Effects of sumatriptan and eletriptan on diseased epicardial coronary arteries.

abstract：BACKGROUND AND METHODS:This opinion paper expanded on the WHO "six-step approach to optimal pharmacotherapy," by detailed exploration of the underlying pharmacological and pathophysiological principles. This exercise led to the identification of a large number of domains of research that should be addressed to make cli...

journal_title：European journal of clinical pharmacology

authors： Rongen GA,Marquet P,van Gerven JMA,EACPT research working group.

更新日期：2020-11-18 00:00:00

abstract：OBJECTIVE:Valsartan (V), a specific inhibitor of the angiotensin II receptor subtype, AT1, has been developed for treatment of hypertension. Combination therapy with a beta-adrenoceptor blocking agent might be considered in cases with insufficient efficacy of V alone. Therefore, an interaction trial was performed to ev...

journal_title：European journal of clinical pharmacology

authors： Czendlik CH,Sioufi A,Preiswerk G,Howald H

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:The effect of age on the pharmacokinetics and pharmacodynamics of prazosin (alpha 1 adrenoceptor blocker) was studied in 20 healthy volunteers. PATIENTS:Ten elderly (61-81 y) and ten young (23-28 y) subjects were studied. All subjects received 1 mg of prazosin orally in a fasting state. Serial blood samples ...

journal_title：European journal of clinical pharmacology

authors： Andros E,Detmar-Hanna D,Suteparuk S,Gal J,Gerber JG

更新日期：1996-01-01 00:00:00

abstract：PURPOSE:Persistence to statins is low, in part due to lack of perception of cardiovascular (CV) risk. High values of low-density lipoprotein cholesterol (LDL-C) might increase the motivation for patients to be persistent. We investigated whether the baseline LDL-C value influences the discontinuation of statin treatmen...

journal_title：European journal of clinical pharmacology

authors： Citarella A,Linder M,Kieler H,Berglind IA,Sundström A,Wettermark B,Andersen M

更新日期：2016-03-01 00:00:00

abstract：:The effect of the angiotensin converting enzyme inhibitor, perindopril, on autonomic function was assessed in a double blind, placebo controlled, crossover study in 10 normotensive males. Eight milligram of perindopril given orally lowered blood pressure without a change in heart rate. Perindopril enhanced the vagally...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Lees KR,Reid JL

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To gain insight into the experiences and handling of adverse drug reactions (ADRs) by the staffs of public primary healthcare (PHC) clinics in Eastern Cape Province, South Africa, as well as their perceptions of related adherence challenges in the treatment and follow-up of human immunodeficiency virus (HIV)-po...

journal_title：European journal of clinical pharmacology

authors： Ruud KW,Srinivas SC,Toverud EL

更新日期：2012-09-01 00:00:00

abstract：:General equations are derived for the disposition functions of any compartment in a linear mammillary model, when the system input occurs into a peripheral compartment. Laplace transforms and matrix algebra are used to derive these equations. Equations describing the time-course of a drug in any compartment are readil...

journal_title：European journal of clinical pharmacology

authors： Vaughan DP,Mallard DJ,Trainor A,Mitchard M

更新日期：1975-02-28 00:00:00

abstract：PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

journal_title：European journal of clinical pharmacology

authors： Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:We investigated the effects of treatment with Saint John's wort (hypericum perforatum) extract on the urinary excretion of D-glucaric acid, 6beta-hydroxycortisol, and free cortisol in order to assess the effect of this extract on the activity of hepatic xenobiotic metabolizing enzymes. METHODS:Forty-eight he...

journal_title：European journal of clinical pharmacology

authors： Bauer S,Störmer E,Kerb R,Johne A,Brockmöller J,Roots I

更新日期：2002-12-01 00:00:00

abstract：:To elucidate the effect of Nicorandil on myocardial energy metabolism and myocardial sympathetic activity, we administered Nicorandil orally to eight patients with angina pectoris prior to exercise testing. Arterial and coronary sinus levels of lactate, ammonia, hypoxanthine (HX), adrenaline and noradrenaline were mea...

journal_title：European journal of clinical pharmacology

authors： Ogino K,Osaki S,Noguchi N,Kitamura H,Omodani H,Kato M,Hisatome I,Matsumoto T,Kinugawa T,Miyakoda H

更新日期：1995-01-01 00:00:00

abstract：:Procainamide was given to 20 patients with normal renal function as an i.v. bolus of 500 mg followed by 1.0 or 1.5 g eight-hourly by mouth in the form of a slow release preparation (Durules). 97.6 +/- 27.1 (SD)% of the oral procainamide was absorbed, the absorption half life being 1.54 h. The elimination half life fol...

journal_title：European journal of clinical pharmacology

authors： Tilstone WJ,Lawson DH,Campbell W,Hutton I,Lawrie TD

更新日期：1978-12-01 00:00:00

abstract：:The effect of treatment with diflunisal on the steady-state pharmacokinetics of indomethacin has been studied in 16 healthy volunteers. The steady-state plasma concentration and AUC of indomethacin were significantly increased two- to threefold during treatment with diflunisal and its total clearance and total volume ...

journal_title：European journal of clinical pharmacology

authors： Van Hecken A,Verbesselt R,Tjandra-Maga TB,De Schepper PJ

更新日期：1989-01-01 00:00:00

abstract：:The maternofetal transfer of the beta 1-selective adrenergic antagonist celiprolol has been studied in four hypertensive pregnant women. Fetal plasma concentrations were about 25-50% of the levels found on the maternal side. There was no significant difference between the plasma concentrations of the two enantiomers i...

journal_title：European journal of clinical pharmacology

authors： Kofahl B,Henke D,Hettenbach A,Mutschler E

更新日期：1993-01-01 00:00:00

abstract：:Changes in venous haemodynamics were studied after administration of a single dose of 3 g Heptaminol Adenosine Phosphate (HAP) to 30 subjects with primary varicose veins. Strain gauge plethysmography was used to observe changes in venous volume and in maximal venous outflow, 1, 2, 3 and 4 h after dosing. A significant...

journal_title：European journal of clinical pharmacology

authors： Schmidt C,Gavoille R,Perez P,Schmitt J

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To study the impact of gemfibrozil co-administration on the pharmacokinetics of sitagliptin in healthy Indian male volunteers. METHODS:A randomized open label two-period crossover study involving 12 healthy Indian male volunteers was conducted at a single center. In each phase, the volunteers were administered...

journal_title：European journal of clinical pharmacology

authors： K P A,Meda VS,Kucherlapati VS,Dubala A,M D,P R AV,K E,B S

更新日期：2012-05-01 00:00:00

abstract：:The concentration of Torasemide in plasma, dialysate and ultrafiltrate were determined during one haemofiltration and three dialyses. Results show that Torasemide is not significantly eliminated from the blood by these technics. ...

journal_title：European journal of clinical pharmacology

authors： Loute G,Adam A,Ers P,Heremans C,Willems B

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). METHODS:A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis...

journal_title：European journal of clinical pharmacology

authors： Joy MS,Boyette T,Hu Y,Wang J,La M,Hogan SL,Stewart PW,Falk RJ,Dooley MA,Smith PC

更新日期：2010-11-01 00:00:00

abstract：:(1) Plasma protein binding of salicylate was studied in 14 patients with cutaneous hepatic porphyria (CHP) and 11 normal subjects using ultrafiltration with centrifugation (membrane cones) and continuous ultrafiltrations. (2) Albumin and haemoglobin levels were significantly reduced in patients with CHP, and salicylat...

journal_title：European journal of clinical pharmacology

authors： Steele WH,Boobis SW,Moore MR,Goldberg A,Brodie MJ,Summer DJ

更新日期：1978-06-19 00:00:00

abstract：OBJECTIVE:Although the treatment of schizophrenia with many second generation antipsychotics is known to be associated with metabolic changes, such as hyperglycemia or hypercholesterolemia, the underlying mechanisms of these adverse reactions remain unclear. In light of the recent focus on the involvement of semicarbaz...

journal_title：European journal of clinical pharmacology

authors： Roessner V,Weber A,Becker A,Beck G,Frieling H,Bleich S

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Aflibercept, a fully humanized vascular endothelial growth factor (VEGF)-targeted agent, has emerged as an effective therapy in the treatment of various solid tumors. We carried out an up-to-date meta-analysis to determine the risk of fatal adverse events (FAEs) in cancer patients treated with aflibercept. MET...

journal_title：European journal of clinical pharmacology

authors： Qi WX,Tang LN,Shen Z,Yao Y

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:The efficacy, safety, tolerability and speed of onset of the hypotensive action of the combination of oral enalapril (10 mg) prazosin (1 mg) and hydrochlorothiazide (50 mg) has been assessed in 12 Nigerians with severe hypertension (Diastolic BP > or = 115 mmHg). PATIENTS:The ages of the patients ranged from...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Afolabi MA,Balogun MO,Adigun AQ,Ajayi OE,Akintomide AO

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:A four-drug cytochrome P450 (CYP) phenotyping cocktail was developed to rapidly and safely determine CYP2D6, CYP2C19, CYP2C9 and CYP1A2 enzyme activity and phenotype. METHODS:The cocktail consisted of the single CYP phenotyping probes of 50 mg tramadol (CYP2D6), 20 mg omeprazole (CYP2C19), 25 mg losartan (C...

journal_title：European journal of clinical pharmacology

authors： Pedersen RS,Damkier P,Christensen MM,Brosen K

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of topical administration of atorvastatin (ATV) on the acute radiation-induced skin toxicity in patients with breast cancer. PATIENTS AND METHODS:Seventy breast cancer patients were ra...

journal_title：European journal of clinical pharmacology

authors： Ghasemi A,Ghashghai Z,Akbari J,Yazdani-Charati J,Salehifar E,Hosseinimehr SJ

更新日期：2019-02-01 00:00:00

abstract：:We have shown that apparent nonlinearities in the pharmacokinetics of chloroquine and wide variability in reported kinetic values are possibly artefacts of experimental design. We have used simulated data based on linear equations to demonstrate that chloroquine kinetics may appear to be dose-dependent if samples are ...

journal_title：European journal of clinical pharmacology

authors： Tett SE,Cutler DJ

更新日期：1987-01-01 00:00:00

abstract：:Plasma concentrations of nitrazepam were measured by gas-liquid chromatography in: young healthy volunteers, in geriatric and psychiatric patients and in epileptic children. The disposition of nitrazepam was described in terms of a two-compartment open model. After a single oral dose of nitrazepam 5 mg the most promin...

journal_title：European journal of clinical pharmacology

authors： Kangas L,Iisalo E,Kanto J,Lehtinen V,Pynnönen S,Ruikka I,Salminen J,Sillanpää M,Syvälahti E

更新日期：1979-04-17 00:00:00

abstract：OBJECTIVE:After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD:The CYP2D6 phen...

journal_title：European journal of clinical pharmacology

authors： Monek O,Paintaud G,Bechtel Y,Miguet JP,Mantion G,Bechtel PR

更新日期：1998-03-01 00:00:00

abstract：INTRODUCTION:In order to discover how well the discipline of clinical pharmacology (CP) has developed in Europe, a questionnaire survey was undertaken in 31 countries. METHODS:The senior delegate of each of the 31 countries on the Council of the European Association for Clinical Pharmacology and Therapeutics (EACPT) w...

journal_title：European journal of clinical pharmacology

authors： Orme M,Sjöqvist F

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:To determine the response of haemodynamic and oxygen-transport parameters to phenylephrine in a dose-response fashion in septic non-hypotensive, vasodilated surgical intensive care unit (ICU) patients. DESIGN:Prospective study. SETTING:Surgical ICU of a tertiary care, university medical centre. PATIENTS:Te...

journal_title：European journal of clinical pharmacology

authors： Flancbaum L,Dick M,Dasta J,Sinha R,Choban P

更新日期：1997-01-01 00:00:00

abstract：:Twenty-nine cases of self-poisoning with antidepressants (amitriptyline, imipramine, clomipramine, maprotiline, doxepine, nortriptyline, opipramol) were examined by frequent observation of CNS effects, heart rate, blood pressure and standard ECG, 24h-ECG-monitoring, measurement of systolic time intervals, EEG recordin...

journal_title：European journal of clinical pharmacology

authors： Pedersen OL,Gram LF,Kristensen CB,Møller M,Thayssen P,Bjerre M,Kragh-SøRensen P,Klitgaard NA,Sindrup E,Hole P,Brinklø M

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:To assess the effect of ciprofloxacin on the pharmacokinetics of ropivacaine. METHODS. In a double-blind, randomised, cross-over study, nine healthy volunteers were treated for 2.5 days with 500 mg oral ciprofloxacin or placebo twice daily. On day 3, they received a single dose of 0.6 mg/kg ropivacaine intrav...

journal_title：European journal of clinical pharmacology

authors： Jokinen MJ,Olkkola KT,Ahonen J,Neuvonen PJ

更新日期：2003-02-01 00:00:00