Binding of four sulphonamides to human albumin.

abstract：:Unstable angina is a clinical syndrome characterized by increased rate and severity of angina pectoris attacks and, sometimes but not always, accompanied by ECG changes similar to those seen in coronary insufficiency. According to the present conception of the pathogenesis, ruptures at points of high-grade stenosis in...

journal_title：European journal of clinical pharmacology

authors： Bleifeld W

更新日期：1990-01-01 00:00:00

abstract：:To assess the type and degree of innovation of the cardiovascular drugs centrally approved in the European Union between 1995 and 2002. Sources of information were the European Public Assessment Reports and the Summaries of Product Characteristics published by the European Medicines Evaluation Agency. The Agency appro...

journal_title：European journal of clinical pharmacology

authors： Garattini S,Bertele' V

更新日期：2003-11-01 00:00:00

abstract：:This is the first report of the use of DHM 32-550 a dehydrogenated peptide ergot alkaloid with both alpha and beta adrenoceptor blocking activity, in patients with angina-like chest pain. Five patients were studied to assess a dose/response relationship. No deleterious effects on blood pressure occurred at either rest...

journal_title：European journal of clinical pharmacology

authors： Handler CE,Sowton E

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:The survival of esophageal and gastric cancer patients treated with chemotherapy is rarely assessed outside of clinical trials. Therefore, we compared the effectiveness of various curative or palliative chemotherapy regimens on the survival of esophageal and gastric cancer patients in a "real world" clinical se...

journal_title：European journal of clinical pharmacology

authors： Ekheden I,Ebrahim F,Ólafsdóttir H,Raaschou P,Wettermark B,Henriksson R,Ye W

更新日期：2020-07-01 00:00:00

abstract：:To assess the duration of the antihypertensive effect of the dihydropiridine calcium antagonist felodipine in conventional (C-F) and slow-release (ER-F) formulations, 12 patients with essential hypertension underwent ambulatory blood pressure monitoring (ABPM) at the end of a 2-week treatment period with C-F 5 mg b.d....

journal_title：European journal of clinical pharmacology

authors： Porcellati C,Verdecchia P,Gatteschi C,Benemio G,Guerrieri M,Boldrini F,Pollavini G

更新日期：1989-01-01 00:00:00

abstract：:Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

journal_title：European journal of clinical pharmacology

authors： Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

更新日期：1992-01-01 00:00:00

abstract：:Twenty patients (5 females, 15 males) with severe heart failure (NYHA IV), due to coronary artery disease in 14, and congestive cardiomyopathy in 6, received an intravenous bolus of the calcium blocker nisoldipine 0.2 mg followed by a continuous infusion of 0.2 micrograms.kg-1.min-1. Haemodynamic measurements were per...

journal_title：European journal of clinical pharmacology

authors： Erlemeier HH,Kupper W,Bleifeld W

更新日期：1990-01-01 00:00:00

abstract：:The pharmacokinetic parameters of deacetyl metipranolol were determined after i.v. infusion of increasing doses (6-25mg) in 17 normal volunteers. In a second cross-over trial, deacetyl metipranolol 10 and 20mg were infused in a further 10 subjects, and in a third trial another 20 volunteers received metipranolol 40mg ...

journal_title：European journal of clinical pharmacology

authors： Abshagen U,Betzien G,Kaufmann B,Endele G

更新日期：1982-01-01 00:00:00

abstract：PURPOSE:To assess, with all available trial information, whether the assessment of the PRECIS-2 nine domains could provide a clear distinction between medicine masked pragmatic randomized controlled trials (pRCTs) and open-label pRCTs. METHODS:A search was conducted of participant-level pRCTs on medicines published on...

journal_title：European journal of clinical pharmacology

authors： Dal-Ré R

更新日期：2020-10-26 00:00:00

abstract：:The aim of laboratory screening in Phase I is to exclude subjects with subclinical illness, who might be at increased risk in the study, and who might also adversely influence interpretation of the results. A new method for laboratory screening, based on Bayesian probability theory, is proposed, which consists of: 1. ...

journal_title：European journal of clinical pharmacology

authors： Sibille M,Vital Durand D

更新日期：1990-01-01 00:00:00

abstract：OBJECTIVE:To study the main comedications associated with major bleeding during anticoagulant therapy with coumarins in a non-selected population under everyday circumstances. METHODS:The study population for this retrospective cohort study included all new users of phenprocoumon or acenocoumarol aged 40-80 years, dur...

journal_title：European journal of clinical pharmacology

authors： Penning-van Beest F,Erkens J,Petersen KU,Koelz HR,Herings R

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVE:Troglitazone is an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which has been shown to improve the metabolic control of type 2 diabetes. Troglitazone undergoes hepatic metabolism to an inactive sulphate conjugate and an oxidative quinone metabolite with minor activity. The ob...

journal_title：European journal of clinical pharmacology

authors： Ott P,Ranek L,Young MA

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Use of analgesic drugs in acute renal colic varies widely in different countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency pr...

journal_title：European journal of clinical pharmacology

authors： Jean R,Ducasse JL,Montastruc JL,Lapeyre-Mestre M

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVES:A temporal relationship between the increasing use of antibiotics and the increasing levels of antibiotic resistance has been established for Streptococcus pneumoniae. There are also data that support the presence of a geographic correlation between the level of resistance and the pattern of use among differ...

journal_title：European journal of clinical pharmacology

authors： Boccia D,Alegiani SS,Pantosti A,Moro ML,Traversa G

更新日期：2004-04-01 00:00:00

abstract：:We examined the pharmacokinetics of nifedipine after acute and sustained oral therapy and the potential haemodynamic interaction between nifedipine and sublingual nitroglycerin in nine patients with chronic stable angina. Nifedipine pharmacokinetics after a single oral dose and sustained dosing (three times daily for ...

journal_title：European journal of clinical pharmacology

authors： Boje KM,Fung HL,Yoshitomi K,Parker JO

更新日期：1987-01-01 00:00:00

abstract：:The pharmacokinetics of loprazolam have been studied in eight healthy male volunteers after single and repeated 2 mg oral doses taken at night, for eight nights. The absorption and disposition of unchanged drug (HPLC-GC assay) and receptor active benzodiazepine-type materials (radioreceptor assay) were examined after ...

journal_title：European journal of clinical pharmacology

authors： Stevens LA,Bevan CD,Salmon J,Krieger J,Perianu M,LeGo A

更新日期：1983-01-01 00:00:00

abstract：:We have studied pharmacokinetics of a new H2-receptor antagonist, TZU-0460, in patients with varying degrees of renal impairment. The apparent volume of distribution at steady-state was 1.70 l/kg, and the plasma protein binding of TZU-0460 or its active metabolite, desacetyl TZU-0460 was less than 10% in normal subjec...

journal_title：European journal of clinical pharmacology

authors： Takabatake T,Ohta H,Yamamoto Y,Ishida Y,Hara H,Nakamura S,Ushiogi Y,Satoh S,Hattori N

更新日期：1986-01-01 00:00:00

abstract：:The kinetics of triamterene and its active phase II metabolite were studied in 32 patients with various degrees of impaired renal function; the creatinine clearances ranged from 135 to 10 ml/min. The area under the plasma concentration-time curves (AUC) for triamterene were not influenced by kidney function, but the A...

journal_title：European journal of clinical pharmacology

authors： Knauf H,Möhrke W,Mutschler E

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:To determine whether two of the major operational stressors associated with military missions in Afghanistan: dry heat and long durations of soldier patrol (SP), alter the pharmacokinetics of ibuprofen. METHODS:Thirteen healthy and physically fit participants (19-32 years) were randomized to a four-arm crossov...

journal_title：European journal of clinical pharmacology

authors： Boscarino C,Edginton AN,Peng H,Riggs KW,Szeitz A,Cheung B

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The influence of nevirapine (NVP) on lopinavir (LPV) pharmacokinetics was investigated by a population analysis based on a non-linear mixed-effect modelling method. METHODS:In this analysis, 95 HIV-1 infected patients were studied [52 treated with LPV/ritonavir (400/100 mg twice a day) plus nucleoside revers...

journal_title：European journal of clinical pharmacology

authors： Dailly E,Reliquet V,Raffi F,Jolliet P

更新日期：2005-04-01 00:00:00

abstract：:The acute effects on monophasic action potentials (MAP), QT interval, and right ventricle effective refractory period (V-ERP) of propranolol 0.2 mg.kg-1 body weight have been studied in 10 patients with coronary artery disease. The median duration of MAP at 90% repolarization (MAP90) was shortened from 238 to 228 ms a...

journal_title：European journal of clinical pharmacology

authors： Endresen K,Amlie JP

更新日期：1990-01-01 00:00:00

abstract：:The systemic availability of oral zidovudine has been studied in 13 patients with the acquired immunodeficiency syndrome (AIDS) dosed either fasting or with breakfast. The mean peak plasma concentration and AUC of zidovudine were significantly 2.8- and 1.4-times higher in fasting patients than in those treated during ...

journal_title：European journal of clinical pharmacology

authors： Lotterer E,Ruhnke M,Trautmann M,Beyer R,Bauer FE

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:To analyse the contribution of adverse drug reactions (ADR) to hospital readmissions. METHODS:This was a case-control study in which unscheduled admissions of patients who had been admitted to the hospital during the two previous months were assessed during a 21-month period. The patient was considered a cas...

journal_title：European journal of clinical pharmacology

authors： Ruiz B,García M,Aguirre U,Aguirre C

更新日期：2008-07-01 00:00:00

abstract：PURPOSE:To assess the effect of a small economic inducement on the rate of spontaneous reporting of adverse drug reactions (ADRs) and the attitudes of general practitioners and physicians towards reporting of ADRs. METHOD:One intervention and one control county were selected for the study. Written information about th...

journal_title：European journal of clinical pharmacology

authors： Bäckström M,Mjörndal T

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:Evidence exists to suggest that diclofenac is metabolised by CYP2C9. The present study was undertaken in order to evaluate the effect of the single CYP2C9*3 variant on drug metabolism using diclofenac as a probe drug. METHODS:A single dose of diclofenac was administered orally to 12 healthy subjects in whom...

journal_title：European journal of clinical pharmacology

authors： Shimamoto J,Ieiri I,Urae A,Kimura M,Irie S,Kubota T,Chiba K,Ishizaki T,Otsubo K,Higuchi S

更新日期：2000-04-01 00:00:00

abstract：:The effect of ethanol intake on disopyramide elimination was examined in an open crossover study in six healthy volunteers. No effect of ethanol on the elimination half-life or total body clearance of disopyramide was found, although it did decrease the percentage of mono-N-dealkylated disopyramide excreted in the uri...

journal_title：European journal of clinical pharmacology

authors： Olsen H,Bredesen JE,Lunde PK

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:The purpose of this study is to investigate the effect of two of the most important functional CYP1A2 variations -3860G > A and -163C > A on carbamazepine pharmacokinetics in Serbian pediatric epileptic patients. METHODS:The study involved 40 Serbian pediatric epileptic patients on steady-state carbamazepine t...

journal_title：European journal of clinical pharmacology

authors： Djordjevic N,Milovanovic DD,Radovanovic M,Radosavljevic I,Obradovic S,Jakovljevic M,Milovanovic D,Milovanovic JR,Jankovic S

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To determine the patterns of consumption in calcium channel blockers (CCB) groups in the Czech Republic between 1992 and 1999 and make a comparison with selected countries. METHODS:This was part of a drug utilization study using WHO methodology [Anatomical Therapeutic Chemical classification/defined daily do...

journal_title：European journal of clinical pharmacology

authors： Dolezal T,Nemecek K,Krsiak M

更新日期：2002-10-01 00:00:00

abstract：:In eight patients with uncomplicated non insulin dependent diabetes mellitus, serum insulin levels, serum C-peptide levels and blood glucose levels were measured before and after oral administration of glibenclamide 0.1 mg/kg body weight and a test meal, or after a test meal alone. The rise in serum insulin levels per...

journal_title：European journal of clinical pharmacology

authors： Mulder H,Schopman W Sr,van der Lely AJ

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to define the pharmacokinetic profile of free carbamazepine (F-CBZ) in adult Omani epileptic patients in order to improve on dosing schedules through population pharmacokinetic analysis using the NONMEM program. METHOD:Steady-state trough F-CBZ serum concentrations, carbamazepine (C...

journal_title：European journal of clinical pharmacology

authors： Deleu D,Aarons L,Ahmed IA

更新日期：2001-06-01 00:00:00