Current trends in endotoxin detection and analysis of endotoxin-protein interactions.

Abstract:

:Endotoxin is a type of pyrogen that can be found in Gram-negative bacteria. Endotoxin can form a stable interaction with other biomolecules thus making its removal difficult especially during the production of biopharmaceutical drugs. The prevention of endotoxins from contaminating biopharmaceutical products is paramount as endotoxin contamination, even in small quantities, can result in fever, inflammation, sepsis, tissue damage and even lead to death. Highly sensitive and accurate detection of endotoxins are keys in the development of biopharmaceutical products derived from Gram-negative bacteria. It will facilitate the study of the intermolecular interaction of an endotoxin with other biomolecules, hence the selection of appropriate endotoxin removal strategies. Currently, most researchers rely on the conventional LAL-based endotoxin detection method. However, new methods have been and are being developed to overcome the problems associated with the LAL-based method. This review paper highlights the current research trends in endotoxin detection from conventional methods to newly developed biosensors. Additionally, it also provides an overview of the use of electron microscopy, dynamic light scattering (DLS), fluorescence resonance energy transfer (FRET) and docking programs in the endotoxin-protein analysis.

journal_name

Crit Rev Biotechnol

authors

Dullah EC,Ongkudon CM

doi

10.3109/07388551.2016.1141393

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

251-261

issue

2

eissn

0738-8551

issn

1549-7801

journal_volume

37

pub_type

杂志文章,评审
  • Medicinal halophytes: potent source of health promoting biomolecules with medical, nutraceutical and food applications.

    abstract::Salt-tolerant plants grow in a wide variety of saline habitats, from coastal regions, salt marshes and mudflats to inland deserts, salt flats and steppes. Halophytes living in these extreme environments have to deal with frequent changes in salinity level. This can be done by developing adaptive responses including th...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2011.630647

    authors: Ksouri R,Ksouri WM,Jallali I,Debez A,Magné C,Hiroko I,Abdelly C

    更新日期:2012-12-01 00:00:00

  • Biotechnological potential of microbial α-galactosidases.

    abstract::The enzyme α-galactosidase (α-D-galactoside galactohydrolase; EC 3.2.1.22) catalyzes the hydrolysis of α-1,6-linked galactose residues in oligosaccharides and polymeric galactomannan. The α-galactosidases are of particular interest in view of their many potential biotechnological and medical applications. These enzyme...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.794124

    authors: Katrolia P,Rajashekhara E,Yan Q,Jiang Z

    更新日期:2014-12-01 00:00:00

  • Metabolic engineering of plant L-ascorbic acid biosynthesis: recent trends and applications.

    abstract::Vitamin C (L-ascorbic acid; AsA) is the major soluble antioxidant found in plants and is also an essential component of human nutrition. Although numerous biotechnological methods have been exploited to increase its yield, pressures such as commercial competition and environmental concerns make it urgent to find a new...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388550701503626

    authors: Zhang L,Wang Z,Xia Y,Kai G,Chen W,Tang K

    更新日期:2007-07-01 00:00:00

  • Optimization protocols and improved strategies of cross-linked enzyme aggregates technology: current development and future challenges.

    abstract::Cross-linked enzyme aggregate (CLEA) technology has been regarded as an effective carrier-free immobilization method. This method is very attractive due to its simplicity and robustness, as well as for the possibility of using the crude enzyme extract and the opportunity to co-immobilize multiple different enzymes. Th...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.795516

    authors: Cui JD,Jia SR

    更新日期:2015-03-01 00:00:00

  • Plant-pathogen interactions: toward development of next-generation disease-resistant plants.

    abstract::Briskly evolving phytopathogens are dire threats to our food supplies and threaten global food security. From the recent advances made toward high-throughput sequencing technologies, understanding of pathogenesis and effector biology, and plant innate immunity, translation of these means into new control tools is bein...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2015.1134437

    authors: Nejat N,Rookes J,Mantri NL,Cahill DM

    更新日期:2017-03-01 00:00:00

  • Endophytes, biotransforming microorganisms, and engineering microbial factories for triterpenoid saponins production.

    abstract::Triterpenoid saponins are structurally diverse secondary metabolites. They are the main active ingredient of many medicinal plants and have a wide range of pharmacological effects. Traditional production of triterpenoid saponins, directly extracted from cultivated plants, cannot meet the rapidly growing demand of phar...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2020.1869691

    authors: Yao L,Wang J,He J,Huang L,Gao W

    更新日期:2021-01-20 00:00:00

  • Enzyme research and applications in biotechnological intensification of biogas production.

    abstract::Biogas technology provides an alternative source of energy to fossil fuels in many parts of the world. Using local resources such as agricultural crop remains, municipal solid wastes, market wastes and animal waste, energy (biogas), and manure are derived by anaerobic digestion. The hydrolysis process, where the compl...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2011.595384

    authors: Parawira W

    更新日期:2012-06-01 00:00:00

  • Protein secretion in Corynebacterium glutamicum.

    abstract::Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the industrial production of amino acids, such as glutamate and lysine, for decades. Due to several characteristics - its ability to secrete properly folded and functional target proteins into culture broth, its low levels of endogenous ex...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2016.1206059

    authors: Liu X,Zhang W,Zhao Z,Dai X,Yang Y,Bai Z

    更新日期:2017-06-01 00:00:00

  • Hooked on α-d-galactosidases: from biomedicine to enzymatic synthesis.

    abstract::α-d-Galactosidases (EC 3.2.1.22) are enzymes employed in a number of useful bio-based applications. We have depicted a comprehensive general survey of α-d-galactosidases from different origin with special emphasis on marine example(s). The structures of natural α-galactosyl containing compounds are described. In addit...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2014.949618

    authors: Bakunina IY,Balabanova LA,Pennacchio A,Trincone A

    更新日期:2016-01-01 00:00:00

  • A methodological combined framework for roadmapping biosensor research: a fault tree analysis approach within a strategic technology evaluation frame.

    abstract::Biosensor technology began in the 1960s to revolutionize instrumentation and measurement. Despite the glucose sensor market success that revolutionized medical diagnostics, and artificial pancreas promise currently the approval stage, the industry is reluctant to capitalize on other relevant university-produced knowle...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.790339

    authors: Siontorou CG,Batzias FA

    更新日期:2014-03-01 00:00:00

  • Recent advances in small RNA mediated plant-virus interactions.

    abstract::Small RNAs (sRNA) are reported to play pivotal roles in the epigenetic and post-transcriptional regulation of gene expression during growth, development, and stress response in plants. Recently, the involvement of two different classes of sRNAs namely, miRNAs (microRNAs), and siRNAs (small interfering RNAs) in biotic ...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2019.1597830

    authors: Prasad A,Sharma N,Muthamilarasan M,Rana S,Prasad M

    更新日期:2019-06-01 00:00:00

  • Technological trends and market perspectives for production of microbial oils rich in omega-3.

    abstract::In recent years, foods that contain omega-3 lipids have emerged as important promoters of human health. These lipids are essential for the functional development of the brain and retina, and reduction of the risk of cardiovascular and Alzheimer's diseases. The global market for omega-3 production, particularly docosah...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2016.1213221

    authors: Finco AMO,Mamani LDG,Carvalho JC,de Melo Pereira GV,Thomaz-Soccol V,Soccol CR

    更新日期:2017-08-01 00:00:00

  • Producing selenium-enriched eggs and meat to improve the selenium status of the general population.

    abstract::The role of selenium (Se) in human health and diseases has been discussed in detail in several recent reviews, with the main conclusion being that selenium deficiency is recognised as a global problem which urgently needs resolution. Since selenium content in plant-based food depends on its availability from soil, the...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388550802658030

    authors: Fisinin VI,Papazyan TT,Surai PF

    更新日期:2009-01-01 00:00:00

  • A review on the nucleic acid constituents in mushrooms: nucleobases, nucleosides and nucleotides.

    abstract::Mushrooms have become increasingly important as a reliable food source. They have also been recognized as an important source of bioactive compounds of high nutritional and medicinal values. The nucleobases, nucleosides and nucleotides found in mushrooms play important roles in the regulation of various physiological ...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2017.1399102

    authors: Phan CW,Wang JK,Cheah SC,Naidu M,David P,Sabaratnam V

    更新日期:2018-08-01 00:00:00

  • Carbon, nitrogen and phosphorus removal mechanisms of aerobic granules.

    abstract::Aerobic granules are the potential tools to develop modern wastewater treatment technologies with improved nutrient removal efficiency. These granules have several promising advantages over conventional activated sludge-based wastewater treatment processes. This technology has the potential of reducing the infrastruct...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2018.1451481

    authors: Sarma SJ,Tay JH

    更新日期:2018-11-01 00:00:00

  • Kinetic modeling of Chinese hamster ovary cell culture: factors and principles.

    abstract::As a host for therapeutic protein expression, Chinese hamster ovary (CHO) cells are widely utilized in the mainstream biopharmaceutical industry. Cell culture process development plays an important role in transitioning laboratory research to manufacturing. Among different mathematic tools, kinetic modeling is commonl...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2019.1711015

    authors: Tang P,Xu J,Louey A,Tan Z,Yongky A,Liang S,Li ZJ,Weng Y,Liu S

    更新日期:2020-03-01 00:00:00

  • Bioflocculation in natural and engineered systems: current perspectives.

    abstract::Microorganisms have the tendency to accumulate at interfaces through the release of extracellular polymeric substances to form aggregates such as films or flocs. This physical association leads to different modes of interactions among cells and the subsequent development of functionally and metabolically diverse conso...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2018.1451984

    authors: Srivastava A,Seo SH,Ko SR,Ahn CY,Oh HM

    更新日期:2018-12-01 00:00:00

  • Biological methods for speciation of heavy metals: different approaches.

    abstract::Heavy metals are found in their different forms in the environment. The distribution, mobility, and toxicity of metals are strongly related to these different forms. This necessitates the exploration of different methods for the remediation and speciation of heavy metals. Some direct and indirect physico-chemical meth...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388550903284462

    authors: Singh N,Gadi R

    更新日期:2009-01-01 00:00:00

  • Polyhydroxyalkanoates - what are the uses? Current challenges and perspectives.

    abstract::Over the past few decades, a considerable attention has been focused on the microbial polyhydroxyalkanoates (PHAs) owing to its multifaceted properties, i.e. biodegradability, biocompatibility, non-toxicity and thermo-plasticity. This article presents a critical review of the foregoing research, current trends and fut...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2014.913548

    authors: Masood F,Yasin T,Hameed A

    更新日期:2015-01-01 00:00:00

  • Nitrilase: a promising biocatalyst in industrial applications for green chemistry.

    abstract::Nitrilases are widely distributed in nature and are able to hydrolyze nitriles into their corresponding carboxylic acids and ammonia. In industry, nitrilases have been used as green biocatalysts for the production of high value-added products. To date, biocatalysts are considered to be important alternatives to chemic...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2020.1827367

    authors: Shen JD,Cai X,Liu ZQ,Zheng YG

    更新日期:2021-02-01 00:00:00

  • Endophytic fungi: resource for gibberellins and crop abiotic stress resistance.

    abstract::The beneficial effects of endophytes on plant growth are important for agricultural ecosystems because they reduce the need for fertilizers and decrease soil and water pollution while compensating for environmental perturbations. Endophytic fungi are a novel source of bioactive secondary metabolites; moreover, recentl...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.800018

    authors: Khan AL,Hussain J,Al-Harrasi A,Al-Rawahi A,Lee IJ

    更新日期:2015-03-01 00:00:00

  • Microbial diversity in support of anaerobic biomass valorization.

    abstract::Microbial diversity provides an immense reservoir of functions and supports key steps in maintaining ecosystem balance through matter decomposition processes and nutrient recycling. The use of microorganisms for biomolecule production is now common, but often involves single-strain cultures. In this review, we highlig...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2015.1100584

    authors: Jobard M,Pessiot J,Nouaille R,Fonty G,Sime-Ngando T

    更新日期:2017-02-01 00:00:00

  • Seed biology and in vitro seed germination of Cypripedium.

    abstract::Cypripedium orchids have high horticultural value. The populations of most species are very geographically restricted and they are becoming increasingly rare due to the destruction of native habitats and illegal collection. Reduction of the commercial value through large-scale propagation in vitro is a preferable opti...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.841117

    authors: Zeng S,Zhang Y,Teixeira da Silva JA,Wu K,Zhang J,Duan J

    更新日期:2014-12-01 00:00:00

  • Enzymatic modifications of cephalosporins by cephalosporin acylase and other enzymes.

    abstract::Semisynthetic cephalosporins are important antibacterials in clinical practice. Semisynthetic cephalosporins are manufactured by derivatizing 7-aminocephalosporanic acid (7-ACA) and its desacetylated form. Microbial enzymes such as D-amino acid oxidase, glutaryl-7-ACA acylase and cephalosporin esterase are being used ...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388550600718630

    authors: Sonawane VC

    更新日期:2006-04-01 00:00:00

  • Advances in directed molecular evolution of reporter genes.

    abstract::Many reporter genes, such as gfp, gusA, and lacZ, are widely used for research into plants, animals, and microorganisms. Reporter genes, which offer high levels of sensitivity and convenience of detection, have been utilized in transgenic technology, promoter analysis, drug screening, and other areas. Directed molecul...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2011.593503

    authors: Xiong AS,Peng RH,Zhuang J,Davies J,Zhang J,Yao QH

    更新日期:2012-06-01 00:00:00

  • An overview of fungal biopolymers: bioemulsifiers and biosurfactants compounds production.

    abstract::Fungal biopolymers have gained considerable attention from the scientific community for various applications due to their biological and physicochemical properties. The wide applications in several areas, especially in the food industry as a bioemulsifier and in the agricultural area as a biosurfactant, have expanded ...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2020.1805405

    authors: Luft L,Confortin TC,Todero I,Zabot GL,Mazutti MA

    更新日期:2020-12-01 00:00:00

  • Developments in the study and applications of bacterial transformations of selenium species.

    abstract::Microbial bio-transformations of the essential trace element selenium are now recognized to occur among a wide variety of microorganisms. These transformations are used to convert this element into its assimilated form of selenocysteine, which is at the active center of a number of key enzymes, and to produce selenium...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章

    doi:10.1080/07388551.2020.1811199

    authors: Ojeda JJ,Merroun ML,Tugarova AV,Lampis S,Kamnev AA,Gardiner PHE

    更新日期:2020-12-01 00:00:00

  • Transport and transcriptional regulation of oil production in plants.

    abstract::Triacylglycerol (TAG) serves as an energy reservoir and phospholipids as build blocks of biomembrane to support plant life. They also provide human with foods and nutrients. Multi-compartmentalized biosynthesis, trafficking or cross-membrane transport of lipid intermediates or precursors and their regulatory mechanism...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.1080/07388551.2016.1212185

    authors: Manan S,Chen B,She G,Wan X,Zhao J

    更新日期:2017-08-01 00:00:00

  • Critical analysis of protein signaling networks involved in the regulation of plant secondary metabolism: focus on anthocyanins.

    abstract::Anthocyanin biosynthesis in Arabidopsis is a convenient and relatively simple model for investigating the basic principles of secondary metabolism regulation. In recent years, many publications have described links between anthocyanin biosynthesis and general defense reactions in plants as well as photomorphogenesis a...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2016.1141391

    authors: Bulgakov VP,Avramenko TV,Tsitsiashvili GS

    更新日期:2017-09-01 00:00:00

  • The human microbiota associated with overall health.

    abstract::Human body harbors diverse microbes, the main components include bacteria, eukaryotes and viruses. Emerging evidences show that the human microbiota is intrinsically linked with overall health. The development of next-generation sequencing provides an unprecedented opportunity to investigate the complex microbial comm...

    journal_title:Critical reviews in biotechnology

    pub_type: 杂志文章,评审

    doi:10.3109/07388551.2013.819485

    authors: Xu X,Wang Z,Zhang X

    更新日期:2015-03-01 00:00:00