Methodologies for the isolation of alternative binders with improved clinical potentiality over conventional antibodies.

abstract：:Lactic acid, an anaerobic product of glycolysis, can be theoretically produced by synthetic route; however, it is commercially produced by homo-fermentative batch mode of operations. Factors affecting its production and strategies improving it are considered while devising an optimized protocol. Although a hetero-ferm...

journal_title：Critical reviews in biotechnology

authors： Yadav AK,Chaudhari AB,Kothari RM

更新日期：2011-03-01 00:00:00

abstract：:Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the industrial production of amino acids, such as glutamate and lysine, for decades. Due to several characteristics - its ability to secrete properly folded and functional target proteins into culture broth, its low levels of endogenous ex...

journal_title：Critical reviews in biotechnology

authors： Liu X,Zhang W,Zhao Z,Dai X,Yang Y,Bai Z

更新日期：2017-06-01 00:00:00

abstract：:Butanol is a precursor of many industrial chemicals, and a fuel that is more energetic, safer and easier to handle than ethanol. Fermentative biobutanol can be produced using renewable carbon sources such as agro-industrial residues and lignocellulosic biomass. Solventogenic clostridia are known as the most preeminent...

journal_title：Critical reviews in biotechnology

authors： Jiménez-Bonilla P,Wang Y

更新日期：2018-05-01 00:00:00

abstract：:Many algae have immense capability to sorb metals, and there is considerable potential for using them to treat wastewaters. Metal sorption involves binding on the cell surface and to intracellular ligands. The adsorbed metal is several times greater than intracellular metal. Carboxyl group is most important for metal ...

journal_title：Critical reviews in biotechnology

authors： Mehta SK,Gaur JP

更新日期：2005-07-01 00:00:00

abstract：:Anthocyanin biosynthesis in Arabidopsis is a convenient and relatively simple model for investigating the basic principles of secondary metabolism regulation. In recent years, many publications have described links between anthocyanin biosynthesis and general defense reactions in plants as well as photomorphogenesis a...

journal_title：Critical reviews in biotechnology

authors： Bulgakov VP,Avramenko TV,Tsitsiashvili GS

更新日期：2017-09-01 00:00:00

abstract：:Hydrodynamic cavitation (HC) is a process technology with potential for application in different areas including environmental, food processing, and biofuels production. Although HC is an undesirable phenomenon for hydraulic equipment, the net energy released during this process is enough to accelerate certain chemica...

journal_title：Critical reviews in biotechnology

authors： Terán Hilares R,Ramos L,da Silva SS,Dragone G,Mussatto SI,Santos JCD

更新日期：2018-06-01 00:00:00

abstract：:Endophytic microbes are present in nearly all of the plant species known to date but how they enter and flourish inside a host plant and display multiple benefits like plant growth promotion (PGP), biodegradation, and stress alleviation are still unexplored. Until now, the majority of the research has been conducted a...

journal_title：Critical reviews in biotechnology

authors： Dubey A,Malla MA,Kumar A,Dayanandan S,Khan ML

更新日期：2020-12-01 00:00:00

abstract：:The role of selenium (Se) in human health and diseases has been discussed in detail in several recent reviews, with the main conclusion being that selenium deficiency is recognised as a global problem which urgently needs resolution. Since selenium content in plant-based food depends on its availability from soil, the...

journal_title：Critical reviews in biotechnology

authors： Fisinin VI,Papazyan TT,Surai PF

更新日期：2009-01-01 00:00:00

abstract：:Cross-linked enzyme aggregate (CLEA) technology has been regarded as an effective carrier-free immobilization method. This method is very attractive due to its simplicity and robustness, as well as for the possibility of using the crude enzyme extract and the opportunity to co-immobilize multiple different enzymes. Th...

journal_title：Critical reviews in biotechnology

authors： Cui JD,Jia SR

更新日期：2015-03-01 00:00:00

abstract：:Many reporter genes, such as gfp, gusA, and lacZ, are widely used for research into plants, animals, and microorganisms. Reporter genes, which offer high levels of sensitivity and convenience of detection, have been utilized in transgenic technology, promoter analysis, drug screening, and other areas. Directed molecul...

journal_title：Critical reviews in biotechnology

authors： Xiong AS,Peng RH,Zhuang J,Davies J,Zhang J,Yao QH

更新日期：2012-06-01 00:00:00

abstract：:Calf rennet, which consists of over 90% chymosin, is commonly used in cheese industries for the curdling of milk. Various animal, plant and microbial sources have been exploited as possible alternatives to calf rennet. The coagulating properties of the enzymatic preparations (coagulants) from these sources differ in t...

journal_title：Critical reviews in biotechnology

authors： Kumar A,Grover S,Sharma J,Batish VK

更新日期：2010-12-01 00:00:00

abstract：:Filamentous fungi comprise an abundance of gene clusters that encode high-value metabolites, whereas affluent gene clusters remain silent during laboratory conditions. Complex cellular metabolism further limits these metabolite yields. Therefore, diverse strategies such as genetic engineering and chemical mutagenesis ...

journal_title：Critical reviews in biotechnology

authors： Deng H,Bai Y,Fan TP,Zheng X,Cai Y

更新日期：2020-03-01 00:00:00

abstract：:Alginate has been widely used in various applications since its first extraction. What makes this biopolymer useful is its high biocompatibility and humid gelation conditions. Both of these features bring it into prominence as an ideal immobilization material. However, there are some complicated aspects of cell immobi...

journal_title：Critical reviews in biotechnology

authors： Selimoglu SM,Elibol M

更新日期：2010-06-01 00:00:00

abstract：:Natural cellular microenvironment consists of spatiotemporal gradients of multiple physical (e.g. extracellular matrix stiffness, porosity and stress/strain) and chemical cues (e.g. morphogens), which play important roles in regulating cell behaviors including spreading, proliferation, migration, differentiation and a...

journal_title：Critical reviews in biotechnology

authors： Wang L,Li Y,Huang G,Zhang X,Pingguan-Murphy B,Gao B,Lu TJ,Xu F

更新日期：2016-01-01 00:00:00

abstract：:Protein glycosylation is post-translational modification (PTM) which is important for pharmacokinetics and immunogenicity of recombinant glycoprotein therapeutics. As a result of variations in monosaccharide composition, glycosidic linkages and glycan branching, glycosylation introduces considerable complexity and het...

journal_title：Critical reviews in biotechnology

authors： Goh JB,Ng SK

更新日期：2018-09-01 00:00:00

abstract：:Triterpenoid saponins are structurally diverse secondary metabolites. They are the main active ingredient of many medicinal plants and have a wide range of pharmacological effects. Traditional production of triterpenoid saponins, directly extracted from cultivated plants, cannot meet the rapidly growing demand of phar...

journal_title：Critical reviews in biotechnology

authors： Yao L,Wang J,He J,Huang L,Gao W

更新日期：2021-01-20 00:00:00

abstract：:Lipopolysaccharide (LPS), the major component of the outer membrane of Gram-negative bacteria, often pose a serious risk not only when delivered in the bloodstream but also in air, the environment and several industrial fields such as pharmaceutics or food. LPS is constituted of three regions; the O-specific chain, th...

journal_title：Critical reviews in biotechnology

authors： Basauri A,González-Fernández C,Fallanza M,Bringas E,Fernandez-Lopez R,Giner L,Moncalián G,de la Cruz F,Ortiz I

更新日期：2020-05-01 00:00:00

abstract：:Briskly evolving phytopathogens are dire threats to our food supplies and threaten global food security. From the recent advances made toward high-throughput sequencing technologies, understanding of pathogenesis and effector biology, and plant innate immunity, translation of these means into new control tools is bein...

journal_title：Critical reviews in biotechnology

authors： Nejat N,Rookes J,Mantri NL,Cahill DM

更新日期：2017-03-01 00:00:00

abstract：:Utilization of microbial oil for biodiesel production has gained growing interest due to the increase in prices and the shortage of the oils and fats traditionally used in biodiesel production. However, it is still in the laboratory study stage due to the high cost of production. Employing organic wastes as raw materi...

journal_title：Critical reviews in biotechnology

authors： Chen J,Li J,Zhang X,Tyagi RD,Dong W

更新日期：2018-09-01 00:00:00

abstract：:Salt-tolerant plants grow in a wide variety of saline habitats, from coastal regions, salt marshes and mudflats to inland deserts, salt flats and steppes. Halophytes living in these extreme environments have to deal with frequent changes in salinity level. This can be done by developing adaptive responses including th...

journal_title：Critical reviews in biotechnology

authors： Ksouri R,Ksouri WM,Jallali I,Debez A,Magné C,Hiroko I,Abdelly C

更新日期：2012-12-01 00:00:00

abstract：:Arbuscular mycorrhizal fungi (AMF) form widespread symbiotic associations with 80% of known land plants. They play a major role in plant nutrition, growth, water absorption, nutrient cycling and protection from pathogens, and as a result, contribute to ecosystem processes. Salinity stress conditions undoubtedly limit ...

journal_title：Critical reviews in biotechnology

authors： Kumar A,Dames JF,Gupta A,Sharma S,Gilbert JA,Ahmad P

更新日期：2015-01-01 00:00:00

abstract：:The enzyme α-galactosidase (α-D-galactoside galactohydrolase; EC 3.2.1.22) catalyzes the hydrolysis of α-1,6-linked galactose residues in oligosaccharides and polymeric galactomannan. The α-galactosidases are of particular interest in view of their many potential biotechnological and medical applications. These enzyme...

journal_title：Critical reviews in biotechnology

authors： Katrolia P,Rajashekhara E,Yan Q,Jiang Z

更新日期：2014-12-01 00:00:00

abstract：:Cancer is a clinical situation caused by uncontrolled cell division and is responsible for a large number of deaths worldwide. Colchicine is a classical antimitotic, tubulin-binding agent (TBA) which is being explored for its antitumor activities, although its tubulin-binding ability leads to some toxicity toward norm...

journal_title：Critical reviews in biotechnology

authors： Dubey KK,Kumar P,Labrou NE,Shukla P

更新日期：2017-12-01 00:00:00

abstract：:Human body harbors diverse microbes, the main components include bacteria, eukaryotes and viruses. Emerging evidences show that the human microbiota is intrinsically linked with overall health. The development of next-generation sequencing provides an unprecedented opportunity to investigate the complex microbial comm...

journal_title：Critical reviews in biotechnology

authors： Xu X,Wang Z,Zhang X

更新日期：2015-03-01 00:00:00

abstract：:Microorganisms have the tendency to accumulate at interfaces through the release of extracellular polymeric substances to form aggregates such as films or flocs. This physical association leads to different modes of interactions among cells and the subsequent development of functionally and metabolically diverse conso...

journal_title：Critical reviews in biotechnology

authors： Srivastava A,Seo SH,Ko SR,Ahn CY,Oh HM

更新日期：2018-12-01 00:00:00

abstract：:Small RNAs (sRNA) are reported to play pivotal roles in the epigenetic and post-transcriptional regulation of gene expression during growth, development, and stress response in plants. Recently, the involvement of two different classes of sRNAs namely, miRNAs (microRNAs), and siRNAs (small interfering RNAs) in biotic ...

journal_title：Critical reviews in biotechnology

authors： Prasad A,Sharma N,Muthamilarasan M,Rana S,Prasad M

更新日期：2019-06-01 00:00:00

abstract：:Filamentous fungi play an important role not only in the bio-manufacturing of value-added products, but also in bioenergy and environmental research. The bioprocess manipulation of filamentous fungi is more difficult than that of other microbial species because of their different pellet morphologies and the presence o...

journal_title：Critical reviews in biotechnology

authors： Zhang J,Zhang J

更新日期：2016-12-01 00:00:00

abstract：:The acetic acid bacteria (AAB) have important roles in food and beverage production, as well as in the bioproduction of industrial chemicals. In recent years, there have been major advances in understanding their taxonomy, molecular biology, and physiology, and in methods for their isolation and identification. AAB ar...

journal_title：Critical reviews in biotechnology

authors： Raspor P,Goranovic D

更新日期：2008-01-01 00:00:00

abstract：:α-d-Galactosidases (EC 3.2.1.22) are enzymes employed in a number of useful bio-based applications. We have depicted a comprehensive general survey of α-d-galactosidases from different origin with special emphasis on marine example(s). The structures of natural α-galactosyl containing compounds are described. In addit...

journal_title：Critical reviews in biotechnology

authors： Bakunina IY,Balabanova LA,Pennacchio A,Trincone A

更新日期：2016-01-01 00:00:00

abstract：:Experimental design is a form of process analysis in which certain factors are selected to obtain the desired responses of interest. It may also be used for the determination of the effects of various independent factors on a dependent factor. The bioengineering discipline includes many different areas of scientific i...

journal_title：Critical reviews in biotechnology

authors： Keskin Gündoğdu T,Deniz İ,Çalışkan G,Şahin ES,Azbar N

更新日期：2016-01-01 00:00:00