Abstract:
:The debrisoquine hydroxylation phenotype was studied in 152 unselected healthy Tasmanian subjects, who were mostly Caucasians of British ancestry. Following a 10 mg oral dose of debrisoquine (D), the ratio of D/4-hydroxydebrisoquine excreted in 8-h urine (metabolic ratio, MR) was determined. MR values were bimodally distributed. Thirteen subjects (8.6%) had MR values from 13.8 to 93.3 and were considered to be poor metabolisers of D, while the others were extensive metabolisers with MR values of 0.04 to 5.4. The D hydroxylation phenotype was not associated with sex. These findings confirm the constancy of D polymorphism in a Caucasian population even after migration to another country.
journal_name
Eur J Clin Pharmacoljournal_title
European journal of clinical pharmacologyauthors
Veronese ME,McLean Sdoi
10.1007/BF00315235subject
Has Abstractpub_date
1991-01-01 00:00:00pages
529-32issue
5eissn
0031-6970issn
1432-1041journal_volume
40pub_type
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journal_title:European journal of clinical pharmacology
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journal_title:European journal of clinical pharmacology
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pub_type: 临床试验,杂志文章,随机对照试验
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