当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine.

Peripheral antihistamine and central sedative effects of single and continuous oral doses of cetirizine and hydroxyzine.

Abstract：

:The peripheral histamine-inhibiting and central sedative effects of single oral doses (SOD) and of repeated administration for one week (steady state, SS), of 20 mg hydroxyzine HCL and 10 mg cetirizine have been assessed in 12 healthy volunteers, in a double-blind placebo-controlled cross-over study. Peripheral H1-receptor antagonism was estimated as the reduction in the area of the flare and the duration of the itch after intradermal injection of histamine 0.1 and 1.0 micrograms. CNS effects were assessed by a battery of computerized neuropsychological tests and seven visual analogue scales. Drug compliance was ascertained by plasma level determinations. Cetirizine 10 mg (SOD) produced a more pronounced peripheral effect than 20 mg hydroxyzine, whereas hydroxyzine but not cetirizine, showed a significant sedative action in the relevant rating scales. These effects vanished during steady state, suggesting adaptation to the initial sedative effect of hydroxyzine in most of the subjects. No sedative effect of cetirizine was demonstrated. There was no impairment at group level in the neuropsychological tests after the SOD or SS treatment. However, six subjects who showed sedation in the analogue ratings after hydroxyzine, displayed significantly impaired performance after hydroxyzine SOD. The findings are discussed in relation to the individual characteristics of the study groups.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Levander S,Ståhle-Bäckdahl M,Hägermark O

doi

10.1007/BF00626365

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

435-9

issue

5

eissn

0031-6970

issn

1432-1041

journal_volume

41

pub_type

临床试验,杂志文章

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