Effects of the Chinese herbal formula "Zuojin Pill" on the pharmacokinetics of dextromethorphan in healthy Chinese volunteers with CYP2D6*10 genotype.

abstract：OBJECTIVE:To develop quality prescribing indicators for general practitioners (GPs) who are non-monitored and not included in pay-for-performance programs, and to determine compliance with incentivized and non-incentivized indicators. STUDY DESIGN:Descriptive cross sectional study. SETTING:Aljarafe Primary Health Car...

journal_title：European journal of clinical pharmacology

authors： Fernández Urrusuno R,Montero Balosa MC,Pérez Pérez P,Pascual de la Pisa B

更新日期：2013-10-01 00:00:00

abstract：:In a double blind, randomised trial, the effects of 1 g aspirin and 1 g paracetamol were compared on bleeding time and platelet aggregation in 40 volunteers (20 females). Also investigated was the relationship between plasma aspirin esterase activity and both bleeding time and platelet aggregation after aspirin. Follo...

journal_title：European journal of clinical pharmacology

authors： Seymour RA,Williams FM,Oxley A,Ward A,Fearns M,Brighan K,Rawlins MD,Jones PM

更新日期：1984-01-01 00:00:00

abstract：:The time-courses of plasma carbamazepine concentrations were followed in six apparently healthy adult subjects who, at different times, took single oral drug doses of 200, 400, 500, 600, 700, 800 and 900 mg. There were some suggestions of impaired bioavailability of the drug when given in tablet form. The following va...

journal_title：European journal of clinical pharmacology

authors： Cotter LM,Eadie MJ,Hooper WD,Lander CM,Smith GA,Tyrer JH

更新日期：1977-12-28 00:00:00

abstract：BACKGROUND AND PURPOSE:The purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of topical administration of atorvastatin (ATV) on the acute radiation-induced skin toxicity in patients with breast cancer. PATIENTS AND METHODS:Seventy breast cancer patients were ra...

journal_title：European journal of clinical pharmacology

authors： Ghasemi A,Ghashghai Z,Akbari J,Yazdani-Charati J,Salehifar E,Hosseinimehr SJ

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:Carvedilol, a beta-adrenoceptor blocking agent with additional alpha(1)-adrenoceptor blocking properties, has been shown to improve left ventricular function in chronic heart failure (CHF). However, its effect on mortality has recently been the subject of controversial discussion. The aim of this meta-analysi...

journal_title：European journal of clinical pharmacology

authors： Schmidt BM,Janson CP,Wehling M

更新日期：1998-06-01 00:00:00

abstract：:The comparative enzyme inducing effects of rifabutin and the chemically related drug rifampicin have been investigated in 8 normal subjects. Rifampicin 600 mg daily for 7 days caused considerable shortening of the antipyrine half-life and a marked increase in antipyrine clearance, associated with an increased rate of ...

journal_title：European journal of clinical pharmacology

authors： Perucca E,Grimaldi R,Frigo GM,Sardi A,Mönig H,Ohnhaus EE

更新日期：1988-01-01 00:00:00

abstract：:We have previously shown that inhaled salbutamol further increases the bronchodilator response after the maximum effect of theophylline has been obtained in patients with severe chronic bronchitis. We now report the results of adding maximally effective doses of theophylline to the maximum response obtainable from sal...

journal_title：European journal of clinical pharmacology

authors： Barclay J,Whiting B,Addis GJ

更新日期：1982-01-01 00:00:00

abstract：:The sulphation of (+) and (-) terbutaline was investigated in specimens of human intestinal mucosa isolated from the duodenum, ileum, ascending colon and sigmoid colon and in specimens of liver and lung. The lung specimens came from 8 current smokers and 11 ex-smokers, the latter having stopped at least 3 months befor...

journal_title：European journal of clinical pharmacology

authors： Pacifici GM,Eligi M,Giuliani L

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:Aflibercept, a fully humanized vascular endothelial growth factor (VEGF)-targeted agent, has emerged as an effective therapy in the treatment of various solid tumors. We carried out an up-to-date meta-analysis to determine the risk of fatal adverse events (FAEs) in cancer patients treated with aflibercept. MET...

journal_title：European journal of clinical pharmacology

authors： Qi WX,Tang LN,Shen Z,Yao Y

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:High-density lipoprotein (HDL)-associated antioxidant paraoxonase (PON) may reduce low-density lipoprotein (LDL) oxidation and prevent atherosclerosis. The aim of this present study was to investigate the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor atorvastatin on hydroge...

journal_title：European journal of clinical pharmacology

authors： Harangi M,Seres I,Varga Z,Emri G,Szilvássy Z,Paragh G,Remenyik E

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:To assess the influence of the P450 oxidoreductase 28 SNP (POR 28) on tacrolimus pharmacokinetics in the Chinese population. METHODS:Seventy-one healthy Chinese volunteers enrolled in the study received an oral dose of 2 mg of tacrolimus after providing written informed consent. CYP3A5 3 was genotyped by polym...

journal_title：European journal of clinical pharmacology

authors： Zhang JJ,Zhang H,Ding XL,Ma S,Miao LY

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the dose-response relationship of increasing doses of oxymetazoline compared with placebo in normal subjects, and to determine the sensitivities of rhinomanometry, acoustic rhinometry and symptoms in discriminating between differing doses of oxymetazoline in normal subjects. METHODS:The study ha...

journal_title：European journal of clinical pharmacology

authors： Taverner D,Bickford L,Shakib S,Tonkin A

更新日期：1999-09-01 00:00:00

abstract：:In 12 patients undergoing coloscopy, 0.5 mg digoxin in aqueous alcoholic solution was injected into the transverse colon. The late maximum of the blood level curve at about 2 hours after the administration suggested delayed absorption of the glycoside. However, the 24 hour urinary excretion of 17 +/- 3.4% in 8 patient...

journal_title：European journal of clinical pharmacology

authors： Ochs H,Bodem G,Schäfer PK,Kodrat G,Dengler HJ

更新日期：1975-12-19 00:00:00

abstract：:Procaine esterase activity in plasma from patients with renal failure is decreased by 40%. Since cyanate is formed from urea and readily carbamylates certain blood proteins, a possible role for cyanate in the depression of plasma esterase activity in uraemic patients was considered. However, in vitro carbamylation of ...

journal_title：European journal of clinical pharmacology

authors： Calvo R,Carlos R,Erill S

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Losartan was given to subjects with known phenotypes of the polymorphic enzymes CYP2D6 and CYP2C19 to study any possible influence on the metabolism of the drug. METHODS:Plasma concentrations of losartan and E-3174 were studied after oral intake of 50 mg losartan in 24 healthy, male, Swedish Caucasian subjec...

journal_title：European journal of clinical pharmacology

authors： Sandwall P,Lo MW,Jonzon B,Dalén P,Furtek C,Ritter M,Alván G,McCrea J,Sjöqvist F

更新日期：1999-06-01 00:00:00

abstract：:Influence of food on the serum concentration and kinetics ambenonium chloride (AMBC) has been examined in thirteen patients with myasthenia gravis (MG). Mean serum concentrations and Cmax during fasting were higher than those in the non-fasting state. The AUC (0-3 h) was also about four-times larger. The drug effects ...

journal_title：European journal of clinical pharmacology

authors： Ohtsubo K,Fujii N,Higuchi S,Aoyama T,Goto I,Tatsuhara T

更新日期：1992-01-01 00:00:00

abstract：:The possible interaction between cetirizine 2 HCl and alcohol was studied in a double-blind, cross-over trial in 36 healthy volunteers. The performance of each volunteer was tested with a battery of five objective psychometric tests, and their subjective feelings were evaluated by visual analogue scales, and by extens...

journal_title：European journal of clinical pharmacology

authors： Doms M,Vanhulle G,Baelde Y,Coulie P,Dupont P,Rihoux JP

更新日期：1988-01-01 00:00:00

abstract：:Ninety-six depressed outpatients from 5 centres were given viloxazine 200-400 mg/day. The treatment produced significant clinical improvement as evaluated by the Hamilton Rating Scale for Depression. Thirteen patients dropped-out because of possible side effects. Many untoward symptoms were described by all the patien...

journal_title：European journal of clinical pharmacology

authors： Maistrello I,Grassi G,Bertolino A,Valerio P,Pistollato G,Soverini S

更新日期：1983-01-01 00:00:00

abstract：PURPOSE:SPT-07A is an intravenous injection of (+)-2-borneol being developed for the treatment of acute ischemic stroke. This study aimed to investigate the pharmacokinetics, pharmacodynamics, safety, tolerability, and mass balance of SPT-07A after sequentially administered single and multiple infusions of SPT-07A at 1...

journal_title：European journal of clinical pharmacology

authors： Wang W,Wang Y,Zhao W,Zhong J,Wang Y,Chen X

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:To study the effect of cisplatin on plasma concentrations and urinary excretion of carnitine in ten patients with different malignancies treated with chemotherapy. METHODS:Carnitine concentrations were determined using a radioenzymatic assay and other metabolites by routine methods of clinical chemistry. Ren...

journal_title：European journal of clinical pharmacology

authors： Heuberger W,Berardi S,Jacky E,Pey P,Krähenbühl S

更新日期：1998-09-01 00:00:00

abstract：PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

journal_title：European journal of clinical pharmacology

authors： Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

更新日期：2013-03-01 00:00:00

abstract：:We have given 12 healthy subjects the H1-antihistamine ebastine (20 mg) or placebo in a double-blind, crossover study for one week each. The subjects were tested for drug effects on Day 6 of each period, and for interactions of ebastine with ethanol (0.8 g.kg-1) on Day 7. On both days, the testing runs were done at ba...

journal_title：European journal of clinical pharmacology

authors： Mattila MJ,Kuitunen T,Plétan Y

更新日期：1992-01-01 00:00:00

abstract：:The effects of short-term lithium (Li) administration on alpha 2-adrenoceptor sensitivity was studied in 10 healthy volunteers and in 15 patients with normothymic, phasic depressive disorders. The GH-clonidine test was used to examine alpha 2-adrenoceptor sensitivity, administered before and after Li treatment (600 mg...

journal_title：European journal of clinical pharmacology

authors： Brambilla F,Catalano M,Lucca A,Smeraldi E

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:To investigate the effects of rifampicin on the pharmacokinetics of itraconazole in humans. METHODS:Our study was conducted with six healthy normal volunteers and three AIDS patients. All subjects received a 200 mg single dose of oral itraconazole on day 1 and day 15 and 600 mg of oral rifampicin once daily ...

journal_title：European journal of clinical pharmacology

authors： Jaruratanasirikul S,Sriwiriyajan S

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:To explore the views and perspectives of children on the unlicensed/off-label use of medicines in children and on the participation of children in clinical trials. METHODS:Focus-group discussions, involving school children, were carried out in a range of primary and secondary schools in Northern Ireland. A ...

journal_title：European journal of clinical pharmacology

authors： Mukattash T,Trew K,Hawwa AF,McElnay JC

更新日期：2012-02-01 00:00:00

abstract：:The pharmacokinetics of oral L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) was studied in 7 normal subjects and 7 patients with familial amyloid polyneuropathy. Each person swallowed a single 300 mg dose in the fasting state, and L-threo-DOPS in plasma and urine was determined by high performance liquid chromatogra...

journal_title：European journal of clinical pharmacology

authors： Suzuki T,Higa S,Sakoda S,Ueji M,Hayashi A,Takaba Y,Nakajima A

更新日期：1982-01-01 00:00:00

abstract：:The pharmacokinetics of theophylline was investigated in five hyperthyroid, five hypothyroid, and five euthyroid patients, all with chronic obstructive pulmonary disease. Wide individual variability was found in theophylline kinetics, but the rate of elimination of theophylline was significantly higher in hyperthyroid...

journal_title：European journal of clinical pharmacology

authors： Pokrajac M,Simić D,Varagić VM

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether an association between the use of selective serotonin reuptake inhibitor (SSRI) antidepressants and abnormal bleeding is demonstrated in a large population study. METHODS:An observational cohort study using cohorts from the Drug Safety Research Unit's prescription event monitoring data...

journal_title：European journal of clinical pharmacology

authors： Layton D,Clark DW,Pearce GL,Shakir SA

更新日期：2001-05-01 00:00:00

abstract：:We have assessed the effect of omeprazole on various endocrine functions in man. Eight healthy subjects took 60 mg omeprazole or placebo daily for 1 week in a double-blind, randomized, cross-over study. On Day 7 basal concentrations of follicle-stimulating hormone (FSH), luteinising hormone (LH), prolactin, testostero...

journal_title：European journal of clinical pharmacology

authors： MacGilchrist AJ,Howden CW,Kenyon CJ,Beastall GH,Reid JL

更新日期：1987-01-01 00:00:00

abstract：:The effect of a single oral dose of 40 mg xipamide on urinary excretion of Na+, K+, Cl-, Ca2+ and Mg2+ in healthy subjects and in patients with varying degrees of renal impairment was compared with various conventional diuretics. Xipamide caused marked excretion of Na+ and Cl-, whereas the diuretic produced only moder...

journal_title：European journal of clinical pharmacology

authors： Knauf H,Mutschler E

更新日期：1984-01-01 00:00:00