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Bioavailability of indomethacin from a modified release system containing indomethacin as the lysine salt.

Abstract：

:The bioavailability of a new controlled release formulation of indomethacin lysine salt in tablets was tested in 6 healthy humans against a conventional indomethacin lysinate formulation in capsules. Both contained 100 mg of the drug, i.e. 70 mg indomethacin. Peak plasma levels were lower and more lasting and the AUC was higher with the new controlled release formulation. The latter on average produced active plasma levels for 12 h, and so it can be recommended for twice daily administration.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Marzo A,Reiner A,Arrigoni Martelli E,Conte U,Colombo P,La Manna A

doi

10.1007/BF00609963

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

85-7

issue

1

eissn

0031-6970

issn

1432-1041

journal_volume

32

pub_type

杂志文章

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