当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Should the acetylator phenotype be determined when prescribing hydralazine for hypertension?

Should the acetylator phenotype be determined when prescribing hydralazine for hypertension?

Abstract：

:The role of acetylator phenotype in determining the response to hydralazine when it was added to diuretic and beta-blocker at doses not exceeding 200 mg daily was examined in 57 hypertensive patients. 81% of rapid acetylators needed 200 mg hydralazine daily compared to 38% of slow acetylators (p less than 0.01). Despite higher doses of hydralazine the blood pressure was controlled in only 27% of rapid acetylators compared to 65% of slow acetylators (p less than 0.02). The relation of acetylator phenotype to blood pressure response was statistically independent of initial blood pressure, age, sex, body weight and serum creatinine (p less than 0.005). Current recommendations on hydralazine dosage are unsatisfactory for the 40% of hypertensive patients who are rapid acetylators. We suggest measurement of the acetylator phenotype in patients who respond incompletely to 200 mg hydralazine daily. About 70% of these patients will be rapid acetylators in whom the dose of hydralazine can be increased safely.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Ramsay LE,Silas JH,Ollerenshaw JD,Tucker GT,Phillips FC,Freestone S

doi

10.1007/BF00546706

subject

Has Abstract

pub_date

1984-01-01 00:00:00

pages

39-42

issue

1

eissn

0031-6970

issn

1432-1041

journal_volume

26

pub_type

杂志文章

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • A meta-analysis of the placebo response in acute migraine and how this response may be influenced by some of the characteristics of clinical trials.

    abstract：:Migraine is the most common cause of vascular headache and a highly prevalent illness. In the last 20 years, the discovery of new agents has increased clinical research on migraine. In most of clinical trials that have been conducted, the efficacy was established using a placebo as a control treatment. The objective o...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00228-005-0088-5

    authors： Macedo A,Farré M,Baños JE

    更新日期：2006-03-01 00:00:00

  • Influence of nifedipine therapy on indocyanine green and oral propranolol pharmacokinetics.

    abstract：:Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00679780

    authors： Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

    更新日期：1989-01-01 00:00:00

  • Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors and special populations. A literature review.

    abstract：PURPOSE:Treatment failures following vancomycin therapy in patients with methicillin-resistant Staphylococcus aureus infections have led to the utilization of higher doses of this antibiotic to achieve the trough concentrations of 10-20 μg/mL recommended by the Infectious Diseases Society of America clinical practice g...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s00228-012-1259-9

    authors： Elyasi S,Khalili H,Dashti-Khavidaki S,Mohammadpour A

    更新日期：2012-09-01 00:00:00

  • Influence and interference of isosorbide dinitrate and food intake on superior mesenteric artery impedance in humans.

    abstract：:The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00196852

    authors： Voet D,Mareels S,Afschrift M,De Buyzere M,Rietzschel E,Duprez D

    更新日期：1995-01-01 00:00:00

  • Protein binding of salicylate in cutaneous hepatic porphyria.

    abstract：:(1) Plasma protein binding of salicylate was studied in 14 patients with cutaneous hepatic porphyria (CHP) and 11 normal subjects using ultrafiltration with centrifugation (membrane cones) and continuous ultrafiltrations. (2) Albumin and haemoglobin levels were significantly reduced in patients with CHP, and salicylat...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00716368

    authors： Steele WH,Boobis SW,Moore MR,Goldberg A,Brodie MJ,Summer DJ

    更新日期：1978-06-19 00:00:00

  • Are systemic levels of non steroidal anti inflammatory drugs relevant to acute upper gastrointestinal haemorrhage?

    abstract：:It is uncertain as to the extent which gastrointestinal (GI) haemorrhage related to NSAIDs is due to a local, topical effect or to an action related to systemic absorption. We hypothesised that, should systemic drug concentrations be of importance, plasma levels of NSAIDs might be higher in patients who had developed ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00316464

    authors： Wynne HA,Rawlins MD

    更新日期：1993-01-01 00:00:00

  • Captopril does not interact with the pharmacodynamics and pharmacokinetics of digitoxin in healthy man.

    abstract：:The chronic oral administration of 0.07 mg digitoxin o.d. for up to 58 days to 12 healthy volunteers caused a small drop in mean heart rate HR (95% CI: -7.9 to -1.6 beats.min-1), in mean diastolic blood pressure (95% CI: -8.3 to -0.4 mmHg), shortening of the QTc-interval (95% CI: -42 to -19 ms), shortening of the HR-c...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF02220626

    authors： de Mey C,Elich D,Schroeter V,Butzer R,Belz GG

    更新日期：1992-01-01 00:00:00

  • Generalization of distribution--free confidence intervals for bioavailability ratios.

    abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00635713

    authors： Steinijans VW,Diletti E

    更新日期：1985-01-01 00:00:00

  • Hospital re-admission associated with adverse drug reactions in patients over the age of 65 years.

    abstract：CONTEXT:Adverse drug reactions (ADRs) are responsible for 5 % of hospital admissions, but hospital re-admission induced by ADRs remains poorly documented. OBJECTIVE:The aim of this study was to estimate the rate of hospital re-admission and the factors associated with re-admission in the patients over the age of 65 ye...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2022-4

    authors： Hauviller L,Eyvrard F,Garnault V,Rousseau V,Molinier L,Montastruc JL,Bagheri H

    更新日期：2016-05-01 00:00:00

  • Application of a radioreceptor assay in a pharmacokinetic study of oxitropium bromide in healthy volunteers after single i.v., oral and inhalation doses.

    abstract：:Oxitropium bromide (OXBR) is a new anticholinergic drug, which is expected to be useful in the treatment of nocturnal asthma. The only pharmacokinetic data were obtained with the 14C-labelled compound. A sensitive radioreceptor assay for the determination of unlabelled OXBR in plasma was developed, based on competitio...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00558132

    authors： Ensing K,de Zeeuw RA,in 't Hout WG,Cornelissen PJ

    更新日期：1989-01-01 00:00:00

  • Topical formulations of fluocinolone acetonide. Are creams, gels and ointments bioequivalent and does dilution affect activity?

    abstract：:The study was done in healthy volunteers to investigate the vasoconstrictor activity of three commercially available formulations of fluocinolone acetonide (Synalar gel, cream and ointment) and to determine whether they were bioequivalent. The influence of dilution of the cream formulation on activity was also examine...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00195919

    authors： Gao HY,Li Wan Po A

    更新日期：1994-01-01 00:00:00

  • Compliance with quality prescribing indicators in terms of their relationship to financial incentives.

    abstract：OBJECTIVE:To develop quality prescribing indicators for general practitioners (GPs) who are non-monitored and not included in pay-for-performance programs, and to determine compliance with incentivized and non-incentivized indicators. STUDY DESIGN:Descriptive cross sectional study. SETTING:Aljarafe Primary Health Car...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-013-1542-4

    authors： Fernández Urrusuno R,Montero Balosa MC,Pérez Pérez P,Pascual de la Pisa B

    更新日期：2013-10-01 00:00:00

  • Pharmaceutical and genetic determinants for interindividual differences of tacrolimus bioavailability in renal transplant recipients.

    abstract：PURPOSE:The pharmacokinetics of orally administered immediate-release, twice-daily (BID) and modified-release, once-daily (QD) formulations of tacrolimus have high interindividual variability. We investigated factors affecting interindividual variability of tacrolimus bioavailability in renal transplant patients. METH...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-013-1514-8

    authors： Niioka T,Kagaya H,Miura M,Numakura K,Saito M,Inoue T,Habuchi T,Satoh S

    更新日期：2013-09-01 00:00:00

  • Antidepressants and suicidal behaviour in late life: a prospective population-based study of use patterns in new users aged 75 and above.

    abstract：PURPOSE:To investigate associations between antidepressant use patterns and risk of fatal and non-fatal suicidal behaviours in older adults who initiated antidepressant therapy. METHOD:A national population-based cohort study conducted among Swedish residents aged ≥ 75 years who initiated antidepressant treatment. Pat...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-017-2360-x

    authors： Hedna K,Andersson Sundell K,Hamidi A,Skoog I,Gustavsson S,Waern M

    更新日期：2018-02-01 00:00:00

  • Effect of grapefruit juice on the pharmacokinetics of tolvaptan, a non-peptide arginine vasopressin antagonist, in healthy subjects.

    abstract：PURPOSE:Tolvaptan is a selective vasopressin V2 receptor antagonist that can be given orally once daily for treatment of clinically significant hypervolemic and euvolemic hyponatremia (US and Europe) or extracellular volume expansion despite taking other diuretics (Japan). In vitro studies indicated that tolvaptan was ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/s00228-011-1106-4

    authors： Shoaf SE,Mallikaarjun S,Bricmont P

    更新日期：2012-02-01 00:00:00

  • Capecitabine plus oxaliplatin (XELOX) compared with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in advanced gastric cancer: meta-analysis of randomized controlled trials.

    abstract：PURPOSE:The study aims to compare the efficacy and safety of capecitabine plus oxaliplatin (XELOX) with 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOXs) in patients with advanced gastric cancer. METHODS:Five databases were searched up to June 2014, without language restrictions. The outcomes included overall respo...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00228-015-1828-9

    authors： Xu HB,Huang F,Su R,Shen FM,Lv QZ

    更新日期：2015-05-01 00:00:00

  • Single ascending oral dose pharmacokinetics and pharmacodynamics study of EV-077: the specific inhibitor of prostanoid- and isoprostane-induced cellular activation.

    abstract：PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-012-1348-9

    authors： Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

    更新日期：2013-03-01 00:00:00

  • Anti-tuberculosis drug concentrations in tuberculosis patients with and without diabetes mellitus.

    abstract：PURPOSE:The aim of the study was to compare plasma concentrations of rifampicin (RMP), isoniazid (INH) and pyrazinamide (PZA) between tuberculosis (TB) patients with and without diabetes mellitus (DM). METHODS:Two-hour post-dosing concentrations of RMP, INH and PZA were determined in adult TB patients that were studie...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2132-z

    authors： Kumar AK,Chandrasekaran V,Kannan T,Murali AL,Lavanya J,Sudha V,Swaminathan S,Ramachandran G

    更新日期：2017-01-01 00:00:00

  • Antidepressants in suicide: differences in fatality and drug utilisation.

    abstract：:All forensic autopsy cases in southern Sweden in 1986-89 in which antidepressant drugs were found in the blood were assessed and the findings related to the sales of antidepressants as expressed as defined daily doses per 1,000 inhabitants per day. There was a total of 272 antidepressant-positive cases, which were div...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00194393

    authors： Malmvik J,Löwenhielm CG,Melander A

    更新日期：1994-01-01 00:00:00

  • Clinical evaluation of labetalol alone and combined with chlorthalidone in essential hypertension: a double-blind multicentre controlled study.

    abstract：:In a multicentre, double-blind, crossover, placebo-controlled study, the antihypertensive effect of labetalol 100 mg and chlorthalidone 10 mg, given alone or in combination, has been assessed in 32 hypertensive patients. The combination had a greater effect in reducing blood pressure than did its separate components. ...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00548395

    authors： Lechi A,Pomari S,Berto R,Buniotto P,Parrinello A,Marini F,Cogo L,Tomasi A,Baretta G

    更新日期：1982-01-01 00:00:00

  • The effect of acarbose on the pharmacokinetics of rosiglitazone.

    abstract：OBJECTIVES:To investigate whether treatment with acarbose alters the pharmacokinetics (PK) of coadministered rosiglitazone. METHODS:Sixteen healthy volunteers (24-59-years old) received a single 8-mg dose of rosiglitazone on day 1, followed by 7 days of repeat dosing with acarbose [100 mg three times daily (t.i.d.) wi...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280100275

    authors： Miller AK,Inglis AM,Culkin KT,Jorkasky DK,Freed MI

    更新日期：2001-05-01 00:00:00

  • Differential effects of Saint John's Wort (hypericum perforatum) on the urinary excretion of D-glucaric acid and 6beta-hydroxycortisol in healthy volunteers.

    abstract：OBJECTIVE:We investigated the effects of treatment with Saint John's wort (hypericum perforatum) extract on the urinary excretion of D-glucaric acid, 6beta-hydroxycortisol, and free cortisol in order to assess the effect of this extract on the activity of hepatic xenobiotic metabolizing enzymes. METHODS:Forty-eight he...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-002-0527-5

    authors： Bauer S,Störmer E,Kerb R,Johne A,Brockmöller J,Roots I

    更新日期：2002-12-01 00:00:00

  • Drug-induced anaphylaxis: a decade review of reporting to the Portuguese Pharmacovigilance Authority.

    abstract：PURPOSE:Anaphylaxis is a potentially fatal systemic adverse drug reaction (ADR). It is an unpredictable and mostly dose-independent event that occurs suddenly following exposure to the causative drug. Our objective was to characterize a case series of anaphylactic reactions reported to the Portuguese Pharmacovigilance ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-012-1376-5

    authors： Ribeiro-Vaz I,Marques J,Demoly P,Polónia J,Gomes ER

    更新日期：2013-03-01 00:00:00

  • Use of anti-asthmatic drugs during pregnancy. 1. Maternal characteristics, pregnancy and delivery complications.

    abstract：OBJECTIVE:To study, in a large cohort, the association between the use of anti-asthmatic drugs during pregnancy and pregnancy complications. METHODS:Using the Swedish Medical Birth Register, we identified 24,369 women who reported the use of anti-asthmatic drugs in early pregnancy and 7778 women who were prescribed su...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-006-0257-1

    authors： Källén B,Otterblad Olausson P

    更新日期：2007-04-01 00:00:00

  • Pharmacokinetics of ethanol in plasma and whole blood: estimation of total body water by the dilution principle.

    abstract：:The pharmacokinetics of ethanol in plasma and whole blood have been investigated and the results used to estimate the volume of total body water (TBW) by means of the dilution principle. Fifteen men (mean age 62 y) were given 0.6 g ethanol/kg body weight as an intravenous infusion over 1 h. The peak concentration of e...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00280133

    authors： Jones AW,Hahn RG,Stalberg HP

    更新日期：1992-01-01 00:00:00

  • The effect of dietary energy and protein deficiency on drug metabolism.

    abstract：:The influence of a diet deficient in energy or protein on hepatic oxidation (Phase I reactions) and glucuronidation (Phase II reactions) in man has been examined. Nine healthy volunteers were fed an energy deficient diet (daily energy intake 4.3 MJ; daily protein intake 0.94 g/kg) and a protein deficient diet (daily e...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00278583

    authors： Hamberg O,Ovesen L,Dorfeldt A,Loft S,Sonne J

    更新日期：1990-01-01 00:00:00

  • The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.

    abstract：OBJECTIVES:Caffeine-containing beverages are generally consumed by Nigerians suffering from malaria and kwashiorkor in the belief that caffeine aids early recovery from these illnesses, which are common in the tropics. However, there are no studies on the influence of these diseases on the absorption and pharmacokineti...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280050734

    authors： Akinyinka OO,Sowunmi A,Honeywell R,Renwick AG

    更新日期：2000-05-01 00:00:00

  • Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.

    abstract：:Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00610057

    authors： Lönnerholm G,Lindström B,Paalzow L,Sedin G

    更新日期：1983-01-01 00:00:00

  • General pharmacokinetic equations for linear mammillary models with drug absorption into peripheral compartments.

    abstract：:General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readil...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00561564

    authors： Vaughan DP,Mallard DJ,Trainor A,Mitchard M

    更新日期：1975-02-28 00:00:00

  • Package inserts for antihypertensive drugs: use by the patients and impact on adverse drug reactions.

    abstract：:In Belgium, all dispensed drugs are provided with package inserts. Traditional physician-orientated inserts are gradually being replaced by patient package inserts (PPIs). The present survey is focused on the use of inserts for antihypertensive drugs and their impact on the reported occurrence and attribution of adver...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00316093

    authors： Van Haecht CH,Vander Stichele R,Bogaert MG

    更新日期：1990-01-01 00:00:00