Current state and prospects of biotechnology in Central and Eastern European countries. Part II: new and preaccession EU countries(CRO, RO, B&H, SRB).

Abstract:

:Innovation holds the potential for economic prosperity. Biotechnology (BT) has proved to be a viable vehicle for the development and utilization of technologies, which has brought not only advances to society, but also career opportunities to nation-states that have enabling conditions. In this review, we assess the current state of BT-related activities within selected new and preaccession EU countries (NPA) of CEE region namely Croatia, Romania, Bosnia and Herzegovina and Serbia, examining educational programs, research activity, enterprises, and the financing systems. The field of BT covers a broad area of activities, including medical, food and agriculture, aquaculture or marine, environmental, biofuels, bioinformatics, and many others. Under the European Commission (EC), member-states are to set their Research and Innovation Strategies for Smart Specialization (RIS3), to identify priorities or strengths in order to develop knowledge intensive economies. As the four countries highlighted in this review are in the early stages of implementing RIS3 or have not yet fully formulated, it presents an opportunity to learn from the successes and failures of those that have already received major structural funds from the EC. A critical point will be the ability of the public and private sectors' actors to align, in the implementation of RIS3 as new investment instruments emerge, and to concentrate efforts on a few select target goals, rather than distribute funding widely without respect to a long-term vision.

journal_name

Crit Rev Biotechnol

authors

Dettenhofer M,Ondrejovič M,Slavica A,Kurtanjek Ž,Tapaloaga D,Rodian Tapaloaga P,Kapur Pojskić L,Durmić-Pašić A,Begović J,Nedović V,Dundar M,Gartland KMA,Miertuš S

doi

10.1080/07388551.2018.1498443

subject

Has Abstract

pub_date

2019-02-01 00:00:00

pages

137-155

issue

1

eissn

0738-8551

issn

1549-7801

journal_volume

39

pub_type

杂志文章,评审
  • Vitamin K series: current status and future prospects.

    abstract::The Vitamin K series, particularly menaquinone, have been attracting research attention, due to the potential in reducing both osteoporosis and cardiovascular diseases. This review provides an overview of the types of vitamin K and their health benefits. This is followed by a critical review of the various biotechnolo...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.832142

    authors: Berenjian A,Mahanama R,Kavanagh J,Dehghani F

    更新日期:2015-06-01 00:00:00

  • Hydrodynamic cavitation as a strategy to enhance the efficiency of lignocellulosic biomass pretreatment.

    abstract::Hydrodynamic cavitation (HC) is a process technology with potential for application in different areas including environmental, food processing, and biofuels production. Although HC is an undesirable phenomenon for hydraulic equipment, the net energy released during this process is enough to accelerate certain chemica...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2017.1369932

    authors: Terán Hilares R,Ramos L,da Silva SS,Dragone G,Mussatto SI,Santos JCD

    更新日期:2018-06-01 00:00:00

  • Chymosin and other milk coagulants: sources and biotechnological interventions.

    abstract::Calf rennet, which consists of over 90% chymosin, is commonly used in cheese industries for the curdling of milk. Various animal, plant and microbial sources have been exploited as possible alternatives to calf rennet. The coagulating properties of the enzymatic preparations (coagulants) from these sources differ in t...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2010.483459

    authors: Kumar A,Grover S,Sharma J,Batish VK

    更新日期:2010-12-01 00:00:00

  • Transport and transcriptional regulation of oil production in plants.

    abstract::Triacylglycerol (TAG) serves as an energy reservoir and phospholipids as build blocks of biomembrane to support plant life. They also provide human with foods and nutrients. Multi-compartmentalized biosynthesis, trafficking or cross-membrane transport of lipid intermediates or precursors and their regulatory mechanism...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2016.1212185

    authors: Manan S,Chen B,She G,Wan X,Zhao J

    更新日期:2017-08-01 00:00:00

  • Current developments in arbuscular mycorrhizal fungi research and its role in salinity stress alleviation: a biotechnological perspective.

    abstract::Arbuscular mycorrhizal fungi (AMF) form widespread symbiotic associations with 80% of known land plants. They play a major role in plant nutrition, growth, water absorption, nutrient cycling and protection from pathogens, and as a result, contribute to ecosystem processes. Salinity stress conditions undoubtedly limit ...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2014.899964

    authors: Kumar A,Dames JF,Gupta A,Sharma S,Gilbert JA,Ahmad P

    更新日期:2015-01-01 00:00:00

  • Polyhydroxyalkanoates - what are the uses? Current challenges and perspectives.

    abstract::Over the past few decades, a considerable attention has been focused on the microbial polyhydroxyalkanoates (PHAs) owing to its multifaceted properties, i.e. biodegradability, biocompatibility, non-toxicity and thermo-plasticity. This article presents a critical review of the foregoing research, current trends and fut...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2014.913548

    authors: Masood F,Yasin T,Hameed A

    更新日期:2015-01-01 00:00:00

  • The filamentous fungal pellet and forces driving its formation.

    abstract::Filamentous fungi play an important role not only in the bio-manufacturing of value-added products, but also in bioenergy and environmental research. The bioprocess manipulation of filamentous fungi is more difficult than that of other microbial species because of their different pellet morphologies and the presence o...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2015.1084262

    authors: Zhang J,Zhang J

    更新日期:2016-12-01 00:00:00

  • Advanced technologies for improved expression of recombinant proteins in bacteria: perspectives and applications.

    abstract::Prokaryotic expression systems are superior in producing valuable recombinant proteins, enzymes and therapeutic products. Conventional microbial technology is evolving gradually and amalgamated with advanced technologies in order to give rise to improved processes for the production of metabolites, recombinant biophar...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2015.1084264

    authors: Gupta SK,Shukla P

    更新日期:2016-12-01 00:00:00

  • Advances in directed molecular evolution of reporter genes.

    abstract::Many reporter genes, such as gfp, gusA, and lacZ, are widely used for research into plants, animals, and microorganisms. Reporter genes, which offer high levels of sensitivity and convenience of detection, have been utilized in transgenic technology, promoter analysis, drug screening, and other areas. Directed molecul...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2011.593503

    authors: Xiong AS,Peng RH,Zhuang J,Davies J,Zhang J,Yao QH

    更新日期:2012-06-01 00:00:00

  • Homogeneous biocatalysis in organic solvents and water-organic mixtures.

    abstract::Biocatalysis in non-aqueous media has undergone tremendous development during the last decade, and numerous reactions have been introduced and optimized for synthetic applications. In contrast to aqueous enzymology, biotransformations in organic solvents offer unique industrially attractive advantages, such as: drasti...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:

    authors: Castro GR,Knubovets T

    更新日期:2003-01-01 00:00:00

  • Hydrogel-based methods for engineering cellular microenvironment with spatiotemporal gradients.

    abstract::Natural cellular microenvironment consists of spatiotemporal gradients of multiple physical (e.g. extracellular matrix stiffness, porosity and stress/strain) and chemical cues (e.g. morphogens), which play important roles in regulating cell behaviors including spreading, proliferation, migration, differentiation and a...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2014.993588

    authors: Wang L,Li Y,Huang G,Zhang X,Pingguan-Murphy B,Gao B,Lu TJ,Xu F

    更新日期:2016-01-01 00:00:00

  • Recent trends in ionic liquid (IL) tolerant enzymes and microorganisms for biomass conversion.

    abstract::Second generation biofuel production depends on lignocellulosic (LC) biomass transformation into simple sugars and their subsequent fermentation into alcohols. However, the main obstacle in this process is the efficient breakdown of the recalcitrant cellulose to sugar monomers. Hence, efficient feedstock pretreatment ...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.843069

    authors: Portillo Mdel C,Saadeddin A

    更新日期:2015-01-01 00:00:00

  • Developments in the study and applications of bacterial transformations of selenium species.

    abstract::Microbial bio-transformations of the essential trace element selenium are now recognized to occur among a wide variety of microorganisms. These transformations are used to convert this element into its assimilated form of selenocysteine, which is at the active center of a number of key enzymes, and to produce selenium...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2020.1811199

    authors: Ojeda JJ,Merroun ML,Tugarova AV,Lampis S,Kamnev AA,Gardiner PHE

    更新日期:2020-12-01 00:00:00

  • Enhancing mainstream nitrogen removal by employing nitrate/nitrite-dependent anaerobic methane oxidation processes.

    abstract::Due to serious eutrophication in water bodies, nitrogen removal has become a critical stage for wastewater treatment plants (WWTPs) over past decades. Conventional biological nitrogen removal processes are based on nitrification and denitrification (N/DN), and are suffering from several major drawbacks, including subs...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2019.1598333

    authors: Liu T,Hu S,Guo J

    更新日期:2019-08-01 00:00:00

  • Microbial diversity in support of anaerobic biomass valorization.

    abstract::Microbial diversity provides an immense reservoir of functions and supports key steps in maintaining ecosystem balance through matter decomposition processes and nutrient recycling. The use of microorganisms for biomolecule production is now common, but often involves single-strain cultures. In this review, we highlig...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2015.1100584

    authors: Jobard M,Pessiot J,Nouaille R,Fonty G,Sime-Ngando T

    更新日期:2017-02-01 00:00:00

  • Solid-state fermentation systems-an overview.

    abstract::Starting with a brief history of solid-state fermentation (SSF), major aspects of SSF are reviewed, which include factors affecting SSF, biomass, fermentors, modeling, industrial microbial enzymes, organic acids, secondary metabolites, and bioremediation. Physico-chemical and environmental factors such as inoculum typ...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388550590925383

    authors: Krishna C

    更新日期:2005-01-01 00:00:00

  • White rot fungi and advanced combined biotechnology with nanomaterials: promising tools for endocrine-disrupting compounds biotransformation.

    abstract::Endocrine-disrupting compounds (EDCs) can interfere with endocrine systems and bio-accumulate through the food chain and even decrease biodiversity in contaminated areas. This review discusses a critical overview of recent research progress in the biotransformation of EDCs (including polychlorinated biphenyl and nonyl...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2017.1386613

    authors: Huang D,Guo X,Peng Z,Zeng G,Xu P,Gong X,Deng R,Xue W,Wang R,Yi H,Liu C

    更新日期:2018-08-01 00:00:00

  • Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges.

    abstract::Cross-linked enzyme aggregate (CLEA) technology has been regarded as an effective carrier-free immobilization method. This method is very attractive due to its simplicity and robustness, as well as for the possibility of using the crude enzyme extract and the opportunity to co-immobilize multiple different enzymes. Th...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.795516

    authors: Cui JD,Jia SR

    更新日期:2015-03-01 00:00:00

  • Bioconversion of renewable resources into lactic acid: an industrial view.

    abstract::Lactic acid, an anaerobic product of glycolysis, can be theoretically produced by synthetic route; however, it is commercially produced by homo-fermentative batch mode of operations. Factors affecting its production and strategies improving it are considered while devising an optimized protocol. Although a hetero-ferm...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388550903420970

    authors: Yadav AK,Chaudhari AB,Kothari RM

    更新日期:2011-03-01 00:00:00

  • Endophytes, biotransforming microorganisms, and engineering microbial factories for triterpenoid saponins production.

    abstract::Triterpenoid saponins are structurally diverse secondary metabolites. They are the main active ingredient of many medicinal plants and have a wide range of pharmacological effects. Traditional production of triterpenoid saponins, directly extracted from cultivated plants, cannot meet the rapidly growing demand of phar...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2020.1869691

    authors: Yao L,Wang J,He J,Huang L,Gao W

    更新日期:2021-01-20 00:00:00

  • Impact of host cell line choice on glycan profile.

    abstract::Protein glycosylation is post-translational modification (PTM) which is important for pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result of variations in monosaccharide composition, glycosidic linkages and glycan branching, glycosylation introduces considerable complexity and het...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2017.1416577

    authors: Goh JB,Ng SK

    更新日期:2018-09-01 00:00:00

  • Multifaceted roles of aquaporins as molecular conduits in plant responses to abiotic stresses.

    abstract::Abiotic stress has become a challenge to food security due to occurrences of climate change and environmental degradation. Plants initiate molecular, cellular and physiological changes to respond and adapt to various types of abiotic stress. Understanding of plant response mechanisms will aid in strategies aimed at im...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2014.973367

    authors: Srivastava AK,Penna S,Nguyen DV,Tran LS

    更新日期:2016-01-01 00:00:00

  • Green synthesis approach: extraction of chitosan from fungus mycelia.

    abstract::Chitosan, copolymer of glucosamine and N-acetyl glucosamine is mainly derived from chitin, which is present in cell walls of crustaceans and some other microorganisms, such as fungi. Chitosan is emerging as an important biopolymer having a broad range of applications in different fields. On a commercial scale, chitosa...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2012.717217

    authors: Dhillon GS,Kaur S,Brar SK,Verma M

    更新日期:2013-12-01 00:00:00

  • Seed biology and in vitro seed germination of Cypripedium.

    abstract::Cypripedium orchids have high horticultural value. The populations of most species are very geographically restricted and they are becoming increasingly rare due to the destruction of native habitats and illegal collection. Reduction of the commercial value through large-scale propagation in vitro is a preferable opti...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.841117

    authors: Zeng S,Zhang Y,Teixeira da Silva JA,Wu K,Zhang J,Duan J

    更新日期:2014-12-01 00:00:00

  • Metabolic engineering of plant L-ascorbic acid biosynthesis: recent trends and applications.

    abstract::Vitamin C (L-ascorbic acid; AsA) is the major soluble antioxidant found in plants and is also an essential component of human nutrition. Although numerous biotechnological methods have been exploited to increase its yield, pressures such as commercial competition and environmental concerns make it urgent to find a new...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388550701503626

    authors: Zhang L,Wang Z,Xia Y,Kai G,Chen W,Tang K

    更新日期:2007-07-01 00:00:00

  • Endophytic fungi: resource for gibberellins and crop abiotic stress resistance.

    abstract::The beneficial effects of endophytes on plant growth are important for agricultural ecosystems because they reduce the need for fertilizers and decrease soil and water pollution while compensating for environmental perturbations. Endophytic fungi are a novel source of bioactive secondary metabolites; moreover, recentl...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.800018

    authors: Khan AL,Hussain J,Al-Harrasi A,Al-Rawahi A,Lee IJ

    更新日期:2015-03-01 00:00:00

  • Protein secretion in Corynebacterium glutamicum.

    abstract::Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the industrial production of amino acids, such as glutamate and lysine, for decades. Due to several characteristics - its ability to secrete properly folded and functional target proteins into culture broth, its low levels of endogenous ex...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2016.1206059

    authors: Liu X,Zhang W,Zhao Z,Dai X,Yang Y,Bai Z

    更新日期:2017-06-01 00:00:00

  • Plants endophytes: unveiling hidden agenda for bioprospecting toward sustainable agriculture.

    abstract::Endophytic microbes are present in nearly all of the plant species known to date but how they enter and flourish inside a host plant and display multiple benefits like plant growth promotion (PGP), biodegradation, and stress alleviation are still unexplored. Until now, the majority of the research has been conducted a...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2020.1808584

    authors: Dubey A,Malla MA,Kumar A,Dayanandan S,Khan ML

    更新日期:2020-12-01 00:00:00

  • Biotechnological potential of microbial α-galactosidases.

    abstract::The enzyme α-galactosidase (α-D-galactoside galactohydrolase; EC 3.2.1.22) catalyzes the hydrolysis of α-1,6-linked galactose residues in oligosaccharides and polymeric galactomannan. The α-galactosidases are of particular interest in view of their many potential biotechnological and medical applications. These enzyme...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.794124

    authors: Katrolia P,Rajashekhara E,Yan Q,Jiang Z

    更新日期:2014-12-01 00:00:00

  • Methodologies for the isolation of alternative binders with improved clinical potentiality over conventional antibodies.

    abstract::The availability of binders to different functional domains of the same protein or to physiologically co-operating proteins allows for the simultaneous inhibition of independent downstream signaling pathways. This multi-target approach represents a promising therapeutic strategy, as demonstrated in the case of the syn...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2012.665353

    authors: de Marco A

    更新日期:2013-03-01 00:00:00