The continuing challenge of providing drug information services to diminish the knowledge--practice gap in medical practice.

abstract：:Twenty patients (5 females, 15 males) with severe heart failure (NYHA IV), due to coronary artery disease in 14, and congestive cardiomyopathy in 6, received an intravenous bolus of the calcium blocker nisoldipine 0.2 mg followed by a continuous infusion of 0.2 micrograms.kg-1.min-1. Haemodynamic measurements were per...

journal_title：European journal of clinical pharmacology

authors： Erlemeier HH,Kupper W,Bleifeld W

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To study the distribution of the thiopurine methyltransferase (TPMT) genotype among azathioprine (Aza)-tolerant and -intolerant patients with various disorders, and to investigate a possible relationship with the Aza metabolite levels. METHODS:Forty-six Aza-tolerant and six Aza-intolerant patients had the TP...

journal_title：European journal of clinical pharmacology

authors： Reuther LO,Vainer B,Sonne J,Larsen NE

更新日期：2004-01-01 00:00:00

abstract：:We have evaluated the pharmacokinetics of high doses of clonidine, as used in the prophylactic treatment of alcohol withdrawal syndrome, in 11 alcohol-dependent patients undergoing surgery for oesophagogastrectomy. Clonidine was given in a bolus of 150 micrograms followed by a continuous infusion. After a mean period ...

journal_title：European journal of clinical pharmacology

authors： Fauler J,Verner L

更新日期：1993-01-01 00:00:00

abstract：CONTEXT:Adverse drug reactions (ADRs) are responsible for 5 % of hospital admissions, but hospital re-admission induced by ADRs remains poorly documented. OBJECTIVE:The aim of this study was to estimate the rate of hospital re-admission and the factors associated with re-admission in the patients over the age of 65 ye...

journal_title：European journal of clinical pharmacology

authors： Hauviller L,Eyvrard F,Garnault V,Rousseau V,Molinier L,Montastruc JL,Bagheri H

更新日期：2016-05-01 00:00:00

abstract：:In patients requiring a high or low dose of theophylline the pharmacokinetics of theophylline and enprofylline were studied. The low-dose group took an average daily dose of 8.91 mg/kg body wt. and the high-dose group 24.75 mg/kg body wt. The average half-life of theophylline in the former was 7.11 h and in the latter...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Weeke B

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The European Committee for Human Medicinal Products (CHMP) requested a multinational study with the aim to investigate the risk of acute liver failure (ALF) leading to registration for transplantation in patients exposed to non-steroidal anti-inflammatory drugs (NSAIDs). The method of this multinational, multic...

journal_title：European journal of clinical pharmacology

authors： Gulmez SE,Larrey D,Pageaux GP,Lignot-Maleyran S,de Vries C,Sturkenboom M,Perez-Gutthann S,Bénichou J,Bissoli F,Horsmans Y,Bernuau J,Stricker B,Thorburn D,Blin P,Moore N

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:The incidence of osteoporosis-related fractures will increase substantially over the coming decades as the population ages globally. This has important economic and public health implications, contributing substantially to morbidity and excess mortality in this population. METHODS:When prescribing for older pa...

journal_title：European journal of clinical pharmacology

authors： Brewer L,Williams D,Moore A

更新日期：2011-04-01 00:00:00

abstract：OBJECTIVE:To investigate adherence to prescription in a female population aged 35-65 years. DESIGN:Postal questionnaire study of 2991 randomly sampled 35- to 64-year-old women in seven provinces of central Sweden. METHODS:The study was performed in 1995 as a cross-sectional postal questionnaire study in seven countie...

journal_title：European journal of clinical pharmacology

authors： Bardel A,Wallander MA,Svärdsudd K

更新日期：2007-03-01 00:00:00

abstract：:Lorcainide is a promising antiarrhythmic agent that belongs to the class of local anesthetics. It was tested in 7 patients with malignant ventricular arrhythmias that were resistant to other antiarrhythmic agents. Lorcainide was effective in all cases (complete disappearance of arrhythmias in 6 cases and more than 50%...

journal_title：European journal of clinical pharmacology

authors： Cocco G,Strozzi C

更新日期：1978-11-16 00:00:00

abstract：:The effect of AS-4370 on gastric emptying was investigated in healthy adults using 99mTc-DTPA. Single doses of AS-4370 2.5, 5 or 10 mg or placebo were administered to 12 subjects in a controlled, double-blind, cross-over study. Tests were performed twice weekly in each subject. Thirty min after administration of test ...

journal_title：European journal of clinical pharmacology

authors： Kanaizumi T,Nakano H,Matsui Y,Ishikawa H,Shimizu R,Park S,Kuriya N

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To describe the frequency and types of drug-related problems (DRPs) in hospitalised patients, and to identify risk factors for DRPs and the drugs most frequently causing them. METHODS:From May to December 2002, 827 patients from six internal medicine and two rheumatology departments in five hospitals in Norw...

journal_title：European journal of clinical pharmacology

authors： Blix HS,Viktil KK,Reikvam A,Moger TA,Hjemaas BJ,Pretsch P,Vraalsen TF,Walseth EK

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:In elderly patients, both falls and impaired memory are considerable medical problems. Hypnotics, which are frequently administered to this patient group for the treatment of insomnia, should ideally not impair equilibrium or memory functions. This double-blind, randomised, four-way, cross-over study investig...

journal_title：European journal of clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Tarral A,Gandon JM

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:To examine the impact of medication and medical conditions on the fall risk in older hospitalized patients. DESIGN:Matched case-control study. SETTING:Large regional hospital in a mid-sized German city. SUBJECTS:Four hundred eighty-one inpatients aged ≥ 65 years who fell during hospitalization ("cases") an...

journal_title：European journal of clinical pharmacology

authors： Wedmann F,Himmel W,Nau R

更新日期：2019-08-01 00:00:00

abstract：PURPOSE:It is well known that CPT-11 (irinotecan) is biotransformed to its active metabolite, SN-38, by carboxylesterase in the liver and other tissues. However, little is known about its pharmacokinetics (PK) when administered intraperitoneally. The aim of our study was to develop a population pharmacokinetic model fo...

journal_title：European journal of clinical pharmacology

authors： Ahn BJ,Choi MK,Park YS,Lee J,Park SH,Park JO,Lim HY,Kang WK,Ko JW,Yim DS

更新日期：2010-12-01 00:00:00

abstract：:The effect of dexfenfluramine (dF) on body weight, blood pressure and noradrenergic activity were studied in 30 obese hypertensive patients randomly divided into two groups and treated for 3 months either with dF (30 mg daily; 16 subjects) or placebo (Pl; 14 subjects). 11 patients from the dF group and 9 patients give...

journal_title：European journal of clinical pharmacology

authors： Kolanowski J,Younis LT,Vanbutsele R,Detry JM

更新日期：1992-01-01 00:00:00

abstract：PURPOSE:We have developed a model for integrated medicines management, including tools and activities for medication reconciliation and medication review. In this study, we focus on improving the quality of the discharge summary including the medication report to reduce medication errors in the transition from hospital...

journal_title：European journal of clinical pharmacology

authors： Bergkvist A,Midlöv P,Höglund P,Larsson L,Bondesson A,Eriksson T

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVE:Databases of subjects receiving antidepressants provide evidence on the use of drugs in typical patients and settings under real-world conditions. This study analysed a general practice database to estimate the prevalence of antidepressant drug use, describe the use of these compounds by gender and age and es...

journal_title：European journal of clinical pharmacology

authors： Pietraru C,Barbui C,Poggio L,Tognoni G

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Spinal-cord injury (SCI) is a leading cause of neuropathic pain (NP). Current pharmaceutical treatments for NP in SCI patients are not effective. Two promising options are gabapentin (GP) and pregabalin (PB). Their predominant mechanism of action is believed to be the inhibition of calcium currents, leading ...

journal_title：European journal of clinical pharmacology

authors： Tzellos TG,Papazisis G,Amaniti E,Kouvelas D

更新日期：2008-09-01 00:00:00

abstract：:The effect of procainamide (P) on left ventricular function as measured by the systolic time intervals (STI) was studied in 14 patients with primary myocardial disease. P, 7.5 mg/kg body weight, was given intravenously at a rate of 100 mg per minute. Administration of P produced a decrease in left ventricular performa...

journal_title：European journal of clinical pharmacology

authors： Geleris P,Boudoulas H,Schaal SF,Lewis RP,Lima JJ

更新日期：1980-10-01 00:00:00

abstract：OBJECTIVE:Valsartan (V), a specific inhibitor of the angiotensin II receptor subtype, AT1, has been developed for treatment of hypertension. Combination therapy with a beta-adrenoceptor blocking agent might be considered in cases with insufficient efficacy of V alone. Therefore, an interaction trial was performed to ev...

journal_title：European journal of clinical pharmacology

authors： Czendlik CH,Sioufi A,Preiswerk G,Howald H

更新日期：1997-01-01 00:00:00

abstract：:The pharmacokinetics of naproxen have been examined in 13 elderly patients (mean age 84.2 years) and in 9 younger patients (mean age 53.9 years) at the end of a 21 day course of therapy with naproxen 500 mg b.d. The mean pre-dose concentration on days 19, 20 and 21 was significantly higher in the elderly patients than...

journal_title：European journal of clinical pharmacology

authors： McVerry RM,Lethbridge J,Martin N,Mukerjee SK,Littler T,Tallis R,Sibeon R,Orme ML

更新日期：1986-01-01 00:00:00

abstract：:Differences in the plasma concentrations of drugs after oral administration are caused by two main factors: variation in absorption ratios and in the distribution processes in the body. A new method for the dissection of both types of factors is discussed. The method uses a reference regression of the AUC-values to th...

journal_title：European journal of clinical pharmacology

authors： Betzien G,Kaufmann B,Schneider B

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:Our aim was to observe the impact of CYP3A4*1G genetic polymorphism on lipid-lowering efficacy of statins. METHODS:We studied 217 unrelated hyperlipidemic patients who prospectively received atorvastatin and 199 patients who received simvastatin as a single-agent therapy (20 mg day(-1) p.o.) for 4 weeks. Genot...

journal_title：European journal of clinical pharmacology

authors： Gao Y,Zhang LR,Fu Q

更新日期：2008-09-01 00:00:00

abstract：:The four sulphonamides studied--furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid--bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the fou...

journal_title：European journal of clinical pharmacology

authors： Zini R,d'Athis P,Hoareau A,Tillement JP

更新日期：1976-06-15 00:00:00

abstract：:The pharmacokinetics of intravenous chloramphenicol has been studied in 42 patients with liver disease and in 8 controls. The half-life of chloramphenicol (t 1/2) was increased in the various liver disorders, the metabolic clearance rate (MCR) and apparent volume of distribution (Vd) were decreased and the area under ...

journal_title：European journal of clinical pharmacology

authors： Narang AP,Datta DV,Nath N,Mathur VS

更新日期：1981-01-01 00:00:00

abstract：PURPOSE:In this review, we focus on the clinical and radiological aspects related to the biological therapy of ankylosing spondylitis (AS), axial spondyloarthritis (SpA) and psoriatic arthritis (PsA). METHODS:A review was carried out in the main medical databases to evaluate the available literature. RESULTS:Even if ...

journal_title：European journal of clinical pharmacology

authors： Maruotti N,Cantatore FP

更新日期：2014-09-01 00:00:00

abstract：:Potentiation of the anticoagulant-effect of warfarin by amiodarone was studied in 30 patients. Thirteen received both drugs concurrently, and 17 received warfarin alone and the combination sequentially. Warfarin doses were adjusted to maintain the prothrombin time between 25-30% of control and its kinetics were compar...

journal_title：European journal of clinical pharmacology

authors： Almog S,Shafran N,Halkin H,Weiss P,Farfel Z,Martinowitz U,Bank H

更新日期：1985-01-01 00:00:00

abstract：:Piretanide 60 mg was administered intravenously over 30 min to 15 men with different degrees of renal failure. The mean piretanide serum concentration at the end of the infusion period was 5.72 +/- 1.51 micrograms/ml. Serum piretanide concentration-time curves declined biexponentially and 24 hours after medication the...

journal_title：European journal of clinical pharmacology

authors： Walter U,Röckel A,Lahn W,Heidland A,Heptner W

更新日期：1985-01-01 00:00:00

abstract：:Investigations were undertaken to evaluate which uraemic solutes decrease drug protein binding. This was done by performing HPLC-fractionation of uraemic biological fluids and studying the effect of addition of a lyophilisate of each fraction to normal plasma containing standard quantities of radiolabelled drugs. From...

journal_title：European journal of clinical pharmacology

authors： Vanholder R,De Smet R,Ringoir S

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVES:An increased risk of all-cause and cardiovascular mortality in users of anxiolytic-hypnotic drugs (AHD) has been reported, and use of analgesics may be an additional factor. Therefore, we examined the association of AHD and analgesic use, alone and in combination, with all-cause and ischaemic heart disease (...

journal_title：European journal of clinical pharmacology

authors： Merlo J,Hedblad B,Ogren M,Ranstam J,Ostergren PO,Ekedahl A,Hanson BS,Isacsson SO,Liedholm H,Melander A

更新日期：1996-01-01 00:00:00