Hooked on α-d-galactosidases: from biomedicine to enzymatic synthesis.

abstract：:Over the past few decades, a considerable attention has been focused on the microbial polyhydroxyalkanoates (PHAs) owing to its multifaceted properties, i.e. biodegradability, biocompatibility, non-toxicity and thermo-plasticity. This article presents a critical review of the foregoing research, current trends and fut...

journal_title：Critical reviews in biotechnology

authors： Masood F,Yasin T,Hameed A

更新日期：2015-01-01 00:00:00

abstract：:Due to serious eutrophication in water bodies, nitrogen removal has become a critical stage for wastewater treatment plants (WWTPs) over past decades. Conventional biological nitrogen removal processes are based on nitrification and denitrification (N/DN), and are suffering from several major drawbacks, including subs...

journal_title：Critical reviews in biotechnology

authors： Liu T,Hu S,Guo J

更新日期：2019-08-01 00:00:00

abstract：:Global gel-free proteomic analysis by mass spectrometry has been widely used as an important tool for exploring complex biological systems at the whole genome level. Simultaneous analysis of a large number of protein species is a complicated and challenging task. The challenges exist throughout all stages of a global ...

journal_title：Critical reviews in biotechnology

authors： Nie L,Wu G,Zhang W

更新日期：2008-01-01 00:00:00

abstract：:The availability of binders to different functional domains of the same protein or to physiologically co-operating proteins allows for the simultaneous inhibition of independent downstream signaling pathways. This multi-target approach represents a promising therapeutic strategy, as demonstrated in the case of the syn...

journal_title：Critical reviews in biotechnology

authors： de Marco A

更新日期：2013-03-01 00:00:00

abstract：:Lactic acid, an anaerobic product of glycolysis, can be theoretically produced by synthetic route; however, it is commercially produced by homo-fermentative batch mode of operations. Factors affecting its production and strategies improving it are considered while devising an optimized protocol. Although a hetero-ferm...

journal_title：Critical reviews in biotechnology

authors： Yadav AK,Chaudhari AB,Kothari RM

更新日期：2011-03-01 00:00:00

abstract：:Innovation holds the potential for economic prosperity. Biotechnology (BT) has proved to be a viable vehicle for the development and utilization of technologies, which has brought not only advances to society, but also career opportunities to nation-states that have enabling conditions. In this review, we assess the c...

journal_title：Critical reviews in biotechnology

authors： Dettenhofer M,Ondrejovič M,Slavica A,Kurtanjek Ž,Tapaloaga D,Rodian Tapaloaga P,Kapur Pojskić L,Durmić-Pašić A,Begović J,Nedović V,Dundar M,Gartland KMA,Miertuš S

更新日期：2019-02-01 00:00:00

abstract：:A large number of rice agronomic traits are complex, multi factorial and polygenic. As the mechanisms and genes determining grain size and yield are largely unknown, the identification of regulatory genes related to grain development remains a preeminent approach in rice genetic studies and breeding programs. Genes re...

journal_title：Critical reviews in biotechnology

authors： Azizi P,Osman M,Hanafi MM,Sahebi M,Rafii MY,Taheri S,Harikrishna JA,Tarinejad AR,Mat Sharani S,Yusuf MN

更新日期：2019-11-01 00:00:00

abstract：:As a host for therapeutic protein expression, Chinese hamster ovary (CHO) cells are widely utilized in the mainstream biopharmaceutical industry. Cell culture process development plays an important role in transitioning laboratory research to manufacturing. Among different mathematic tools, kinetic modeling is commonl...

journal_title：Critical reviews in biotechnology

authors： Tang P,Xu J,Louey A,Tan Z,Yongky A,Liang S,Li ZJ,Weng Y,Liu S

更新日期：2020-03-01 00:00:00

abstract：:Butanol is a precursor of many industrial chemicals, and a fuel that is more energetic, safer and easier to handle than ethanol. Fermentative biobutanol can be produced using renewable carbon sources such as agro-industrial residues and lignocellulosic biomass. Solventogenic clostridia are known as the most preeminent...

journal_title：Critical reviews in biotechnology

authors： Jiménez-Bonilla P,Wang Y

更新日期：2018-05-01 00:00:00

abstract：:The 2014 Ebola outbreak, the largest recorded, took us largely unprepared, with no available vaccine or specific treatment. In this context, the World Health Organization declared that the humanitarian use of experimental therapies against Ebola Virus (EBOV) is ethical. In particular, an experimental treatment consist...

journal_title：Critical reviews in biotechnology

authors： González-González E,Alvarez MM,Márquez-Ipiña AR,Trujillo-de Santiago G,Rodríguez-Martínez LM,Annabi N,Khademhosseini A

更新日期：2017-02-01 00:00:00

abstract：:Briskly evolving phytopathogens are dire threats to our food supplies and threaten global food security. From the recent advances made toward high-throughput sequencing technologies, understanding of pathogenesis and effector biology, and plant innate immunity, translation of these means into new control tools is bein...

journal_title：Critical reviews in biotechnology

authors： Nejat N,Rookes J,Mantri NL,Cahill DM

更新日期：2017-03-01 00:00:00

abstract：:Plant based medicines have gained popularity worldwide due to their almost negligible side effects. In India, the three traditional medicinal systems, namely homeopathy, Ayurveda and Siddha rely heavily on plants for medicinal formulations. To prevent the indiscriminate collection of these valuable medicinal plants an...

journal_title：Critical reviews in biotechnology

authors： Sarwat M,Nabi G,Das S,Srivastava PS

更新日期：2012-03-01 00:00:00

abstract：:Cancer is a clinical situation caused by uncontrolled cell division and is responsible for a large number of deaths worldwide. Colchicine is a classical antimitotic, tubulin-binding agent (TBA) which is being explored for its antitumor activities, although its tubulin-binding ability leads to some toxicity toward norm...

journal_title：Critical reviews in biotechnology

authors： Dubey KK,Kumar P,Labrou NE,Shukla P

更新日期：2017-12-01 00:00:00

abstract：:The emergence of new gene-editing technologies is profoundly transforming human therapeutics, agriculture, and industrial biotechnology. Advances in clustered regularly interspaced short palindromic repeats (CRISPR) have created a fertile environment for mass-scale manufacturing of cost-effective products ranging from...

journal_title：Critical reviews in biotechnology

authors： Brinegar K,K Yetisen A,Choi S,Vallillo E,Ruiz-Esparza GU,Prabhakar AM,Khademhosseini A,Yun SH

更新日期：2017-11-01 00:00:00

abstract：:Since several decades ago, the application of pervaporation (PV) technology has been mainly aimed at the separation of different types of water-organic, organic-water and organic-organic mixtures, reaching its large-scale application in industry for the dehydration of organics. Today, the versatility and high selectiv...

journal_title：Critical reviews in biotechnology

authors： Castro-Muñoz R,Galiano F,Figoli A

更新日期：2019-11-01 00:00:00

abstract：:Triacylglycerol (TAG) serves as an energy reservoir and phospholipids as build blocks of biomembrane to support plant life. They also provide human with foods and nutrients. Multi-compartmentalized biosynthesis, trafficking or cross-membrane transport of lipid intermediates or precursors and their regulatory mechanism...

journal_title：Critical reviews in biotechnology

authors： Manan S,Chen B,She G,Wan X,Zhao J

更新日期：2017-08-01 00:00:00

abstract：:Utilization of microbial oil for biodiesel production has gained growing interest due to the increase in prices and the shortage of the oils and fats traditionally used in biodiesel production. However, it is still in the laboratory study stage due to the high cost of production. Employing organic wastes as raw materi...

journal_title：Critical reviews in biotechnology

authors： Chen J,Li J,Zhang X,Tyagi RD,Dong W

更新日期：2018-09-01 00:00:00

abstract：:Fungal biopolymers have gained considerable attention from the scientific community for various applications due to their biological and physicochemical properties. The wide applications in several areas, especially in the food industry as a bioemulsifier and in the agricultural area as a biosurfactant, have expanded ...

journal_title：Critical reviews in biotechnology

authors： Luft L,Confortin TC,Todero I,Zabot GL,Mazutti MA

更新日期：2020-12-01 00:00:00

abstract：:Protein glycosylation is post-translational modification (PTM) which is important for pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result of variations in monosaccharide composition, glycosidic linkages and glycan branching, glycosylation introduces considerable complexity and het...

journal_title：Critical reviews in biotechnology

authors： Goh JB,Ng SK

更新日期：2018-09-01 00:00:00

abstract：:Microbial diversity provides an immense reservoir of functions and supports key steps in maintaining ecosystem balance through matter decomposition processes and nutrient recycling. The use of microorganisms for biomolecule production is now common, but often involves single-strain cultures. In this review, we highlig...

journal_title：Critical reviews in biotechnology

authors： Jobard M,Pessiot J,Nouaille R,Fonty G,Sime-Ngando T

更新日期：2017-02-01 00:00:00

abstract：:Erythritol is a natural sweetener commonly used in the food and pharmaceutical industries. Produced by microorganisms as an osmoprotectant, it is an ideal sucrose substitute for diabetics or overweight persons due to its almost zero calorie content. Currently, erythritol is produced on an industrial scale through the ...

journal_title：Critical reviews in biotechnology

authors： Rzechonek DA,Dobrowolski A,Rymowicz W,Mirończuk AM

更新日期：2018-06-01 00:00:00

abstract：:The beneficial effects of endophytes on plant growth are important for agricultural ecosystems because they reduce the need for fertilizers and decrease soil and water pollution while compensating for environmental perturbations. Endophytic fungi are a novel source of bioactive secondary metabolites; moreover, recentl...

journal_title：Critical reviews in biotechnology

authors： Khan AL,Hussain J,Al-Harrasi A,Al-Rawahi A,Lee IJ

更新日期：2015-03-01 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) form widespread symbiotic associations with 80% of known land plants. They play a major role in plant nutrition, growth, water absorption, nutrient cycling and protection from pathogens, and as a result, contribute to ecosystem processes. Salinity stress conditions undoubtedly limit ...

journal_title：Critical reviews in biotechnology

authors： Kumar A,Dames JF,Gupta A,Sharma S,Gilbert JA,Ahmad P

更新日期：2015-01-01 00:00:00

abstract：:Vitamin C (L-ascorbic acid; AsA) is the major soluble antioxidant found in plants and is also an essential component of human nutrition. Although numerous biotechnological methods have been exploited to increase its yield, pressures such as commercial competition and environmental concerns make it urgent to find a new...

journal_title：Critical reviews in biotechnology

authors： Zhang L,Wang Z,Xia Y,Kai G,Chen W,Tang K

更新日期：2007-07-01 00:00:00

abstract：:Anthocyanin biosynthesis in Arabidopsis is a convenient and relatively simple model for investigating the basic principles of secondary metabolism regulation. In recent years, many publications have described links between anthocyanin biosynthesis and general defense reactions in plants as well as photomorphogenesis a...

journal_title：Critical reviews in biotechnology

authors： Bulgakov VP,Avramenko TV,Tsitsiashvili GS

更新日期：2017-09-01 00:00:00

abstract：:Nitrilases are widely distributed in nature and are able to hydrolyze nitriles into their corresponding carboxylic acids and ammonia. In industry, nitrilases have been used as green biocatalysts for the production of high value-added products. To date, biocatalysts are considered to be important alternatives to chemic...

journal_title：Critical reviews in biotechnology

authors： Shen JD,Cai X,Liu ZQ,Zheng YG

更新日期：2021-02-01 00:00:00

abstract：:Cross-linked enzyme aggregate (CLEA) technology has been regarded as an effective carrier-free immobilization method. This method is very attractive due to its simplicity and robustness, as well as for the possibility of using the crude enzyme extract and the opportunity to co-immobilize multiple different enzymes. Th...

journal_title：Critical reviews in biotechnology

authors： Cui JD,Jia SR

更新日期：2015-03-01 00:00:00

abstract：:Filamentous fungi play an important role not only in the bio-manufacturing of value-added products, but also in bioenergy and environmental research. The bioprocess manipulation of filamentous fungi is more difficult than that of other microbial species because of their different pellet morphologies and the presence o...

journal_title：Critical reviews in biotechnology

authors： Zhang J,Zhang J

更新日期：2016-12-01 00:00:00

abstract：:Many algae have immense capability to sorb metals, and there is considerable potential for using them to treat wastewaters. Metal sorption involves binding on the cell surface and to intracellular ligands. The adsorbed metal is several times greater than intracellular metal. Carboxyl group is most important for metal ...

journal_title：Critical reviews in biotechnology

authors： Mehta SK,Gaur JP

更新日期：2005-07-01 00:00:00

abstract：:Hydrodynamic cavitation (HC) is a process technology with potential for application in different areas including environmental, food processing, and biofuels production. Although HC is an undesirable phenomenon for hydraulic equipment, the net energy released during this process is enough to accelerate certain chemica...

journal_title：Critical reviews in biotechnology

authors： Terán Hilares R,Ramos L,da Silva SS,Dragone G,Mussatto SI,Santos JCD

更新日期：2018-06-01 00:00:00