The commercialization of genome-editing technologies.

abstract：:Over the past few decades, a considerable attention has been focused on the microbial polyhydroxyalkanoates (PHAs) owing to its multifaceted properties, i.e. biodegradability, biocompatibility, non-toxicity and thermo-plasticity. This article presents a critical review of the foregoing research, current trends and fut...

journal_title：Critical reviews in biotechnology

authors： Masood F,Yasin T,Hameed A

更新日期：2015-01-01 00:00:00

abstract：:Semisynthetic cephalosporins are important antibacterials in clinical practice. Semisynthetic cephalosporins are manufactured by derivatizing 7-aminocephalosporanic acid (7-ACA) and its desacetylated form. Microbial enzymes such as D-amino acid oxidase, glutaryl-7-ACA acylase and cephalosporin esterase are being used ...

journal_title：Critical reviews in biotechnology

authors： Sonawane VC

更新日期：2006-04-01 00:00:00

abstract：:Innovation holds the potential for economic prosperity. Biotechnology (BT) has proved to be a viable vehicle for the development and utilization of technologies, which has brought not only advances to society, but also career opportunities to nation-states that have enabling conditions. In this review, we assess the c...

journal_title：Critical reviews in biotechnology

authors： Dettenhofer M,Ondrejovič M,Slavica A,Kurtanjek Ž,Tapaloaga D,Rodian Tapaloaga P,Kapur Pojskić L,Durmić-Pašić A,Begović J,Nedović V,Dundar M,Gartland KMA,Miertuš S

更新日期：2019-02-01 00:00:00

abstract：:Microbial bio-transformations of the essential trace element selenium are now recognized to occur among a wide variety of microorganisms. These transformations are used to convert this element into its assimilated form of selenocysteine, which is at the active center of a number of key enzymes, and to produce selenium...

journal_title：Critical reviews in biotechnology

authors： Ojeda JJ,Merroun ML,Tugarova AV,Lampis S,Kamnev AA,Gardiner PHE

更新日期：2020-12-01 00:00:00

abstract：:Metabolic engineering is crucial in the development of production strains for platform chemicals, pharmaceuticals and biomaterials from renewable resources. The central carbon metabolism (CCM) of heterotrophs plays an essential role in the conversion of biomass to the cellular building blocks required for growth. Yet,...

journal_title：Critical reviews in biotechnology

authors： Kopp D,Sunna A

更新日期：2020-11-01 00:00:00

abstract：:The enzyme α-galactosidase (α-D-galactoside galactohydrolase; EC 3.2.1.22) catalyzes the hydrolysis of α-1,6-linked galactose residues in oligosaccharides and polymeric galactomannan. The α-galactosidases are of particular interest in view of their many potential biotechnological and medical applications. These enzyme...

journal_title：Critical reviews in biotechnology

authors： Katrolia P,Rajashekhara E,Yan Q,Jiang Z

更新日期：2014-12-01 00:00:00

abstract：:Prokaryotic expression systems are superior in producing valuable recombinant proteins, enzymes and therapeutic products. Conventional microbial technology is evolving gradually and amalgamated with advanced technologies in order to give rise to improved processes for the production of metabolites, recombinant biophar...

journal_title：Critical reviews in biotechnology

authors： Gupta SK,Shukla P

更新日期：2016-12-01 00:00:00

abstract：:Many reporter genes, such as gfp, gusA, and lacZ, are widely used for research into plants, animals, and microorganisms. Reporter genes, which offer high levels of sensitivity and convenience of detection, have been utilized in transgenic technology, promoter analysis, drug screening, and other areas. Directed molecul...

journal_title：Critical reviews in biotechnology

authors： Xiong AS,Peng RH,Zhuang J,Davies J,Zhang J,Yao QH

更新日期：2012-06-01 00:00:00

abstract：:Terpenes are natural products with a remarkable diversity in their chemical structures and they hold a significant market share commercially owing to their distinct applications. These potential molecules are usually derived from terrestrial plants, marine and microbial sources. In vitro production of terpenes using p...

journal_title：Critical reviews in biotechnology

authors： Paramasivan K,Mutturi S

更新日期：2017-12-01 00:00:00

abstract：:Biocatalysis in non-aqueous media has undergone tremendous development during the last decade, and numerous reactions have been introduced and optimized for synthetic applications. In contrast to aqueous enzymology, biotransformations in organic solvents offer unique industrially attractive advantages, such as: drasti...

journal_title：Critical reviews in biotechnology

authors： Castro GR,Knubovets T

更新日期：2003-01-01 00:00:00

abstract：:Mushrooms have become increasingly important as a reliable food source. They have also been recognized as an important source of bioactive compounds of high nutritional and medicinal values. The nucleobases, nucleosides and nucleotides found in mushrooms play important roles in the regulation of various physiological ...

journal_title：Critical reviews in biotechnology

authors： Phan CW,Wang JK,Cheah SC,Naidu M,David P,Sabaratnam V

更新日期：2018-08-01 00:00:00

abstract：:Second generation biofuel production depends on lignocellulosic (LC) biomass transformation into simple sugars and their subsequent fermentation into alcohols. However, the main obstacle in this process is the efficient breakdown of the recalcitrant cellulose to sugar monomers. Hence, efficient feedstock pretreatment ...

journal_title：Critical reviews in biotechnology

authors： Portillo Mdel C,Saadeddin A

更新日期：2015-01-01 00:00:00

abstract：:Global gel-free proteomic analysis by mass spectrometry has been widely used as an important tool for exploring complex biological systems at the whole genome level. Simultaneous analysis of a large number of protein species is a complicated and challenging task. The challenges exist throughout all stages of a global ...

journal_title：Critical reviews in biotechnology

authors： Nie L,Wu G,Zhang W

更新日期：2008-01-01 00:00:00

abstract：:Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the industrial production of amino acids, such as glutamate and lysine, for decades. Due to several characteristics - its ability to secrete properly folded and functional target proteins into culture broth, its low levels of endogenous ex...

journal_title：Critical reviews in biotechnology

authors： Liu X,Zhang W,Zhao Z,Dai X,Yang Y,Bai Z

更新日期：2017-06-01 00:00:00

abstract：:Protein glycosylation is post-translational modification (PTM) which is important for pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result of variations in monosaccharide composition, glycosidic linkages and glycan branching, glycosylation introduces considerable complexity and het...

journal_title：Critical reviews in biotechnology

authors： Goh JB,Ng SK

更新日期：2018-09-01 00:00:00

abstract：:The 2014 Ebola outbreak, the largest recorded, took us largely unprepared, with no available vaccine or specific treatment. In this context, the World Health Organization declared that the humanitarian use of experimental therapies against Ebola Virus (EBOV) is ethical. In particular, an experimental treatment consist...

journal_title：Critical reviews in biotechnology

authors： González-González E,Alvarez MM,Márquez-Ipiña AR,Trujillo-de Santiago G,Rodríguez-Martínez LM,Annabi N,Khademhosseini A

更新日期：2017-02-01 00:00:00

abstract：:The beneficial effects of endophytes on plant growth are important for agricultural ecosystems because they reduce the need for fertilizers and decrease soil and water pollution while compensating for environmental perturbations. Endophytic fungi are a novel source of bioactive secondary metabolites; moreover, recentl...

journal_title：Critical reviews in biotechnology

authors： Khan AL,Hussain J,Al-Harrasi A,Al-Rawahi A,Lee IJ

更新日期：2015-03-01 00:00:00

abstract：:In recent years, foods that contain omega-3 lipids have emerged as important promoters of human health. These lipids are essential for the functional development of the brain and retina, and reduction of the risk of cardiovascular and Alzheimer's diseases. The global market for omega-3 production, particularly docosah...

journal_title：Critical reviews in biotechnology

authors： Finco AMO,Mamani LDG,Carvalho JC,de Melo Pereira GV,Thomaz-Soccol V,Soccol CR

更新日期：2017-08-01 00:00:00

abstract：:Chitosan, copolymer of glucosamine and N-acetyl glucosamine is mainly derived from chitin, which is present in cell walls of crustaceans and some other microorganisms, such as fungi. Chitosan is emerging as an important biopolymer having a broad range of applications in different fields. On a commercial scale, chitosa...

journal_title：Critical reviews in biotechnology

authors： Dhillon GS,Kaur S,Brar SK,Verma M

更新日期：2013-12-01 00:00:00

abstract：:Heavy metals are found in their different forms in the environment. The distribution, mobility, and toxicity of metals are strongly related to these different forms. This necessitates the exploration of different methods for the remediation and speciation of heavy metals. Some direct and indirect physico-chemical meth...

journal_title：Critical reviews in biotechnology

authors： Singh N,Gadi R

更新日期：2009-01-01 00:00:00

abstract：:Proteases have a broad range of applications in industrial processes and products and are representative of most worldwide enzyme sales. The genus Bacillus is probably the most important bacterial source of proteases and is capable of producing high yields of neutral and alkaline proteolytic enzymes with remarkable pr...

journal_title：Critical reviews in biotechnology

authors： Contesini FJ,Melo RR,Sato HH

更新日期：2018-05-01 00:00:00

abstract：:Lactic acid, an anaerobic product of glycolysis, can be theoretically produced by synthetic route; however, it is commercially produced by homo-fermentative batch mode of operations. Factors affecting its production and strategies improving it are considered while devising an optimized protocol. Although a hetero-ferm...

journal_title：Critical reviews in biotechnology

authors： Yadav AK,Chaudhari AB,Kothari RM

更新日期：2011-03-01 00:00:00

abstract：:Bacteriocins produced by lactic acid bacteria (LAB) are well-recognized for their potential as natural food preservatives. These antimicrobial peptides usually do not change the sensorial properties of food products and can be used in combination with traditional preservation methods to ensure microbial stability. In ...

journal_title：Critical reviews in biotechnology

authors： Barbosa AAT,Mantovani HC,Jain S

更新日期：2017-11-01 00:00:00

abstract：:Abiotic stress has become a challenge to food security due to occurrences of climate change and environmental degradation. Plants initiate molecular, cellular and physiological changes to respond and adapt to various types of abiotic stress. Understanding of plant response mechanisms will aid in strategies aimed at im...

journal_title：Critical reviews in biotechnology

authors： Srivastava AK,Penna S,Nguyen DV,Tran LS

更新日期：2016-01-01 00:00:00

abstract：:Human body harbors diverse microbes, the main components include bacteria, eukaryotes and viruses. Emerging evidences show that the human microbiota is intrinsically linked with overall health. The development of next-generation sequencing provides an unprecedented opportunity to investigate the complex microbial comm...

journal_title：Critical reviews in biotechnology

authors： Xu X,Wang Z,Zhang X

更新日期：2015-03-01 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) form widespread symbiotic associations with 80% of known land plants. They play a major role in plant nutrition, growth, water absorption, nutrient cycling and protection from pathogens, and as a result, contribute to ecosystem processes. Salinity stress conditions undoubtedly limit ...

journal_title：Critical reviews in biotechnology

authors： Kumar A,Dames JF,Gupta A,Sharma S,Gilbert JA,Ahmad P

更新日期：2015-01-01 00:00:00

abstract：:Natural cellular microenvironment consists of spatiotemporal gradients of multiple physical (e.g. extracellular matrix stiffness, porosity and stress/strain) and chemical cues (e.g. morphogens), which play important roles in regulating cell behaviors including spreading, proliferation, migration, differentiation and a...

journal_title：Critical reviews in biotechnology

authors： Wang L,Li Y,Huang G,Zhang X,Pingguan-Murphy B,Gao B,Lu TJ,Xu F

更新日期：2016-01-01 00:00:00

abstract：:Since several decades ago, the application of pervaporation (PV) technology has been mainly aimed at the separation of different types of water-organic, organic-water and organic-organic mixtures, reaching its large-scale application in industry for the dehydration of organics. Today, the versatility and high selectiv...

journal_title：Critical reviews in biotechnology

authors： Castro-Muñoz R,Galiano F,Figoli A

更新日期：2019-11-01 00:00:00

abstract：:Nitrilases are widely distributed in nature and are able to hydrolyze nitriles into their corresponding carboxylic acids and ammonia. In industry, nitrilases have been used as green biocatalysts for the production of high value-added products. To date, biocatalysts are considered to be important alternatives to chemic...

journal_title：Critical reviews in biotechnology

authors： Shen JD,Cai X,Liu ZQ,Zheng YG

更新日期：2021-02-01 00:00:00

abstract：:Endophytic microbes are present in nearly all of the plant species known to date but how they enter and flourish inside a host plant and display multiple benefits like plant growth promotion (PGP), biodegradation, and stress alleviation are still unexplored. Until now, the majority of the research has been conducted a...

journal_title：Critical reviews in biotechnology

authors： Dubey A,Malla MA,Kumar A,Dayanandan S,Khan ML

更新日期：2020-12-01 00:00:00