Binding of four sulphonamides to human albumin.

abstract：OBJECTIVE:To evaluate the impact of the two most common CYP2C9 variant alleles (*2 and *3) on the maintenance dose of warfarin and on the quality of anticoagulation control in Brazilians. METHODS:Patients (n = 103) initiated warfarin therapy with 5 mg/day (or 2.5 mg/day when over 80 years old). The international norma...

journal_title：European journal of clinical pharmacology

authors： Lima MV,Ribeiro GS,Mesquita ET,Victer PR,Vianna-Jorge R

更新日期：2008-01-01 00:00:00

abstract：:The hypothesis has been tested that an unusual maternal acetylator phenotype can predispose to congenital malformations in the fetus. The acetylator phenotype of normal caucasian control women and of mothers of malformed children was established by measuring urinary sulphadimidine and its acetylated metabolite. A furt...

journal_title：European journal of clinical pharmacology

authors： Stoll C,Roth MP,Dott B,Doumit N,Alembik Y,Welsch M,Imbs JL

更新日期：1989-01-01 00:00:00

abstract：AIM:The aim of this study was to quantify the reasons and opinions of patients who reported adverse drug reactions (ADRs) in the Netherlands to a pharmacovigilance centre. METHOD:A web-based questionnaire was sent to 1370 patients who had previously reported an ADR to a pharmacovigilance centre. The data were analysed...

journal_title：European journal of clinical pharmacology

authors： van Hunsel F,van der Welle C,Passier A,van Puijenbroek E,van Grootheest K

更新日期：2010-11-01 00:00:00

abstract：:We have compared the effect on ventilation of ketorolac, an injectable non-steroidal analgesic, with that of morphine in a randomized, double-blind, cross-over study, using two doses of ketorolac (10 and 90 mg i.m.) and one of morphine (10 mg i.m.). The effect on ventilation was measured with a CO2 rebreathing techniq...

journal_title：European journal of clinical pharmacology

authors： Bravo LJ,Mattie H,Spierdijk J,Bovill JG,Burm AG

更新日期：1988-01-01 00:00:00

abstract：PURPOSE:We proposed a statistical criterion to detect drug-drug interactions causing adverse drug reactions in spontaneous reporting systems. METHODS:The used criterion quantitatively measures the discrepancy between the observed and expected number of adverse events via chi-square statistics. We compared the performa...

journal_title：European journal of clinical pharmacology

authors： Gosho M,Maruo K,Tada K,Hirakawa A

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS:eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to...

journal_title：European journal of clinical pharmacology

authors： Eppenga WL,Kramers C,Derijks HJ,Wensing M,Wetzels JF,De Smet PA

更新日期：2016-12-01 00:00:00

abstract：PURPOSES:Tacrolimus (TAC) is the most widely used immunosuppressant for the prevention of acute rejection after solid organ transplantation. Its pharmacokinetics (PK) show considerable variability, making TAC a good candidate for therapeutic drug monitoring (TDM). The principal aim of the study was to describe the PK o...

journal_title：European journal of clinical pharmacology

authors： Guy-Viterbo V,Scohy A,Verbeeck RK,Reding R,Wallemacq P,Musuamba FT

更新日期：2013-08-01 00:00:00

abstract：:The effects of metolazone on the protein binding of glibenclamide were studied. It was found that increasing metolazone concentrations up to 100 ng/ml had no significant effect on the protein binding of glibenclamide studied at 10 micrograms/ml. Metolazone is unlikely to cause a clinically significant increase in the ...

journal_title：European journal of clinical pharmacology

authors： George S,McBurney A,Cole A

更新日期：1990-01-01 00:00:00

abstract：:The effects of single oral doses of mequitazine (5 and 10 mg), terfenadine (60 mg) and triprolidine (10 mg) as active controls, and placebo were evaluated on visuo-motor coordination, digit symbol substitution, critical flicker fusion and dynamic visual acuity, and on subjective assessments of mood and well-being in s...

journal_title：European journal of clinical pharmacology

authors： Nicholson AN,Stone BM

更新日期：1983-01-01 00:00:00

abstract：:The disposition of paracetamol following an oral dose of 1.0 g was compared in 10 healthy volunteers, 7 patients with moderate chronic renal failure and 6 patients with end stage renal failure on maintenance haemodialysis. Paracetamol absorption was normal in the patients with renal failure. The mean plasma half-life ...

journal_title：European journal of clinical pharmacology

authors： Prescott LF,Speirs GC,Critchley JA,Temple RM,Winney RJ

更新日期：1989-01-01 00:00:00

abstract：PURPOSE:To develop a limited sampling strategy (LSS) to predict area under the concentration-time curve (AUC) ratios of omeprazole (AUC(OPZ)) to its metabolites 5-hydroxyomeprazole (AUC(5OH)) and omeprazole sulfone (AUC(SUL)) as phenotyping parameters for cytochrome P450 (CYP) 2C19 and 3A. METHODS:Data were obtained f...

journal_title：European journal of clinical pharmacology

authors： Lawson EB,Wu JC,Baldwin RM,Ingelman-Sundberg M,Rosenborg S,Yim DS,Yin OQ,Capparelli EV,Ma JD

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Troglitazone is an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which has been shown to improve the metabolic control of type 2 diabetes. Troglitazone undergoes hepatic metabolism to an inactive sulphate conjugate and an oxidative quinone metabolite with minor activity. The ob...

journal_title：European journal of clinical pharmacology

authors： Ott P,Ranek L,Young MA

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:Oncological patients are at increasing risk of QT prolongation, a risk factor for ventricular arrhythmia. We assessed impact and risk factors for corrected QT (QTc) prolongation during multiple-cycle chemotherapy. METHODS:We enrolled 100 outpatients initiating chemotherapy in a university center specializing i...

journal_title：European journal of clinical pharmacology

authors： Diemberger I,Massaro G,Cubelli M,Rubino D,Quercia S,Martignani C,Ziacchi M,Biffi M,Bernardi A,Cacciari N,Zamagni C,Boriani G

更新日期：2015-08-01 00:00:00

abstract：PURPOSE:To determine whether two of the major operational stressors associated with military missions in Afghanistan: dry heat and long durations of soldier patrol (SP), alter the pharmacokinetics of ibuprofen. METHODS:Thirteen healthy and physically fit participants (19-32 years) were randomized to a four-arm crossov...

journal_title：European journal of clinical pharmacology

authors： Boscarino C,Edginton AN,Peng H,Riggs KW,Szeitz A,Cheung B

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Xanthine oxidase (XO) is one of the two interconvertible forms of xanthine oxidoreductase and well-studied for its role in purine catabolism and that of other purine analogues, drugs especially. Our study investigated the incidence of polymorphism in phenotypes along with the influence of gender and age on e...

journal_title：European journal of clinical pharmacology

authors： Adehin A,Bolaji OO

更新日期：2015-06-01 00:00:00

abstract：:A double blind, placebo-controlled study of the ventilatory effects of three new beta 1-selective adrenoceptor blockers was carried out in eight asthmatic patients. Measurements were performed before and 2, 3 and 4 h after ingestion of a single oral dose of placebo, atenolol 100 mg, metoprolol 100 mg or acebutolol 400...

journal_title：European journal of clinical pharmacology

authors： Greefhorst AP,van Herwaarden CL

更新日期：1981-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. METHODS:A randomized, double-blind, cross-over study design with two phases, which were separated by a washout pe...

journal_title：European journal of clinical pharmacology

authors： Kantola T,Kivistö KT,Neuvonen PJ

更新日期：1999-01-01 00:00:00

abstract：:Infusion of a therapeutic dose of sparteine sulphate, increased the basal plasma insulin level and lowered plasma glucose. When an intravenous glucose tolerance test was performed with the infusion, the total insulin AUC was significantly larger than in absence of sparteine (2025 vs 1464 microU/ml X min), plasma gluco...

journal_title：European journal of clinical pharmacology

authors： Sgambato S,Paolisso G,Passariello N,Varricchio M,D'Onofrio F

更新日期：1987-01-01 00:00:00

abstract：:The frequency distribution of the 8-h urinary ratio of log metoprolol/alpha-hydroxymetoprolol was assessed in 65 healthy, unrelated Jordanian volunteers. There was no apparent bimodality in the frequency distribution of this ratio among the subjects studied. The frequency of the poor metabolizer phenotype of metoprolo...

journal_title：European journal of clinical pharmacology

authors： al-Hadidi HF,Irshaid YM,Rawashdeh NM

更新日期：1994-01-01 00:00:00

abstract：:Blood ciclosporin (Cs) metabolite pattern in 58 liver grafted patients was routinely monitored by HPLC from the first Cs dose after transplantation until discharge from hospital. Eighteen patients with normal kidney function were allocated to Group I and 14 patients in Group II suffered Cs nephrotoxicity during their ...

journal_title：European journal of clinical pharmacology

authors： Christians U,Kohlhaw K,Budniak J,Bleck JS,Schottmann R,Schlitt HJ,Almeida VM,Deters M,Wonigeit K,Pichlmayr R

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:After liver transplantation (LT), genotypic differences between the recipient and the transplanted liver, medications and post-LT complications may all affect drug metabolism. We have studied the effect of two CYP2D6 mutations in the donor and the recipient on post-LT CYP2D6 phenotype. METHOD:The CYP2D6 phen...

journal_title：European journal of clinical pharmacology

authors： Monek O,Paintaud G,Bechtel Y,Miguet JP,Mantion G,Bechtel PR

更新日期：1998-03-01 00:00:00

abstract：:There is conflicting data in the literature as to whether subsensitivity of in-vivo beta 2-adrenoceptor (beta 2-AR) responses in patients with asthma is due to an endogenous defect of beta 2-AR or an effect of exogenous beta 2-agonist therapy. The purpose of the study was to compare in-vitro parameters of lymphocyte b...

journal_title：European journal of clinical pharmacology

authors： Newnham DM,Coutie WJ,McFarlane LC,Lipworth BJ

更新日期：1993-01-01 00:00:00

abstract：INTRODUCTION:Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and beta-arabinofuranosylcytosine, to their active triphosphates. This study was performed to assess the occurrence and frequency of DCK polymorphisms in a predo...

journal_title：European journal of clinical pharmacology

authors： Joerger M,Bosch TM,Doodeman VD,Beijnen JH,Smits PH,Schellens JH

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:To evaluate zolpidem as a mechanism-based inactivator of human CYP3A in vitro, and to assess its metabolic interaction potential with CYP3A drugs (in vitro-in vivo extrapolation; IV-IVE). METHODS:A co- vs. pre-incubation strategy was used to quantify time-dependent inhibition of human liver microsomal (HLM)...

journal_title：European journal of clinical pharmacology

authors： Polasek TM,Sadagopal JS,Elliot DJ,Miners JO

更新日期：2010-03-01 00:00:00

abstract：:The cardiovascular and central nervous system effects of the kappa opioid receptor agonist U-62066E were investigated in ten normal male subjects who received U-62066E or placebo with low or high dose naloxone in a randomized, double blind study. Blood pressure and heart rate in the supine and standing position, plasm...

journal_title：European journal of clinical pharmacology

authors： Rimoy GH,Wright DM,Bhaskar NK,Rubin PC

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Psychotropic drug use among nursing home residents with regard to diagnostic indications and patient- and institution characteristics was analysed. METHODS:A cross-sectional study of medication data from 1552 residents at 23 nursing homes in Bergen, Norway, was performed. Psychotropic drug use (neuroleptics,...

journal_title：European journal of clinical pharmacology

authors： Ruths S,Straand J,Nygaard HA

更新日期：2001-09-01 00:00:00

abstract：:The pharmacokinetics of piretanide, a new loop diuretic, were studied in seven patients with severe liver disease before and after resolution of ascites. The time to maximum concentration was significantly prolonged by the presence of ascites. Tmax after relief of ascites was similar to that seen for normal volunteers...

journal_title：European journal of clinical pharmacology

authors： Shepherd AN,Bouchier IA

更新日期：1985-01-01 00:00:00

abstract：PURPOSE:The aim of this study was to identify structure and language elements affecting the quality of responses from Scandinavian drug information centres (DICs). METHODS:Six different fictitious drug-related queries were sent to each of seven Scandinavian DICs. The centres were blinded for which queries were part of...

journal_title：European journal of clinical pharmacology

authors： Reppe LA,Spigset O,Kampmann JP,Damkier P,Christensen HR,Böttiger Y,Schjøtt J

更新日期：2017-05-01 00:00:00

abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

journal_title：European journal of clinical pharmacology

authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

更新日期：1992-01-01 00:00:00

abstract：:We report the first placebo controlled parallel group study of once daily endralazine (5-20 mg) in hypertension uncontrolled by a beta-blocker plus a diuretic. Following a 4-week run-in period 22 patients with a sitting mean arterial pressure (MAP) greater than 110 mm Hg were entered into the study and received either...

journal_title：European journal of clinical pharmacology

authors： McGourty JC,Silas JH,Pidgeon J

更新日期：1985-01-01 00:00:00