当前位置： SCI文献检索 > EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY期刊下所有文献 > Comparison of nicardipine and propranolol in the treatment of mild and moderate hypertension.

Comparison of nicardipine and propranolol in the treatment of mild and moderate hypertension.

Abstract：

:In a double-blind controlled trial 22 patients with mild or moderate essential hypertension were treated with nicardipine 30 mg t.d.s. and 19 patients with propranolol 80 mg t.d.s. as monotherapy for 24 weeks. Blood pressure in both groups at the end of trial was equally and significantly reduced; systolic pressure 22.2 mmHg and diastolic pressure 15.5 mmHg in the supine position, and 24.4 mmHg and 18.4 mmHg, respectively, in the standing position in those on nicardipine, and by 23.7 and 16.2 mmHg and 28.0 and 19.2 mmHg, respectively, in the propranolol group. There was an initial increase in heart rate in the nicardipine group, but the rise was only moderate (3 beats/min supine p = 0.3219, and 7 beats/min standing, p = 0.0203) at the end of the 24 weeks. In the propranolol group heart rate was reduced markedly. Adverse effects occurred in 77% of patients on nicardipine and in 63% of those on propranolol, and there were no unexpected findings. The effects were mild in both groups and did not lead any patient to stop medication. One patient on propranolol was withdrawn from the trial because of poor blood pressure control and suspected angina pectoris after 5 weeks on active medication. There were no significant changes in blood chemistry, including lipoprotein classes. Overall, in comparison with propranolol, nicardipine was effective, well-tolerated and safe to use in the monotherapy of mild or moderate essential hypertension.

journal_name

Eur J Clin Pharmacol

journal_title

European journal of clinical pharmacology

authors

Naukkarinen VA,Karppinen K,Sarna S

doi

10.1007/BF00544554

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

119-26

issue

2

eissn

0031-6970

issn

1432-1041

journal_volume

33

pub_type

临床试验,杂志文章,随机对照试验

相关文献

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY文献大全
  • Evaluation of pharmacokinetic and pharmacodynamic parameters following single dose of sitagliptin in healthy Indian males.

    abstract：PURPOSE:Sitagliptin, a dipeptidyl peptidase (DPP)-IV inhibitor approved for the treatment of type 2 diabetes, is reported to be more efficacious in Indian patients than non-Indian patient population. The objective of the study was to evaluate pharmacokinetic and pharmacodynamic (PK/PD) parameters of single-dose sitagli...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-018-2433-5

    authors： Sangle GV,Patil M,Deshmukh NJ,Shengule SA,Kamble S,Vuppalavanchu KK,Kale S,Baig MLA,Singh G,Shaikh J,Tripathi J,Aravindababu P

    更新日期：2018-05-01 00:00:00

  • The relationship between pharmacokinetics and pharmacodynamics of enoximone in healthy man.

    abstract：:The relationship between the pharmacokinetics and pharmacodynamics of enoximone, a new positive inotropic agent, was investigated in 6 healthy men. The volunteers received single oral and i.v. doses of 3 and 1 mg/kg, respectively, and placebo in a double-blind cross-over trial. Plasma concentrations of enoximone and i...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00637599

    authors： Belz GG,Meinicke T,Schäfer-Korting M

    更新日期：1988-01-01 00:00:00

  • The use of medication against attention deficit/hyperactivity disorder in Denmark: a drug use study from a patient perspective.

    abstract：AIM:Our aim was to characterize utilization patterns for drugs used to treat attention deficit/hyperactivity disorder (ADHD) on the level of the individual patient among Danish users, focusing on treatment duration, doses used, and concurrent use of ADHD and non-ADHD drugs. METHODS:Using the Danish Registry of Medicin...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-012-1344-0

    authors： Pottegård A,Bjerregaard BK,Glintborg D,Kortegaard LS,Hallas J,Moreno SI

    更新日期：2013-03-01 00:00:00

  • Dose-titration study of alfuzosin, a new alpha 1-adrenoceptor blocker, in essential hypertension.

    abstract：:An open, dose-titration study of alfuzosin, a new selective post-synaptic alpha 1-adrenoceptor antagonist with additional direct vasodilator properties has been performed. After a 3-week run-in placebo period, 12 patients with essential hypertension received alfuzosin 5 mg oral b.d., and then the dose was doubled ever...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00555503

    authors： Leto di Priolo S,Priore P,Cocco G,Sfrisi C,Cazor JL

    更新日期：1988-01-01 00:00:00

  • Associations between CYP2E1 promoter polymorphisms and plasma 1,3-dimethyluric acid/theophylline ratios.

    abstract：OBJECTIVE:Theophylline is metabolized to 1,3-dimethyluric acid (1,3-DMU), 3-methylxanthine, and 1-methylxanthine by CYP1A2 and partly by CYP2E1. Because 1,3-DMU is the major metabolite of theophylline, the 1,3-DMU/theophylline ratio is viewed as a good indicator of theophylline metabolic clearance. Here, we investigate...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-006-0165-4

    authors： Yoon Y,Park HD,Park KU,Kim JQ,Chang YS,Song J

    更新日期：2006-08-01 00:00:00

  • Pharmacokinetics of troglitazone, a PPAR-gamma agonist, in patients with hepatic insufficiency.

    abstract：OBJECTIVE:Troglitazone is an agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), which has been shown to improve the metabolic control of type 2 diabetes. Troglitazone undergoes hepatic metabolism to an inactive sulphate conjugate and an oxidative quinone metabolite with minor activity. The ob...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280050514

    authors： Ott P,Ranek L,Young MA

    更新日期：1998-09-01 00:00:00

  • High prevalence of cytochrome P450 2A6*1A alleles in a black African population of Ghana.

    abstract：OBJECTIVE:We investigated the frequencies of the functionally important variants of the CYP2A6 gene in black African populations. METHODS:Using genomic DNA sequencing, polymerase chain reaction (PCR)-restriction fragment length polymorphism and allele-specific PCR, the allele frequencies of CYP2A6 *1A, *1B, *2, *4A, *...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-004-0854-9

    authors： Gyamfi MA,Fujieda M,Kiyotani K,Yamazaki H,Kamataki T

    更新日期：2005-02-01 00:00:00

  • Cardiocirculatory effects of moclobemide (Ro 11-1163), a new reversible, a short-acting MAO-inhibitor with preferential type A inhibition, in healthy volunteers and depressive patients.

    abstract：:The benzamide-derivative moclobemide (Ro 11-1163) is a new short-acting, reversible MAO-inhibitor, preferentially affecting Type A MAO, which is, being developed as an antidepressant agent. The effect of moclobemide on heart rate, blood pressure, electrocardiographic and systolic time intervals was assessed in eight h...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00543787

    authors： Gasic S,Korn A,Eichler HG,Oberhummer I,Zapotoczky HG

    更新日期：1983-01-01 00:00:00

  • Impact of CYP3A5 polymorphism on trough concentrations and outcomes of tacrolimus minimization during the early period after kidney transplantation.

    abstract：PURPOSE:The purpose of this study is to determine the impacts of CYP3A5 polymorphism on tacrolimus concentration and the proportion of patients within a target therapeutic range during the first week after transplantation together with the 3-month acute rejection rate in kidney transplant patients receiving a minimized...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-015-1990-0

    authors： Yaowakulpatana K,Vadcharavivad S,Ingsathit A,Areepium N,Kantachuvesiri S,Phakdeekitcharoen B,Sukasem C,Sra-Ium S,Sumethkul V,Kitiyakara C

    更新日期：2016-03-01 00:00:00

  • The effects of acute and repeated doses of zolpidem on subjective sleep, psychomotor performance and cognitive function in elderly volunteers.

    abstract：:We gave 24 healthy elderly volunteers with a perceived sleep onset of at least 30 minutes zolpidem 5 mg, zolpidem 10 mg, or placebo for 7 days in a double-blind, three-way, crossover study. The morning after nocturnal dosing, psychomotor performance and cognitive ability were measured using tests which are sensitive t...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF02284957

    authors： Fairweather DB,Kerr JS,Hindmarch I

    更新日期：1992-01-01 00:00:00

  • Influence and interference of isosorbide dinitrate and food intake on superior mesenteric artery impedance in humans.

    abstract：:The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00196852

    authors： Voet D,Mareels S,Afschrift M,De Buyzere M,Rietzschel E,Duprez D

    更新日期：1995-01-01 00:00:00

  • Should the acetylator phenotype be determined when prescribing hydralazine for hypertension?

    abstract：:The role of acetylator phenotype in determining the response to hydralazine when it was added to diuretic and beta-blocker at doses not exceeding 200 mg daily was examined in 57 hypertensive patients. 81% of rapid acetylators needed 200 mg hydralazine daily compared to 38% of slow acetylators (p less than 0.01). Despi...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00546706

    authors： Ramsay LE,Silas JH,Ollerenshaw JD,Tucker GT,Phillips FC,Freestone S

    更新日期：1984-01-01 00:00:00

  • Metabolism of propranolol in the human maternal-placental-foetal unit.

    abstract：:Propranolol (P) and all of its major known metabolites were found in maternal plasma, cord plasma and neonatal plasma in 10 women at term, irrespective of the P doses administered and the time elapsed (up to 15 h) between administration of the last P dose and delivery. The ratios of cord plasma to simultaneous materna...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1007/BF00607078

    authors： Smith MT,Livingstone I,Eadie MJ,Hooper WD,Triggs EJ

    更新日期：1983-01-01 00:00:00

  • Panobinostat PK/PD profile in combination with bortezomib and dexamethasone in patients with relapsed and relapsed/refractory multiple myeloma.

    abstract：PURPOSE:Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study aims to explore exposure-response relationship for panobinostat in this ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-015-1967-z

    authors： Mu S,Kuroda Y,Shibayama H,Hino M,Tajima T,Corrado C,Lin R,Waldron E,Binlich F,Suzuki K

    更新日期：2016-02-01 00:00:00

  • Quantifying behavioural determinants relating to health professional reporting of medication errors: a cross-sectional survey using the Theoretical Domains Framework.

    abstract：PURPOSE:The aims of this study were to quantify the behavioural determinants of health professional reporting of medication errors in the United Arab Emirates (UAE) and to explore any differences between respondents. METHODS:A cross-sectional survey of patient-facing doctors, nurses and pharmacists within three major ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2124-z

    authors： Alqubaisi M,Tonna A,Strath A,Stewart D

    更新日期：2016-11-01 00:00:00

  • Simultaneous study of the pharmacokinetics of intravenous and oral nicardipine using a stable isotope.

    abstract：:The systemic elimination of nicardipine has been studied by an initial oral administration of nicardipine followed 1.25 h later by intravenous injection of the deuterium-labelled molecule (D3 nicardipine). To check that intravenous kinetics was not modified by the oral administration, an i.v. injection of unlabelled n...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/BF00558504

    authors： Guerret M,Cheymol G,Hubert M,Julien-Larose C,Lavene D

    更新日期：1989-01-01 00:00:00

  • Pharmacokinetics of meropenem in subjects with renal insufficiency.

    abstract：:The pharmacokinetics of IV meropenem (500 mg over 30 min) has been studied in 6 healthy volunteers and 26 patients with various degrees of renal impairment. Blood samples were taken at different times over 24 h in healthy subjects and 36 to 48 h in uraemic patients, and four or five urine samples were collected over 2...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00314864

    authors： Leroy A,Fillastre JP,Etienne I,Borsa-Lebás F,Humbert G

    更新日期：1992-01-01 00:00:00

  • Drug therapy management in patients with renal impairment: how to use creatinine-based formulas in clinical practice.

    abstract：PURPOSE:The use of estimated glomerular filtration rate (eGFR) in daily clinical practice. METHODS:eGFR is a key component in drug therapy management (DTM) in patients with renal impairment. eGFR is routinely reported by laboratories whenever a serum creatinine testing is ordered. In this paper, we will discuss how to...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-016-2113-2

    authors： Eppenga WL,Kramers C,Derijks HJ,Wensing M,Wetzels JF,De Smet PA

    更新日期：2016-12-01 00:00:00

  • Main comedications associated with major bleeding during anticoagulant therapy with coumarins.

    abstract：OBJECTIVE:To study the main comedications associated with major bleeding during anticoagulant therapy with coumarins in a non-selected population under everyday circumstances. METHODS:The study population for this retrospective cohort study included all new users of phenprocoumon or acenocoumarol aged 40-80 years, dur...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-005-0947-0

    authors： Penning-van Beest F,Erkens J,Petersen KU,Koelz HR,Herings R

    更新日期：2005-07-01 00:00:00

  • A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers.

    abstract：BACKGROUND:A four-drug cytochrome P450 (CYP) phenotyping cocktail was developed to rapidly and safely determine CYP2D6, CYP2C19, CYP2C9 and CYP1A2 enzyme activity and phenotype. METHODS:The cocktail consisted of the single CYP phenotyping probes of 50 mg tramadol (CYP2D6), 20 mg omeprazole (CYP2C19), 25 mg losartan (C...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00228-013-1561-1

    authors： Pedersen RS,Damkier P,Christensen MM,Brosen K

    更新日期：2013-12-01 00:00:00

  • The unsteady model. An alternative approach to nonlinear pharmacokinetics.

    abstract：:In this paper an alternative approach to nonlinear pharmacokinetics modelling has been developed from first principles. This "Unsteady Model" is able to describe the situation whereby one or more independent drugs and their metabolites compete for free attachment sites in liver, tissue, red blood cells etc. The Unstea...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00615410

    authors： Smith MT,Smith TC

    更新日期：1981-01-01 00:00:00

  • The effect of acarbose on the pharmacokinetics of rosiglitazone.

    abstract：OBJECTIVES:To investigate whether treatment with acarbose alters the pharmacokinetics (PK) of coadministered rosiglitazone. METHODS:Sixteen healthy volunteers (24-59-years old) received a single 8-mg dose of rosiglitazone on day 1, followed by 7 days of repeat dosing with acarbose [100 mg three times daily (t.i.d.) wi...

    journal_title：European journal of clinical pharmacology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s002280100275

    authors： Miller AK,Inglis AM,Culkin KT,Jorkasky DK,Freed MI

    更新日期：2001-05-01 00:00:00

  • Treatment of acute renal colic in a French emergency department: a comparison of simulated cases and real cases in acute pain assessment and management.

    abstract：OBJECTIVE:Use of analgesic drugs in acute renal colic varies widely in different countries. In order to assess the prescribing patterns in acute renal colic in French emergency departments (EDs), the present study compared intentions of prescription, real prescription and evidence-based data in a sample of emergency pr...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280100366

    authors： Jean R,Ducasse JL,Montastruc JL,Lapeyre-Mestre M

    更新日期：2001-11-01 00:00:00

  • The effect of dipyridamole on the pharmacokinetics of metformin: a randomized crossover study in healthy volunteers.

    abstract：PURPOSE:Concomitant treatment with the glucose-lowering drug metformin and the platelet aggregation inhibitor dipyridamole often occurs in patients with type 2 diabetes mellitus who have suffered a cerebrovascular event. The gastrointestinal uptake of metformin is mediated by the human equilibrative nucleoside transpor...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,随机对照试验

    doi：10.1007/s00228-016-2039-8

    authors： El Messaoudi S,Russel FG,Colbers A,Bandell CC,van den Broek PH,Burger DM,Rongen GA,Riksen NP

    更新日期：2016-06-01 00:00:00

  • Is there an association between selective serotonin reuptake inhibitors and risk of abnormal bleeding? Results from a cohort study based on prescription event monitoring in England.

    abstract：OBJECTIVE:To investigate whether an association between the use of selective serotonin reuptake inhibitor (SSRI) antidepressants and abnormal bleeding is demonstrated in a large population study. METHODS:An observational cohort study using cohorts from the Drug Safety Research Unit's prescription event monitoring data...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s002280100263

    authors： Layton D,Clark DW,Pearce GL,Shakir SA

    更新日期：2001-05-01 00:00:00

  • Lack of effect of cimetidine on pharmacodynamics and kinetics of single oral doses of R- and S-acenocoumarol.

    abstract：:The kinetics and dynamics of single doses (5 mg p.o.) of the optical isomers of acenocoumarol (R-AC and S-AC) were followed in healthy subjects and the effect on them of cimetidine 800 mg/day was also investigated. The AC enantiomers differed greatly in their pharmacokinetics. The mean residence time (MRT) of R-AC was...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00542424

    authors： Thijssen HH,Janssen GM,Baars LG

    更新日期：1986-01-01 00:00:00

  • Primary care physicians' behaviors towards risk of iatrogenesis in elderly patients.

    abstract：OBJECTIVES:Iatrogenesis is common in elderly patients. This phenomenon could be reduced by improving awareness of general practitioners (GPs). We studied GPs' prescribing behavior to elderly patients, to identify GP and patient characteristics related to cautious prescribing behaviors. METHODS:The observational study ...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/s00228-006-0125-z

    authors： Fantino B,Voirin N,Laforest L,Fantino F,Chretin S,Van Ganse E

    更新日期：2006-07-01 00:00:00

  • The use of evidence in pharmacovigilance. Case reports as the reference source for drug withdrawals.

    abstract：OBJECTIVE:Withdrawal of a drug from the market for safety reasons is a serious and sometimes complex decision. The scientific evidence supporting drug withdrawals in the past years is critically appraised. METHODS:With data provided by the Spanish Medicines Agency, all drugs withdrawn from the Spanish market for safet...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章,评审

    doi：10.1007/s002280100265

    authors： Arnaiz JA,Carné X,Riba N,Codina C,Ribas J,Trilla A

    更新日期：2001-04-01 00:00:00

  • Effect of sparteine sulphate upon basal and nutrient-induced insulin and glucagon secretion in normal man.

    abstract：:Infusion of a therapeutic dose of sparteine sulphate, increased the basal plasma insulin level and lowered plasma glucose. When an intravenous glucose tolerance test was performed with the infusion, the total insulin AUC was significantly larger than in absence of sparteine (2025 vs 1464 microU/ml X min), plasma gluco...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF00637673

    authors： Sgambato S,Paolisso G,Passariello N,Varricchio M,D'Onofrio F

    更新日期：1987-01-01 00:00:00

  • Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency.

    abstract：:The pharmacokinetics of temocapril hydrochloride, a novel prodrug-type angiotensin-I converting enzyme (ACE) inhibitor, has been studied in patients with mild (Group II) to severe (Group III) renal insufficiency in comparison with subjects with normal renal function (Group I). The pharmacokinetic parameters of the act...

    journal_title：European journal of clinical pharmacology

    pub_type： 杂志文章

    doi：10.1007/BF02284968

    authors： Nakashima M,Yamamoto J,Shibata M,Uematsu T,Shinjo H,Akahori T,Shioya H,Sugiyama K,Kawahara Y

    更新日期：1992-01-01 00:00:00