Influence of the menstrual cycle on theophylline pharmacokinetics in asthmatics.

abstract：:The influence of isosorbide dinitrate (ISDN) and food ingestion on superior mesenteric artery impedance was investigated in 24 healthy volunteers (age 40 +/- 2.7 years). Superior mesenteric artery circulation was assessed by duplex ultrasound. Pulsatility index (PI) was considered as a parameter of vascular resistance...

journal_title：European journal of clinical pharmacology

authors： Voet D,Mareels S,Afschrift M,De Buyzere M,Rietzschel E,Duprez D

更新日期：1995-01-01 00:00:00

abstract：PURPOSE:We proposed a statistical criterion to detect drug-drug interactions causing adverse drug reactions in spontaneous reporting systems. METHODS:The used criterion quantitatively measures the discrepancy between the observed and expected number of adverse events via chi-square statistics. We compared the performa...

journal_title：European journal of clinical pharmacology

authors： Gosho M,Maruo K,Tada K,Hirakawa A

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Tocilizumab, a monoclonal antibody directed against the IL-6 receptor, might block detrimental effects of IL-6 on transplantation. IL-6 plays a considerable role in cytokine storm after stem cell transplantation as well as graft versus host disease, and it has also been shown to be involved in solid organ allog...

journal_title：European journal of clinical pharmacology

authors： Mosharmovahed B,Fatahi Y,Mohebbi B,Ghorbanian SA,Assadiasl S

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:As quinine is mainly metabolised by human liver CYP3A4 and grapefruit juice inhibits CYP3A4, the effect of grapefruit juice on the pharmacokinetics of quinine following a single oral dose of 600 mg quinine sulphate was investigated. METHODS:The study was carried out in ten healthy volunteers using a randomis...

journal_title：European journal of clinical pharmacology

authors： Ho PC,Chalcroft SC,Coville PF,Wanwimolruk S

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:More than 11% of the Caucasian population are heterozygous or homozygous carriers of thiopurine S-methyltransferase (TPMT) mutants and are at risk for toxic side effects when treated with thiopurine drugs. Therefore, screening for TPMT polymorphisms in a patient prior to prescribing these agents is recommende...

journal_title：European journal of clinical pharmacology

authors： Wusk B,Kullak-Ublick GA,Rammert C,von Eckardstein A,Fried M,Rentsch KM

更新日期：2004-03-01 00:00:00

abstract：:Enprofylline 1 mg/kg, a new potent antiasthmatic xanthine derivative, which is mainly eliminated by renal excretion, was given intravenously to 6 normal subjects with and without oral pretreatment with 1 g probenecid. The latter caused a drop in the average total body clearance of enprofylline from 21 to 9.8 l/h, and ...

journal_title：European journal of clinical pharmacology

authors： Borgå O,Larsson R,Lunell E

更新日期：1986-01-01 00:00:00

abstract：PURPOSE:To investigate statin use in the elderly by age (≥ 80 vs. 65-79 years) in relation to established indications. METHODS:A population-based cohort, including data from four registers, encompassing inhabitants in Region Västra Götaland, Sweden, was used. Statin users were defined as those filling statin prescript...

journal_title：European journal of clinical pharmacology

authors： Sundvall H,Fastbom J,Wallerstedt SM,Vitols S

更新日期：2019-07-01 00:00:00

abstract：:Guidelines presented previously for the analysis of plasma concentration versus time data for a drug exhibiting concentration-dependent plasma protein binding were successfully applied to the distributional parameters of a new cephalosporin, ceftriaxone. This approach provided several striking observations when the ph...

journal_title：European journal of clinical pharmacology

authors： McNamara PJ,Gibaldi M,Stoeckel K

更新日期：1983-01-01 00:00:00

abstract：BACKGROUND:A four-drug cytochrome P450 (CYP) phenotyping cocktail was developed to rapidly and safely determine CYP2D6, CYP2C19, CYP2C9 and CYP1A2 enzyme activity and phenotype. METHODS:The cocktail consisted of the single CYP phenotyping probes of 50 mg tramadol (CYP2D6), 20 mg omeprazole (CYP2C19), 25 mg losartan (C...

journal_title：European journal of clinical pharmacology

authors： Pedersen RS,Damkier P,Christensen MM,Brosen K

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:Cytochrome P450 2C9 (CYP2C9) allelic variant carriers have been shown to experience hyper-responsiveness to small doses of oral anticoagulants (OAs) (warfarin or acenocoumarol) and a higher bleeding rate. OBJECTIVES:To determine the relative frequencies of different risk factors for OA overdose including di...

journal_title：European journal of clinical pharmacology

authors： Verstuyft C,Robert A,Morin S,Loriot MA,Flahault A,Beaune P,Funck-Brentano C,Jaillon P,Becquemont L

更新日期：2003-03-01 00:00:00

abstract：:A comparative pharmacokinetic study was performed with two types of suppository each containing 20 mg piroxicam. The bioavailability of piroxicam was studied in 24 healthy volunteers in a double blind, randomised, cross over study. No significant difference was found in the pharmacokinetic parameters [AUC(0-72 h), AUC...

journal_title：European journal of clinical pharmacology

authors： Benkö S,Grézal G,Nagy E,Klebovich I

更新日期：1992-01-01 00:00:00

abstract：AIM:Our aim was to characterize utilization patterns for drugs used to treat attention deficit/hyperactivity disorder (ADHD) on the level of the individual patient among Danish users, focusing on treatment duration, doses used, and concurrent use of ADHD and non-ADHD drugs. METHODS:Using the Danish Registry of Medicin...

journal_title：European journal of clinical pharmacology

authors： Pottegård A,Bjerregaard BK,Glintborg D,Kortegaard LS,Hallas J,Moreno SI

更新日期：2013-03-01 00:00:00

abstract：PURPOSE:Some reports have described arterial hypertension (AH) in patients treated by serotonin reuptake inhibitor (SRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) antidepressants. The mechanism remains discussed, some authors suggesting a role of SERT (SERotonin Transporter) inhibition whereas others discus...

journal_title：European journal of clinical pharmacology

authors： Montastruc JL,Rousseau V,de Canecaude C,Roussin A,Montastruc F

更新日期：2020-09-01 00:00:00

abstract：PURPOSE:Treatment with statins requires close monitoring of serum creatine kinase (CK) levels to prevent myopathy, a common and potentially serious dose-dependent adverse effect of these drugs. We have investigated the correlation between elevated CK levels and polymorphisms in the genes encoding transporters involved ...

journal_title：European journal of clinical pharmacology

authors： Ferrari M,Guasti L,Maresca A,Mirabile M,Contini S,Grandi AM,Marino F,Cosentino M

更新日期：2014-05-01 00:00:00

abstract：:Oral and sublingual isoxsuprine 20 mg were compared with placebo in double blind randomised cross over trial in 7 patients with Raynaud's phenomenon. Skin thermography, plethysmography of the finger tips and direct temperature measurements showed that sublingual isoxsuprine was slightly but consistently superior to th...

journal_title：European journal of clinical pharmacology

authors： Wesseling H,den Heeten A,Wouda AA

更新日期：1981-01-01 00:00:00

abstract：:The pharmacokinetics of amoxycillin in normal male volunteers was studied during the states of bedrest, sleep and ambulation. The absorption and disposition of amoxycillin in ambulatory subjects was found to be comparable to that reported previously by other workers. Serum amoxycillin concentrations were found to be s...

journal_title：European journal of clinical pharmacology

authors： Roberts MS,Denton MJ

更新日期：1980-08-01 00:00:00

abstract：PURPOSE:It is well known that CPT-11 (irinotecan) is biotransformed to its active metabolite, SN-38, by carboxylesterase in the liver and other tissues. However, little is known about its pharmacokinetics (PK) when administered intraperitoneally. The aim of our study was to develop a population pharmacokinetic model fo...

journal_title：European journal of clinical pharmacology

authors： Ahn BJ,Choi MK,Park YS,Lee J,Park SH,Park JO,Lim HY,Kang WK,Ko JW,Yim DS

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVES:Evidence exists to suggest that diclofenac is metabolised by CYP2C9. The present study was undertaken in order to evaluate the effect of the single CYP2C9*3 variant on drug metabolism using diclofenac as a probe drug. METHODS:A single dose of diclofenac was administered orally to 12 healthy subjects in whom...

journal_title：European journal of clinical pharmacology

authors： Shimamoto J,Ieiri I,Urae A,Kimura M,Irie S,Kubota T,Chiba K,Ishizaki T,Otsubo K,Higuchi S

更新日期：2000-04-01 00:00:00

abstract：:The effect of nevirapine once-daily dosing on the pharmacokinetics of methadone and its main metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine, was evaluated in ten HIV positive patients on stable methadone therapy. Nevirapine 200 mg once daily was administered orally from day 1 to day 14. On day 15, nevir...

journal_title：European journal of clinical pharmacology

authors： Arroyo E,Valenzuela B,Portilla J,Climent-Grana E,Pérez-Ruixo JJ,Merino E

更新日期：2007-07-01 00:00:00

abstract：:The inhibitory action of azelastine hydrochloride (Azeptin) on the respiratory burst in peripheral polymorphonuclear leukocytes (PMN) and pulmonary alveolar macrophages (PAM) has been studied. Azeptin in vitro suppressed chemiluminescence and superoxide (O2-) generation by human PMN in a dose- and time-dependent manne...

journal_title：European journal of clinical pharmacology

authors： Ueta E,Osaki T,Kawasaki N,Nomura Y

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:UDP-glucuronosyltransferases (UGTs) UGT1A9 and UGT2B7 are involved in the metabolism of antimalarial dihydroartemisinin and antiretroviral zidovudine. Our aim was to analyze the prevalence of UGT1A9 (chromosome 2) and UGT2B7 (chromosome 4) nonsynonymous single nucleotide polymorphisms (SNPs) in West African (...

journal_title：European journal of clinical pharmacology

authors： Mehlotra RK,Bockarie MJ,Zimmerman PA

更新日期：2007-01-01 00:00:00

abstract：:The effect of indenolol on heart rate and blood pressure at rest and after submaximal workload has been studied in 19 patients with established essential hypertension. A stepwise increase from moderate to submaximal exercise was chosen to mimic challenges normally occurring in daily life. After 4 weeks of once a day i...

journal_title：European journal of clinical pharmacology

authors： Aiello C,Groothold G,Gualtieri S,Irace L,Marini IL,Perna B,Romano A

更新日期：1985-01-01 00:00:00

abstract：:Some physicians regard patients of Geriatric Units as a homogeneous population with respect to digoxin dosage requirements. Others advocate the use of pharmacokinetic models in prescribing digoxin for the elderly. Sixty in-patients of Geriatric Units were studied and the results compared with those previously obtained...

journal_title：European journal of clinical pharmacology

authors： Dobbs RJ,Royston JP,O'Neill CJ,Deshmukh AA,Nicholson PW,Denham MJ,Dobbs SM

更新日期：1987-01-01 00:00:00

abstract：:The bronchodilator effect and side-effects of a single oral dose of enprofylline were compared with the corresponding actions of a therapeutic dose of theophylline in 20 asthmatic patients, in a randomized cross-over clinical trial. Enprofylline 4 mg/kg and theophylline 8 mg/kg produced mean maximum plasma levels of 4...

journal_title：European journal of clinical pharmacology

authors： Laursen LC,Johannesson N,Søndergaard I,Weeke B

更新日期：1984-01-01 00:00:00

abstract：PURPOSE:SPT-07A is an intravenous injection of (+)-2-borneol being developed for the treatment of acute ischemic stroke. This study aimed to investigate the pharmacokinetics, pharmacodynamics, safety, tolerability, and mass balance of SPT-07A after sequentially administered single and multiple infusions of SPT-07A at 1...

journal_title：European journal of clinical pharmacology

authors： Wang W,Wang Y,Zhao W,Zhong J,Wang Y,Chen X

更新日期：2020-06-01 00:00:00

abstract：:The biliary excretion of mebendazole has been investigated in two patients to whom it was given for the treatment of echinococcosis, although it was found to be only partly effective. Oral mebendazole was extensively metabolized and the conjugated parent substance and its metabolites were excreted in the bile. One pat...

journal_title：European journal of clinical pharmacology

authors： Witassek F,Allan RJ,Watson TR,Woodtli W,Ammann R,Bircher J

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:Because of the risk of haemorrhagic disease of the newborn as a result of a deficit in vitamin K, it is generally agreed that newborns should receive vitamin K. However, there is no consensus concerning the route of administration, dose, number of doses, or dose frequency. METHODS:We studied patterns of vita...

journal_title：European journal of clinical pharmacology

authors： Jonville-Bera AP,Autret E

更新日期：1997-01-01 00:00:00

abstract：:17 patients with severe digoxin intoxication were successfully treated with 320 to 480 mg Fab fragments of digoxin-specific IgG from sheep. The infusion period ranged between 0.5 and 7 h. Serum and urine concentrations of digoxin bound to Fab fragments, and in 11 cases unbound Fab fragments in serum, were determined d...

journal_title：European journal of clinical pharmacology

authors： Schaumann W,Kaufmann B,Neubert P,Smolarz A

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVE:In elderly patients, both falls and impaired memory are considerable medical problems. Hypnotics, which are frequently administered to this patient group for the treatment of insomnia, should ideally not impair equilibrium or memory functions. This double-blind, randomised, four-way, cross-over study investig...

journal_title：European journal of clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Tarral A,Gandon JM

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:The aim of the present study was to investigate the pharmacokinetic profile of tramadol hydrochloride in neonates, born from mothers who underwent analgesia with tramadol for the relief of labour pain. METHODS:Intramuscular tramadol (100--250 mg) was administered to 22 mothers giving birth who requested pain...

journal_title：European journal of clinical pharmacology

authors： Claahsen-van der Grinten HL,Verbruggen I,van den Berg PP,Sporken JM,Kollée LA

更新日期：2005-08-01 00:00:00