Kinetic modeling of Chinese hamster ovary cell culture: factors and principles.

abstract：:Small RNAs (sRNA) are reported to play pivotal roles in the epigenetic and post-transcriptional regulation of gene expression during growth, development, and stress response in plants. Recently, the involvement of two different classes of sRNAs namely, miRNAs (microRNAs), and siRNAs (small interfering RNAs) in biotic ...

journal_title：Critical reviews in biotechnology

authors： Prasad A,Sharma N,Muthamilarasan M,Rana S,Prasad M

更新日期：2019-06-01 00:00:00

abstract：:Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, often pose a serious risk not only when delivered in the bloodstream but also in air, the environment and several industrial fields such as pharmaceutics or food. LPS is constituted of three regions; the O-specific chain, th...

journal_title：Critical reviews in biotechnology

authors： Basauri A,González-Fernández C,Fallanza M,Bringas E,Fernandez-Lopez R,Giner L,Moncalián G,de la Cruz F,Ortiz I

更新日期：2020-05-01 00:00:00

abstract：:The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from...

journal_title：Critical reviews in biotechnology

authors： Brinegar K,K Yetisen A,Choi S,Vallillo E,Ruiz-Esparza GU,Prabhakar AM,Khademhosseini A,Yun SH

更新日期：2017-11-01 00:00:00

abstract：:Microbial diversity provides an immense reservoir of functions and supports key steps in maintaining ecosystem balance through matter decomposition processes and nutrient recycling. The use of microorganisms for biomolecule production is now common, but often involves single-strain cultures. In this review, we highlig...

journal_title：Critical reviews in biotechnology

authors： Jobard M,Pessiot J,Nouaille R,Fonty G,Sime-Ngando T

更新日期：2017-02-01 00:00:00

abstract：:Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the industrial production of amino acids, such as glutamate and lysine, for decades. Due to several characteristics - its ability to secrete properly folded and functional target proteins into culture broth, its low levels of endogenous ex...

journal_title：Critical reviews in biotechnology

authors： Liu X,Zhang W,Zhao Z,Dai X,Yang Y,Bai Z

更新日期：2017-06-01 00:00:00

abstract：:The availability of binders to different functional domains of the same protein or to physiologically co-operating proteins allows for the simultaneous inhibition of independent downstream signaling pathways. This multi-target approach represents a promising therapeutic strategy, as demonstrated in the case of the syn...

journal_title：Critical reviews in biotechnology

authors： de Marco A

更新日期：2013-03-01 00:00:00

abstract：:Alginate has been widely used in various applications since its first extraction. What makes this biopolymer useful is its high biocompatibility and humid gelation conditions. Both of these features bring it into prominence as an ideal immobilization material. However, there are some complicated aspects of cell immobi...

journal_title：Critical reviews in biotechnology

authors： Selimoglu SM,Elibol M

更新日期：2010-06-01 00:00:00

abstract：:Lactic acid, an anaerobic product of glycolysis, can be theoretically produced by synthetic route; however, it is commercially produced by homo-fermentative batch mode of operations. Factors affecting its production and strategies improving it are considered while devising an optimized protocol. Although a hetero-ferm...

journal_title：Critical reviews in biotechnology

authors： Yadav AK,Chaudhari AB,Kothari RM

更新日期：2011-03-01 00:00:00

abstract：:Anthocyanin biosynthesis in Arabidopsis is a convenient and relatively simple model for investigating the basic principles of secondary metabolism regulation. In recent years, many publications have described links between anthocyanin biosynthesis and general defense reactions in plants as well as photomorphogenesis a...

journal_title：Critical reviews in biotechnology

authors： Bulgakov VP,Avramenko TV,Tsitsiashvili GS

更新日期：2017-09-01 00:00:00

abstract：:Affinity tags are vital tools for the production of high-throughput recombinant proteins. Several affinity tags, such as the hexahistidine tag, maltose-binding protein, streptavidin-binding peptide tag, calmodulin-binding peptide, c-Myc tag, glutathione S-transferase and FLAG tag, have been introduced for recombinant ...

journal_title：Critical reviews in biotechnology

authors： Soleimanpour S,Hassannia T,Motiee M,Amini AA,Rezaee SA

更新日期：2017-05-01 00:00:00

abstract：:Terpenes are natural products with a remarkable diversity in their chemical structures and they hold a significant market share commercially owing to their distinct applications. These potential molecules are usually derived from terrestrial plants, marine and microbial sources. In vitro production of terpenes using p...

journal_title：Critical reviews in biotechnology

authors： Paramasivan K,Mutturi S

更新日期：2017-12-01 00:00:00

abstract：:Many reporter genes, such as gfp, gusA, and lacZ, are widely used for research into plants, animals, and microorganisms. Reporter genes, which offer high levels of sensitivity and convenience of detection, have been utilized in transgenic technology, promoter analysis, drug screening, and other areas. Directed molecul...

journal_title：Critical reviews in biotechnology

authors： Xiong AS,Peng RH,Zhuang J,Davies J,Zhang J,Yao QH

更新日期：2012-06-01 00:00:00

abstract：:Aerobic granules are the potential tools to develop modern wastewater treatment technologies with improved nutrient removal efficiency. These granules have several promising advantages over conventional activated sludge-based wastewater treatment processes. This technology has the potential of reducing the infrastruct...

journal_title：Critical reviews in biotechnology

authors： Sarma SJ,Tay JH

更新日期：2018-11-01 00:00:00

abstract：:Filamentous fungi comprise an abundance of gene clusters that encode high-value metabolites, whereas affluent gene clusters remain silent during laboratory conditions. Complex cellular metabolism further limits these metabolite yields. Therefore, diverse strategies such as genetic engineering and chemical mutagenesis ...

journal_title：Critical reviews in biotechnology

authors： Deng H,Bai Y,Fan TP,Zheng X,Cai Y

更新日期：2020-03-01 00:00:00

abstract：:The beneficial effects of endophytes on plant growth are important for agricultural ecosystems because they reduce the need for fertilizers and decrease soil and water pollution while compensating for environmental perturbations. Endophytic fungi are a novel source of bioactive secondary metabolites; moreover, recentl...

journal_title：Critical reviews in biotechnology

authors： Khan AL,Hussain J,Al-Harrasi A,Al-Rawahi A,Lee IJ

更新日期：2015-03-01 00:00:00

abstract：:Endotoxin is a type of pyrogen that can be found in Gram-negative bacteria. Endotoxin can form a stable interaction with other biomolecules thus making its removal difficult especially during the production of biopharmaceutical drugs. The prevention of endotoxins from contaminating biopharmaceutical products is paramo...

journal_title：Critical reviews in biotechnology

authors： Dullah EC,Ongkudon CM

更新日期：2017-03-01 00:00:00

abstract：:Due to serious eutrophication in water bodies, nitrogen removal has become a critical stage for wastewater treatment plants (WWTPs) over past decades. Conventional biological nitrogen removal processes are based on nitrification and denitrification (N/DN), and are suffering from several major drawbacks, including subs...

journal_title：Critical reviews in biotechnology

authors： Liu T,Hu S,Guo J

更新日期：2019-08-01 00:00:00

abstract：:Cancer is a clinical situation caused by uncontrolled cell division and is responsible for a large number of deaths worldwide. Colchicine is a classical antimitotic, tubulin-binding agent (TBA) which is being explored for its antitumor activities, although its tubulin-binding ability leads to some toxicity toward norm...

journal_title：Critical reviews in biotechnology

authors： Dubey KK,Kumar P,Labrou NE,Shukla P

更新日期：2017-12-01 00:00:00

abstract：:Nitrilases are widely distributed in nature and are able to hydrolyze nitriles into their corresponding carboxylic acids and ammonia. In industry, nitrilases have been used as green biocatalysts for the production of high value-added products. To date, biocatalysts are considered to be important alternatives to chemic...

journal_title：Critical reviews in biotechnology

authors： Shen JD,Cai X,Liu ZQ,Zheng YG

更新日期：2021-02-01 00:00:00

abstract：:Prokaryotic expression systems are superior in producing valuable recombinant proteins, enzymes and therapeutic products. Conventional microbial technology is evolving gradually and amalgamated with advanced technologies in order to give rise to improved processes for the production of metabolites, recombinant biophar...

journal_title：Critical reviews in biotechnology

authors： Gupta SK,Shukla P

更新日期：2016-12-01 00:00:00

abstract：:Fungal biopolymers have gained considerable attention from the scientific community for various applications due to their biological and physicochemical properties. The wide applications in several areas, especially in the food industry as a bioemulsifier and in the agricultural area as a biosurfactant, have expanded ...

journal_title：Critical reviews in biotechnology

authors： Luft L,Confortin TC,Todero I,Zabot GL,Mazutti MA

更新日期：2020-12-01 00:00:00

abstract：:Microbial bio-transformations of the essential trace element selenium are now recognized to occur among a wide variety of microorganisms. These transformations are used to convert this element into its assimilated form of selenocysteine, which is at the active center of a number of key enzymes, and to produce selenium...

journal_title：Critical reviews in biotechnology

authors： Ojeda JJ,Merroun ML,Tugarova AV,Lampis S,Kamnev AA,Gardiner PHE

更新日期：2020-12-01 00:00:00

abstract：:Proteases have a broad range of applications in industrial processes and products and are representative of most worldwide enzyme sales. The genus Bacillus is probably the most important bacterial source of proteases and is capable of producing high yields of neutral and alkaline proteolytic enzymes with remarkable pr...

journal_title：Critical reviews in biotechnology

authors： Contesini FJ,Melo RR,Sato HH

更新日期：2018-05-01 00:00:00

abstract：:The role of selenium (Se) in human health and diseases has been discussed in detail in several recent reviews, with the main conclusion being that selenium deficiency is recognised as a global problem which urgently needs resolution. Since selenium content in plant-based food depends on its availability from soil, the...

journal_title：Critical reviews in biotechnology

authors： Fisinin VI,Papazyan TT,Surai PF

更新日期：2009-01-01 00:00:00

abstract：:Microorganisms produce biosurfactant (BS)/bioemulsifier (BE) with wide structural and functional diversity which consequently results in the adoption of different techniques to investigate these diverse amphiphilic molecules. This review aims to compile information on different microbial screening methods, surface act...

journal_title：Critical reviews in biotechnology

authors： Satpute SK,Banpurkar AG,Dhakephalkar PK,Banat IM,Chopade BA

更新日期：2010-06-01 00:00:00

abstract：:Recombinant DNA technology enables the creation of well-defined alterations in the genetic material of an organism. Methods to manipulate recombinant DNA in the filamentous fungi (a group of microorganisms that includes species of academic as well as commercial interest) have recently been developed. This has been the...

journal_title：Critical reviews in biotechnology

authors： Rambosek J,Leach J

更新日期：1987-01-01 00:00:00

abstract：:Since several decades ago, the application of pervaporation (PV) technology has been mainly aimed at the separation of different types of water-organic, organic-water and organic-organic mixtures, reaching its large-scale application in industry for the dehydration of organics. Today, the versatility and high selectiv...

journal_title：Critical reviews in biotechnology

authors： Castro-Muñoz R,Galiano F,Figoli A

更新日期：2019-11-01 00:00:00

abstract：:Metabolic engineering is crucial in the development of production strains for platform chemicals, pharmaceuticals and biomaterials from renewable resources. The central carbon metabolism (CCM) of heterotrophs plays an essential role in the conversion of biomass to the cellular building blocks required for growth. Yet,...

journal_title：Critical reviews in biotechnology

authors： Kopp D,Sunna A

更新日期：2020-11-01 00:00:00

abstract：:Biocatalysis in non-aqueous media has undergone tremendous development during the last decade, and numerous reactions have been introduced and optimized for synthetic applications. In contrast to aqueous enzymology, biotransformations in organic solvents offer unique industrially attractive advantages, such as: drasti...

journal_title：Critical reviews in biotechnology

authors： Castro GR,Knubovets T

更新日期：2003-01-01 00:00:00

abstract：:Natural cellular microenvironment consists of spatiotemporal gradients of multiple physical (e.g. extracellular matrix stiffness, porosity and stress/strain) and chemical cues (e.g. morphogens), which play important roles in regulating cell behaviors including spreading, proliferation, migration, differentiation and a...

journal_title：Critical reviews in biotechnology

authors： Wang L,Li Y,Huang G,Zhang X,Pingguan-Murphy B,Gao B,Lu TJ,Xu F

更新日期：2016-01-01 00:00:00