one week (steady state, SS), of 20 mg hydroxyzine HCL and 10 mg cetirizine have been assessed in 12 healthy volunteers, in a double-blind placebo-controlled cross-over study. Peripheral H1-rec...

journal_title：European journal of clinical pharmacology

authors： Levander S,Ståhle-Bäckdahl M,Hägermark O

更新日期：1991-01-01 00:00:00

abstract：:The role of acetylator phenotype in determining the response to hydralazine when it was added to diuretic and beta-blocker at doses not exceeding 200 mg daily was examined in 57 hypertensive patients. 81% of rapid acetylators needed 200 mg hydralazine daily compared to 38% of slow acetylators (p less than 0.01). Despi...

journal_title：European journal of clinical pharmacology

authors： Ramsay LE,Silas JH,Ollerenshaw JD,Tucker GT,Phillips FC,Freestone S

更新日期：1984-01-01 00:00:00

abstract：:The pharmacokinetics of lignocaine has been compared after epidural anaesthesia in diabetics and non-diabetic patients. Epidural lignocaine 8 mg.kg-1 was given to 8 well controlled Type II diabetic and 8 non-diabetic patients and the plasma drug concentration in serial blood samples were measured by HPLC. The plasma l...

journal_title：European journal of clinical pharmacology

authors： Peeyush M,Ravishankar M,Adithan C,Shashindran CH

更新日期：1992-01-01 00:00:00

abstract：:Eight patients were given flunitrazepam 2 mg orally, once daily for 28 consecutive days. The time-course of the plasma concentration of unchanged flunitrazepam and its principal metabolites were studied in detail after the first and last doses. Additional blood samples were collected immediately before administration ...

journal_title：European journal of clinical pharmacology

authors： Wickstrøm E,Amrein R,Haefelfinger P,Hartmann D

更新日期：1980-01-01 00:00:00

abstract：PURPOSE:To investigate the impact of valproic acid (VPA) and genetic polymorphism of the major metabolizing enzyme (UGT1A4, UGT2B7) of lamotrigine (LTG) and VPA on LTG concentration in Chinese epileptic children. METHODS:Three single nucleotide polymorphisms (UGT1A4*3, UGT2B7 -161C > T and UGT2B7*2) were analyzed by p...

journal_title：European journal of clinical pharmacology

authors： Liu L,Zhao L,Wang Q,Qiu F,Wu X,Ma Y

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:We investigated the effects of treatment with Saint John's wort (hypericum perforatum) extract on the urinary excretion of D-glucaric acid, 6beta-hydroxycortisol, and free cortisol in order to assess the effect of this extract on the activity of hepatic xenobiotic metabolizing enzymes. METHODS:Forty-eight he...

journal_title：European journal of clinical pharmacology

authors： Bauer S,Störmer E,Kerb R,Johne A,Brockmöller J,Roots I

更新日期：2002-12-01 00:00:00

abstract：:Sixty patients were treated for 1 year for essential uncomplicated hypertension, 30 with beta-blockers alone (BB) and 30 with BB and chlorthalidone (CTD). BB did not affect serum K+ or Mg++. In the BB-group there was a statistically significant trend towards retention of Mg++ in a loading test, but the effect was clin...

journal_title：European journal of clinical pharmacology

authors： Cocco G,Iselin HU,Strozzi C,Cesana B,Baumeler HR

更新日期：1987-01-01 00:00:00

abstract：:The levels of doxycycline in serum, bile and the gallbladder wall were determined in 25 patients during cholecystectomy, by means of bioassay after previous intravenous administration of doxycycline. The mean biliary level exceeded 20 microgram/ml, and the mean level in the gallbladder wall was greater than 2 microgra...

journal_title：European journal of clinical pharmacology

authors： Moorthi K,Wiederholt K

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:To correct overdosing of drugs requiring adjustment based on renal function in intensive-care patients. METHODS:In a prospective intervention study, we estimated individual glomerular filtration rate and assessed whether medication required dose adjustment based on renal function. Senior clinicians received a ...

journal_title：European journal of clinical pharmacology

authors： Bertsche T,Fleischer M,Pfaff J,Encke J,Czock D,Haefeli WE

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:To develop quality prescribing indicators for general practitioners (GPs) who are non-monitored and not included in pay-for-performance programs, and to determine compliance with incentivized and non-incentivized indicators. STUDY DESIGN:Descriptive cross sectional study. SETTING:Aljarafe Primary Health Car...

journal_title：European journal of clinical pharmacology

authors： Fernández Urrusuno R,Montero Balosa MC,Pérez Pérez P,Pascual de la Pisa B

更新日期：2013-10-01 00:00:00

abstract：:A four-period, two-panel, single-rising-dose study (0.1-100 mg) was conducted in healthy males to investigate the pharmacodynamics, tolerability and pharmacokinetics of MK-0434, a steroid 5 alpha-reductase inhibitor. MK-0434 was associated with a significant reduction in dihydrotestosterone, which was maximal at 24 h ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Depré M,Schwartz JI,Tjandramaga TB,Winchell GA,De Lepeleire I,Ng J,De Schepper PJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:The pharmacokinetics of N(G)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was investigated in patients with septic shock. METHODS:Blood was sampled at intervals before, during and after 12-h infusion of L-NAME 1 mg x kg(-1) x h(-1) in nine septic shock patients for det...

journal_title：European journal of clinical pharmacology

authors： Avontuur JA,Buijk SL,Bruining HA

更新日期：1998-10-01 00:00:00