Do educational meetings and group detailing change adherence to drug formularies in hospitals? A cluster randomized controlled trial.

Abstract:

PURPOSE:The aim of this study was to examine whether educational meetings and group detailing could increase the use of drugs from the ward lists or the drug formulary in hospitals. METHODS:Twelve medical wards from two hospitals were randomized into three groups: control, basic and extended intervention. All wards had a ward list review before interventions. Moreover, the basic intervention consisted of an educational meeting, and the extended intervention included two group detailing sessions. The proportion of drugs used from the ward list or hospital drug formulary (HDF) was the primary outcome. Data (defined daily doses [DDDs], numbers and cost [Euros]) on drugs sold to the wards were retrieved from the two hospitals from 1 July 2011 to 31 August 2012. BASELINE DATA:from July to September 2011, and follow-up data: from June to August 2012. RESULTS:The proportion of formulary drugs used increased for the extended intervention group (0.04, range -0.02 to 0.09) and basic intervention group (0.03, range -0.03 to 0.09) in comparison with a decrease in the control group (-0.01, range -0.03 to -0.02). The interventions did not significantly change odds for selecting drugs from the formulary in comparison with the control group (basic intervention: OR 1.09 [95 % CI 0.81 to 1.46]; extended intervention: OR 1.00 [95 % CI 0.75 to 1.35]). CONCLUSIONS:In this study, educational meetings and group detailing do not significantly improve adherence to ward lists or HDF. The adherence to the formularies at baseline was relatively high, which may explain why the interventions did not have a significant effect.

journal_name

Eur J Clin Pharmacol

authors

Plet HT,Kjeldsen LJ,Christensen Rde P,Nielsen GS,Hallas J

doi

10.1007/s00228-013-1589-2

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

109-16

issue

1

eissn

0031-6970

issn

1432-1041

journal_volume

70

pub_type

杂志文章,随机对照试验
  • The influence of fenflumizole on platelet aggregation in patients with unstable angina pectoris.

    abstract::We have studied the antiaggregatory effect of fenflumizole, a new non-steroidal antiinflammatory imidazole derivative, in ten patients with unstable angina pectoris. We have measured the aggregation induced by arachidonic acid (AA), ADP, and collagen, and serum or plasma concentrations of beta-thromboglobulin (beta-TG...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00606628

    authors: Grauholt AM,Grande P,Wadt J

    更新日期:1987-01-01 00:00:00

  • Should the acetylator phenotype be determined when prescribing hydralazine for hypertension?

    abstract::The role of acetylator phenotype in determining the response to hydralazine when it was added to diuretic and beta-blocker at doses not exceeding 200 mg daily was examined in 57 hypertensive patients. 81% of rapid acetylators needed 200 mg hydralazine daily compared to 38% of slow acetylators (p less than 0.01). Despi...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00546706

    authors: Ramsay LE,Silas JH,Ollerenshaw JD,Tucker GT,Phillips FC,Freestone S

    更新日期:1984-01-01 00:00:00

  • Long-term nicotine substitution after application of a 16-hour nicotine patch in smoking cessation.

    abstract::The purpose of the study was to examine long-term nicotine substitution and its variability during use of a nicotine patch. In two smoking cessation studies a 16-h nicotine patch, releasing 15 mg nicotine, was applied daily for 16 h over 12 weeks, to 167 smokers. Salivary cotinine was highly correlated with plasma cot...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF02280755

    authors: Nørregaard J,Tønnesen P,Simonsen K,Säwe U

    更新日期:1992-01-01 00:00:00

  • Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations.

    abstract:OBJECTIVE:UDP-glucuronosyltransferases (UGTs) UGT1A9 and UGT2B7 are involved in the metabolism of antimalarial dihydroartemisinin and antiretroviral zidovudine. Our aim was to analyze the prevalence of UGT1A9 (chromosome 2) and UGT2B7 (chromosome 4) nonsynonymous single nucleotide polymorphisms (SNPs) in West African (...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-006-0206-z

    authors: Mehlotra RK,Bockarie MJ,Zimmerman PA

    更新日期:2007-01-01 00:00:00

  • Effects of probenecid on enprofylline kinetics in man.

    abstract::Enprofylline 1 mg/kg, a new potent antiasthmatic xanthine derivative, which is mainly eliminated by renal excretion, was given intravenously to 6 normal subjects with and without oral pretreatment with 1 g probenecid. The latter caused a drop in the average total body clearance of enprofylline from 21 to 9.8 l/h, and ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00614308

    authors: Borgå O,Larsson R,Lunell E

    更新日期:1986-01-01 00:00:00

  • Influence of triazolam on thermal heat balance in poor sleepers.

    abstract::The influence of a benzodiazepine (triazolam) on the body temperature of poor sleepers during nights disturbed by airplane noises has been examined. Subjects were divided into 3 groups each of 8 men. Following a double-blind design, Group A (controls) received a placebo for 6 consecutive nights, Group B received 0.25 ...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00544042

    authors: Libert JP,Weber LD,Amoros C,Muzet A,Ehrhart J,Follenius M

    更新日期:1984-01-01 00:00:00

  • Dopamine pharmacokinetics in critically ill newborn infants.

    abstract::Dopamine is frequently used in critically ill newborn infants for treatment of shock and cardiac failure, but its pharmacokinetics has not been evaluated using a specific analytical method. Steady-state arterial plasma concentrations of dopamine were measured in 11 seriously ill infants receiving dopamine infusion, 5-...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00279976

    authors: Bhatt-Mehta V,Nahata MC,McClead RE,Menke JA

    更新日期:1991-01-01 00:00:00

  • Prazosin depression of baroreflex function in hypertensive man.

    abstract::Prazosin is a post synaptic alpha adrenergic blocker effective in hypertension, whose hypotensive effect is unaccompanied by reflex tachycardia or hyperreninemia, nor by other evidence of increased sympathetic activity. We studied the baroreceptor reflex arc as a potential mediator of these effects. Twenty-two essenti...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00606418

    authors: Sasso EH,O'Connor DT

    更新日期:1982-01-01 00:00:00

  • Optimal sampling strategies for darunavir and external validation of the underlying population pharmacokinetic model.

    abstract:PURPOSE:A variety of diagnostic methods are available to validate the performance of population pharmacokinetic models. Internal validation, which applies these methods to the model building dataset and to additional data generated through Monte Carlo simulations, is often sufficient, but external validation, which req...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-020-03036-2

    authors: Stillemans G,Belkhir L,Vandercam B,Vincent A,Haufroid V,Elens L

    更新日期:2020-11-11 00:00:00

  • The use of medication against attention deficit/hyperactivity disorder in Denmark: a drug use study from a patient perspective.

    abstract:AIM:Our aim was to characterize utilization patterns for drugs used to treat attention deficit/hyperactivity disorder (ADHD) on the level of the individual patient among Danish users, focusing on treatment duration, doses used, and concurrent use of ADHD and non-ADHD drugs. METHODS:Using the Danish Registry of Medicin...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-012-1344-0

    authors: Pottegård A,Bjerregaard BK,Glintborg D,Kortegaard LS,Hallas J,Moreno SI

    更新日期:2013-03-01 00:00:00

  • Sex-by-formulation interaction in bioequivalence trials with transdermal patches.

    abstract:PURPOSE:The existence of a sex-by-formulation interaction in bioequivalence studies implies that the bioequivalence results (i.e., the test/reference ratio of the pharmacokinetic parameters) obtained in one sex are not similar to those obtained in the other sex. Therefore, results obtained in studies including only mal...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00228-019-02632-1

    authors: González-Rojano E,Marcotegui J,Morales-Alcelay S,Álvarez C,Gordon J,Abad-Santos F,García-Arieta A

    更新日期:2019-06-01 00:00:00

  • Dose dependence of the 14C-aminopyrine breath test. Intrasubject comparison of tracer and pharmacological doses.

    abstract::Although the aminopyrine breath test has received much attention, the question has not yet been settled whether pharmacological or tracer doses of the drug should be used. Nine volunteers were given 14C-aminopyrine 9 mg/kg or a tracer amount, in a randomized sequence and according to a crossover design. The specific a...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00609866

    authors: Gikalov I,Bircher J

    更新日期:1977-11-14 00:00:00

  • Altered pharmacokinetics of lignocaine after epidural injection in type II diabetics.

    abstract::The pharmacokinetics of lignocaine has been compared after epidural anaesthesia in diabetics and non-diabetic patients. Epidural lignocaine 8 mg.kg-1 was given to 8 well controlled Type II diabetic and 8 non-diabetic patients and the plasma drug concentration in serial blood samples were measured by HPLC. The plasma l...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF02333021

    authors: Peeyush M,Ravishankar M,Adithan C,Shashindran CH

    更新日期:1992-01-01 00:00:00

  • Hyperforin in St. John's wort drug interactions.

    abstract::Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John's wort (Hypericum perforatum L.; SJW) and prescription drugs. Co-medication with SJW resulted in decreased plasma conce...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,评审

    doi:10.1007/s00228-006-0096-0

    authors: Madabushi R,Frank B,Drewelow B,Derendorf H,Butterweck V

    更新日期:2006-03-01 00:00:00

  • Pharmacodynamics of ticlopidine in man in relation to plasma and blood cell concentration.

    abstract::In 6 normal volunteers given single oral doses of 250,500 and 1000 mg ticlopidine (T), the peak plasma level of unchanged drug was reached after about 2 h. There was no correlation between the plasma T level and its inhibitory effect on platelet function, expressed as % inhibition of ADP-induced aggregation. By means ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00626364

    authors: DiPerri T,Pasini FL,Frigerio C,Blardi P,Centini F,Messa GL,Ghezzi A,Volpi L

    更新日期:1991-01-01 00:00:00

  • Pharmacokinetics and organ distribution of intravenous and oral methylene blue.

    abstract:OBJECTIVE:To determine the pharmacokinetics and organ distribution of i.v. and oral methylene blue, which is used to prevent ifosfamide-induced encephalopathy in oncology. METHODS:The concentration of methylene blue in whole blood was measured using high-performance liquid chromatography in seven volunteers after i.v....

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s002280000124

    authors: Peter C,Hongwan D,Küpfer A,Lauterburg BH

    更新日期:2000-06-01 00:00:00

  • Effect of cholestyramine and colestipol on the absorption of phenytoin.

    abstract::The hypocholesterolemic cation resins, cholestyramine and colestipol, have variable effects on the absorption parameters of a number of lipophillic, anion drugs. Because of the unpredictable nature of this interaction, we have assessed in human volunteers the effect of these resins on the rate and total absorption of ...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00542221

    authors: Callaghan JT,Tsuru M,Holtzman JL,Hunninghake DB

    更新日期:1983-01-01 00:00:00

  • The impact of acetylsalicylic acid dosed at bedtime on circadian rhythms of blood pressure in the high-risk group of cardiovascular patients-a randomized, controlled trial.

    abstract:PURPOSE:Time of drug administration may significantly influence its effect. The aim of the present study was to investigate the effect of ASA (administrated in the morning or in the evening) on the anti-hypertensive effect and diurnal blood pressure profile in the high-risk group of cardiovascular patients. METHODS:Al...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-020-02997-8

    authors: Krasińska B,Paluszkiewicz L,Miciak-Ławicka E,Krasinski M,Rzymski P,Tykarski A,Krasiński Z

    更新日期:2021-01-01 00:00:00

  • Single ascending oral dose pharmacokinetics and pharmacodynamics study of EV-077: the specific inhibitor of prostanoid- and isoprostane-induced cellular activation.

    abstract:PURPOSE:This study was performed to determine the oral pharmacokinetics (PK) of EV-077 and its effects on pharmacodynamic (PD) markers. EV-077 blocks prostanoid-induced and isoprostane-induced cellular activation, and is in development for the treatment of vascular inflammation and associated complications of type-2 di...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s00228-012-1348-9

    authors: Richardson A,Sakariassen KS,Meyer JP,Alberts P,Sorensen AS

    更新日期:2013-03-01 00:00:00

  • Factors associated with adherence to drug therapy: a population-based study.

    abstract:OBJECTIVE:To investigate adherence to prescription in a female population aged 35-65 years. DESIGN:Postal questionnaire study of 2991 randomly sampled 35- to 64-year-old women in seven provinces of central Sweden. METHODS:The study was performed in 1995 as a cross-sectional postal questionnaire study in seven countie...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-006-0246-4

    authors: Bardel A,Wallander MA,Svärdsudd K

    更新日期:2007-03-01 00:00:00

  • A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy.

    abstract:PURPOSE:The objective of this work was to develop a population pharmacokinetic model for a prolonged-release granule formulation of valproic acid (VPA) in children with epilepsy and to determine the doses providing a VPA trough concentration (Ctrough) within the target range (50-100 mg/L). METHODS:Ninety-eight childre...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-018-2444-2

    authors: Rodrigues C,Chhun S,Chiron C,Dulac O,Rey E,Pons G,Jullien V

    更新日期:2018-06-01 00:00:00

  • The scientific basis of rational prescribing. A guide to precision clinical pharmacology based on the WHO 6-step method.

    abstract:BACKGROUND AND METHODS:This opinion paper expanded on the WHO "six-step approach to optimal pharmacotherapy," by detailed exploration of the underlying pharmacological and pathophysiological principles. This exercise led to the identification of a large number of domains of research that should be addressed to make cli...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-020-03044-2

    authors: Rongen GA,Marquet P,van Gerven JMA,EACPT research working group.

    更新日期:2020-11-18 00:00:00

  • How many patients and blood levels are necessary for population pharmacokinetic analysis? A study of a one compartment model applied to cyclosporine.

    abstract:OBJECTIVE:This paper describes a method to determine the number of patients and the number of blood levels which are appropriate for a pharmacokinetic population analysis. METHODS:We studied this question by performing 203 runs of population analysis, using the NPEM algorithm with a one compartment model, starting wit...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s002280050199

    authors: Bréant V,Charpiat B,Sab JM,Maire P,Jelliffe RW

    更新日期:1996-01-01 00:00:00

  • Acute effects of drinking grapefruit juice on the pharmacokinetics and dynamics of felodipine--and its potential clinical relevance.

    abstract::The effect of drinking grapefruit juice on the acute pharmacokinetic and haemodynamic actions of the dihydropyridine calcium antagonist felodipine given as a 5 mg plain tablet has been studied in nine, healthy, middle-aged males. Compared to water, grapefruit juice caused an increase in Cmax from mean 6 to 16 nmol.l-1...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00266354

    authors: Edgar B,Bailey D,Bergstrand R,Johnsson G,Regårdh CG

    更新日期:1992-01-01 00:00:00

  • A double blind comparative trial of nomifensin and desimipramine in depression. Relationship between treatment and phenylethylamine excretion.

    abstract::The effect of nomifensin (Hoechst 36984), a synthetic psychotropic drug whose structure differs from MAO inhibitors and tricyclics, was studied in a double blind comparative trial with desimipramine in patients with various depressive syndromes. Forty-three patients (23 in the nomifensin group and 20 in the desimipram...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF00609468

    authors: Acébal E,Subirá S,Spatz J,Faleni R,Merzbacher B,Gales A,Moizeszowicz J

    更新日期:1976-06-15 00:00:00

  • The cardiovascular and central nervous system effects in the human of U-62066E. A selective opioid receptor agonist.

    abstract::The cardiovascular and central nervous system effects of the kappa opioid receptor agonist U-62066E were investigated in ten normal male subjects who received U-62066E or placebo with low or high dose naloxone in a randomized, double blind study. Blood pressure and heart rate in the supine and standing position, plasm...

    journal_title:European journal of clinical pharmacology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/BF00192549

    authors: Rimoy GH,Wright DM,Bhaskar NK,Rubin PC

    更新日期:1994-01-01 00:00:00

  • Methylergometrine antagonizes 5 HT in the temporal artery.

    abstract::Methylergometrine, the main metabolite of methysergide, has 40-times greater 5 HT antagonistic potency than methysergide in isolated segments of human temporal artery. It is suggested that methylergometrine is the "active" drug when methysergide is used in migraine prophylaxis, and that the two compounds should be com...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00610384

    authors: Tfelt-Hansen P,Jansen I,Edvinsson L

    更新日期:1987-01-01 00:00:00

  • Efficacy and safety of BRAF inhibitors and anti-CTLA4 antibody in melanoma patients-real-world data.

    abstract:PURPOSE:In the management of melanoma, BRAF inhibitors yield fast disease control; however, the duration of response does not last very long. Ipilimumab-an anti-CTLA4 antibody on the other hand-provides longer-lasting results of treatment but achieves less favorable responses. The aim of this study was to assess the ef...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/s00228-018-2590-6

    authors: Polkowska M,Ekk-Cierniakowski P,Czepielewska E,Kozłowska-Wojciechowska M

    更新日期:2019-03-01 00:00:00

  • Pharmacokinetics of cephacetrile in patients undergoing haemodialysis.

    abstract::The pharmacokinetics of cephacetrile were studied after its administration as a single i.v. bolus injection of 15 mg/kg body weight to 11 patients with terminal renal inpairment undergoing haemodialysis for 6 h. A two-compartment kinetic model was used to describe the biphasic decrease in plasma concentration. The qua...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00644966

    authors: Dominguez-Gil A,Lanao JM,Tabernero JM,Rodriguez Commes JL,de Castro S

    更新日期:1979-08-01 00:00:00

  • Transient neutropenia after intravenous injection of vindesine in patients with lung cancer.

    abstract::We have found transient circulating neutropenia and pulmonary sequestration of neutrophils after the intravenous injection of vindesine, a microtubule disruptor. Experiment 1 Ten patients with lung cancer were given a bolus intravenous injection of 3 mg.m-2 vindesine (Fildesine(r)). In all patients, total leukocyte an...

    journal_title:European journal of clinical pharmacology

    pub_type: 杂志文章

    doi:10.1007/BF00193474

    authors: Aoshiba K,Nagai A,Ueno H,Konno K

    更新日期:1994-01-01 00:00:00