Quantifying behavioural determinants relating to health professional reporting of medication errors: a cross-sectional survey using the Theoretical Domains Framework.

Abstract:

PURPOSE:The aims of this study were to quantify the behavioural determinants of health professional reporting of medication errors in the United Arab Emirates (UAE) and to explore any differences between respondents. METHODS:A cross-sectional survey of patient-facing doctors, nurses and pharmacists within three major hospitals of Abu Dhabi, the UAE. An online questionnaire was developed based on the Theoretical Domains Framework (TDF, a framework of behaviour change theories). Principal component analysis (PCA) was used to identify components and internal reliability determined. Ethical approval was obtained from a UK university and all hospital ethics committees. RESULTS:Two hundred and ninety-four responses were received. Questionnaire items clustered into six components of knowledge and skills, feedback and support, action and impact, motivation, effort and emotions. Respondents generally gave positive responses for knowledge and skills, feedback and support and action and impact components. Responses were more neutral for the motivation and effort components. In terms of emotions, the component with the most negative scores, there were significant differences in terms of years registered as health professional (those registered longest most positive, p = 0.002) and age (older most positive, p < 0.001) with no differences for gender and health profession. CONCLUSION:Emotional-related issues are the dominant barrier to reporting and are common to all professions. There is a need to develop, test and implement an intervention to impact health professionals' emotions. Such an intervention should focus on evidence-based behaviour change techniques of reducing negative emotions, focusing on emotional consequences and providing social support. KEY MESSAGES:• This research used the Theoretical Domains Framework to quantify the behavioural determinants of health professional reporting of medication errors. • Questionnaire items relating to emotions surrounding reporting generated the most negative responses with significant differences in terms of years registered as health professional (those registered longest most positive) and age (older most positive) with no differences for gender and health profession. • Interventions based on behaviour change techniques mapped to emotions should be prioritised for development.

journal_name

Eur J Clin Pharmacol

authors

Alqubaisi M,Tonna A,Strath A,Stewart D

doi

10.1007/s00228-016-2124-z

subject

Has Abstract

pub_date

2016-11-01 00:00:00

pages

1401-1411

issue

11

eissn

0031-6970

issn

1432-1041

pii

10.1007/s00228-016-2124-z

journal_volume

72

pub_type

杂志文章
  • Influence of nifedipine therapy on indocyanine green and oral propranolol pharmacokinetics.

    abstract::Nine healthy adults were administered indocyanine green (ICG) 0.5 mg.kg-1 IV alone and after the administration of the following oral drugs: nifedipine 10 mg, propranolol 80 mg, propranolol 80 mg and nifedipine 10 mg, and propranolol 80 mg after nifedipine 10 mg every 8 h for 5 days. Heart rate and mean arterial blood...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00679780

    authors: Bauer LA,Murray K,Horn JR,Opheim K,Olsen J

    更新日期:1989-01-01 00:00:00

  • Correlation between propranolol in plasma and urine, renin-aldosterone system and blood pressure in essential hypertension.

    abstract::Thirty patients with mild or moderate essential hypertension, and a fixed elevation of diastolic blood pressure, were randomly allocated to three groups and treated with propranolol 40 mg x 4 (Group 1), 80 mg x 4 (group 2) and 160 mg x 4 (Group 3). Blood pressure (BP), pulse rate (PR), plasma renin activity (PRA), pla...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00618774

    authors: Pedersen EB,Kornerup HJ,Pedersen OL,Andreasen F,Bjerregaard P

    更新日期:1981-01-01 00:00:00

  • The potential of cytokines as safety biomarkers for drug-induced liver injury.

    abstract::Drug-induced liver injury (DILI) is an event that has a detrimental impact on drug development and patient safety; therefore the identification of novel biomarkers that are both sensitive and specific to the liver would have great benefit. Inflammation is known to be associated with human cases of DILI, and given the ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00228-010-0862-x

    authors: Laverty HG,Antoine DJ,Benson C,Chaponda M,Williams D,Kevin Park B

    更新日期:2010-10-01 00:00:00

  • Effects of disopyramide on repolarisation and intraventricular conduction in man.

    abstract::Right ventricular repolarisation and refractoriness after therapeutic doses of disopyramide have been studied in 10 patients with coronary artery disease by recording monophasic action potentials (MAP) during programmed stimulation. Using 2 catheters, with the tip of one in the apex and the other in the outflow tract ...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00558240

    authors: Endresen K,Amlie JP,Forfang K

    更新日期:1988-01-01 00:00:00

  • Education on prescribing for older patients in the Netherlands: a curriculum mapping.

    abstract:PURPOSE:Pharmacology and pharmacotherapy education is being increasingly integrated in medical curricula, which might lead to a specific loss of knowledge in these subjects. This, in turn, could lead to harmful prescribing errors, especially in vulnerable older patients. METHODS:Teachers who coordinated education in D...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-015-1830-2

    authors: Keijsers CJ,de Wit JE,Tichelaar J,Brouwers JR,de Wildt DJ,de Vries PG,Jansen PA

    更新日期:2015-05-01 00:00:00

  • Pharmacokinetics and beta-blocking effects of transdermal timolol.

    abstract::The pharmacokinetic profiles of transdermal timolol 6 and 24 mg (as 5 and 20% w/v patches) was studied in four healthy young volunteers. To assess its bioavailability, the pharmacokinetics of an IV infusion of timolol maleate 5 mg was also determined in the same subjects. When the 20% (w/v) timolol patch was applied, ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00315551

    authors: Kubota K,Yamada T,Kikuchi K,Koyama E,Ishizaki T

    更新日期:1993-01-01 00:00:00

  • Role of active metabolites in the use of opioids.

    abstract::The opioid class of drugs, a large group, is mainly used for the treatment of acute and chronic persistent pain. All are eliminated from the body via metabolism involving principally CYP3A4 and the highly polymorphic CYP2D6, which markedly affects the drug's function, and by conjugation reactions mainly by UGT2B7. In ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00228-008-0570-y

    authors: Coller JK,Christrup LL,Somogyi AA

    更新日期:2009-02-01 00:00:00

  • Reported adverse drug reactions during the use of inhaled steroids in children with asthma in the Netherlands.

    abstract:OBJECTIVES:Inhaled corticosteroids (ICS) are widely used in the treatment of asthma. We studied the suspected adverse drug reactions (sADRs) reported during the use of ICS in the Netherlands. METHODS:In the Netherlands, health professionals and patients can report suspected ADRs to the Pharmacovigilance Centre Lareb. ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-006-0102-6

    authors: de Vries TW,de Langen-Wouterse JJ,van Puijenbroek E,Duiverman EJ,de Jong-Van den Berg LT

    更新日期:2006-05-01 00:00:00

  • Effects of ACE inhibition on endurance exercise haemodynamics in trained subjects with mild hypertension.

    abstract::The aim of the study was to examine the effect of chronic angiotensin converting enzyme inhibition on haemodynamics and left ventricular performance during long-lasting exercise at the anaerobic threshold. For this purpose exercise haemodynamics and left ventricular performance were assessed in 14 physically trained h...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00194331

    authors: Palatini P,Bongiovi S,Mario L,Mormino P,Raule G,Pessina AC

    更新日期:1995-01-01 00:00:00

  • Protein binding of drugs in plasma, interstitial fluid and tissues: effect on pharmacokinetics.

    abstract::Drug binding in the interstitial fluid as well as in the plasma must be taken into account when considering the pharmacokinetics of drugs which are highly bound to plasma proteins and have a relatively small apparent volume of distribution (V). The half-life and apparent volume of distribution of such a drug can be af...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00609592

    authors: Faed EM

    更新日期:1981-01-01 00:00:00

  • Variability of beta-blocker pharmacokinetics in young volunteers.

    abstract::Plasma concentrations of metoprolol, propranolol oxprenolol, acebutolol and its metabolite diacetolol were measured after single oral doses in young health volunteers. In order to assessed the inter- and intra-subject variability the following pharmacokinetic parameters were compared: AUC0(24), Cmax, tmax and t 1/2. T...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF01061375

    authors: Jack DB,Quarterman CP,Zaman R,Kendall MJ

    更新日期:1982-01-01 00:00:00

  • Effect of flunitrazepam as an oral hypnotic on 24-hour blood pressure in healthy volunteers.

    abstract:PURPOSE:The present study was carried out in order to assess the effects of chronic administration of flunitrazepam (as an oral hypnotic) on 24-h blood pressure (BP) and heart rate (HR) in healthy young adults. MATERIALS AND METHODS:Following a 2-week placebo run-in period, 28 healthy volunteers (13 males and 15 femal...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00228-018-2466-9

    authors: Bosone D,Fogari R,Zoppi A,D'Angelo A,Ghiotto N,Perini G,Ramusino MC,Costa A

    更新日期:2018-08-01 00:00:00

  • Impaired cimetidine absorption due to antacids and metoclopramide.

    abstract::In 8 healthy subjects the absorption of cimetidine was investigated when given alone, together with 60 ml aluminium/magnesium hydroxide containing antacid (neutralising capacity 26 mmol HCl/10 ml), and together with liquid metoclopramide 14 mg. The antacid significantly (P less than 0.01) reduced the bioavailability (...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00544602

    authors: Gugler R,Brand M,Somogyi A

    更新日期:1981-01-01 00:00:00

  • Grapefruit juice inhibits 7-hydroxylation of coumarin in healthy volunteers.

    abstract::The effect of grapefruit juice on the urinary excretion of 7-hydroxycoumarin after oral administration of 10 mg coumarin, as an index of cytochrome P450 dependent coumarin metabolism, has been investigated in an open, randomised cross over study in 13 healthy volunteers (7 female, 6 male). The percentage of 7-hydroxyc...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00199885

    authors: Merkel U,Sigusch H,Hoffmann A

    更新日期:1994-01-01 00:00:00

  • Effect of cholestyramine and colestipol on the absorption of phenytoin.

    abstract::The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00542221

    authors: Callaghan JT,Tsuru M,Holtzman JL,Hunninghake DB

    更新日期:1983-01-01 00:00:00

  • Haemodynamic effects and kinetics of concomitant intravenous disopyramide and atenolol in patients with ischaemic heart disease.

    abstract::The haemodynamic effects of concomitant intravenous administration of disopyramide (Norpace) and atenolol (Tenormin) were studied in a cross-over trial in 7 patients with ischaemic heart disease. Following 150 mg disopyramide i.v. the cardiac index (CI) and stroke volume index (SVI) decreased by 14% and 26%, respectiv...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00614295

    authors: Bonde J,Pedersen LE,Angelo HR,Trap-Jensen J,Svendsen TL,Kampmann JP

    更新日期:1986-01-01 00:00:00

  • Variation in the binding affinity of warfarin and phenprocoumon to human serum albumin in relation to surgery.

    abstract::The binding equilibria of warfarin and phenprocoumon with defatted human serum albumin were studied by equilibrium dialysis in 33 mM sodium phosphate buffer, pH 7.4, 37 degrees C. The binding isotherms for both ligands were consistent with binding to two similar and independent sites in the albumin molecule. The bindi...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00315474

    authors: Vorum H,Jørgensen HR,Brodersen R

    更新日期:1993-01-01 00:00:00

  • Effects of a new oral hypoglycaemic agent, repaglinide, on metabolic control in sulphonylurea-treated patients with NIDDM.

    abstract::We have evaluated the effects of repaglinide, a new non-sulphonylurea oral hypoglycaemic agent that has a stimulatory effect on insulin secretion. Forty-four patients with NIDDM, already treated with a sulphonylurea, took part in an open, randomised, group comparison study of 12 weeks duration, during which they recei...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00315490

    authors: Wolffenbuttel BH,Nijst L,Sels JP,Menheere PP,Müller PG,Kruseman AC

    更新日期:1993-01-01 00:00:00

  • Long-term effects of glipizide on insulin secretion and blood glucose control in patients with non-insulin-dependent diabetes mellitus.

    abstract::Of 23 patients with non-insulin-dependent diabetes mellitus (NIDDM), whose fasting blood glucose had not reached less than or equal to 6.0 mmol.l-1 after 10 weeks of dietary regulation, 15, who had had a weight reduction of -2.8 kg by dietary control, did achieve a fasting blood glucose less than or equal to 6.0 mmol....

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00314924

    authors: Bitzén PO,Melander A,Scherstén B,Svensson M,Wåhlin-Boll E

    更新日期:1992-01-01 00:00:00

  • Effect of carbamazepine on psychomotor performance in näive subjects.

    abstract::The effect of a single dose of carbamazepine (CBZ), 10 mg kg-1, on a battery of simple psychomotor tests was investigated in 12 healthy subjects (6 male, 6 female) in a balanced randomised double blind placebo controlled cross-over study. Psychomotor testing and blood sampling for total and free plasma CBZ, and CBZ 10...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00614193

    authors: MacPhee GJ,Goldie C,Roulston D,Potter L,Agnew E,Laidlaw J,Brodie MJ

    更新日期:1986-01-01 00:00:00

  • Underuse of lipid-lowering drugs and factors associated with poor adherence: a real practice analysis in Italy.

    abstract:BACKGROUND:Many studies have indicated the adequate use of lipid-lowering drugs (LLDs) as a factor in reducing the risk of cardiovascular disease. However, in clinical practice, a very high percentage of patients are not adequately treated. OBJECTIVE:To analyze the management of hypercholesterolemia in a non-experimen...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-005-0911-z

    authors: Di Martino M,Degli Esposti L,Ruffo P,Bustacchini S,Catte A,Sturani A,Degli Esposti E

    更新日期:2005-05-01 00:00:00

  • Association between statin-induced creatine kinase elevation and genetic polymorphisms in SLCO1B1, ABCB1 and ABCG2.

    abstract:PURPOSE:Treatment with statins requires close monitoring of serum creatine kinase (CK) levels to prevent myopathy, a common and potentially serious dose-dependent adverse effect of these drugs. We have investigated the correlation between elevated CK levels and polymorphisms in the genes encoding transporters involved ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-014-1661-6

    authors: Ferrari M,Guasti L,Maresca A,Mirabile M,Contini S,Grandi AM,Marino F,Cosentino M

    更新日期:2014-05-01 00:00:00

  • Plasma theophylline and caffeine and plasma clearance of theophylline during theophylline treatment in the first year of life.

    abstract::Plasma concentrations of caffeine and theophylline were simultaneously determined in 17 preterm infants after oral administration of aminophylline for treatment of apnoea. The ratio of caffeine/theophylline concentration in plasma increased during the first 2 weeks of treatment, owing to the longer time required for c...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00610057

    authors: Lönnerholm G,Lindström B,Paalzow L,Sedin G

    更新日期:1983-01-01 00:00:00

  • Deflazacort in the treatment of haematologic disorders.

    abstract::Glucocorticoids (GCs) exert different activities that are useful for the treatment of several haematologic disorders. The synergistic effect with cytotoxic drugs is important for the therapy of lymphoproliferative diseases. The inhibition of macrophages prevents acute haemolysis and platelets destruction in autoimmune...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF01844200

    authors: Gobbi M,Scudeletti M

    更新日期:1993-01-01 00:00:00

  • Drug prescription in diabetic patients in Stockholm in 1992 and 1995--change over time.

    abstract:OBJECTIVE:To describe and compare the distribution of prescribed drugs in diabetic patients between 1992 and 1995. METHODS:Two cross-sectional surveys of a random selection of medical records of diabetic patients, from three community health centres (CHCs) in the Stockholm metropolitan area, were carried out. The age ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s002280050285

    authors: Wändell PE,Brorsson B,Aberg H

    更新日期:1997-01-01 00:00:00

  • Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers.

    abstract:INTRODUCTION:Deoxycytidine kinase (DCK) is the rate-limiting enzyme of the intracellular phosphorylation of nucleoside anticancer drugs, including gemcitabine and beta-arabinofuranosylcytosine, to their active triphosphates. This study was performed to assess the occurrence and frequency of DCK polymorphisms in a predo...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-006-0162-7

    authors: Joerger M,Bosch TM,Doodeman VD,Beijnen JH,Smits PH,Schellens JH

    更新日期:2006-08-01 00:00:00

  • Press coverage and sales of Xenical in Sweden, 1998-2000.

    abstract:OBJECTIVE:The anti-obesity drug Xenical (orlistat, Roche) was launched on the Swedish market in February 1999. The sales peaked in May 1999 and then declined. The purpose of this study was to investigate the press coverage of Xenical during the period 1998-2000 and, if possible, relate press attention to Xenical sales ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-005-0914-9

    authors: Brounéus F,Dahlin A,Beermann B

    更新日期:2005-06-01 00:00:00

  • Pharmacokinetics of 3H-phenylephrine in man.

    abstract::7-3H-phenylephrine was given to 15 volunteers by a short-infusion n = 4) or p.o. (10 volunteers, 1 patient with porto-caval anastomosis). Analysis of serum for free 3H-phenylephrine and fractionation of urinary radioactivity was performed by ion-exchange and thin-layer chromatography. As almost the same 3H-activity wa...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00637623

    authors: Hengstmann JH,Goronzy J

    更新日期:1982-01-01 00:00:00

  • Population pharmacokinetics of CPT-11 (irinotecan) in gastric cancer patients with peritoneal seeding after its intraperitoneal administration.

    abstract:PURPOSE:It is well known that CPT-11 (irinotecan) is biotransformed to its active metabolite, SN-38, by carboxylesterase in the liver and other tissues. However, little is known about its pharmacokinetics (PK) when administered intraperitoneally. The aim of our study was to develop a population pharmacokinetic model fo...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-010-0885-3

    authors: Ahn BJ,Choi MK,Park YS,Lee J,Park SH,Park JO,Lim HY,Kang WK,Ko JW,Yim DS

    更新日期:2010-12-01 00:00:00

  • A comparison of the pharmacokinetics of mefloquine in healthy Thai volunteers and in Thai patients with falciparum malaria.

    abstract::We have studied the kinetics of a single oral dose of mefloquine (750 mg) in 12 Thai patients with falciparum malaria and have compared the results with those of a previous study in 12 healthy Thai volunteers. All the patients responded to treatment with a mean parasite clearance time of 66.6 h and a mean fever cleara...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00637607

    authors: Karbwang J,Back DJ,Bunnag D,Breckenridge AM

    更新日期:1988-01-01 00:00:00