Abstract:
PURPOSE:Multiple commercial, open-source, and academic software tools exist for objective quantification of lung density in computed tomography (CT) images. The purpose of this study was to evaluate the intersoftware reproducibility of CT lung density measurements. METHODS:Computed tomography images from 50 participants from the COPDGeneTM cohort study were randomly selected for analysis; n = 10 participants across each global initiative for chronic obstructive lung disease (GOLD) grade (GOLD 0-IV). Academic-based groups (n = 4) and commercial vendors (n = 4) participated anonymously to generate CT lung density measurements using their software tools. Computed tomography total lung volume (TLV), percentage of the low attenuation areas in the lung with Hounsfield unit (HU) values below -950HU (LAA950 ), and the HU value corresponding to the 15th percentile on the parenchymal density histogram (Perc15) were included in the analysis. The intersoftware bias and reproducibility coefficient (RDC) was generated with and without quality assurance (QA) for manual correction of the lung segmentation; intrasoftware bias and RDC was also generated by repeated measurements on the same images. RESULTS:Intersoftware mean bias was within ±0.22 mL, ±0.46%, and ±0.97 HU for TLV, LAA950 and Perc15, respectively. The RDC was 0.35 L, 1.2% and 1.8 HU for TLV, LAA950 and Perc15, respectively. Intersoftware RDC remained unchanged following QA: 0.35 L, 1.2% and 1.8 HU for TLV, LAA950 and Perc15, respectively. All software investigated had an intrasoftware RDC of 0. The RDC was comparable for TLV, LAA950 and Perc15 measurements, respectively, for academic-based groups/commercial vendor-based software tools: 0.39 L/0.32 L, 1.2%/1.2%, and 1.7 HU/1.6 HU. Multivariable regression analysis showed that academic-based software tools had greater within-subject standard deviation of TLV than commercial vendors, but no significant differences between academic and commercial groups were found for LAA950 or Perc15 measurements. CONCLUSIONS:Computed tomography total lung volume and lung density measurement bias and reproducibility was reported across eight different software tools. Bias was negligible across vendors, reproducibility was comparable for software tools generated by academic-based groups and commercial vendors, and segmentation QA had negligible impact on measurement variability between software tools. In summary, results from this study report the amount of additional measurement variability that should be accounted for when using different software tools to measure lung density longitudinally with well-standardized image acquisition protocols. However, intrasoftware reproducibility was deterministic for all cases so use of the same software tool to reduce variability for serial studies is highly recommended.
journal_name
Med Physjournal_title
Medical physicsauthors
Kirby M,Hatt C,Obuchowski N,Humphries SM,Sieren J,Lynch DA,Fain SB,QIBA Lung Density Committee.doi
10.1002/mp.14130subject
Has Abstractpub_date
2020-07-01 00:00:00pages
2962-2969issue
7eissn
0094-2405issn
2473-4209journal_volume
47pub_type
杂志文章相关文献
MEDICAL PHYSICS文献大全abstract:PURPOSE:Brachytherapy with 106 Ru/106 Rh plaques offers good outcomes for small-to-medium choroidal melanomas and retinoblastomas. The dose measurement of the plaques is challenging, due to the small range of the emitted beta particles and steep dose gradients involved. The scarce publications on film dosimetry of 106 ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12777
更新日期:2018-04-01 00:00:00
abstract::In proton therapy, it is important to evaluate the field irradiated with protons and the deposited dose distribution in a patient's body. Positron emitters generated through fragmentation reactions of target nuclei can be used for this purpose. By detecting the annihilation gamma rays from the positron emitters, the a...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2712572
更新日期:2007-05-01 00:00:00
abstract:PURPOSE:It is important for many quantitative brain studies to label meaningful anatomical regions in MR brain images. However, due to high complexity of brain structures and ambiguous boundaries between different anatomical regions, the anatomical labeling of MR brain images is still quite a challenging task. In many ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4940399
更新日期:2016-02-01 00:00:00
abstract:PURPOSE:To design a fast Winston Lutz (fWL) algorithm for accurate analysis of radiation isocenter from images without edge detection or center of mass calculations. METHODS:An algorithm has been developed to implement the Winston Lutz test for mechanical/ radiation isocenter agreement using an electronic portal imagi...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3524227
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:One technical barrier to patient-specific computed tomography (CT) dosimetry has been the lack of computational tools for the automatic patient-specific multi-organ segmentation of CT images and rapid organ dose quantification. When previous CT images are available for the same body region of the patient, the a...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.14131
更新日期:2020-06-01 00:00:00
abstract::In this paper, we describe an algorithm to segment a needle from a three-dimensional (3D) ultrasound image by using two orthogonal two-dimensional (2D) image projections. Not only is the needle more conspicuous in a projected (volume-rendered) image, but its direction in 3D lies in the plane defined by the projection ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.1538231
更新日期:2003-02-01 00:00:00
abstract:PURPOSE:The extensive use of computed tomography (CT) in diagnostic procedures is accompanied by a growing need for more accurate and patient-specific dosimetry techniques. Optically stimulated luminescent dosimeters (OSLDs) offer a potential solution for patient-specific CT point-based surface dosimetry by measuring a...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4914398
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:The aim of the study was to evaluate the impact of multileaf collimator (MLC) leaf width on treatment adaptation and delivery accuracy for concurrent treatment of the prostate and pelvic lymph nodes with intensity modulated radiation therapy (IMRT). METHODS:Seventy-five kilovoltage cone beam CTs (KV-CBCT) from...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4803499
更新日期:2013-06-01 00:00:00
abstract::Mammography is the most effective method for breast cancer screening available today. However, the low positive predictive value of breast biopsy resulting from mammogram interpretation leads to approximately 70% unnecessary biopsies with benign outcomes. To reduce the high number of unnecessary breast biopsies, sever...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2786864
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:Intraoperative electron radiation therapy (IOERT) involves the delivery of a high radiation dose during tumor resection in a shorter time than other radiation techniques, thus improving local control of tumors. However, a linear accelerator device is needed to produce the beam safely. Mobile linear accelerators...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12482
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:X-ray phase-contrast tomography (PCT) is a rapidly emerging imaging modality for reconstructing estimates of an object's three-dimensional x-ray refractive index distribution. Unlike conventional x-ray computed tomography methods, the statistical properties of the reconstructed images in PCT remain unexplored. ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3267548
更新日期:2010-01-01 00:00:00
abstract::The use of characteristic-line radiation from rare-earth targets bombarded by high-energy (up to 1 MeV) electron beams has been evaluated as an x-ray source for dual energy K-edge subtraction imaging of the human coronary arteries. Two characteristic-line x-ray sources, one using the split K alpha 1 and K alpha 2 line...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.596648
更新日期:1991-09-01 00:00:00
abstract::The variance in the number of x-ray photons absorbed by a detector is derived from theoretical considerations. The distributions in the number of x-ray photons produced by the x-ray tube, transmitted through the patient, and absorbed by the detector are described. These distributions are compounded to yield a distribu...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.595393
更新日期:1983-07-01 00:00:00
abstract:PURPOSE:To quantify detector perturbation effects in megavoltage small photon fields and support the theoretical explanation on the nature of quality correction factors in these conditions. METHODS:In this second paper, a modern approach to radiation dosimetry is defined for any detector and applied to small photon fi...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4930798
更新日期:2015-10-01 00:00:00
abstract:PURPOSE:Automated detection of solitary pulmonary nodules using positron emission tomography (PET) and computed tomography (CT) images shows good sensitivity; however, it is difficult to detect nodules in contact with normal organs, and additional efforts are needed so that the number of false positives (FPs) can be fu...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4948498
更新日期:2016-06-01 00:00:00
abstract::A statistical analysis has been made of ionometrically measured parameters related to the central-axis output, the beam symmetry, the beam flatness, and the depth dose for the 6-MV x-ray beam from the Therac-6 linear accelerator. The means and coefficients of variation of the measurements are determined on a monthly b...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.595642
更新日期:1984-09-01 00:00:00
abstract::In this paper, two new boundary tracing algorithms for segmentation of breast masses are presented. These new algorithms are based on the dynamic programming-based boundary tracing (DPBT) algorithm proposed in Timp and Karssemeijer, [S. Timp and N. Karssemeijer, Med. Phys. 31, 958-971 (2004)] The DPBT algorithm contai...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2791034
更新日期:2007-11-01 00:00:00
abstract::Ultrasound contrast agents consist of microscopically small encapsulated bubbles that oscillate upon insonification. To enhance diagnostic ultrasound imaging techniques and to explore therapeutic applications, these medical microbubbles have been studied with the aid of high-speed photography. We filmed medical microb...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2133718
更新日期:2005-12-01 00:00:00
abstract::The introduction of negative pions into cancer therapy has required the construction of large new proton accelerators together with special magnetic systems to form and direct the pion beam to a patient. A summary is presented of the fundamental properties of pions and of the methods used to study the therapeutic beam...
journal_title:Medical physics
pub_type: 杂志文章,评审
doi:10.1118/1.594868
更新日期:1981-05-01 00:00:00
abstract:PURPOSE:The management of thoracic malignancies with radiation therapy is complicated by continuous target motion. In this study, a real time motion analysis approach is proposed to improve the accuracy of patient setup. METHODS:For 11 lung cancer patients a long training fluoroscopy was acquired before the first trea...
journal_title:Medical physics
pub_type: 临床试验,杂志文章
doi:10.1118/1.4794489
更新日期:2013-04-01 00:00:00
abstract::The NSD equation, D = 1850 x T0.11 x N0.24, is a celebrated transmogrification of Cohen's two well-known collations of data on response to clinical irradiations (3 degrees erythema and 0.90 ablation of skin cancer) in which the relation of D and T is fixed by the data selected by Cohen and the additional constraint th...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.595034
更新日期:1981-11-01 00:00:00
abstract:PURPOSE:To determine the accuracy of VMAT treatment planning and delivery for patients undergoing radiotherapy in the head and neck. METHOD AND MATERIALS:A dosimetric study of a typical head and neck treatment plan has been carried out using Chamber, film and TLD's placed inside an anthropomorphic phantom. Lateral and...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735478
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:To evaluate the availability and performance of pencil beam algorithm for fast neutrons radiotherapy dose calculations and to achieve improvements in universality, speed and inhomogeneities corrections. METHODS:Pencil beam (PB) method uses integration of dose kernel cross field size to estimate dose distributi...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4735630
更新日期:2012-06-01 00:00:00
abstract:PURPOSE:A high resolution, water equivalent, optical and passive x-ray dosimeter has been constructed using plastic scintillator and optical fiber. This dosimeter has a peak edge-on spatial resolution of 100 μm in one dimension, with a 10 μm resolution dosimeter under investigation. The dosimeter design has a potential...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1002/mp.12209
更新日期:2017-05-01 00:00:00
abstract::This paper investigates the effect of the waterproofing sleeve on the calibration of kilovoltage photon beams (50-300 kV). The sleeve effect correction factor, ps has been calculated using the Monte Carlo method as the ratios of the air kerma in an air cavity of a cylindrical chamber without the waterproofing sleeve t...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.598039
更新日期:1997-09-01 00:00:00
abstract:PURPOSE:In a recent paper by Bouchard et al. [Med. Phys. 36(10), 4654-4663 (2009)], a theoretical model of quality correction factors for idealistic so-called plan-class specific reference (PCSR) fields was proposed. The reasoning was founded on the definition of PCSR fields made earlier by Alfonso et al. [Med. Phys. 3...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.3684952
更新日期:2012-03-01 00:00:00
abstract:PURPOSE:Repeated brain MRI scans are performed in many clinical scenarios, such as follow up of patients with tumors and therapy response assessment. In this paper, the authors show an approach to utilize former scans of the patient for the acceleration of repeated MRI scans. METHODS:The proposed approach utilizes the...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4928148
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:Treatments like radiotherapy and focused ultrasound in the abdomen require accurate motion tracking, in order to optimize dosage delivery to the target and minimize damage to critical structures and healthy tissues around the target. 4D ultrasound is a promising modality for motion tracking during such treatmen...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4890091
更新日期:2014-08-01 00:00:00
abstract::Stereotactic X-ray mammography (SM) and ultrasound (US) guidance are both commonly used for breast biopsy. While SM provides three-dimensional (3D) targeting information and US provides real-time guidance, both have limitations. SM is a long and uncomfortable procedure and the US guided procedure is inherently two dim...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.2794175
更新日期:2007-11-01 00:00:00
abstract:PURPOSE:Potential collision between the patient∕couch and the gantry could delay the start of the treatment and reduce clinical efficiency. The ability to accurately detect possible collisions during the treatment planning phase is desired. Such collision detection should account for the specific proton gantry design, ...
journal_title:Medical physics
pub_type: 杂志文章
doi:10.1118/1.4760988
更新日期:2012-11-01 00:00:00