Clinical Pharmacology in European health care-outcome of a questionnaire study in 31 countries.

Abstract:

INTRODUCTION:In order to discover how well the discipline of clinical pharmacology (CP) has developed in Europe, a questionnaire survey was undertaken in 31 countries. METHODS:The senior delegate of each of the 31 countries on the Council of the European Association for Clinical Pharmacology and Therapeutics (EACPT) was approached personally. This study was not an official EACPT survey. RESULTS:Based on the results of the completed survey forms, CP is recognized as an academic discipline in teaching and research fields in 28 of the 31 participating countries, but as a medical specialty in only 22 of these 31 countries. Surprisingly, France and Italy were two of the nine countries where CP was not recognized as a medical specialty. In 50 % of the countries where CP was recognized as a medical specialty, this recognition had occurred more than 30 years ago. The training of clinical pharmacologists in terms of years after internship varied between the countries. In eight countries the training was predominantly in internal medicine with shorter periods in pharmacology. In 11 countries the training was predominantly in CP, and in six countries there was dual training in pharmacology and clinical medicine. The training played a decisive role in terms of the clinical functions undertaken in health care. There was considerable variation in the numbers of clinical pharmacologists in each country, with the total figure varying between ≤ 10 to 600. In terms of the number of clinical pharmacologists per million inhabitants, nine countries have ≤ 1 (Belgium, Bulgaria, France, Greece, Italy, Lithuania, Poland, Turkey and UK) while four have ≥ 10 (Hungary, Norway, Slovakia and Sweden). Stumbling blocks which inhibit the development of CP as a discipline in health care are the lack of defined functions and consultant posts for clinical pharmacologists in health care in many countries and the underrepresentation of CP in pre- and postgraduate curricula. CONCLUSION:The majority of the responding countries suggested that EACPT should prioritize that CP becomes recognized and accredited as a European medical specialty.

journal_name

Eur J Clin Pharmacol

authors

Orme M,Sjöqvist F

doi

10.1007/s00228-013-1519-3

subject

Has Abstract

pub_date

2013-09-01 00:00:00

pages

1635-9

issue

9

eissn

0031-6970

issn

1432-1041

journal_volume

69

pub_type

杂志文章
  • Socio-economic inequalities in first-time use of antidepressants: a population-based study.

    abstract:OBJECTIVE:To analyse whether first-time use of antidepressants (incidence) and selection of TCAs (tricyclic antidepressants) versus new-generation drugs are associated with socio-economic status and psychiatric history. METHOD:We conducted a population-based cohort study using registry data covering Funen County, Denm...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-003-0723-y

    authors: Hansen DG,Søndergaard J,Vach W,Gram LF,Rosholm JU,Mortensen PB,Kragstrup J

    更新日期:2004-03-01 00:00:00

  • The influence of cimetidine versus ranitidine on doxepin pharmacokinetics.

    abstract::The effect of cimetidine and ranitidine on doxepin pharmacokinetics was studied in 6 healthy volunteers. Each subject completed 3 study phases: Treatment A, 9 consecutive doses of 50 mg doxepin (once daily); Treatment B, same as Treatment A but co-administration of cimetidine 600 mg b.i.d. starting after the sixth dox...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00542189

    authors: Sutherland DL,Remillard AJ,Haight KR,Brown MA,Old L

    更新日期:1987-01-01 00:00:00

  • Delayed elimination of triamterene and its active metabolite in chronic renal failure.

    abstract::The kinetics of triamterene and its active phase II metabolite were studied in 32 patients with various degrees of impaired renal function; the creatinine clearances ranged from 135 to 10 ml/min. The area under the plasma concentration-time curves (AUC) for triamterene were not influenced by kidney function, but the A...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00609885

    authors: Knauf H,Möhrke W,Mutschler E

    更新日期:1983-01-01 00:00:00

  • Variability of coumarin 7- and 3-hydroxylation in a Jordanian population is suggestive of a functional polymorphism in cytochrome P450 CYP2A6.

    abstract:OBJECTIVE:To determine the variability of coumarin 7- and 3-hydroxylation in a human population and to evaluate the evidence for the existence of genetic polymorphism in these pathways. 7-Hydroxylation of coumarin is considered to be a detoxication pathway, whilst 3-hydroxylation, which predominates in rats, leads to h...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s002280050489

    authors: Hadidi H,Irshaid Y,Vågbø CB,Brunsvik A,Cholerton S,Zahlsen K,Idle JR

    更新日期:1998-07-01 00:00:00

  • Impact of CYP2D6 polymorphisms on the pharmacokinetics of lovastatin in Chinese subjects.

    abstract:PURPOSE:Although CYP3A4/5 enzymes play the predominant role in the metabolism of simvastatin and lovastatin, polymorphisms in CYP2D6 were reported to be associated with the cholesterol-lowering effect and/or tolerability of simvastatin. This study was performed to examine whether common CYP2D6 polymorphisms affect the ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-011-1202-5

    authors: Yin OQ,Mak VW,Hu M,Fok BS,Chow MS,Tomlinson B

    更新日期:2012-06-01 00:00:00

  • Correction to: Pharmacoepidemiology resources in Ireland-an introduction to pharmacy claims data.

    abstract::In the 3rd paragraph and 2nd line of the Conclusion section the correct sentence should be: It is now important to encourage policy and decision makers to facilitate and accommodate future linkage of data. ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,已发布勘误

    doi:10.1007/s00228-017-2358-4

    authors: Sinnott SJ,Bennett K,Cahir C

    更新日期:2017-11-01 00:00:00

  • Generalization of distribution--free confidence intervals for bioavailability ratios.

    abstract::The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00635713

    authors: Steinijans VW,Diletti E

    更新日期:1985-01-01 00:00:00

  • Simultaneous determination of therapeutic plasma concentrations of pethidine and norpethidine in man by electron capture gas chromatography.

    abstract::An analytical procedure for the simultaneous determination of pethidine and its N-Demethylated metabolite, norpethidine, in plasma is described. Pethidine and norpethidine are separated by partition chromatography, converted to the trichloroethyl carbamate with trichloroethyl chloroformate and determined by electron c...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00561790

    authors: Hartvig P,Karlsson KE,Lindbert C,Boréus LO

    更新日期:1977-01-01 00:00:00

  • 2-Mercaptopropionate, a novel metabolite formed during treatment with 2-mercaptopropionyl-glycine in cystinuria.

    abstract::A new acid thiol, 2-mercaptopropionate, has been identified by GC-MS in urine from cystinuric patients on treatment with 2-mercaptopropionylglycine. The amount excreted was 50-300 mumol/24h and it was correlated with the oral dose of 2-mercaptopropionyl-glycine. The observation may be of clinical importance as the met...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00871000

    authors: Mårtensson J,Denneberg T,Kågedal B

    更新日期:1986-01-01 00:00:00

  • Prediction of phenotype for acetylation and for debrisoquine hydroxylation by DNA-tests in healthy human volunteers.

    abstract::The debrisoquine/sparteine-type polymorphism of drug oxidation and the polymorphism for acetylation are two common inherited variations in human drug metabolism. The phenotypes for hydroxylation and acetylation can be predicted be newly developed methods based on mutation-specific amplification of DNA by the polymeras...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02220616

    authors: Graf T,Broly F,Hoffmann F,Probst M,Meyer UA,Howald H

    更新日期:1992-01-01 00:00:00

  • Pharmacokinetic drug interaction between gemfibrozil and sitagliptin in healthy Indian male volunteers.

    abstract:PURPOSE:To study the impact of gemfibrozil co-administration on the pharmacokinetics of sitagliptin in healthy Indian male volunteers. METHODS:A randomized open label two-period crossover study involving 12 healthy Indian male volunteers was conducted at a single center. In each phase, the volunteers were administered...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00228-011-1177-2

    authors: K P A,Meda VS,Kucherlapati VS,Dubala A,M D,P R AV,K E,B S

    更新日期:2012-05-01 00:00:00

  • The use of a cyclosporin-ketoconazole combination: making renal transplantation affordable in developing countries.

    abstract:OBJECTIVES:The costs of immunosuppressive drugs in renal transplant recipients remains prohibitively high. Ketoconazole (KZ) has, in limited studies, been shown to significantly reduce the dose of cyclosporin (CyA) after renal transplantation. We report our long-term experience with the use of KZ in a large group of re...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-004-0745-0

    authors: Gerntholtz T,Pascoe MD,Botha JF,Halkett J,Kahn D

    更新日期:2004-05-01 00:00:00

  • Simultaneous study of the pharmacokinetics of intravenous and oral nicardipine using a stable isotope.

    abstract::The systemic elimination of nicardipine has been studied by an initial oral administration of nicardipine followed 1.25 h later by intravenous injection of the deuterium-labelled molecule (D3 nicardipine). To check that intravenous kinetics was not modified by the oral administration, an i.v. injection of unlabelled n...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00558504

    authors: Guerret M,Cheymol G,Hubert M,Julien-Larose C,Lavene D

    更新日期:1989-01-01 00:00:00

  • Gender differences in statin prescription rates, adequacy of dosing, and association of statin therapy with outcome after heart failure hospitalization: a retrospective analysis in a community setting.

    abstract:PURPOSE:The existence of gender differences in the management of statin therapy among patients with chronic heart failure (HF) is still poorly investigated. We aimed at exploring the effect of gender on statin prescription rates and adequacy of dosing and on the association between statin therapy and all-cause 1-year m...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-015-1980-2

    authors: Ballo P,Balzi D,Barchielli A,Turco L,Franconi F,Zuppiroli A

    更新日期:2016-03-01 00:00:00

  • Overdosage of antidepressants: clinical and pharmacokinetic aspects.

    abstract::Twenty-nine cases of self-poisoning with antidepressants (amitriptyline, imipramine, clomipramine, maprotiline, doxepine, nortriptyline, opipramol) were examined by frequent observation of CNS effects, heart rate, blood pressure and standard ECG, 24h-ECG-monitoring, measurement of systolic time intervals, EEG recordin...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00637499

    authors: Pedersen OL,Gram LF,Kristensen CB,Møller M,Thayssen P,Bjerre M,Kragh-SøRensen P,Klitgaard NA,Sindrup E,Hole P,Brinklø M

    更新日期:1982-01-01 00:00:00

  • Parental reporting of adverse drug events and other drug-related problems in children in Finland.

    abstract:PURPOSE:Drug-related problems (DRPs) are common in paediatric pharmacotherapy, but few studies describe them from the parents' perspective. In the present survey, we have investigated the lifetime prevalence and type of DRPs in children in Finland. METHODS:This was a population-based survey of a random sample of 6,000...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00228-012-1426-z

    authors: Lindell-Osuagwu L,Sepponen K,Farooqui S,Kokki H,Hämeen-Anttila K,Vainio K

    更新日期:2013-04-01 00:00:00

  • Effect of aprepitant, a moderate CYP3A4 inhibitor, on bosutinib exposure in healthy subjects.

    abstract:PURPOSE:Bosutinib is an oral, dual Src and Abl tyrosine kinase inhibitor (TKI) approved for the treatment of Philadelphia chromosome-positive chronic myeloid leukemia resistant or intolerant to prior TKI therapy. Bosutinib is primarily metabolized by cytochrome P450 (CYP) 3A4, suggesting drug interaction potential with...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00228-016-2108-z

    authors: Hsyu PH,Pignataro DS,Matschke K

    更新日期:2017-01-01 00:00:00

  • Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women.

    abstract:PURPOSE:To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes. METHODS:In 20 healthy non-pregnant women aged 18-45 years, the serum concent...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-010-0906-2

    authors: Kjærstad MB,Nielsen F,Nøhr-Jensen L,Zwisler S,Brøsen K,Andersen HR

    更新日期:2010-12-01 00:00:00

  • Effects of FCE20700, a new PGE2 derivative, on gastric acid secretion and cytoprotective processes in man.

    abstract::The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within-subjects design. For 30-270 min following i.g. administration the effect of FCE20...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00606626

    authors: Caldara R,Guslandi M,Carbone M,Masci E,Cantù A,Ferrari C,Barbieri C,Dubini A

    更新日期:1987-01-01 00:00:00

  • Effects of a new oral hypoglycaemic agent, repaglinide, on metabolic control in sulphonylurea-treated patients with NIDDM.

    abstract::We have evaluated the effects of repaglinide, a new non-sulphonylurea oral hypoglycaemic agent that has a stimulatory effect on insulin secretion. Forty-four patients with NIDDM, already treated with a sulphonylurea, took part in an open, randomised, group comparison study of 12 weeks duration, during which they recei...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00315490

    authors: Wolffenbuttel BH,Nijst L,Sels JP,Menheere PP,Müller PG,Kruseman AC

    更新日期:1993-01-01 00:00:00

  • The pharmacokinetics of vancomycin in patients with severe acute pancreatitis.

    abstract:OBJECTIVE:The aim of this study was to evaluate the pharmacokinetics of vancomycin in patients with severe acute pancreatitis (SAP). METHODS:Sixty-seven patients with SAP were included. The FPIA method was used to measure vancomycin serum trough concentrations, and the pharmacokinetic parameters were calculated using ...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00228-016-2018-0

    authors: He J,Mao EQ,Feng J,Jiang HT,Yang WH,Chen EZ

    更新日期:2016-06-01 00:00:00

  • Effect of roxithromycin on the pharmacokinetics of lovastatin in volunteers.

    abstract:OBJECTIVE:To investigate the influence of concomitant administration of roxithromycin on the plasma pharmacokinetics of lovastatin. METHODS:In an open, randomized, crossover study, 12 healthy volunteers received 80 mg lovastatin orally either alone or concomitantly with 300 mg roxithromycin after 5-day pretreatment wi...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s00228-001-0385-6

    authors: Bucher M,Mair G,Kees F

    更新日期:2002-01-01 00:00:00

  • Intracolonic bioavailability of human calcitonin in man.

    abstract::Human calcitonin (hCT) injected into the lumen of the descending colon of normal human subjects was absorbed within minutes and could be recognized intact in plasma as shown by RIA in combination with reverse-phase HPLC. The absorption was low and variable, with bioavailabilities ranging from 0.01% to 2.7% relative to...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF02285096

    authors: Beglinger C,Born W,Muff R,Drewe J,Dreyfuss JL,Bock A,Mackay M,Fischer JA

    更新日期:1992-01-01 00:00:00

  • Pharmacokinetics of intravenous and oral chlordesmethyldiazepam in patients on regular haemodialysis.

    abstract::The pharmacokinetics of a single 2 mg IV dose of chlordesmethyldiazepam has been studied in 11 patients with renal failure on regular haemodialysis and in 11 age-matched healthy controls. The kinetics was also examined after a single 2 mg oral dose in 6 of the 11 renal failure patients. After intravenous administratio...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00280109

    authors: Sennesael J,Verbeelen D,Vanhaelst L,Pirola R,Bareggi SR

    更新日期:1991-01-01 00:00:00

  • Absorption and metabolism in man of 16-epi-gitoxin, a new semi-synthetic cardioactive glycoside.

    abstract::The pharmacokinetics of 3H-16-epi-gitoxin have been investigated after oral administration: The peak serum level occurred after 30-60 min, and its subsequent decline was in two phases with half-lives of 3.5 and 19.5 h, respectively. Within 3 days 66-70% of the administered radioactivity were eliminated by renal excret...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00562938

    authors: Haustein KO

    更新日期:1977-07-19 00:00:00

  • Pharmacokinetics and protein binding of cefazolin in morbidly obese patients.

    abstract:PURPOSE:The aim of this study was to assess the pharmacokinetics and protein binding of cefazolin in morbidly obese patients undergoing bariatric surgery, to study the influence of bodyweight measures and age on pharmacokinetic parameters and to evaluate unbound cefazolin concentrations over time in this population. M...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/s00228-011-1048-x

    authors: van Kralingen S,Taks M,Diepstraten J,van de Garde EM,van Dongen EP,Wiezer MJ,van Ramshorst B,Vlaminckx B,Deneer VH,Knibbe CA

    更新日期:2011-10-01 00:00:00

  • Pharmacokinetic study of i.v. infusions of adriamycin.

    abstract::The plasma pharmacokinetics of adriamycin has been studied in 21 cancer patients (31-85 years old) without liver tumours after short (3.00 min) and prolonged (45 min-16 h) i.v. infusions. The area under the plasma concentration-time curve and the maximum plasma concentration compensated for dose variation showed a mor...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00609693

    authors: Eksborg S,Strandler HS,Edsmyr F,Näslund I,Tahvanainen P

    更新日期:1985-01-01 00:00:00

  • Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model.

    abstract:PURPOSE:A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model building dataset and to additional data generated through Monte Carlo simulations, is often sufficient, but external validation, which req...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-020-03036-2

    authors: Stillemans G,Belkhir L,Vandercam B,Vincent A,Haufroid V,Elens L

    更新日期:2020-11-11 00:00:00

  • Dose dependence of the 14C-aminopyrine breath test. Intrasubject comparison of tracer and pharmacological doses.

    abstract::Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given 14C-aminopyrine 9 mg/kg or a tracer amount, in a randomized sequence and according to a crossover design. The specific a...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00609866

    authors: Gikalov I,Bircher J

    更新日期:1977-11-14 00:00:00

  • The pharmacokinetics of the antimigraine compound zolmitriptan in Japanese and Caucasian subjects.

    abstract:BACKGROUND:Zolmitriptan is a 5HT(1B/1D) receptor agonist effective in the acute treatment of migraine. Clinical trials in the USA and Europe have demonstrated the optimal oral therapeutic dose to be 2.5 mg. The 2.5-mg oral tablet has recently been licensed in Japan. OBJECTIVE:To compare the pharmacokinetics of zolmitr...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/s00228-002-0461-6

    authors: Yates RA,Tateno M,Nairn K,Ikegami A,Dane A,Kemp J

    更新日期:2002-07-01 00:00:00