Abstract:
:Filamentous fungi comprise an abundance of gene clusters that encode high-value metabolites, whereas affluent gene clusters remain silent during laboratory conditions. Complex cellular metabolism further limits these metabolite yields. Therefore, diverse strategies such as genetic engineering and chemical mutagenesis have been developed to activate these cryptic pathways and improve metabolite productivity. However, lower efficiencies of gene modifications and screen tools delayed the above processes. To address the above issues, this review describes an alternative design-construction evaluation optimization (DCEO) approach. The DCEO tool provides theoretical and practical principles to identify potential pathways, modify endogenous pathways, integrate exogenous pathways, and exploit novel pathways for their diverse metabolites and desirable productivities. This DCEO method also offers different tactics to balance the cellular metabolisms, facilitate the genetic engineering, and exploit the scalable metabolites in filamentous fungi.
journal_name
Crit Rev Biotechnoljournal_title
Critical reviews in biotechnologyauthors
Deng H,Bai Y,Fan TP,Zheng X,Cai Ydoi
10.1080/07388551.2019.1709798subject
Has Abstractpub_date
2020-03-01 00:00:00pages
180-198issue
2eissn
0738-8551issn
1549-7801journal_volume
40pub_type
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