Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine.

abstract：:The effect of the angiotensin converting enzyme inhibitor, perindopril, on autonomic function was assessed in a double blind, placebo controlled, crossover study in 10 normotensive males. Eight milligram of perindopril given orally lowered blood pressure without a change in heart rate. Perindopril enhanced the vagally...

journal_title：European journal of clinical pharmacology

authors： Ajayi AA,Lees KR,Reid JL

更新日期：1986-01-01 00:00:00

abstract：:We have evaluated the pharmacokinetics of high doses of clonidine, as used in the prophylactic treatment of alcohol withdrawal syndrome, in 11 alcohol-dependent patients undergoing surgery for oesophagogastrectomy. Clonidine was given in a bolus of 150 micrograms followed by a continuous infusion. After a mean period ...

journal_title：European journal of clinical pharmacology

authors： Fauler J,Verner L

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To assess the potential damage to patients from the inappropriate use of placebo. METHODS:Pivotal clinical trials of new drugs were evaluated for the treatment of multiple sclerosis following effective treatment with beta interferons and glatiramer acetate. The differences in the relapse rate between the exp...

journal_title：European journal of clinical pharmacology

authors： Garattini S,Bertelé V,Banzi R

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:Databases of subjects receiving antidepressants provide evidence on the use of drugs in typical patients and settings under real-world conditions. This study analysed a general practice database to estimate the prevalence of antidepressant drug use, describe the use of these compounds by gender and age and es...

journal_title：European journal of clinical pharmacology

authors： Pietraru C,Barbui C,Poggio L,Tognoni G

更新日期：2001-10-01 00:00:00

abstract：PURPOSE:The role of pharmacogenomics, clinical and demographic parameters in pharmacokinetic predictions was evaluated in patients receiving mycophenolic acid (MPA). METHODS:A cohort study design of patients with glomerulonephritis secondary to lupus nephritis and anti-neutrophil cytoplasmic antibody (ANCA) vasculitis...

journal_title：European journal of clinical pharmacology

authors： Joy MS,Boyette T,Hu Y,Wang J,La M,Hogan SL,Stewart PW,Falk RJ,Dooley MA,Smith PC

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVE:Entacapone is a peripherally acting catechol O-methyltransferase (COMT) inhibitor used as an adjunct to each daily levodopa/dopa decarboxylase (DDC) inhibitor dose in the treatment of Parkinson's disease. Parkinsonian patients with advanced disease and motor fluctuations take several doses of levodopa daily, ...

journal_title：European journal of clinical pharmacology

authors： Rouru J,Gordin A,Huupponen R,Huhtala S,Savontaus E,Korpela K,Reinikainen K,Scheinin M

更新日期：1999-08-01 00:00:00

abstract：:The effect of indenolol on heart rate and blood pressure at rest and after submaximal workload has been studied in 19 patients with established essential hypertension. A stepwise increase from moderate to submaximal exercise was chosen to mimic challenges normally occurring in daily life. After 4 weeks of once a day i...

journal_title：European journal of clinical pharmacology

authors： Aiello C,Groothold G,Gualtieri S,Irace L,Marini IL,Perna B,Romano A

更新日期：1985-01-01 00:00:00

abstract：:The confidence interval approach to bioavailability assessment depends first on selection of the confidence level, usually 95%, and then determination of the confidence limits for the expected bioavailability ratio AUC(Test)/AUC(Reference). In practice, however, it is sometimes of greater interest to know the probabil...

journal_title：European journal of clinical pharmacology

authors： Steinijans VW,Diletti E

更新日期：1985-01-01 00:00:00

abstract：:The aim of this multicentre randomised double blind study was to compare the efficacy and safety of the 200-300 mg sustained release diltiazem formulation administered once daily (200-300 SR) with standard diltiazem (D) given three or four times daily to patients with stable angina. Patients aged 59 years, with a repr...

journal_title：European journal of clinical pharmacology

authors： Trimarco B,Radzik D,Van Mieghem W,Neveux E,Wajman A,Attali P,Ponsonnaille J

更新日期：1995-01-01 00:00:00

abstract：:The antihypertensive effects of urapidil and clonidine have been studied in a double-blind cross-over trial in 11 hypertensive outpatients with mild to moderate hypertension, at rest and during isometric exercise. Urapidil 30 mg b.i.d. significantly decreased the standing diastolic blood pressure (p less than 0.05) an...

journal_title：European journal of clinical pharmacology

authors： Kanniainen E,Heikkilä O,Jääskeläinen T,Lilja M,Jounela AJ

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The aim of our study was to evaluate the impact of CYP3A4, CYP3A5, and ABCB1 polymorphisms on donepezil disposition and clinical outcome. METHODS:Fifty-four Italian patients diagnosed with probable mild to moderate Alzheimer's disease, treated with donepezil (37 patients 5 mg/day, 17 patients 10 mg/day) were g...

journal_title：European journal of clinical pharmacology

authors： Magliulo L,Dahl ML,Lombardi G,Fallarini S,Villa LM,Biolcati A,Scordo MG

更新日期：2011-01-01 00:00:00

abstract：:Idrapril is the prototype of a new class of ACE inhibitors, characterised by the presence of a hydroxdmic group. Six untreated in-patients with essential hypertension were given single oral doses of the calcium salt of idrapril, idrapril calcium (200 mg) and placebo according to a double blind, randomised experimental...

journal_title：European journal of clinical pharmacology

authors： Taddei S,Ghiadoni L,Mattei P,Sudano I,Duranti P,Favilla S,Virdis A,Romagnoli A,Criscuoli M,Coppini A

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:Although studies have shown the efficacy of laquinimod (LAQ) on disease progression in patients with multiple sclerosis (MS), there is some controversy about whether it improves the types of outcomes and side effects. The main purpose of the present study was to systematically review and meta-analyze the effica...

journal_title：European journal of clinical pharmacology

authors： Rouhi F,Mohammadpour Z,Noureini SK,Abbastabar H,Harirchian MH,Bitarafan S

更新日期：2020-05-01 00:00:00

abstract：:Amitriptyline has clinically important interactions with ethanol. Five healthy volunteers received 25 mg of amitriptyline orally, preceded by one hour and followed for eight hours by oral ethanol (or juice), dosed to achieve and maintain blood ethanol concentrations of 800 mg/l. In the presence of ethanol, amitriptyli...

journal_title：European journal of clinical pharmacology

authors： Dorian P,Sellers EM,Reed KL,Warsh JJ,Hamilton C,Kaplan HL,Fan T

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:Pharmacodynamic studies of naloxone require opioid agonism. Steady state condition may be achieved by remifentanil TCI (target controlled infusion). Opioid agonism can be measured by pupillometry. It is not known whether there are arteriovenous concentration differences for naloxone. The aim was thus to further...

journal_title：European journal of clinical pharmacology

authors： Tylleskar I,Skulberg AK,Skarra S,Nilsen T,Dale O

更新日期：2018-12-01 00:00:00

abstract：:Fifteen mild to moderate hypertensives were submitted to exercise testing using a bicycle ergometer with a fixed load. Heart rate, blood pressure and ECG were recorded throughout 5 min exercise and 10 min recovery. Oxygen uptake was measured during the final minute of exercise and blood glucose estimation and serum dr...

journal_title：European journal of clinical pharmacology

authors： Hackett GI,Harrison P,Kershaw S

更新日期：1983-01-01 00:00:00

abstract：:Dopamine is frequently used in critically ill newborn infants for treatment of shock and cardiac failure, but its pharmacokinetics has not been evaluated using a specific analytical method. Steady-state arterial plasma concentrations of dopamine were measured in 11 seriously ill infants receiving dopamine infusion, 5-...

journal_title：European journal of clinical pharmacology

authors： Bhatt-Mehta V,Nahata MC,McClead RE,Menke JA

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:Concomitant treatment with the glucose-lowering drug metformin and the platelet aggregation inhibitor dipyridamole often occurs in patients with type 2 diabetes mellitus who have suffered a cerebrovascular event. The gastrointestinal uptake of metformin is mediated by the human equilibrative nucleoside transpor...

journal_title：European journal of clinical pharmacology

authors： El Messaoudi S,Russel FG,Colbers A,Bandell CC,van den Broek PH,Burger DM,Rongen GA,Riksen NP

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:There are concerns regarding appropriate use of antibiotics in dentistry practice. Data on dental antibiotic prescribing patterns by dentists is relatively limited. This nationwide study aimed to examine dentists' antibiotic prescriptions in a diagnosis-based manner in Turkey. METHODS:This retrospective study ...

journal_title：European journal of clinical pharmacology

authors： Koyuncuoglu CZ,Aydin M,Kirmizi NI,Aydin V,Aksoy M,Isli F,Akici A

更新日期：2017-08-01 00:00:00

abstract：:The antihypertensive effect of labetalol (L) was compared with that of clonidine (C) in a randomized cross-over study in 17 hypertensive outpatients on bendrofluazide (B). After treatment for two weeks with B(5 mg qd), either L (100 mg tid) or C (0.1 mg tid) was given and their doses were titrated at 2-weekly visits u...

journal_title：European journal of clinical pharmacology

authors： Lilja M,Jounela AJ,Karppanen H

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Drug utilization studies have applied different methods to various data types to describe medication use, which hampers comparisons across populations. The aim of this study was to describe the time trends in antidepressant prescribing in the last decade and the variation in the prevalence, calculated in a unif...

journal_title：European journal of clinical pharmacology

authors： Abbing-Karahagopian V,Huerta C,Souverein PC,de Abajo F,Leufkens HG,Slattery J,Alvarez Y,Miret M,Gil M,Oliva B,Hesse U,Requena G,de Vries F,Rottenkolber M,Schmiedl S,Reynolds R,Schlienger RG,de Groot MC,Klungel OH,va

更新日期：2014-07-01 00:00:00

abstract：OBJECTIVES:Digoxin is a well-known probe for the activity of P-glycoprotein. The objective of this work was to apply different methods for covariate selection in non-linear mixed-effect models to study the relationship between the pharmacokinetic parameters of digoxin and the genotype for two major exons located on the...

journal_title：European journal of clinical pharmacology

authors： Comets E,Verstuyft C,Lavielle M,Jaillon P,Becquemont L,Mentré F

更新日期：2007-05-01 00:00:00

abstract：PURPOSE:Aflibercept, a fully humanized vascular endothelial growth factor (VEGF)-targeted agent, has emerged as an effective therapy in the treatment of various solid tumors. We carried out an up-to-date meta-analysis to determine the risk of fatal adverse events (FAEs) in cancer patients treated with aflibercept. MET...

journal_title：European journal of clinical pharmacology

authors： Qi WX,Tang LN,Shen Z,Yao Y

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:The existence of a sex-by-formulation interaction in bioequivalence studies implies that the bioequivalence results (i.e., the test/reference ratio of the pharmacokinetic parameters) obtained in one sex are not similar to those obtained in the other sex. Therefore, results obtained in studies including only mal...

journal_title：European journal of clinical pharmacology

authors： González-Rojano E,Marcotegui J,Morales-Alcelay S,Álvarez C,Gordon J,Abad-Santos F,García-Arieta A

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Many studies have indicated the adequate use of lipid-lowering drugs (LLDs) as a factor in reducing the risk of cardiovascular disease. However, in clinical practice, a very high percentage of patients are not adequately treated. OBJECTIVE:To analyze the management of hypercholesterolemia in a non-experimen...

journal_title：European journal of clinical pharmacology

authors： Di Martino M,Degli Esposti L,Ruffo P,Bustacchini S,Catte A,Sturani A,Degli Esposti E

更新日期：2005-05-01 00:00:00

abstract：:A randomized, single-blind trial of repeated intravenous infusion of Brinase was carried out in 70 petients with severe chronic limb ischemia, who were candidates for lumbar sympathectomy or amputation. The enzyme caused s significant increase in calf and ankle pressure index. At six months follow-up, the clinical res...

journal_title：European journal of clinical pharmacology

authors： Verhaeghe R,Verstraete M,Schetz J,Vanhove P,Suy R,Vermylen J

更新日期：1979-09-01 00:00:00

abstract：PURPOSE:To investigate if the ordinary use of a vaginal suppository containing miconazole results in systemic absorption that is sufficient to affect the activities of CYP1A2 and CYP3A4, which are major drug- and steroid-metabolising enzymes. METHODS:In 20 healthy non-pregnant women aged 18-45 years, the serum concent...

journal_title：European journal of clinical pharmacology

authors： Kjærstad MB,Nielsen F,Nøhr-Jensen L,Zwisler S,Brøsen K,Andersen HR

更新日期：2010-12-01 00:00:00

abstract：:Influence of food on the serum concentration and kinetics ambenonium chloride (AMBC) has been examined in thirteen patients with myasthenia gravis (MG). Mean serum concentrations and Cmax during fasting were higher than those in the non-fasting state. The AUC (0-3 h) was also about four-times larger. The drug effects ...

journal_title：European journal of clinical pharmacology

authors： Ohtsubo K,Fujii N,Higuchi S,Aoyama T,Goto I,Tatsuhara T

更新日期：1992-01-01 00:00:00

abstract：CONTEXT:Adverse drug reactions (ADRs) are responsible for 5 % of hospital admissions, but hospital re-admission induced by ADRs remains poorly documented. OBJECTIVE:The aim of this study was to estimate the rate of hospital re-admission and the factors associated with re-admission in the patients over the age of 65 ye...

journal_title：European journal of clinical pharmacology

authors： Hauviller L,Eyvrard F,Garnault V,Rousseau V,Molinier L,Montastruc JL,Bagheri H

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:To determine whether patients with idiopathic systemic lupus erythematosus (SLE) are associated with impaired CYP2D6 activity and to gain insight into whether there is an association between particular CYP2D6 genotypes and susceptibility to SLE, and whether CYP2D6 polymorphism is linked to any specific clini...

journal_title：European journal of clinical pharmacology

authors： Kortunay S,Bozkurt A,Bathum L,Basci NE,Calgüneri M,Brøsen K,Kayaalp SO

更新日期：1999-03-01 00:00:00