Binding of four sulphonamides to human albumin.

Abstract:

:The four sulphonamides studied--furosemide, tolbutamide, sulfafurazole and sulfonamidochlorobenzoic acid--bind to human albumin at the same sites but with decreasing affinity. These sites are also common to other drugs, namely acenocoumarin, chlorophenoxyisobutyric acid, phenylbutazone and warfarin. In plasma, the four sulphonamides considered bind mainly to albumin, but also, at higher concentrations, to globulins, to an extent that increases as their affinity for albumin lessens.

journal_name

Eur J Clin Pharmacol

authors

Zini R,d'Athis P,Hoareau A,Tillement JP

doi

10.1007/BF00609473

subject

Has Abstract

pub_date

1976-06-15 00:00:00

pages

139-45

issue

2

eissn

0031-6970

issn

1432-1041

journal_volume

10

pub_type

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